LOCUS       NM_173139               1670 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus G protein subunit alpha transducin 3 (Gnat3),
            mRNA.
ACCESSION   NM_173139 XM_346682
VERSION     NM_173139.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1670)
  AUTHORS   Yamamoto,Y., Yokoyama,T. and Nakamuta,N.
  TITLE     Morphology of GNAT3-immunoreactive chemosensory cells in the nasal
            cavity and pharynx of the rat
  JOURNAL   J Anat 239 (2), 290-306 (2021)
   PUBMED   33677835
  REMARK    GeneRIF: Morphology of GNAT3-immunoreactive chemosensory cells in
            the nasal cavity and pharynx of the rat.
REFERENCE   2  (bases 1 to 1670)
  AUTHORS   Feng,R., Qian,C., Liu,Q., Jin,Y., Liu,L., Li,S., Liao,Y., Zhou,H.,
            Liu,W., Rayner,C.K. and Ma,J.
  TITLE     Expression of sweet taste receptor and gut hormone secretion in
            modelled type 2 diabetes
  JOURNAL   Gen Comp Endocrinol 252, 142-149 (2017)
   PUBMED   28782537
  REMARK    GeneRIF: Sweet taste molecules of T1R2, T1R3, alpha-gustducin and
            TRPM5 in ileum were dramatically higher than those in duodenum
            (P<0.01 for each).
REFERENCE   3  (bases 1 to 1670)
  AUTHORS   Voigt,A., Hubner,S., Lossow,K., Hermans-Borgmeyer,I., Boehm,U. and
            Meyerhof,W.
  TITLE     Genetic labeling of Tas1r1 and Tas2r131 taste receptor cells in
            mice
  JOURNAL   Chem Senses 37 (9), 897-911 (2012)
   PUBMED   23010799
REFERENCE   4  (bases 1 to 1670)
  AUTHORS   Krasteva,G., Canning,B.J., Hartmann,P., Veres,T.Z., Papadakis,T.,
            Muhlfeld,C., Schliecker,K., Tallini,Y.N., Braun,A., Hackstein,H.,
            Baal,N., Weihe,E., Schutz,B., Kotlikoff,M., Ibanez-Tallon,I. and
            Kummer,W.
  TITLE     Cholinergic chemosensory cells in the trachea regulate breathing
  JOURNAL   Proc Natl Acad Sci U S A 108 (23), 9478-9483 (2011)
   PUBMED   21606356
REFERENCE   5  (bases 1 to 1670)
  AUTHORS   Haga,M. and Yoshie,S.
  TITLE     Fixation conditions affect the immunoreactivity of gustducin in rat
            vallate taste buds
  JOURNAL   Arch Histol Cytol 73 (2), 91-93 (2010)
   PUBMED   21566335
  REMARK    GeneRIF: The staining protocols, especially the fixation time,
            cause discrepancies in gustducin immunoreactivities.
REFERENCE   6  (bases 1 to 1670)
  AUTHORS   He,W., Danilova,V., Zou,S., Hellekant,G., Max,M., Margolskee,R.F.
            and Damak,S.
  TITLE     Partial rescue of taste responses of alpha-gustducin null mice by
            transgenic expression of alpha-transducin
  JOURNAL   Chem Senses 27 (8), 719-727 (2002)
   PUBMED   12379596
REFERENCE   7  (bases 1 to 1670)
  AUTHORS   Huang,L., Shanker,Y.G., Dubauskaite,J., Zheng,J.Z., Yan,W.,
            Rosenzweig,S., Spielman,A.I., Max,M. and Margolskee,R.F.
  TITLE     Ggamma13 colocalizes with gustducin in taste receptor cells and
            mediates IP3 responses to bitter denatonium
  JOURNAL   Nat Neurosci 2 (12), 1055-1062 (1999)
   PUBMED   10570481
REFERENCE   8  (bases 1 to 1670)
  AUTHORS   Wong,G.T., Gannon,K.S. and Margolskee,R.F.
  TITLE     Transduction of bitter and sweet taste by gustducin
  JOURNAL   Nature 381 (6585), 796-800 (1996)
   PUBMED   8657284
  REMARK    Erratum:[Nature 1996 Oct 10;383(6600):557]
REFERENCE   9  (bases 1 to 1670)
  AUTHORS   Hoon,M.A., Northup,J.K., Margolskee,R.F. and Ryba,N.J.
  TITLE     Functional expression of the taste specific G-protein,
            alpha-gustducin
  JOURNAL   Biochem J 309 (Pt 2) (Pt 2), 629-636 (1995)
   PUBMED   7626029
REFERENCE   10 (bases 1 to 1670)
  AUTHORS   McLaughlin,S.K., McKinnon,P.J. and Margolskee,R.F.
  TITLE     Gustducin is a taste-cell-specific G protein closely related to the
            transducins
  JOURNAL   Nature 357 (6379), 563-569 (1992)
   PUBMED   1608467
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 27, 2020 this sequence version replaced NM_173139.1.
            
            Sequence Note: This sequence has been modified as follows: removed
            35 bp suspected to be vector contamination from the 3' end.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X65747.1, SRR26643288.17556.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676807 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-231               JAXUCZ010000004.1  18104102-18104332   c
            232-274             JAXUCZ010000004.1  18087126-18087168   c
            275-416             JAXUCZ010000004.1  18082697-18082838   c
            417-574             JAXUCZ010000004.1  18075481-18075638   c
            575-703             JAXUCZ010000004.1  18071479-18071607   c
            704-833             JAXUCZ010000004.1  18059096-18059225   c
            834-987             JAXUCZ010000004.1  18058749-18058902   c
            988-1670            JAXUCZ010000004.1  18054551-18055233   c
FEATURES             Location/Qualifiers
     source          1..1670
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..1670
                     /gene="Gnat3"
                     /gene_synonym="gnat-3; Hg1e"
                     /note="G protein subunit alpha transducin 3"
                     /db_xref="GeneID:286924"
                     /db_xref="RGD:727817"
     exon            1..231
                     /gene="Gnat3"
                     /gene_synonym="gnat-3; Hg1e"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1178
                     /gene="Gnat3"
                     /gene_synonym="gnat-3; Hg1e"
                     /EC_number="2.3.1.4"
                     /note="gustducin alpha-3 chain; guanine nucleotide binding
                     protein, alpha transducing 3; heterotrimeric guanine
                     nucleotide-binding protein 1e"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein G(t) subunit
                     alpha-3"
                     /protein_id="NP_775162.1"
                     /db_xref="GeneID:286924"
                     /db_xref="RGD:727817"
                     /translation="MGSGISSESKESAKRSKELEKKLQEDAERDARTVKLLLLGAGES
                     GKSTIVKQMKIIHKNGYSKQECMEFKAVVYSNTLQSILAIVKAMTTLGIDYVNPRSRE
                     DQQLLLSMANTLEDGDMTPQLAEIIKRLWGDPGIQACFERASEYQLNDSAAYYLNDLD
                     RLTAPGYVPNEQDVLHSRVKTTGIIETQFSFKDLNFRMFDVGGQRSERKKWIHCFEGV
                     TCIIFCAALSAYDMVLVEDEEVNRMHESLHLFNSICNHKYFATTSIVLFLNKKDLFQE
                     KVTKVHLSICFPEYTGPNTFEDAGNYIKNQFLDLNLKKEDKEIYSHMTCATDTQNVKF
                     VFDAVTDIIIKENLKDCGLF"
     exon            232..274
                     /gene="Gnat3"
                     /gene_synonym="gnat-3; Hg1e"
                     /inference="alignment:Splign:2.1.0"
     exon            275..416
                     /gene="Gnat3"
                     /gene_synonym="gnat-3; Hg1e"
                     /inference="alignment:Splign:2.1.0"
     exon            417..574
                     /gene="Gnat3"
                     /gene_synonym="gnat-3; Hg1e"
                     /inference="alignment:Splign:2.1.0"
     exon            575..703
                     /gene="Gnat3"
                     /gene_synonym="gnat-3; Hg1e"
                     /inference="alignment:Splign:2.1.0"
     exon            704..833
                     /gene="Gnat3"
                     /gene_synonym="gnat-3; Hg1e"
                     /inference="alignment:Splign:2.1.0"
     exon            834..987
                     /gene="Gnat3"
                     /gene_synonym="gnat-3; Hg1e"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1670
                     /gene="Gnat3"
                     /gene_synonym="gnat-3; Hg1e"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gactggtgcc tgctgttggg agcactgctc ttacgatcta tctctaaacc actgctgtgc
       61 tctgtgtttg aaaactttga gcaaatcaac tgcccgtcct ctaacagcaa aagatgggaa
      121 gtggaattag ttcagagagc aaggagtcag ccaaaaggtc caaagaactg gagaagaagc
      181 ttcaggaaga tgctgaacgg gatgcaagaa ctgtgaagtt gctgctatta ggagcaggtg
      241 aatctggaaa aagtactatt gttaaacaaa tgaagatcat ccacaagaat ggttacagta
      301 aacaagaatg catggagttt aaagcagtgg tttacagtaa cacgttgcag tccatcctgg
      361 ccattgtgaa agccatgact acactaggga ttgattatgt caatccgaga agtagagagg
      421 accaacaact gcttctctcc atggcaaaca cactagaaga tggtgacatg acgcctcagt
      481 tggctgaaat aattaaacgt ctgtggggcg atccaggaat tcaagcctgc ttcgaaaggg
      541 catctgaata ccagctcaat gactctgcag cttactacct taatgactta gatagactca
      601 cagcccctgg gtatgtgcca aatgaacaag acgttctaca ttcccgggtg aaaaccactg
      661 gtatcattga aactcaattc tcctttaaag acttgaactt cagaatgttt gatgtaggtg
      721 gccagagatc agaaagaaag aaatggatcc actgctttga aggagtgacg tgcattatat
      781 tttgtgcagc cctaagtgcc tacgacatgg tacttgtaga agatgaagag gtgaacagaa
      841 tgcatgaaag tcttcacctc ttcaacagca tctgtaatca caagtatttt gcaaccacct
      901 ccattgttct gtttcttaac aagaaagatc tcttccagga gaaagtgacc aaggtgcacc
      961 tcagcatctg tttcccagaa tacactggac caaatacatt cgaagatgca gggaactaca
     1021 tcaagaacca gttcctagac ctgaacttaa aaaaagaaga taaggaaatc tattctcaca
     1081 tgacctgcgc tactgacaca caaaacgtca aattcgtgtt tgatgccgtg acagatataa
     1141 taataaaaga gaacctcaaa gactgtgggc tcttctgagc aacctgtttg ctaccacttg
     1201 tgatggctgt agtcttttta agacataaaa aggtgctgtg tattagcttg gatagatatt
     1261 aactgattta gaaatgtgac tagcattata aaacaaaaaa attcacacaa aaatgttact
     1321 gtgatatcac gtatatctgg gtacggtttt cttggggaat ggagggtaga gttgctgatg
     1381 ttctaaatct gaaatctgat gtatcttggt aactgtcaca atatacattc atgctactaa
     1441 agttttttgg aagtgagctg taagtgacca atttttaatc atagagtaaa cctcagaatg
     1501 tgctataaca ttgccccagc tagattttga aagcattcaa agtcatgtct gttctacaga
     1561 aactgtacaa aatgatacaa ggtataattt tggtcatcag cctttcaatt aggctgccac
     1621 aagcacacac agtacatgct tttattgatg ggaaattgta tgtgtaaaat
//
