LOCUS       NM_031036               6256 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus G protein subunit alpha q (Gnaq), mRNA.
ACCESSION   NM_031036
VERSION     NM_031036.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6256)
  AUTHORS   Sun,X., Li,G.P., Huang,P., Wei,L.G., Guo,J.Z., Ao,L.J., Lu,D. and
            Chen,S.C.
  TITLE     Gnaq Protects PC12 Cells from Oxidative Damage by Activation of
            Nrf2 and Inhibition of NF-kB
  JOURNAL   Neuromolecular Med 22 (3), 401-410 (2020)
   PUBMED   32253686
  REMARK    GeneRIF: Gnaq Protects PC12 Cells from Oxidative Damage by
            Activation of Nrf2 and Inhibition of NF-kB.
REFERENCE   2  (bases 1 to 6256)
  AUTHORS   Garwain,O., Yerramilli,V.S., Romero,K. and Scarlata,S.
  TITLE     The Galphaq/phospholipase Cbeta signaling system represses tau
            aggregation
  JOURNAL   Cell Signal 71, 109620 (2020)
   PUBMED   32247043
  REMARK    GeneRIF: The Galphaq/phospholipase Cbeta signaling system represses
            tau aggregation.
REFERENCE   3  (bases 1 to 6256)
  AUTHORS   Pearce,K.M., Bell,M., Linthicum,W.H., Wen,Q., Srinivasan,J.,
            Rangamani,P. and Scarlata,S.
  TITLE     Galphaq-mediated calcium dynamics and membrane tension modulate
            neurite plasticity
  JOURNAL   Mol Biol Cell 31 (7), 683-694 (2020)
   PUBMED   31825720
  REMARK    GeneRIF: Galphaq-mediated calcium dynamics and membrane tension
            modulate neurite plasticity.
REFERENCE   4  (bases 1 to 6256)
  AUTHORS   Qifti,A., Garwain,O. and Scarlata,S.
  TITLE     Mechanical Stretch Redefines Membrane Galphaq-Calcium Signaling
            Complexes
  JOURNAL   J Membr Biol 252 (4-5), 307-315 (2019)
   PUBMED   31011763
  REMARK    GeneRIF: Mechanical Stretch Redefines Membrane Galphaq-Calcium
            Signaling Complexes.
REFERENCE   5  (bases 1 to 6256)
  AUTHORS   Atef,M.E. and Anand-Srivastava,M.B.
  TITLE     Role of PKCdelta in Enhanced Expression of Gqalpha/PLCbeta1
            Proteins and VSMC Hypertrophy in Spontaneously Hypertensive Rats
  JOURNAL   PLoS One 11 (7), e0157955 (2016)
   PUBMED   27379421
  REMARK    GeneRIF: Enhanced activation of protein kinase C delta (PKCdelta)
            in vascular smooth muscle cell (VSMC) from hypertensive rats (SHR)
            increases the expression of G alpha protein q (Gqalpha) and
            phospholipase C beta1 (PLCbeta1) proteins and results in VSMC
            hypertrophy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6256)
  AUTHORS   Haley,J.E., Abogadie,F.C., Delmas,P., Dayrell,M., Vallis,Y.,
            Milligan,G., Caulfield,M.P., Brown,D.A. and Buckley,N.J.
  TITLE     The alpha subunit of Gq contributes to muscarinic inhibition of the
            M-type potassium current in sympathetic neurons
  JOURNAL   J Neurosci 18 (12), 4521-4531 (1998)
   PUBMED   9614229
REFERENCE   7  (bases 1 to 6256)
  AUTHORS   Offermanns,S., Hashimoto,K., Watanabe,M., Sun,W., Kurihara,H.,
            Thompson,R.F., Inoue,Y., Kano,M. and Simon,M.I.
  TITLE     Impaired motor coordination and persistent multiple climbing fiber
            innervation of cerebellar Purkinje cells in mice lacking Galphaq
  JOURNAL   Proc Natl Acad Sci U S A 94 (25), 14089-14094 (1997)
   PUBMED   9391157
REFERENCE   8  (bases 1 to 6256)
  AUTHORS   Friedman,E., Jin,L.Q., Cai,G.P., Hollon,T.R., Drago,J., Sibley,D.R.
            and Wang,H.Y.
  TITLE     D1-like dopaminergic activation of phosphoinositide hydrolysis is
            independent of D1A dopamine receptors: evidence from D1A knockout
            mice
  JOURNAL   Mol Pharmacol 51 (1), 6-11 (1997)
   PUBMED   9016340
REFERENCE   9  (bases 1 to 6256)
  AUTHORS   Jefferies,S.R., Barkmeier,W.W. and Gwinnett,A.J.
  TITLE     Three composite finishing systems: a multisite in vitro evaluation
  JOURNAL   J Esthet Dent 4 (6), 181-185 (1992)
   PUBMED   1299289
REFERENCE   10 (bases 1 to 6256)
  AUTHORS   Lesch,K.P. and Manji,H.K.
  TITLE     Signal-transducing G proteins and antidepressant drugs: evidence
            for modulation of alpha subunit gene expression in rat brain
  JOURNAL   Biol Psychiatry 32 (7), 549-579 (1992)
   PUBMED   1333286
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Feb 10, 2021 this sequence version replaced NM_031036.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.4832.1,
                                           SRR26643429.5154.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-231               JAXUCZ010000001.1  222852453-222852683
            232-416             JAXUCZ010000001.1  222939443-222939627
            417-571             JAXUCZ010000001.1  223031928-223032082
            572-700             JAXUCZ010000001.1  223049314-223049442
            701-830             JAXUCZ010000001.1  223052138-223052267
            831-984             JAXUCZ010000001.1  223087878-223088031
            985-6256            JAXUCZ010000001.1  223093483-223098754
FEATURES             Location/Qualifiers
     source          1..6256
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..6256
                     /gene="Gnaq"
                     /gene_synonym="Galphaq"
                     /note="G protein subunit alpha q"
                     /db_xref="GeneID:81666"
                     /db_xref="RGD:620770"
     exon            1..231
                     /gene="Gnaq"
                     /gene_synonym="Galphaq"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1175
                     /gene="Gnaq"
                     /gene_synonym="Galphaq"
                     /note="guanine nucleotide binding protein alpha q subunit;
                     guanine nucleotide-binding protein alpha-q; heterotrimeric
                     guanine nucleotide-binding protein alpha q subunit;
                     guanine nucleotide binding protein, alpha q polypeptide;
                     guanine nucleotide regulatory protein G alpha q; guanine
                     nucleotide binding protein (G protein), q polypeptide"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein G(q) subunit
                     alpha"
                     /protein_id="NP_112298.2"
                     /db_xref="GeneID:81666"
                     /db_xref="RGD:620770"
                     /translation="MTLESIMACCLSEEAKEARRINDEIERQLRRDKRDARRELKLLL
                     LGTGESGKSTFIKQMRIIHGSGYSDEDKRGFTKLVYQNIFTAMQAMIRAMDTLKIPYK
                     YEHNKAHAQLVREVDVEKVSAFENPYVDAIKSLWNDPGIQECYDRRREYQLSDSTKYY
                     LNDLDRVADPSYLPTQQDVLRVRVPTTGIIEYPFDLQSVIFRMVDVGGQRSERRKWIH
                     CFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKK
                     DLLEEKIMYSHLVDYFPEYDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDT
                     ENIRFVFAAVKDTILQLNLKEYNLV"
     exon            232..416
                     /gene="Gnaq"
                     /gene_synonym="Galphaq"
                     /inference="alignment:Splign:2.1.0"
     exon            417..571
                     /gene="Gnaq"
                     /gene_synonym="Galphaq"
                     /inference="alignment:Splign:2.1.0"
     exon            572..700
                     /gene="Gnaq"
                     /gene_synonym="Galphaq"
                     /inference="alignment:Splign:2.1.0"
     exon            701..830
                     /gene="Gnaq"
                     /gene_synonym="Galphaq"
                     /inference="alignment:Splign:2.1.0"
     exon            831..984
                     /gene="Gnaq"
                     /gene_synonym="Galphaq"
                     /inference="alignment:Splign:2.1.0"
     exon            985..6256
                     /gene="Gnaq"
                     /gene_synonym="Galphaq"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgccgc tgcctcgggg gagcgagggc ggagggcgtg tgtgcgcgcg tgtgagcagg
       61 gcgccggcgg ggctgcagcg aggcacttcg gaagaatgac tctggagtcc atcatggcgt
      121 gctgcctgag cgaggaggcc aaggaagccc ggaggatcaa cgacgagatc gagcggcagc
      181 tgcgcaggga caagcgcgac gcccgccggg agctcaagct gctgctgctg gggacagggg
      241 agagtggcaa gagtaccttc attaagcaga tgaggatcat ccacgggtcg gggtactctg
      301 atgaagacaa gaggggcttt accaaactgg tgtatcagaa catctttaca gccatgcagg
      361 ccatgatcag agctatggac actctcaaga tcccatacaa gtatgaacac aataaggctc
      421 atgcacaatt ggttcgagag gttgatgtgg agaaggtgtc tgcttttgag aatccatatg
      481 tagacgcaat aaagagcttg tggaatgatc ctggaatcca ggaatgctac gatagacggc
      541 gagaatatca gctatctgac tctaccaaat actatctgaa cgacttggac cgtgtggctg
      601 acccttccta tctgcctaca caacaagatg tgcttagagt tcgagtcccc accacaggga
      661 tcattgagta ccccttcgac ttacagagtg tcatcttcag aatggtcgat gtaggaggcc
      721 aaaggtcaga gagaagaaaa tggatacact gctttgaaaa cgtcacctcg atcatgtttc
      781 tggtagcgct tagcgaatac gatcaagttc ttgtggagtc agacaatgag aaccgaatgg
      841 aggagagcaa agcactcttt agaaccatta tcacatatcc ctggttccag aactcctctg
      901 ttattctgtt cttaaacaag aaagatcttc tagaggagaa aattatgtat tcccacctag
      961 tcgactactt cccagaatat gatggacccc agagagatgc ccaggcagca cgagaattca
     1021 tcctgaagat gttcgtggac ctgaaccccg acagtgacaa aatcatctac tcgcacttca
     1081 cgtgtgccac agacacggag aacatccgct tcgtgtttgc tgctgtcaag gacaccatcc
     1141 tgcagctgaa cctgaaggag tacaatctgg tgtgaccacg cctcccagaa cccattcttc
     1201 ccttccccat gggctgttga agataaacaa gagggactgt acttctgtgg aaaacaattt
     1261 gcataatact aatttattgc cgtcctggac tctgtgagcg tgtccgcaga gccgtagtaa
     1321 atattgtgat tttatttaaa ctcttcagag gaaaccggat gctgaagtgc agtcccagca
     1381 cacttcctct ttttttaggc aaacctcgac tcgacgtatt ttaaattttc agtcattcac
     1441 tcacagtata aaagcactcc tgtcattcat tcattctctc tccccctctc tcttctctct
     1501 cttccattcc ttgccttctt cctcctcccc tttcctgttg accaaaacaa ggctgatttt
     1561 tcttcttcct gttccatacc ttccttctga ttttattttc cctcattacc atggccttta
     1621 ccctaattcc actcttgggc agtttctctc tcgaatgaca cggtcaggac agtgtcattc
     1681 agctgaagcc gccttacagc agcgtccttt accagtggtt ctgctgaagg caggagcata
     1741 tgtattccta ctatggtttt aaatgtatct ctggatgcac atcacatcta gtatttcttt
     1801 ttcaatacat acatacatgc atacatacat atatatgtat aatatatata ttgtcttgtc
     1861 tcacttggac tagggcggtg ggtgtcttat ctttgggtgc agactttcgg ccacagctgg
     1921 attgctcaga ggaatatatg gaagtcagga atatatggag ggcacaggcc gtgaagaagt
     1981 ccttgcttct ccgggctgtg tgctgcgtcc ttccgctctt ccttgcttcc gtttatgtct
     2041 ctttagtttt tcgccctctc tttaaaccac agacgccaaa tgatacggca acagacacta
     2101 cattccccag cggctgctgc cacagccctc ttgtagcttc ttcgttttct gtttgtttct
     2161 agctgtcctt tgctcctatt tccctttgtg tttgggccat aattttaaat taatttttat
     2221 tatgggtata tgttgccaaa gccagatttt tataaggcaa aataaattaa gaatttaaac
     2281 agttaaagcc agtgtctcaa aatgtcagca ttaagacagt gagggagaca acagctgggt
     2341 gtgaaccaga agcactcatt gccaaacagt tgctaactga actgctccct ctcacggtcc
     2401 gttcttttct tcccctcagt gtcagtgcca gtgtccagat gaccagtgta gaaaagtacc
     2461 ctgtgtgctt tgtcatgagc tctgcttata tctctttatt ggcactagtt ttattagctc
     2521 tttatgttct ttaagtttaa gggaatctgc caagaacact agttgatagt attatcctga
     2581 aaccttttat ttggggagca aatagtgagc tggctttacc accttcagga tcttgaattg
     2641 gtcacttgaa cttaaggaag acttgtgaat ttattcaaaa gtcaccgctc agtgttctgt
     2701 caagcatgta tttttgtgac gatcatacta ggagagatgt ttggaattct ccatgtgcaa
     2761 tttgtcagca gatgcaaacc atgccgagca tatatgagtg agcctgtcaa gcagcctgca
     2821 tcagtcagta tgtgatttaa gtagatggtg agcgctctaa ggctgcgggg aagtttagcc
     2881 tgatctggtc tcattagagc ttggcactaa tctcaacttc catgtaaatc acctttcttg
     2941 aatagcaaag ctgggagagg gaacagctca ctgtatgagc actgaaactg ctgactgtag
     3001 tcaagtgttc tcatgtgtta ctccccggct tttctatccc ttgctctaga aagcccctgt
     3061 aatttaatta acagactgcc tgtaggtaca gtgcaattac aaatgctctg atcgttgtac
     3121 atacatctct cttgatattg caacatccat actggctttt aatcattaat gttttggcag
     3181 attgaatgtg ctgtattgat atgtatctat gtaattgtat tgtatgtctt atagctaatt
     3241 cacattttga ataatgttat tttatttact tttttaagag aggagaatgt aaatttgtca
     3301 gtttatttct gactagggat atttttttcc atttagaaaa gaagaaaaaa aaaaaaaaaa
     3361 cccttactat cgtacagagc ggtactagca ttgtgctgtc taaaatcatt tgcacattcc
     3421 tgagtagagg tgtgctgacc taagacccaa aggtaatttc atagcaaaca cacaacatcc
     3481 gtcagagctt ttatacaaac acggagacca actttgtaga ccttttgcca tttgacctgg
     3541 ggttggaata tgagctttta tacgattcat attcttattt ggcaaatgca cagtttagca
     3601 ttacctctct gatggccttt attagaaagg cagttttaga agctattgtg atccactaag
     3661 gaaatgtttt atcagctaga gaccactgct tgcctgaaag ggcaacctta aatttggtgc
     3721 agcaaaaaaa aacaaaaaca aaaaaaaaaa ataacaaata aaacaaaaac aaaaaacaaa
     3781 acaaaaaaaa aaaacaaaaa agacaaaaaa gaaaaaaaag taacatttga tggcctgcag
     3841 tgtacagaga aaacctcatc ccaggatcat aagtgttaac agtcctaagg aaccgagctg
     3901 ttctgtctat tagagctgta gtggatgtgg ttgaaccatg ctgatatcca gctcagagct
     3961 gctgagtacg gcagagagag gtggccacgg cgtctttctg aattgaggat gcagcttgct
     4021 gtgcagagtt gaagtctgtg gcctcactgc acatcctggg gtgcatgaca ggatcccttc
     4081 ttttgagaaa ggaaaacatt gatcacccta gctgcagtga tgcctggaca cctaattgta
     4141 tccacactag tcaatgaagc taaaaataat tttgttgttg tttcttgttt ggggttttat
     4201 tgaaggggtg aggggcggga agggcttctc agttttgtac aaaaacaaag tttactcatg
     4261 ctttctcttc tattgtgatt gcaagcgttc ctgttgtcga tgctctaggt aatggaggct
     4321 tgtgaggagt gttatggtga cttgggcatg tcttattcag aagaaaaaca cagaccacag
     4381 aaacctttcc tcagcatccc aaggcaagca gccatctccc gagtcactca gcacgagtgt
     4441 gccgtttaca gatgatgtct cccttttgtg tgtgatgcgg cagttcccac ccacagagaa
     4501 ttcctatttg taaattggag gtttatacta tgccttacag agcttaaatt cagaagtctg
     4561 tgcctcatgt ctgaaacaaa gggaaaacac gcacccatgc aaaagtcagt gggtcttaca
     4621 gagcctgttg ggttttcctt actgtttccg taggaagagc tctgttgaat gtcctgagta
     4681 gctgggaaat tcttaggagc ctgcatgtgt tgtttactgg caggtggcat ccacagcgat
     4741 atttagagaa caccctggaa cttgggggct cggggttttg ttttgttttg ttttgtttag
     4801 attacattag caggcctaat cgttttaaaa ggtaattcag ccaaagggca atttactttt
     4861 tgtacttcag acttatattg attgtcaagt tgtacgaatt gtaatttaaa aatttatact
     4921 gccacatgat tgtaaattta agttgtctta agtaggaatt ggtgaaaagc tgtttatgct
     4981 ggatttgggt caaaatgact tgattacttg caaaaaaata aaaataataa tgggaagaaa
     5041 gggctgcata acaagacacc gcaagactca gaccctcaga tgaccccaga tgaccctcag
     5101 atgaccccag cccctttgtt ttcagtttct caagagaacg aatgaagtga aatatagcag
     5161 aatgttaacc catataaaaa taaagtgtac ccaaatattg taatgtatat tgctgctctt
     5221 cttaaaatta agtaagggtc ttaagccact caagtggtta gtaacagcat cttaattgat
     5281 acaaataagg ttagttgggc atacattaat attttattcc aaagagaaat ctttggttag
     5341 aaagacatac aaaaatggaa gctaacactg tgtctgtctg tccccccaca cttccagcgt
     5401 atgcagtgtt aagagatatc ctggcacttg tatctttggg attccatttt ggttctcgaa
     5461 cattgggaaa aacaaatggc ttggttctgt gtgattaggc caaggttggg gaagctagac
     5521 acctgccatt ccacagataa cttgctgaac gtctacactc tgttttcctt gcagtaatac
     5581 tgtttcctgc catctccccg cttctgccac cctgcaatag cacccttgcc tctagagcca
     5641 ttggtccaga gtatgcatgc acacctgatg cacagaggtg cccagatatg tcctcccacc
     5701 ttccatatct accacggaga tgccatcacg ccataaaatc tgaacccagt gatgaataca
     5761 tttacatgtt aaaaaaacag ccacttggta aaaatcagat cttacttaga taaaggaatt
     5821 ctggctttca tagaagcttc ggtagtcagg aagaaaacgc agggaggaag atcattcagc
     5881 aagctgtttg tagggttaga aaaggaagta aaaacactat ctaagtctgt ctgggtcact
     5941 ttcattgaaa cacgtttctg gcagatttcc tcaaaggact ctaactgaag cctctggcca
     6001 gactctgcat cgaccctcat gtggaagacc tgactagatc tgtgtactta gggagttttg
     6061 tcaaaaacat ttttaacttg cagtatttaa aaaaaatcat atttactgtt cttaaaatgt
     6121 cattcaaatg catgtattgt ctattgtttg gggatgggaa ctagtttttc aaaaaaaaaa
     6181 aaaaaaaagg aacacctaat gttgtataat gccccgatga tcttactggt taaaaataca
     6241 gtattttcgg ccataa
//
