LOCUS       NM_001013119            1159 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus G protein subunit alpha 13 (Gna13), mRNA.
ACCESSION   NM_001013119 XM_221066
VERSION     NM_001013119.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1159)
  AUTHORS   Wang,Y., Chen,D., Zhang,Y., Wang,P., Zheng,C., Zhang,S., Yu,B.,
            Zhang,L., Zhao,G., Ma,B., Cai,Z., Xie,N., Huang,S., Liu,Z., Mo,X.,
            Guan,Y., Wang,X., Fu,Y., Ma,D., Wang,Y. and Kong,W.
  TITLE     Novel Adipokine, FAM19A5, Inhibits Neointima Formation After Injury
            Through Sphingosine-1-Phosphate Receptor 2
  JOURNAL   Circulation 138 (1), 48-63 (2018)
   PUBMED   29453251
REFERENCE   2  (bases 1 to 1159)
  AUTHORS   Jiang,L.I., Wang,J.E. and Sternweis,P.C.
  TITLE     Regions on adenylyl cyclase VII required for selective regulation
            by the G13 pathway
  JOURNAL   Mol Pharmacol 83 (3), 587-593 (2013)
   PUBMED   23229509
REFERENCE   3  (bases 1 to 1159)
  AUTHORS   Zhang,Y., Fu,C., Asico,L.D., Villar,V.A., Ren,H., He,D., Wang,Z.,
            Yang,J., Jose,P.A. and Zeng,C.
  TITLE     Role of Galpha(12)- and Galpha(13)-protein subunit linkage of D(3)
            dopamine receptors in the natriuretic effect of D(3) dopamine
            receptor in kidney
  JOURNAL   Hypertens Res 34 (9), 1011-1016 (2011)
   PUBMED   21633357
  REMARK    GeneRIF: It was concluded that a D3 receptor interaction with
            Galpha12/Galpha13 that increases sodium excretion may have a role
            in the regulation of blood pressure.
REFERENCE   4  (bases 1 to 1159)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   5  (bases 1 to 1159)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   6  (bases 1 to 1159)
  AUTHORS   Gu,J.L., Muller,S., Mancino,V., Offermanns,S. and Simon,M.I.
  TITLE     Interaction of G alpha(12) with G alpha(13) and G alpha(q)
            signaling pathways
  JOURNAL   Proc Natl Acad Sci U S A 99 (14), 9352-9357 (2002)
   PUBMED   12077299
REFERENCE   7  (bases 1 to 1159)
  AUTHORS   Klages,B., Brandt,U., Simon,M.I., Schultz,G. and Offermanns,S.
  TITLE     Activation of G12/G13 results in shape change and
            Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse
            platelets
  JOURNAL   J Cell Biol 144 (4), 745-754 (1999)
   PUBMED   10037795
REFERENCE   8  (bases 1 to 1159)
  AUTHORS   Jho,E.H. and Malbon,C.C.
  TITLE     Galpha12 and Galpha13 mediate differentiation of P19 mouse
            embryonal carcinoma cells in response to retinoic acid
  JOURNAL   J Biol Chem 272 (39), 24461-24467 (1997)
   PUBMED   9305907
REFERENCE   9  (bases 1 to 1159)
  AUTHORS   Macrez-Lepretre,N., Kalkbrenner,F., Morel,J.L., Schultz,G. and
            Mironneau,J.
  TITLE     G protein heterotrimer Galpha13beta1gamma3 couples the angiotensin
            AT1A receptor to increases in cytoplasmic Ca2+ in rat portal vein
            myocytes
  JOURNAL   J Biol Chem 272 (15), 10095-10102 (1997)
   PUBMED   9092554
REFERENCE   10 (bases 1 to 1159)
  AUTHORS   Offermanns,S., Mancino,V., Revel,J.P. and Simon,M.I.
  TITLE     Vascular system defects and impaired cell chemokinesis as a result
            of Galpha13 deficiency
  JOURNAL   Science 275 (5299), 533-536 (1997)
   PUBMED   8999798
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY553632.1.
            
            On Apr 20, 2005 this sequence version replaced XM_221066.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY553631.1, AY553632.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1159
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="SHR"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..1159
                     /gene="Gna13"
                     /gene_synonym="Galpha13"
                     /note="G protein subunit alpha 13"
                     /db_xref="GeneID:303634"
                     /db_xref="RGD:1310221"
     CDS             1..1134
                     /gene="Gna13"
                     /gene_synonym="Galpha13"
                     /note="guanine nucleotide binding protein, alpha 13; G
                     alpha-13; guanine nucleotide binding protein (G protein),
                     alpha 13"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein subunit
                     alpha-13"
                     /protein_id="NP_001013137.1"
                     /db_xref="GeneID:303634"
                     /db_xref="RGD:1310221"
                     /translation="MADFLPSRSVLSVCFPGCVLTNGEAEQQRKSKEIDKCLSREKTY
                     VKRLVKILLLGAGESGKSTFLKQMRIIHGQDFDQRAREEFRPTIYSNVIKGMRVLVDA
                     REKLHIPWGDNKNQVHGDKLMAFDTRAPMAAQGMVETRVFLQYLPAIRALWDDSGIQN
                     AYDRRREFQLGESVKYFLDNLDKLGVPDYIPSQQDILLARRPTKGIHEYDFEIKNVPF
                     KMVDVGGQRSERKRWFECFDSVTSILFLVSSSEFDQVLMEDRLTNRLTESLNIFETIV
                     NNRVFSNVSIILFLNKTDLLEEKVQVVSIKDYFLEFEGDPHCLRDVQKFLVECFRGKR
                     RDQQQRPLYHHFTTAINTENIRLVFRDVKDTILHDNLKQLMLQ"
     exon            1..283
                     /gene="Gna13"
                     /gene_synonym="Galpha13"
                     /inference="alignment:Splign:2.1.0"
     exon            284..510
                     /gene="Gna13"
                     /gene_synonym="Galpha13"
                     /inference="alignment:Splign:2.1.0"
     exon            511..561
                     /gene="Gna13"
                     /gene_synonym="Galpha13"
                     /inference="alignment:Splign:2.1.0"
     exon            562..1159
                     /gene="Gna13"
                     /gene_synonym="Galpha13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcggact tcctgccgtc gcgctccgtg ctgtccgtgt gcttcccggg ctgcgtgctg
       61 acgaacggcg aggccgagca gcagcgcaag tccaaggaga tcgacaaatg cctgtcgcgg
      121 gagaagacct acgtgaagcg gctggtgaag atcctgctgc tgggcgcggg cgagagcggc
      181 aagtccacct tcctgaagca gatgcggatc atccacggcc aggacttcga ccagcgcgcg
      241 cgcgaggagt tccgccccac catctacagc aacgtgatca aaggtatgag ggtgctggta
      301 gatgcccgag agaagcttca tattccctgg ggagataaca aaaaccaggt ccacggagac
      361 aagttgatgg catttgatac ccgagctccc atggctgccc aggggatggt ggagactcga
      421 gtttttttgc agtatcttcc tgctataaga gccttatggg atgacagtgg catacagaat
      481 gcctacgatc ggcgccggga attccaactg ggtgagtctg taaagtattt cctggataac
      541 ttggataaac ttggagtacc ggactacatt ccgtcacagc aagatattct gcttgccaga
      601 agacccacca aaggcatcca tgagtatgac tttgaaatta aaaatgttcc tttcaaaatg
      661 gttgacgtag gtggccagag atcagaacgg aaacgttggt ttgaatgctt tgacagtgtg
      721 acatcaatac tcttccttgt ttcttcaagt gagtttgacc aggtgcttat ggaggaccgc
      781 ctgaccaacc gcctcacaga gtccctgaac atttttgaaa caattgtcaa taaccgggtt
      841 ttcagcaatg tctctataat tctcttctta aacaagacag acttgcttga ggagaaagtg
      901 caagttgtaa gcatcaaaga ctatttccta gaatttgaag gggaccctca ctgcttaaga
      961 gacgtccaaa agtttctggt ggaatgcttc cgggggaaac gccgggacca gcagcagagg
     1021 ccgctgtacc accacttcac caccgccatc aacacagaga acatccgcct tgtgttccga
     1081 gacgtgaagg acacgatcct tcatgacaac ctcaagcagc ttatgctcca gtgatgagga
     1141 gactcgctgt tttaatacc
//
