LOCUS       NM_001191836            3030 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Rattus norvegicus G protein subunit alpha L (Gnal), mRNA.
ACCESSION   NM_001191836 XM_341626
VERSION     NM_001191836.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3030)
  AUTHORS   El Atiallah,I., Ponterio,G., Meringolo,M., Martella,G.,
            Sciamanna,G., Tassone,A., Montanari,M., Mancini,M., Castagno,A.N.,
            Yu-Taeger,L., Nguyen,H.H.P., Bonsi,P. and Pisani,A.
  TITLE     Loss-of-function of GNAL dystonia gene impairs striatal dopamine
            receptors-mediated adenylyl cyclase/ cyclic AMP signaling pathway
  JOURNAL   Neurobiol Dis 191, 106403 (2024)
   PUBMED   38182074
  REMARK    GeneRIF: Loss-of-function of GNAL dystonia gene impairs striatal
            dopamine receptors-mediated adenylyl cyclase/ cyclic AMP signaling
            pathway.
REFERENCE   2  (bases 1 to 3030)
  AUTHORS   Makeyeva,Y., Nicol,C., Ledger,W.L. and Ryugo,D.K.
  TITLE     Immunocytochemical Localization of Olfactory-signaling Molecules in
            Human and Rat Spermatozoa
  JOURNAL   J Histochem Cytochem 68 (7), 491-513 (2020)
   PUBMED   32603211
REFERENCE   3  (bases 1 to 3030)
  AUTHORS   Yu-Taeger,L., Ott,T., Bonsi,P., Tomczak,C., Wassouf,Z.,
            Martella,G., Sciamanna,G., Imbriani,P., Ponterio,G., Tassone,A.,
            Schulze-Hentrich,J.M., Goodchild,R., Riess,O., Pisani,A.,
            Grundmann-Hauser,K. and Nguyen,H.P.
  TITLE     Impaired dopamine- and adenosine-mediated signaling and plasticity
            in a novel rodent model for DYT25 dystonia
  JOURNAL   Neurobiol Dis 134, 104634 (2020)
   PUBMED   31678405
REFERENCE   4  (bases 1 to 3030)
  AUTHORS   Song,H., Fang,S., Gao,J., Wang,J., Cao,Z., Guo,Z., Huang,Q., Qu,Y.,
            Zhou,H. and Yu,J.
  TITLE     Quantitative Proteomic Study Reveals Up-Regulation of cAMP
            Signaling Pathway-Related Proteins in Mild Traumatic Brain Injury
  JOURNAL   J Proteome Res 17 (2), 858-869 (2018)
   PUBMED   29215295
  REMARK    GeneRIF: cAMP signaling pathway-related proteins, Pde10a and Gnal,
            may play important roles in the pathogenesis and recovery of mild
            traumatic brain injury.
REFERENCE   5  (bases 1 to 3030)
  AUTHORS   Goncalves,I., Hubbard,P.C., Tomas,J., Quintela,T., Tavares,G.,
            Caria,S., Barreiros,D. and Santos,C.R.
  TITLE     'Smelling' the cerebrospinal fluid: olfactory signaling molecules
            are expressed in and mediate chemosensory signaling from the
            choroid plexus
  JOURNAL   FEBS J 283 (9), 1748-1766 (2016)
   PUBMED   26934374
  REMARK    GeneRIF: The major components of the olfactory transduction pathway
            in the rat choroid plexus have been determined, including odorant
            receptors, Galphaolf, adenylate cyclase 3 and CNGA2.
REFERENCE   6  (bases 1 to 3030)
  AUTHORS   Belluscio,L., Gold,G.H., Nemes,A. and Axel,R.
  TITLE     Mice deficient in G(olf) are anosmic
  JOURNAL   Neuron 20 (1), 69-81 (1998)
   PUBMED   9459443
REFERENCE   7  (bases 1 to 3030)
  AUTHORS   Lelianova,V.G., Davletov,B.A., Sterling,A., Rahman,M.A.,
            Grishin,E.V., Totty,N.F. and Ushkaryov,Y.A.
  TITLE     Alpha-latrotoxin receptor, latrophilin, is a novel member of the
            secretin family of G protein-coupled receptors
  JOURNAL   J Biol Chem 272 (34), 21504-21508 (1997)
   PUBMED   9261169
REFERENCE   8  (bases 1 to 3030)
  AUTHORS   Herve,D., Rogard,M. and Levi-Strauss,M.
  TITLE     Molecular analysis of the multiple Golf alpha subunit mRNAs in the
            rat brain
  JOURNAL   Brain Res Mol Brain Res 32 (1), 125-134 (1995)
   PUBMED   7494450
REFERENCE   9  (bases 1 to 3030)
  AUTHORS   Menco,B.P., Tekula,F.D., Farbman,A.I. and Danho,W.
  TITLE     Developmental expression of G-proteins and adenylyl cyclase in
            peripheral olfactory systems. Light microscopic and
            freeze-substitution electron microscopic immunocytochemistry
  JOURNAL   J Neurocytol 23 (11), 708-727 (1994)
   PUBMED   7861185
REFERENCE   10 (bases 1 to 3030)
  AUTHORS   Jones,D.T. and Reed,R.R.
  TITLE     Golf: an olfactory neuron specific-G protein involved in odorant
            signal transduction
  JOURNAL   Science 244 (4906), 790-795 (1989)
   PUBMED   2499043
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1 and S80376.1.
            
            On Feb 26, 2015 this sequence version replaced NM_001191836.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.74464.1,
                                           SRR26643299.63174.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-526               JAXUCZ010000018.1  62892257-62892782
            527-599             JAXUCZ010000018.1  62937587-62937659
            600-654             JAXUCZ010000018.1  62938680-62938734
            655-774             JAXUCZ010000018.1  62938934-62939053
            775-813             JAXUCZ010000018.1  62993196-62993234
            814-1250            S80376.1           1212-1648
            1251-1312           JAXUCZ010000018.1  63024857-63024918
            1313-1380           JAXUCZ010000018.1  63027920-63027987
            1381-3030           JAXUCZ010000018.1  63030861-63032510
FEATURES             Location/Qualifiers
     source          1..3030
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..3030
                     /gene="Gnal"
                     /gene_synonym="Golf; Olf; RGD1305940"
                     /note="G protein subunit alpha L"
                     /db_xref="GeneID:24611"
                     /db_xref="RGD:2715"
     exon            1..526
                     /gene="Gnal"
                     /gene_synonym="Golf; Olf; RGD1305940"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..1527
                     /gene="Gnal"
                     /gene_synonym="Golf; Olf; RGD1305940"
                     /note="guanine nucleotide-binding protein G(olf), alpha
                     subunit; adenylate cyclase-stimulating G alpha protein,
                     olfactory type; Olf-alpha protein (olfactory
                     neuron-specific G protein); guanine nucleotide binding
                     protein, alpha stimulating, olfactory type; guanine
                     nucleotide binding protein, alpha activating activity
                     polypeptide, olfactory type"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein G(olf)
                     subunit alpha"
                     /protein_id="NP_001178765.1"
                     /db_xref="GeneID:24611"
                     /db_xref="RGD:2715"
                     /translation="MGLCYSLRPLLFGSSGDAPCEDSEPCAEDAQPSAARAPAPAPIP
                     APAPVGTLLRRGDGRIPASARSPVELQNRRRQEQLRAEEREAAKEARKVSRGIDRMLR
                     EQKRDLQQTHRLLLLGAGESGKSTIVKQMRILHVNGFNPEEKKQKILDIRKNVKDAIV
                     TIVSAMSTIIPPVPLANPENQFRSDYIKSIAPITDFEYSQEFFDHVKKLWDDEGVKAC
                     FERSNEYQLIDCAQYFLERIDSVSLVDYTPTDQDLLRCRVLTSGIFETRFQVDKVNFH
                     MFDVGGQRDERRKWIQCFNDVTAIIYVAACSSYNMVIREDNNTNRLRESLDLFESIWN
                     NRWLRTISIILFLNKQDMLAEKVLAGKSKIEDYFPEYANYTVPEDATPDAGEDPKVTR
                     AKFFIRDLFLRISTATGDGKHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLKQYELL
                     "
     exon            527..599
                     /gene="Gnal"
                     /gene_synonym="Golf; Olf; RGD1305940"
                     /inference="alignment:Splign:2.1.0"
     exon            600..654
                     /gene="Gnal"
                     /gene_synonym="Golf; Olf; RGD1305940"
                     /inference="alignment:Splign:2.1.0"
     exon            655..774
                     /gene="Gnal"
                     /gene_synonym="Golf; Olf; RGD1305940"
                     /inference="alignment:Splign:2.1.0"
     exon            775..872
                     /gene="Gnal"
                     /gene_synonym="Golf; Olf; RGD1305940"
                     /inference="alignment:Splign:2.1.0"
     exon            873..927
                     /gene="Gnal"
                     /gene_synonym="Golf; Olf; RGD1305940"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1001
                     /gene="Gnal"
                     /gene_synonym="Golf; Olf; RGD1305940"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1060
                     /gene="Gnal"
                     /gene_synonym="Golf; Olf; RGD1305940"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1181
                     /gene="Gnal"
                     /gene_synonym="Golf; Olf; RGD1305940"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1312
                     /gene="Gnal"
                     /gene_synonym="Golf; Olf; RGD1305940"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1380
                     /gene="Gnal"
                     /gene_synonym="Golf; Olf; RGD1305940"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..3030
                     /gene="Gnal"
                     /gene_synonym="Golf; Olf; RGD1305940"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttcggagga tgcacaatgg cccctccggg cagtgagggg ccgtggcccc ggagccggac
       61 ctaccgcagc cacgccccgc agccggaccc ccggggtccg agtgcagcgc tgccttcgga
      121 gtcggccaga gctccggtct gacccgcggg gacttgcccg cgccccgcgc ctcgatgggc
      181 ctgtgctaca gcctacggcc gctgctcttc gggagctcgg gggacgcccc ctgtgaggac
      241 tctgagccgt gcgctgagga tgctcagccc agcgccgccc gggccccggc cccggccccg
      301 atcccagccc cggctccggt ggggaccctg ctccggcgag gcgacggccg gatccccgca
      361 agcgcgaggt cgccagtcga gctgcagaac cgccggcgac aggagcagct gcgagccgag
      421 gagcgcgagg cagctaagga ggcgaggaaa gtaagccggg gtatcgaccg catgctgcgc
      481 gaacagaagc gcgacctgca gcagacgcac cggctcctgc tcttgggggc tggtgagtcc
      541 gggaaaagca ctatagtcaa acagatgagg atcctacacg tcaatggctt caaccccgag
      601 gaaaagaagc agaaaattct ggacatcagg aaaaatgtca aagatgctat tgtgacaatc
      661 gtttcagcaa tgagtaccat aatacctcca gttccactgg ccaaccctga gaaccagttt
      721 cggtcagatt acatcaagag catagcccct atcactgact ttgaatattc ccaggagttc
      781 tttgaccacg tgaagaagct gtgggatgat gagggagtga aggcctgctt tgagagatcc
      841 aacgagtacc agctgatcga ctgtgcacaa tacttcctgg aaaggattga cagcgtgagt
      901 ctggttgact acacacccac agaccaggac ctactcagat gcagagtgct gacatcaggg
      961 atctttgaga cacgattcca agtggacaaa gtgaactttc acatgtttga cgttggaggc
     1021 cagagggatg agagaagaaa atggatccag tgttttaacg atgtcactgc catcatctat
     1081 gtggcagcct gcagcagcta caacatggtg atccgggaag ataacaacac caacagactc
     1141 cgggagtcgc tggacctgtt tgaaagcatc tggaataaca ggtggttacg aaccatttcc
     1201 atcatcctgt tcttgaacaa acaagatatg ctggcagaaa aagtcttggc agggaagtca
     1261 aaaattgaag actatttccc ggagtatgcc aactatactg tccctgaaga tgcaacacca
     1321 gatgcaggag aagatcccaa agttacaaga gccaagttct ttatccggga tctgttcttg
     1381 aggatcagca cagccacggg tgatggcaaa cattactgct accctcactt cacctgcgcc
     1441 gtggacacag agaacatccg cagagtgttc aacgattgtc gtgacatcat ccagagaatg
     1501 cacctcaagc agtacgaact cttgtgaggg ccacccaccc acccctcctc ctcctcactg
     1561 ctgcctttcc tccctcttga ccaccccatg aggcagcata tccccctagc ctgcgtgtct
     1621 gtccaccccg agccaaggta gggagtagtg agtgtctagt gtcatcggac tgccgtctgt
     1681 cctgtcctag gtatgcctat gtgtgaccac caagcctctg gctacctctg ttccccaagg
     1741 tttggttctg tgactttgtt ttcactggac aaaacagcct cccaccacca atttgtatcc
     1801 ccgtatcacc ctctgggtgg tactgcagtg gattttctct gggtgggaat ctatttattc
     1861 tttgatggaa tggttgatgg gttgaatcat caaagacagc ttggtgaacg ggggaaatac
     1921 attgttttca agttatcaag catgatcaca aaactgtccg gacagtgcca cgcacttggt
     1981 ttttcccttt ataaaaggtt gggctaccca gtgtctgccc cttctggtct gcattggccc
     2041 agggcttaaa gcagatccac gtcagcaaca gaagacgagg acctttttca gccacagttg
     2101 caatggctat aagccttggg catttgggtt agagcacttc tgggagcctt ttacacttgg
     2161 gcagaaagcc ggccacattc actactaatg gtgtcctgtc tataaacaag gggtcctcta
     2221 caccttcctg atagctgggc atagtccttc ctgtcttctt tctgttgttg ctttaccaga
     2281 ctgtacagac cacaagatgt actactcttt tctgtggcta ctccagaagc ctccttgtag
     2341 agttccgtgc cttggtggcg gctatacctg taaggaaacg tgtccctcct gtgccaagca
     2401 gcctgcagtc cacacagcct gctgcttcac agtggggaat cagtagtatc tgcccatctt
     2461 aggatatttt tatcaggttg gcacttatgg aagactcggt gattttagaa tcatccactt
     2521 taccagcagt atcttcccaa cactgaaact gttgcagcca cccgctttta ctgctccaaa
     2581 cctgagctgc tgcacacatt gggatgaccc gctttcaagg cttaaattac aatcaattct
     2641 tttttcaggg ttctaagggg ttccccccca ctcccctctc aaggtgatca gttttcaatg
     2701 accccttcaa gttctgtagt caggagcagg ccaaccatcc cttagttaag ttctacacac
     2761 aggccaccaa acaagaaacc ggtggtcaga ggaaagcaca ggggtgtcca tgttgtatat
     2821 ggctgaggac aataaggatg atgtcatctg aagatgaaat atacaaaact acttatttat
     2881 tatctgtctc tctatttgct agggatgagc ccagcaccta gtgcatgcta ggcaagcact
     2941 ctacagctag tccatatccc cagccacaac tccagccctc acaaaaacct ttattttaaa
     3001 tataaagaca aaataaatgg cttctcctca
//
