LOCUS       NM_001108780            2169 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus G protein subunit alpha transducin 1 (Gnat1),
            mRNA.
ACCESSION   NM_001108780 XM_001074432 XM_343480
VERSION     NM_001108780.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2169)
  AUTHORS   Chaya,T., Tsutsumi,R., Varner,L.R., Maeda,Y., Yoshida,S. and
            Furukawa,T.
  TITLE     Cul3-Klhl18 ubiquitin ligase modulates rod transducin translocation
            during light-dark adaptation
  JOURNAL   EMBO J 38 (23), e101409 (2019)
   PUBMED   31696965
REFERENCE   2  (bases 1 to 2169)
  AUTHORS   Arshavsky,V.Y. and Burns,M.E.
  TITLE     Photoreceptor signaling: supporting vision across a wide range of
            light intensities
  JOURNAL   J Biol Chem 287 (3), 1620-1626 (2012)
   PUBMED   22074925
  REMARK    Review article
REFERENCE   3  (bases 1 to 2169)
  AUTHORS   Won,J., Shi,L.Y., Hicks,W., Wang,J., Hurd,R., Naggert,J.K.,
            Chang,B. and Nishina,P.M.
  TITLE     Mouse model resources for vision research
  JOURNAL   J Ophthalmol 2011, 391384 (2011)
   PUBMED   21052544
REFERENCE   4  (bases 1 to 2169)
  AUTHORS   Westfall,J.E., Hoyt,C., Liu,Q., Hsiao,Y.C., Pierce,E.A.,
            Page-McCaw,P.S. and Ferland,R.J.
  TITLE     Retinal degeneration and failure of photoreceptor outer segment
            formation in mice with targeted deletion of the Joubert syndrome
            gene, Ahi1
  JOURNAL   J Neurosci 30 (26), 8759-8768 (2010)
   PUBMED   20592197
REFERENCE   5  (bases 1 to 2169)
  AUTHORS   Lobanova,E.S., Finkelstein,S., Herrmann,R., Chen,Y.M., Kessler,C.,
            Michaud,N.A., Trieu,L.H., Strissel,K.J., Burns,M.E. and
            Arshavsky,V.Y.
  TITLE     Transducin gamma-subunit sets expression levels of alpha- and
            beta-subunits and is crucial for rod viability
  JOURNAL   J Neurosci 28 (13), 3510-3520 (2008)
   PUBMED   18367617
REFERENCE   6  (bases 1 to 2169)
  AUTHORS   Seiler,M.J., Aramant,R.B. and Ball,S.L.
  TITLE     Photoreceptor function of retinal transplants implicated by
            light-dark shift of S-antigen and rod transducin
  JOURNAL   Vision Res 39 (15), 2589-2596 (1999)
   PUBMED   10396627
REFERENCE   7  (bases 1 to 2169)
  AUTHORS   Dryja,T.P., Hahn,L.B., Reboul,T. and Arnaud,B.
  TITLE     Missense mutation in the gene encoding the alpha subunit of rod
            transducin in the Nougaret form of congenital stationary night
            blindness
  JOURNAL   Nat Genet 13 (3), 358-360 (1996)
   PUBMED   8673138
REFERENCE   8  (bases 1 to 2169)
  AUTHORS   Ruiz-Avila,L., McLaughlin,S.K., Wildman,D., McKinnon,P.J.,
            Robichon,A., Spickofsky,N. and Margolskee,R.F.
  TITLE     Coupling of bitter receptor to phosphodiesterase through transducin
            in taste receptor cells
  JOURNAL   Nature 376 (6535), 80-85 (1995)
   PUBMED   7596440
REFERENCE   9  (bases 1 to 2169)
  AUTHORS   McLaughlin,S.K., McKinnon,P.J., Spickofsky,N., Danho,W. and
            Margolskee,R.F.
  TITLE     Molecular cloning of G proteins and phosphodiesterases from rat
            taste cells
  JOURNAL   Physiol Behav 56 (6), 1157-1164 (1994)
   PUBMED   7878085
REFERENCE   10 (bases 1 to 2169)
  AUTHORS   Lerea,C.L., Bunt-Milam,A.H. and Hurley,J.B.
  TITLE     Alpha transducin is present in blue-, green-, and red-sensitive
            cone photoreceptors in the human retina
  JOURNAL   Neuron 3 (3), 367-376 (1989)
   PUBMED   2534964
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Oct 25, 2007 this sequence version replaced NM_001108780.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760386, SAMEA5760389
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               JAXUCZ010000008.1  117234146-117234311 c
            167-209             JAXUCZ010000008.1  117232773-117232815 c
            210-351             JAXUCZ010000008.1  117232519-117232660 c
            352-509             JAXUCZ010000008.1  117232269-117232426 c
            510-638             JAXUCZ010000008.1  117232033-117232161 c
            639-768             JAXUCZ010000008.1  117231690-117231819 c
            769-922             JAXUCZ010000008.1  117231372-117231525 c
            923-1114            JAXUCZ010000008.1  117231064-117231255 c
            1115-2169           JAXUCZ010000008.1  117229575-117230629 c
FEATURES             Location/Qualifiers
     source          1..2169
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2169
                     /gene="Gnat1"
                     /gene_synonym="Hg1f"
                     /note="G protein subunit alpha transducin 1"
                     /db_xref="GeneID:363143"
                     /db_xref="RGD:1304683"
     exon            1..166
                     /gene="Gnat1"
                     /gene_synonym="Hg1f"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1113
                     /gene="Gnat1"
                     /gene_synonym="Hg1f"
                     /note="rod-type transducin alpha subunit; guanine
                     nucleotide binding protein, alpha transducing 1; guanine
                     nucleotide binding protein (G protein), alpha transducing
                     1; guanine nucleotide binding protein (G protein), alpha
                     transducing activity polypeptide 1; heterotrimeric guanine
                     nucleotide-binding protein 1f"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein G(t) subunit
                     alpha-1"
                     /protein_id="NP_001102250.2"
                     /db_xref="GeneID:363143"
                     /db_xref="RGD:1304683"
                     /translation="MGAGASAEEKHSRELEKKLKEDAEKDARTVKLLLLGAGESGKST
                     IVKQMKIIHQDGYSLEECLEFIAIIYGNTLQSILAIVRAMTTLNIQYGDSARQDDARK
                     LMHMADTIEEGTMPKEMSDIIQRLWKDSGIQACFDRASEYQLNDSAGYYLSDLERLVT
                     PGYVPTEQDVLRSRVKTTGIIETQFSFKDLNFRMFDVGGQRSERKKWIHCFEGVTCII
                     FIAALSAYDMVLVEDDEVNRMHESLHLFNSICNHRYFATTSIVLFLNKKDVFSEKIKK
                     AHLSICFPDYDGPNTYDDAGNYIKVQFLELNMRRDVKEIYSHMTCATDTQNVKFVFDA
                     VTDIIIKENLKDCGLF"
     exon            167..209
                     /gene="Gnat1"
                     /gene_synonym="Hg1f"
                     /inference="alignment:Splign:2.1.0"
     exon            210..351
                     /gene="Gnat1"
                     /gene_synonym="Hg1f"
                     /inference="alignment:Splign:2.1.0"
     exon            352..509
                     /gene="Gnat1"
                     /gene_synonym="Hg1f"
                     /inference="alignment:Splign:2.1.0"
     exon            510..638
                     /gene="Gnat1"
                     /gene_synonym="Hg1f"
                     /inference="alignment:Splign:2.1.0"
     exon            639..768
                     /gene="Gnat1"
                     /gene_synonym="Hg1f"
                     /inference="alignment:Splign:2.1.0"
     exon            769..922
                     /gene="Gnat1"
                     /gene_synonym="Hg1f"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1114
                     /gene="Gnat1"
                     /gene_synonym="Hg1f"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..2169
                     /gene="Gnat1"
                     /gene_synonym="Hg1f"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaggttgtc tgaggaggcc agaggctgcc taccctgtcc ctttgcctgc tgctgggacc
       61 atgggggctg gggccagcgc tgaggagaag cactccagag agctggaaaa gaagctgaaa
      121 gaagacgctg agaaggacgc acggaccgtg aagctgctgc ttctgggtgc gggtgaatcc
      181 gggaaaagca ctattgtcaa gcagatgaag attatccacc aggacgggta ttcgctggaa
      241 gaatgcctcg agttcatcgc catcatctat ggcaacactc tgcagtccat cctggccatc
      301 gtgagggcta tgaccacgct caacattcag tatggagatt cggctcggca ggacgatgcc
      361 cggaagctga tgcacatggc ggatactatt gaggaaggca caatgcccaa ggagatgtca
      421 gacatcattc agcgcctgtg gaaggactcc ggtatccaag cttgctttga ccgagcctca
      481 gaataccaac tcaatgactc tgctggctac tacctttcag acctagagcg tctggtgact
      541 ccaggatacg tgcccactga gcaggatgtg ttgcgttctc gtgtcaaaac cactggtatt
      601 atcgagactc aattttcctt caaggacctc aacttcagaa tgttcgatgt gggcgggcag
      661 cgttctgagc gcaaaaagtg gatccactgc tttgagggtg tgacgtgcat cattttcatc
      721 gctgcgctga gcgcttacga catggtgctg gtggaggacg acgaagtgaa ccgaatgcac
      781 gagagcctgc acctgttcaa cagcatctgc aatcaccgct acttcgccac gacgtccatc
      841 gtgctcttcc tcaacaagaa ggacgttttc tccgagaaga taaaaaaggc acacctcagc
      901 atctgctttc ccgattacga tggacctaac acttacgacg atgccggcaa ctacatcaaa
      961 gtgcagttcc tggagcttaa catgcgacgt gatgtgaagg agatctattc ccacatgacc
     1021 tgcgctaccg acacacagaa cgtcaagttt gtctttgacg ccgtcaccga cattatcatc
     1081 aaggagaacc tcaaagactg cgggctcttc tgagatacct gaattcatgt ctgccccgta
     1141 ccctgagact ctgtatccct acagccctgt agtcccctta aataacgtct attcctcaag
     1201 ctgcctctcc catagccgca cacccaaagc tctgaggctt gacgtgcaga ccctccccca
     1261 agtacccaac tctaccctgc ttttcaccgc ctggctgcac tggcctcttg gacctacggc
     1321 agccagcctc agctaggact tgggacagct ggagctcaga gtgactcagc agtgccctag
     1381 tgacccgtct ccagcaccat cggccacccc catcagcagc agctcaccag cagatcccgg
     1441 ttcaccaaac agccctccct ccccagtttc cacgaagggc ttgaggtctc cctccctcaa
     1501 gaagtaggcc ggtccagcct gctgcctgca tatgacaact ccaacacctg tctacccagt
     1561 ggtcagtggc tgtccctccc agtagcctga ggagtccaaa gtccaagctc tggtctttga
     1621 agcctcgcac agagaaatta gtgactttga cttgggtgcc aggaaaagat tcaagccaaa
     1681 cccattccca aatactgggc tcagggtttc tcctagtccc ttctccctct gggtcttgcc
     1741 cctctgtcct tggacacttc cacaccacac ctcgtccacc cacacacaat acgcagggct
     1801 tgctggttaa ggtatgctgt atcgaaggac agtgttattg acatagggat gaccaataat
     1861 gaagccacac tgaggggtgg ctcagagcag agtccagccc ctattgatca accatgggta
     1921 aagaatatcc cgtgtaaggt tacaggcaat tccatgtgac cacgtcgtcc cttctgattc
     1981 aggccctata gcttgggagg gaggactgaa aaaccatgcc taaaccatta gagacaatgc
     2041 cccacatctc ccagccactt ctcctgccac ctttgcttaa gcctgcagac cagagacagt
     2101 gttgctggta gaggcaagct ctccttccct tagctaacta cagattcagc aataaatctt
     2161 tgcaccagg
//
