LOCUS       NM_001414909            5546 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus G protein subunit alpha o1 (Gnao1), transcript
            variant A, mRNA.
ACCESSION   NM_001414909 XM_008772321
VERSION     NM_001414909.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5546)
  AUTHORS   Xu,S., Yu,W., Zhang,X., Wang,W. and Wang,X.
  TITLE     The regulatory role of Gnao1 protein in diabetic encephalopathy in
            KK-Ay mice and streptozotocin-induced diabetic rats
  JOURNAL   Brain Res 1792, 148012 (2022)
   PUBMED   35839930
  REMARK    GeneRIF: The regulatory role of Gnao1 protein in diabetic
            encephalopathy in KK-Ay mice and streptozotocin-induced diabetic
            rats.
REFERENCE   2  (bases 1 to 5546)
  AUTHORS   Zeng,B., Mou,T.C., Doukov,T.I., Steiner,A., Yu,W.,
            Papasergi-Scott,M., Tall,G.G., Hagn,F. and Sprang,S.R.
  TITLE     Structure, Function, and Dynamics of the Galpha Binding Domain of
            Ric-8A
  JOURNAL   Structure 27 (7), 1137-1147 (2019)
   PUBMED   31155309
  REMARK    GeneRIF: Structure, function, and dynamics of the Galpha binding
            domain of Ric-8A have been reported.
REFERENCE   3  (bases 1 to 5546)
  AUTHORS   Yang,J., Cai,W., Lu,X., Liu,S. and Zhao,S.
  TITLE     RNA-Sequencing Analyses Demonstrate the Involvement of Canonical
            Transient Receptor Potential Channels in Rat Tooth Germ Development
  JOURNAL   Front Physiol 8, 455 (2017)
   PUBMED   28706494
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5546)
  AUTHORS   Simon,K., Hennen,S., Merten,N., Blattermann,S., Gillard,M.,
            Kostenis,E. and Gomeza,J.
  TITLE     The Orphan G Protein-coupled Receptor GPR17 Negatively Regulates
            Oligodendrocyte Differentiation via Galphai/o and Its Downstream
            Effector Molecules
  JOURNAL   J Biol Chem 291 (2), 705-718 (2016)
   PUBMED   26620557
  REMARK    GeneRIF: stimulation of GPR17 by the small molecule agonist
            MDL29,951 (2-carboxy-4,6-dichloro-1H-indole-3-propionic acid)
            decreases myelin basic protein expression levels mainly by
            triggering the Galphai/o signaling pathway.
REFERENCE   5  (bases 1 to 5546)
  AUTHORS   Moller,D., Kling,R.C., Skultety,M., Leuner,K., Hubner,H. and
            Gmeiner,P.
  TITLE     Functionally selective dopamine D, D receptor partial agonists
  JOURNAL   J Med Chem 57 (11), 4861-4875 (2014)
   PUBMED   24831693
REFERENCE   6  (bases 1 to 5546)
  AUTHORS   Andreopoulos,S., Li,P.P. and Warsh,J.J.
  TITLE     Developmental expression of G alpha o and G alpha s isoforms in
            PC12 cells: relationship to neurite outgrowth
  JOURNAL   Brain Res Dev Brain Res 88 (1), 30-36 (1995)
   PUBMED   7493405
REFERENCE   7  (bases 1 to 5546)
  AUTHORS   Campbell,V., Berrow,N., Brickley,K., Page,K., Wade,R. and
            Dolphin,A.C.
  TITLE     Voltage-dependent calcium channel beta-subunits in combination with
            alpha 1 subunits, have a GTPase activating effect to promote the
            hydrolysis of GTP by G alpha o in rat frontal cortex
  JOURNAL   FEBS Lett 370 (1-2), 135-140 (1995)
   PUBMED   7544301
REFERENCE   8  (bases 1 to 5546)
  AUTHORS   Strittmatter,S.M., Valenzuela,D., Kennedy,T.E., Neer,E.J. and
            Fishman,M.C.
  TITLE     G0 is a major growth cone protein subject to regulation by GAP-43
  JOURNAL   Nature 344 (6269), 836-841 (1990)
   PUBMED   2158629
REFERENCE   9  (bases 1 to 5546)
  AUTHORS   Jones,D.T. and Reed,R.R.
  TITLE     Molecular cloning of five GTP-binding protein cDNA species from rat
            olfactory neuroepithelium
  JOURNAL   J Biol Chem 262 (29), 14241-14249 (1987)
   PUBMED   2820999
REFERENCE   10 (bases 1 to 5546)
  AUTHORS   Itoh,H., Kozasa,T., Nagata,S., Nakamura,S., Katada,T., Ui,M.,
            Iwai,S., Ohtsuka,E., Kawasaki,H., Suzuki,K. et al.
  TITLE     Molecular cloning and sequence determination of cDNAs for alpha
            subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go
            from rat brain
  JOURNAL   Proc Natl Acad Sci U S A 83 (11), 3776-3780 (1986)
   PUBMED   3086867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Dec 14, 2022 this sequence version replaced XM_008772321.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1364610.1,
                                           SRR26643289.42189.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840111, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-864               JAXUCZ010000019.1  11197574-11198437   c
            865-907             JAXUCZ010000019.1  11197334-11197376   c
            908-1049            JAXUCZ010000019.1  11111196-11111337   c
            1050-1210           JAXUCZ010000019.1  11064539-11064699   c
            1211-1339           JAXUCZ010000019.1  11059618-11059746   c
            1340-1469           JAXUCZ010000019.1  11058718-11058847   c
            1470-1623           JAXUCZ010000019.1  11055019-11055172   c
            1624-5546           JAXUCZ010000019.1  11049186-11053108   c
FEATURES             Location/Qualifiers
     source          1..5546
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p12"
     gene            1..5546
                     /gene="Gnao1"
                     /gene_synonym="Gnao; Hg1g; RATBPGTPC"
                     /note="G protein subunit alpha o1"
                     /db_xref="GeneID:50664"
                     /db_xref="RGD:628732"
     exon            1..864
                     /gene="Gnao1"
                     /gene_synonym="Gnao; Hg1g; RATBPGTPC"
                     /inference="alignment:Splign:2.1.0"
     CDS             747..1811
                     /gene="Gnao1"
                     /gene_synonym="Gnao; Hg1g; RATBPGTPC"
                     /note="isoform A is encoded by transcript variant A;
                     GTP-binding protein alpha o; guanine nucleotide-binding
                     protein G(o) subunit alpha; guanine nucleotide binding
                     protein, alpha O polypeptide 1; guanine nucleotide binding
                     protein (G protein), alpha activating activity polypeptide
                     O; heterotrimeric guanine nucleotide-binding protein 1g"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein G(o) subunit
                     alpha isoform A"
                     /protein_id="NP_001401838.1"
                     /db_xref="GeneID:50664"
                     /db_xref="RGD:628732"
                     /translation="MGCTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGES
                     GKSTIVKQMKIIHEDGFSGEDVKQYKPVVYSNTIQSLAAIVRAMDTLGVEYGDKERKA
                     DSKMVCDVVSRMEDTEPFSAELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSL
                     DRIGAADYQPTEQDILRTRVKTTGIVETHFTFKNLHFRLFDVGGQRSERKKWIHCFED
                     VTAIIFCVALSGYDQVLHEDETTNRMHESLKLFDSICNNKWFTDTSIILFLNKKDIFE
                     EKIKKSPLTICFPEYTGPSAFTEAVAHIQGQYESKNKSAHKEVYSHVTCATDTNNIQF
                     VFDAVTDVIIAKNLRGCGLY"
     exon            865..907
                     /gene="Gnao1"
                     /gene_synonym="Gnao; Hg1g; RATBPGTPC"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1049
                     /gene="Gnao1"
                     /gene_synonym="Gnao; Hg1g; RATBPGTPC"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1210
                     /gene="Gnao1"
                     /gene_synonym="Gnao; Hg1g; RATBPGTPC"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1339
                     /gene="Gnao1"
                     /gene_synonym="Gnao; Hg1g; RATBPGTPC"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1469
                     /gene="Gnao1"
                     /gene_synonym="Gnao; Hg1g; RATBPGTPC"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1623
                     /gene="Gnao1"
                     /gene_synonym="Gnao; Hg1g; RATBPGTPC"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..5546
                     /gene="Gnao1"
                     /gene_synonym="Gnao; Hg1g; RATBPGTPC"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcccgcct cttctcgcgc tccccgctgg ccgcggctct ctcgcgctct ccctgtctcc
       61 tgtccgctcc gccgagcgat gcgagttctg ggccccggcg acgccgcctc cagctagaga
      121 tctgcacccc tcacccccgg cccggccctc tgcccagccc tgccctgcgc gcgggggtcg
      181 gagaaggcgc cgcggacgca ccgacggccg aggagcggcg atgcacatgc actagcggca
      241 ccccctaact cactccctcc acaccccgcg ccgccgccgc cgccaccgcc tccgcctccg
      301 cctcctcctc cgcctccggc agccgcggca gaaggaccca ccctgccccc caccccaccc
      361 tccgccggct ccggctgcgg atccagcctc gactcctatt ttatttattt tgggtcgtgc
      421 actagtctcg gtgcctgcaa cccgcgcctc ccgggcccgc gggcgcctcc tctctcggct
      481 ccggagcccc agaccccggc caccctcacc tcgacacccc cagaccccag ccagccgccg
      541 ctaatcttcg ccgctggaat cttgatagag gctgtccttt tggggggatt ctggtctttc
      601 gacaattttg ttcccaacca aggaaaggat atcgtgattt tctccccttt gagcccaggc
      661 tctgctctgt gggggggtgg ggggcgcgcc gacccgagga gtcgtgccag ccgagtcgtg
      721 cgggctgtgg cagggaaggg gccaccatgg gatgtactct gagcgcagag gagagagccg
      781 ccctcgagcg gagcaaggcg attgagaaaa atctcaaaga agatggcatc agcgccgcca
      841 aagacgtgaa attactcctg ctgggggctg gagaatcagg aaaaagcacc attgtgaagc
      901 agatgaagat catccatgaa gatggcttct ctggagaaga cgtaaagcag tacaagcctg
      961 tcgtctacag caacaccatc cagtctctgg cagccattgt gcgggccatg gatactctgg
     1021 gcgtggagta tggtgacaag gagaggaagg cagactccaa gatggtgtgt gacgtggtga
     1081 gtcgcatgga ggacactgaa ccattctctg cagaactgct ttctgccatg atgcgactct
     1141 ggggcgactc ggggatccag gagtgcttca accgatctcg ggagtatcag ctcaacgact
     1201 ctgccaaata ctacctggac agcttggatc ggattggagc cgctgactac cagcccaccg
     1261 agcaggacat cctccgaacc agggtcaaaa caactggcat cgtagaaacc cacttcacct
     1321 tcaagaacct ccacttcagg ctgtttgacg ttgggggcca gcgatctgaa cgtaagaagt
     1381 ggatccactg cttcgaggat gtcacggcca tcatcttctg tgtcgcactc agcggctatg
     1441 accaggtgct ccacgaggac gaaaccacga accgcatgca tgagtctctg aagctttttg
     1501 acagcatctg caacaacaag tggttcacag acacttcgat catcctgttt ctcaacaaga
     1561 aggacatatt tgaggagaag atcaagaagt ccccactcac catctgcttc cctgaataca
     1621 caggccccag tgccttcaca gaagctgtgg ctcatatcca agggcagtat gagagtaaga
     1681 ataagtcagc tcacaaggag gtctacagcc atgtcacctg tgccacggac accaacaaca
     1741 tccagttcgt ctttgatgcc gtgacagatg tcatcatcgc caaaaacctg cggggctgtg
     1801 gcctctactg agccctggcc tcccacccag cctgccactc actcctcccc tggacccaga
     1861 gctctgccgc cgctcagatg ccctattcag tgaagaaaac cccagaggct ggcctggggg
     1921 gcagcaggag gcatcctctg agcgtcccaa ctccaactgc atgacacgtg ggaagagggt
     1981 tgggcagagg catggagcac acaccacaag gccagagacc actcatgcca cctgggtgct
     2041 gctcactggt cagctgcgtc tcttactcag aggccgggtg ggcagcactg ccatctggtt
     2101 cagaatgggc atgtcctgtt ctctgcacct cctgctcggt gtcctggtga tagggtggcc
     2161 ggcagagtgg cccgcggcag gcgctgcttg gtcaggagat agttgatgct ttccttaggg
     2221 tctgtttggt agagggcggt tccgtcgaca aaagccaaca tggagtcagg ccacttttgg
     2281 ggtgcaaaga ctcagacctt ggggaggggt tctctcctcc ttcaccttgg atcttggccc
     2341 ttctctggtc atcttccctt gcccttgggc tccccaggat actcagccct gactcccacg
     2401 ggactgggaa tattccttaa aactggctga ctgcaaaggg gtgttggtgg agtaacagtc
     2461 ctgcgccaca gaaggggagg gcttgagggg caggcagctc tttcctgata ggctaatggt
     2521 gagccctgag aatgccatct gctgcatcta ctcacacagg ctcagctgcc ctgggcggca
     2581 gtgagtagac aggccacagg cttcaggtca cagacagagc aggcagcagc cttgccactg
     2641 gagagtgtgt aggcagaagc ataggaaact taggagccag ctctgaagcc agaaccctgc
     2701 tttactccac ccttggtcag gaagtagaaa gcccatggta tattcctggt ctcggggcaa
     2761 gcagtgagcc agcaccctga agggtgggct caggagaagt gtaaaccaca gacacacggc
     2821 tagcccctgg gttggtgaga gccctaggaa cccagggacg ggctttactt cagagattcc
     2881 ccagcagaaa agggtggtgt ggttcttagc aaccctagcc tcagctgact ttggacagcc
     2941 agcacatgtc cctgccactc ctagacatct ccagtcagct ggtacagcca gtgggtggga
     3001 cgggcttgaa tgctcaatgg caggctgtac tgaaggatgt agatgtgcag tcaagaaagg
     3061 tccctgcctc ctcaagccct gtattttcct ggccttcact ctgagtcctg ctctgtcaca
     3121 gggcaggcag gaccctggcc ctctttcata gtccccatgt ccttgccacc agctctggac
     3181 ttgttggttc caacaagaac agaactctgg gtggtctagg gagacacaag gaccttcccc
     3241 agtgccaaag cttatcgggg taatcctctg gggagctcac cccagtctgg gtgacccttt
     3301 gaggagtcca ccccagtctg agtgatcctc tggggagctt accccagtct ggttgcctcg
     3361 cccttccctc tccacccata tttgcctcca ctgtatatat ccctgtcatc ttaggaccct
     3421 gtgccatgta caaggggtga cagaagagcc tggagaccgc agtctcagtg atctgttgtg
     3481 atggcgaagg ccaattcagt ccttggacca acagcagcac ccctgggtgt ggccacccgt
     3541 ctacagactg taaccccaag tttaaaagca cctgctgtca ggggatctta gccaagcccc
     3601 attctttaag atcacttcca ggaagggaga cgtcaccacc cctaagtact cccctacagc
     3661 ttcccatccc ccgtgcggcc cctccagatc actgcagctc agctgcggga gccctcggct
     3721 agaaccgggg cctgtaccca gccctcccgc tcctgtctcc agggctgcct tctcccccac
     3781 ctactgtgtt cagcctagtg ccgtgctcgc ccttagtgct cagagctgtc tacttgaagc
     3841 ctcaagaatg tggtccatag ggaaagctgg cctgcctccc acccatgtca tcaccagcag
     3901 ctctaccatg ggggacaaat gcgtgtggca gatgaatctt ggcgccgccg tggctttggg
     3961 gatgggggaa gtgttgaaag tgaccagatc aagggaatgt gcagtggcgg tgtcccccga
     4021 gggcccatgc tagtttctga gtcagcaggc caggtggaag ccagtttcta ggaagagtgt
     4081 cttctccaca ttcagagaac tgtgcctgtt gcctaggtgc ctgtggccaa gtcctgtgcc
     4141 ctgtgcccat gtccattcca agaatcttcc ctttaagcat aggcagaggc ctctgagctg
     4201 tggagagtgc tgctgggctc tgtacggggg cgggaatgga atcctcccat tccgagccac
     4261 tcattagtag tattggcctt cagcctttct cgatcccttc ggtggatgga gcccctagat
     4321 cctggcgccc tgtcccctag tcccctcttg tgtgccatgc agaagatctc catcgtctca
     4381 gcctcgaagc caggcccaca tactgtgggg gctggaggct cctgacctgt gtggtctgca
     4441 ctgggtagca ctgagtgccc tgttcaaccc catccccagg atgtccacag aggttgacag
     4501 tgcttcactc cgacccttgc ctcctgcaga gaatactgcc acagaggtgt gcctgtgatt
     4561 cccacgtact gcatgctata gccagtgaga ccagggtgca cgctcctgac ctcctcccct
     4621 tcatctgacc caggctcttg acatggagat ccactacacc caggagagac ccttccagat
     4681 cttccctcct gacccagtag tagcctgtca ccctcttcta aagatcctga gggcacagag
     4741 cattttccag ctgccacccc tcttttctgg gcctcctggt aagctccagg tgtgtggctt
     4801 ccaggaaccc agtcctgagg ctccagctcc attgtatctg aggcactgag acaagcaccc
     4861 tccaaggtgg taatcccatc aaggtacaag ctaaagaaag ttccagcatc ccaaaggaca
     4921 gggccagggc tgtaatcagg cttccccaca ccccaccgcc cagtaaggag agccttgtac
     4981 acatctgctt agagagcggg gctcagcctc acagacatcc cccaccccct gtgccagatt
     5041 atggccatgt caaagaggga gccggaagaa aaccagaatt tatggccccc actcaaaagt
     5101 cctgggcctc taggcagagt gctctaccct ctgacagaca caaaaggcca ctaacagaaa
     5161 cagcaccctt cccagcaacc ctcatgtcct cctcccgccc gtcccctcag cctcctgcac
     5221 cagccacagt tgcctgccca gcatggacag cagctgtaca cttcctgtgt tctccctgac
     5281 ttccgacttg acccctgtgg cctatgcgca cacaccctca agtcccaggc cagaggctgg
     5341 gcaccctacg ttccccttag cagccttggg tgtaccaacc ccaccccctg acccaccgcc
     5401 atcacctacc ctcacctcat taactgtaat tttgtaagaa gagtgacttg ctggttaata
     5461 aatacctagt tattgtaata atttattggc tgccataatg tatttattag taacccacca
     5521 ttaataaaaa gtgccagctc tttcta
//
