LOCUS       NM_001108950            1525 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus G protein subunit alpha transducin 2 (Gnat2),
            mRNA.
ACCESSION   NM_001108950 XM_001070101 XM_345271
VERSION     NM_001108950.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1525)
  AUTHORS   Arshavsky,V.Y. and Burns,M.E.
  TITLE     Photoreceptor signaling: supporting vision across a wide range of
            light intensities
  JOURNAL   J Biol Chem 287 (3), 1620-1626 (2012)
   PUBMED   22074925
  REMARK    Review article
REFERENCE   2  (bases 1 to 1525)
  AUTHORS   Won,J., Shi,L.Y., Hicks,W., Wang,J., Hurd,R., Naggert,J.K.,
            Chang,B. and Nishina,P.M.
  TITLE     Mouse model resources for vision research
  JOURNAL   J Ophthalmol 2011, 391384 (2011)
   PUBMED   21052544
REFERENCE   3  (bases 1 to 1525)
  AUTHORS   Umino,Y., Solessio,E. and Barlow,R.B.
  TITLE     Speed, spatial, and temporal tuning of rod and cone vision in mouse
  JOURNAL   J Neurosci 28 (1), 189-198 (2008)
   PUBMED   18171936
REFERENCE   4  (bases 1 to 1525)
  AUTHORS   Chen,J., Wu,M., Sezate,S.A. and McGinnis,J.F.
  TITLE     Light threshold-controlled cone alpha-transducin translocation
  JOURNAL   Invest Ophthalmol Vis Sci 48 (7), 3350-3355 (2007)
   PUBMED   17591908
REFERENCE   5  (bases 1 to 1525)
  AUTHORS   Alexander,J.J., Umino,Y., Everhart,D., Chang,B., Min,S.H., Li,Q.,
            Timmers,A.M., Hawes,N.L., Pang,J.J., Barlow,R.B. and Hauswirth,W.W.
  TITLE     Restoration of cone vision in a mouse model of achromatopsia
  JOURNAL   Nat Med 13 (6), 685-687 (2007)
   PUBMED   17515894
REFERENCE   6  (bases 1 to 1525)
  AUTHORS   Nusinowitz,S., Ridder,W.H. 3rd and Ramirez,J.
  TITLE     Temporal response properties of the primary and secondary
            rod-signaling pathways in normal and Gnat2 mutant mice
  JOURNAL   Exp Eye Res 84 (6), 1104-1114 (2007)
   PUBMED   17408617
REFERENCE   7  (bases 1 to 1525)
  AUTHORS   Chang,B., Dacey,M.S., Hawes,N.L., Hitchcock,P.F., Milam,A.H.,
            Atmaca-Sonmez,P., Nusinowitz,S. and Heckenlively,J.R.
  TITLE     Cone photoreceptor function loss-3, a novel mouse model of
            achromatopsia due to a mutation in Gnat2
  JOURNAL   Invest Ophthalmol Vis Sci 47 (11), 5017-5021 (2006)
   PUBMED   17065522
REFERENCE   8  (bases 1 to 1525)
  AUTHORS   Ueda,T., Ugawa,S., Yamamura,H., Imaizumi,Y. and Shimada,S.
  TITLE     Functional interaction between T2R taste receptors and G-protein
            alpha subunits expressed in taste receptor cells
  JOURNAL   J Neurosci 23 (19), 7376-7380 (2003)
   PUBMED   12917372
REFERENCE   9  (bases 1 to 1525)
  AUTHORS   Kohl,S., Baumann,B., Rosenberg,T., Kellner,U., Lorenz,B.,
            Vadala,M., Jacobson,S.G. and Wissinger,B.
  TITLE     Mutations in the cone photoreceptor G-protein alpha-subunit gene
            GNAT2 in patients with achromatopsia
  JOURNAL   Am J Hum Genet 71 (2), 422-425 (2002)
   PUBMED   12077706
REFERENCE   10 (bases 1 to 1525)
  AUTHORS   Lerea,C.L., Bunt-Milam,A.H. and Hurley,J.B.
  TITLE     Alpha transducin is present in blue-, green-, and red-sensitive
            cone photoreceptors in the human retina
  JOURNAL   Neuron 3 (3), 367-376 (1989)
   PUBMED   2534964
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 25, 2010 this sequence version replaced NM_001108950.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments, including that of the mouse
            ortholog, NM_008141.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.9065.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494, SAMN16676787
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                JAXUCZ010000002.1  198414920-198414945
            27-199              JAXUCZ010000002.1  198415054-198415226
            200-242             JAXUCZ010000002.1  198417052-198417094
            243-384             JAXUCZ010000002.1  198417361-198417502
            385-542             JAXUCZ010000002.1  198418139-198418296
            543-671             JAXUCZ010000002.1  198419908-198420036
            672-801             JAXUCZ010000002.1  198420254-198420383
            802-955             JAXUCZ010000002.1  198422865-198423018
            956-1525            JAXUCZ010000002.1  198423453-198424022
FEATURES             Location/Qualifiers
     source          1..1525
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1525
                     /gene="Gnat2"
                     /note="G protein subunit alpha transducin 2"
                     /db_xref="GeneID:365901"
                     /db_xref="RGD:1309514"
     exon            1..26
                     /gene="Gnat2"
                     /inference="alignment:Splign:2.1.0"
     exon            27..199
                     /gene="Gnat2"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1146
                     /gene="Gnat2"
                     /note="guanine nucleotide binding protein (G protein),
                     alpha transducing activity polypeptide 2; guanine
                     nucleotide binding protein, alpha transducing 2; guanine
                     nucleotide binding protein (G protein), alpha transducing
                     2"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein G(t) subunit
                     alpha-2"
                     /protein_id="NP_001102420.2"
                     /db_xref="GeneID:365901"
                     /db_xref="RGD:1309514"
                     /translation="MGSGISAEDKELAKRSRELEKKLQEDADKEAKTVKLLLLGAGES
                     GKSTIVKQMKIIHQDGYSPEECLEFKSVIYGNVLQSILAIIRAMSTLGIDYAEPSCAE
                     AGRQLNNLADSTEEGTMPSELVEVIRKLWKDGGVQACFDRAAEFQLNDSASYYLNQLD
                     RITDPDYLPNEQDVLRSRVKTTGIIETKFSVKDLNFRMFDVGGQRSERKKWIHCFEGV
                     TCIIFCAALSAYDMVLVEDDEVNRMHESLHLFNSICNHKFFAATSIVLFLNKKDLFEE
                     KIKKVHLSICFPEYDGNNSYEDAGNYIKSQFLDLNMRKDVKEIYSHMTCATDTQNVKF
                     VFDAVTDIIIKENLKDCGLF"
     exon            200..242
                     /gene="Gnat2"
                     /inference="alignment:Splign:2.1.0"
     exon            243..384
                     /gene="Gnat2"
                     /inference="alignment:Splign:2.1.0"
     exon            385..542
                     /gene="Gnat2"
                     /inference="alignment:Splign:2.1.0"
     exon            543..671
                     /gene="Gnat2"
                     /inference="alignment:Splign:2.1.0"
     exon            672..801
                     /gene="Gnat2"
                     /inference="alignment:Splign:2.1.0"
     exon            802..955
                     /gene="Gnat2"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1525
                     /gene="Gnat2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgggctag ggagtctgga gccaagatag gaagaattga agagccagag aaaacgtccc
       61 ttctctgagg ggacagcaga gatggggagt ggcatcagtg ctgaggacaa agaacttgcc
      121 aagaggtcca gggagctgga aaagaagctg caggaggatg ctgacaagga agccaagact
      181 gtcaagctgc tgctgcttgg tgcgggagag tcagggaaga gcacgatcgt caaacaaatg
      241 aagatcattc accaggatgg ctactcaccc gaagaatgcc tagaattcaa atctgtcatc
      301 tatgggaacg tgttgcagtc catcctggct atcatcagag ccatgtccac actaggcatt
      361 gactatgctg aaccaagctg tgcggaagcg gggagacagc tcaacaacct ggctgactcc
      421 accgaggagg ggaccatgcc ttccgagctg gtggaggtca tcagaaagtt gtggaaggac
      481 ggtggagttc aagcctgctt tgacagagcc gcagagttcc agctcaatga ctcggcatct
      541 tattacctga accagctgga ccggattaca gaccctgact acctccctaa tgagcaagac
      601 gtgcttcgat ccagagtcaa gacaacaggc atcatcgaga ccaagttttc tgtaaaagat
      661 ttgaatttta ggatgtttga cgtgggaggg cagagatcag agaggaagaa atggatccac
      721 tgctttgagg gagtcacctg catcattttc tgtgctgctc ttagcgccta tgacatggtg
      781 ctggtggagg atgacgaggt gaatcgcatg catgagtctc tacatctgtt caacagcatc
      841 tgtaaccaca agttctttgc ggctacttcc attgttctct ttctcaacaa gaaggacctc
      901 tttgaggaaa aaattaagaa agtccacctc agtatctgtt tcccggagta tgacggcaac
      961 aattcctatg aggatgccgg gaattacatc aagagtcagt tccttgacct caacatgagg
     1021 aaagatgtca aagagatcta cagccacatg acttgtgcta cggacacaca gaacgtcaaa
     1081 tttgtgtttg atgcagtcac agacattatc atcaaggaaa acctcaagga ctgtgggctc
     1141 ttttaatgct cggttcctcc gatatattat tttataagca agcttagaat ccgaggcttc
     1201 atgcagaaaa ttagtcaaca cgtatcagaa catgacaaat gagcccatcg agttggtgac
     1261 agagaagacg ttcacaactg ttagtagtgt ggccagcaca ctttaaagac ggcatggcca
     1321 gtgatcctaa agcccaggtt tgagtactgg cttctctgtg atgaaggtaa ctccctcgct
     1381 tactttacag ggtcattgtg aagagcacaa acataactga agggaggcac aggatggctg
     1441 ctgtggttgg ccacagaaag ccgccatgac agctccaatt gatgggctac catacttggg
     1501 attaataaac tatctcagag cctaa
//
