LOCUS       NP_112298                359 aa            linear   ROD 01-APR-2024
DEFINITION  guanine nucleotide-binding protein G(q) subunit alpha [Rattus
            norvegicus].
ACCESSION   NP_112298
VERSION     NP_112298.2
DBSOURCE    REFSEQ: accession NM_031036.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 359)
  AUTHORS   Sun,X., Li,G.P., Huang,P., Wei,L.G., Guo,J.Z., Ao,L.J., Lu,D. and
            Chen,S.C.
  TITLE     Gnaq Protects PC12 Cells from Oxidative Damage by Activation of
            Nrf2 and Inhibition of NF-kB
  JOURNAL   Neuromolecular Med 22 (3), 401-410 (2020)
   PUBMED   32253686
  REMARK    GeneRIF: Gnaq Protects PC12 Cells from Oxidative Damage by
            Activation of Nrf2 and Inhibition of NF-kB.
REFERENCE   2  (residues 1 to 359)
  AUTHORS   Garwain,O., Yerramilli,V.S., Romero,K. and Scarlata,S.
  TITLE     The Galphaq/phospholipase Cbeta signaling system represses tau
            aggregation
  JOURNAL   Cell Signal 71, 109620 (2020)
   PUBMED   32247043
  REMARK    GeneRIF: The Galphaq/phospholipase Cbeta signaling system represses
            tau aggregation.
REFERENCE   3  (residues 1 to 359)
  AUTHORS   Pearce,K.M., Bell,M., Linthicum,W.H., Wen,Q., Srinivasan,J.,
            Rangamani,P. and Scarlata,S.
  TITLE     Galphaq-mediated calcium dynamics and membrane tension modulate
            neurite plasticity
  JOURNAL   Mol Biol Cell 31 (7), 683-694 (2020)
   PUBMED   31825720
  REMARK    GeneRIF: Galphaq-mediated calcium dynamics and membrane tension
            modulate neurite plasticity.
REFERENCE   4  (residues 1 to 359)
  AUTHORS   Qifti,A., Garwain,O. and Scarlata,S.
  TITLE     Mechanical Stretch Redefines Membrane Galphaq-Calcium Signaling
            Complexes
  JOURNAL   J Membr Biol 252 (4-5), 307-315 (2019)
   PUBMED   31011763
  REMARK    GeneRIF: Mechanical Stretch Redefines Membrane Galphaq-Calcium
            Signaling Complexes.
REFERENCE   5  (residues 1 to 359)
  AUTHORS   Atef,M.E. and Anand-Srivastava,M.B.
  TITLE     Role of PKCdelta in Enhanced Expression of Gqalpha/PLCbeta1
            Proteins and VSMC Hypertrophy in Spontaneously Hypertensive Rats
  JOURNAL   PLoS One 11 (7), e0157955 (2016)
   PUBMED   27379421
  REMARK    GeneRIF: Enhanced activation of protein kinase C delta (PKCdelta)
            in vascular smooth muscle cell (VSMC) from hypertensive rats (SHR)
            increases the expression of G alpha protein q (Gqalpha) and
            phospholipase C beta1 (PLCbeta1) proteins and results in VSMC
            hypertrophy.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 359)
  AUTHORS   Haley,J.E., Abogadie,F.C., Delmas,P., Dayrell,M., Vallis,Y.,
            Milligan,G., Caulfield,M.P., Brown,D.A. and Buckley,N.J.
  TITLE     The alpha subunit of Gq contributes to muscarinic inhibition of the
            M-type potassium current in sympathetic neurons
  JOURNAL   J Neurosci 18 (12), 4521-4531 (1998)
   PUBMED   9614229
REFERENCE   7  (residues 1 to 359)
  AUTHORS   Offermanns,S., Hashimoto,K., Watanabe,M., Sun,W., Kurihara,H.,
            Thompson,R.F., Inoue,Y., Kano,M. and Simon,M.I.
  TITLE     Impaired motor coordination and persistent multiple climbing fiber
            innervation of cerebellar Purkinje cells in mice lacking Galphaq
  JOURNAL   Proc Natl Acad Sci U S A 94 (25), 14089-14094 (1997)
   PUBMED   9391157
REFERENCE   8  (residues 1 to 359)
  AUTHORS   Friedman,E., Jin,L.Q., Cai,G.P., Hollon,T.R., Drago,J., Sibley,D.R.
            and Wang,H.Y.
  TITLE     D1-like dopaminergic activation of phosphoinositide hydrolysis is
            independent of D1A dopamine receptors: evidence from D1A knockout
            mice
  JOURNAL   Mol Pharmacol 51 (1), 6-11 (1997)
   PUBMED   9016340
REFERENCE   9  (residues 1 to 359)
  AUTHORS   Jefferies,S.R., Barkmeier,W.W. and Gwinnett,A.J.
  TITLE     Three composite finishing systems: a multisite in vitro evaluation
  JOURNAL   J Esthet Dent 4 (6), 181-185 (1992)
   PUBMED   1299289
REFERENCE   10 (residues 1 to 359)
  AUTHORS   Lesch,K.P. and Manji,H.K.
  TITLE     Signal-transducing G proteins and antidepressant drugs: evidence
            for modulation of alpha subunit gene expression in rat brain
  JOURNAL   Biol Psychiatry 32 (7), 549-579 (1992)
   PUBMED   1333286
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Dec 5, 2020 this sequence version replaced NP_112298.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.4832.1,
                                           SRR26643429.5154.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..359
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     Protein         1..359
                     /product="guanine nucleotide-binding protein G(q) subunit
                     alpha"
                     /note="guanine nucleotide binding protein alpha q subunit;
                     guanine nucleotide-binding protein alpha-q; heterotrimeric
                     guanine nucleotide-binding protein alpha q subunit;
                     guanine nucleotide binding protein, alpha q polypeptide;
                     guanine nucleotide regulatory protein G alpha q; guanine
                     nucleotide binding protein (G protein), q polypeptide"
                     /calculated_mol_wt=42027
     Region          40..353
                     /region_name="G-alpha"
                     /note="Alpha subunit of G proteins (guanine nucleotide
                     binding); cd00066"
                     /db_xref="CDD:206639"
     Region          41..54
                     /region_name="G1 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01230"
                     /note="propagated from UniProtKB/Swiss-Prot (P82471.2)"
     Site            order(46,51..53,186,205,208,274..275,277,330..331)
                     /site_type="other"
                     /note="GTP/Mg2+ binding site [chemical binding]"
                     /db_xref="CDD:206639"
     Site            46..53
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:206639"
     Site            order(47..49,77,81,85,88,91..92,110,113,154,183,208,216,
                     220)
                     /site_type="active"
                     /note="GoLoco binding site [active]"
                     /db_xref="CDD:206639"
     Region          178..186
                     /region_name="G2 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01230"
                     /note="propagated from UniProtKB/Swiss-Prot (P82471.2)"
     Site            181..189
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206639"
     Site            186
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206639"
     Site            order(187,189,191,202,204,208..210,212,215..216,218..221)
                     /site_type="other"
                     /note="beta - gamma complex interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:206639"
     Site            order(189,214,217..218,221)
                     /site_type="other"
                     /note="adenylyl cyclase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:206639"
     Region          201..210
                     /region_name="G3 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01230"
                     /note="propagated from UniProtKB/Swiss-Prot (P82471.2)"
     Site            205..208
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206639"
     Site            206..222
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:206639"
     Region          270..277
                     /region_name="G4 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01230"
                     /note="propagated from UniProtKB/Swiss-Prot (P82471.2)"
     Site            274..277
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206639"
     Site            order(322..333,335..338)
                     /site_type="active"
                     /note="putative receptor binding site [active]"
                     /db_xref="CDD:206639"
     Region          329..334
                     /region_name="G5 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01230"
                     /note="propagated from UniProtKB/Swiss-Prot (P82471.2)"
     Site            330..332
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:206639"
     CDS             1..359
                     /gene="Gnaq"
                     /gene_synonym="Galphaq"
                     /coded_by="NM_031036.3:96..1175"
                     /db_xref="GeneID:81666"
                     /db_xref="RGD:620770"
ORIGIN      
        1 mtlesimacc lseeakearr indeierqlr rdkrdarrel kllllgtges gkstfikqmr
       61 iihgsgysde dkrgftklvy qniftamqam iramdtlkip ykyehnkaha qlvrevdvek
      121 vsafenpyvd aikslwndpg iqecydrrre yqlsdstkyy lndldrvadp sylptqqdvl
      181 rvrvpttgii eypfdlqsvi frmvdvggqr serrkwihcf envtsimflv alseydqvlv
      241 esdnenrmee skalfrtiit ypwfqnssvi lflnkkdlle ekimyshlvd yfpeydgpqr
      301 daqaarefil kmfvdlnpds dkiiyshftc atdtenirfv faavkdtilq lnlkeynlv
//
