LOCUS       NM_031034               3345 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus G protein subunit alpha 12 (Gna12), mRNA.
ACCESSION   NM_031034
VERSION     NM_031034.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3345)
  AUTHORS   Wang,Y., Chen,D., Zhang,Y., Wang,P., Zheng,C., Zhang,S., Yu,B.,
            Zhang,L., Zhao,G., Ma,B., Cai,Z., Xie,N., Huang,S., Liu,Z., Mo,X.,
            Guan,Y., Wang,X., Fu,Y., Ma,D., Wang,Y. and Kong,W.
  TITLE     Novel Adipokine, FAM19A5, Inhibits Neointima Formation After Injury
            Through Sphingosine-1-Phosphate Receptor 2
  JOURNAL   Circulation 138 (1), 48-63 (2018)
   PUBMED   29453251
REFERENCE   2  (bases 1 to 3345)
  AUTHORS   Wang,Z., Guan,W., Han,Y., Ren,H., Tang,X., Zhang,H., Liu,Y., Fu,J.,
            He,D., Asico,L.D., Jose,P.A., Zhou,L., Chen,L. and Zeng,C.
  TITLE     Stimulation of Dopamine D3 Receptor Attenuates Renal
            Ischemia-Reperfusion Injury via Increased Linkage With Galpha12
  JOURNAL   Transplantation 99 (11), 2274-2284 (2015)
   PUBMED   25989500
  REMARK    GeneRIF: Suggest that activation of D3R, by decreasing
            Galpha12-induced renal damage, may exert a protective effect from
            renal I/R injury.
REFERENCE   3  (bases 1 to 3345)
  AUTHORS   Gan,X., Wang,J., Wang,C., Sommer,E., Kozasa,T., Srinivasula,S.,
            Alessi,D., Offermanns,S., Simon,M.I. and Wu,D.
  TITLE     PRR5L degradation promotes mTORC2-mediated PKC-delta
            phosphorylation and cell migration downstream of Galpha12
  JOURNAL   Nat Cell Biol 14 (7), 686-696 (2012)
   PUBMED   22609986
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3345)
  AUTHORS   Zhang,Y., Fu,C., Asico,L.D., Villar,V.A., Ren,H., He,D., Wang,Z.,
            Yang,J., Jose,P.A. and Zeng,C.
  TITLE     Role of Galpha(12)- and Galpha(13)-protein subunit linkage of D(3)
            dopamine receptors in the natriuretic effect of D(3) dopamine
            receptor in kidney
  JOURNAL   Hypertens Res 34 (9), 1011-1016 (2011)
   PUBMED   21633357
  REMARK    GeneRIF: It was concluded that a D3 receptor interaction with
            Galpha12/Galpha13 that increases sodium excretion may have a role
            in the regulation of blood pressure.
REFERENCE   5  (bases 1 to 3345)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   6  (bases 1 to 3345)
  AUTHORS   Zhu,D., Kosik,K.S., Meigs,T.E., Yanamadala,V. and Denker,B.M.
  TITLE     Galpha12 directly interacts with PP2A: evidence FOR
            Galpha12-stimulated PP2A phosphatase activity and dephosphorylation
            of microtubule-associated protein, tau
  JOURNAL   J Biol Chem 279 (53), 54983-54986 (2004)
   PUBMED   15525651
  REMARK    GeneRIF: Galpha12 has a role in direct regulation of PP2A activity
            and tau phosphorylation
REFERENCE   7  (bases 1 to 3345)
  AUTHORS   Zheng,S., Yu,P., Zeng,C., Wang,Z., Yang,Z., Andrews,P.M.,
            Felder,R.A. and Jose,P.A.
  TITLE     Galpha12- and Galpha13-protein subunit linkage of D5 dopamine
            receptors in the nephron
  JOURNAL   Hypertension 41 (3), 604-610 (2003)
   PUBMED   12623966
  REMARK    GeneRIF: Dopamine receptor D5 is linked to Galpha12 in the nephron.
REFERENCE   8  (bases 1 to 3345)
  AUTHORS   Gu,J.L., Muller,S., Mancino,V., Offermanns,S. and Simon,M.I.
  TITLE     Interaction of G alpha(12) with G alpha(13) and G alpha(q)
            signaling pathways
  JOURNAL   Proc Natl Acad Sci U S A 99 (14), 9352-9357 (2002)
   PUBMED   12077299
REFERENCE   9  (bases 1 to 3345)
  AUTHORS   Klages,B., Brandt,U., Simon,M.I., Schultz,G. and Offermanns,S.
  TITLE     Activation of G12/G13 results in shape change and
            Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse
            platelets
  JOURNAL   J Cell Biol 144 (4), 745-754 (1999)
   PUBMED   10037795
REFERENCE   10 (bases 1 to 3345)
  AUTHORS   Jho,E.H. and Malbon,C.C.
  TITLE     Galpha12 and Galpha13 mediate differentiation of P19 mouse
            embryonal carcinoma cells in response to retinoic acid
  JOURNAL   J Biol Chem 272 (39), 24461-24467 (1997)
   PUBMED   9305907
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Sep 27, 2011 this sequence version replaced NM_031034.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D85760.1, SRR22582419.1147353.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-336               JAXUCZ010000012.1  18919629-18919964
            337-552             JAXUCZ010000012.1  18963504-18963719
            553-603             JAXUCZ010000012.1  18995987-18996037
            604-3345            JAXUCZ010000012.1  18997444-19000185
FEATURES             Location/Qualifiers
     source          1..3345
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..3345
                     /gene="Gna12"
                     /gene_synonym="Hg1m1"
                     /note="G protein subunit alpha 12"
                     /db_xref="GeneID:81663"
                     /db_xref="RGD:71018"
     exon            1..336
                     /gene="Gna12"
                     /gene_synonym="Hg1m1"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1173
                     /gene="Gna12"
                     /gene_synonym="Hg1m1"
                     /note="guanine nucleotide binding protein, alpha 12;
                     guanine nucleotide binding protein (G protein) alpha 12; g
                     alpha-12; heterotrimeric guanine nucleotide-binding
                     protein 1m1"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein subunit
                     alpha-12"
                     /protein_id="NP_112296.1"
                     /db_xref="GeneID:81663"
                     /db_xref="RGD:71018"
                     /translation="MSGVVRTLSRCLLPAEAGARERRAGAARDAEREARRRSRDIDAL
                     LARERRAVRRLVKILLLGAGESGKSTFLKQMRIIHGREFDQKALLEFRDTIFDNILKG
                     SRVLVDARDKLGIPWQHSENEKHGMFLMAFENKAGLPVEPATFQLYVPALSALWRDSG
                     IREAFSRRSEFQLGESVKYFLDNLDRIGQLNYFPSKQDILLARKATKGIVEHDFVIKK
                     IPFKMVDVGGQRSQRQKWFQCFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFE
                     TIVNNKLFFNVSIILFLNKMDLLVEKVKSVSIKKHFPDFKGDPHRLEDVQRYLVQCFD
                     RKRRNRGKPLFHHFTTAIDTENIRFVFHAVKDTILQENLKDIMLQ"
     exon            337..552
                     /gene="Gna12"
                     /gene_synonym="Hg1m1"
                     /inference="alignment:Splign:2.1.0"
     exon            553..603
                     /gene="Gna12"
                     /gene_synonym="Hg1m1"
                     /inference="alignment:Splign:2.1.0"
     exon            604..3345
                     /gene="Gna12"
                     /gene_synonym="Hg1m1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggcggggc gcggccgcgg cctgagggcg gtcatgtccg gggtggtgcg gaccctcagc
       61 cgctgcttgc tgccggccga ggccggagcc cgcgagcgca gggcgggcgc ggcgcgcgac
      121 gcggaacgcg aggcccgacg gcgcagccgc gacatcgacg cgctgctggc ccgcgagcgg
      181 cgcgcggtgc ggcggctggt caagatcttg ctgctgggcg ccggcgagag cggcaagtcc
      241 accttcctca agcagatgcg catcatccac ggccgggagt tcgaccagaa ggcgctgctg
      301 gagttccgcg acaccatctt cgacaacatc cttaagggct cgagggtgct tgtagacgct
      361 cgggacaagc ttggcattcc ctggcagcac tctgagaacg agaagcacgg gatgtttctg
      421 atggccttcg agaacaaggc agggctgcct gtggagcctg ccaccttcca gctctacgtt
      481 ccagccctga gcgcactctg gagagactcc gggatcaggg aagccttcag ccgcagaagc
      541 gagttccagc tgggtgagtc agtgaagtac ttcctggata acttagaccg gattggccag
      601 ctgaactact tccccagtaa gcaagacatc ctgttggcta gaaaggccac caagggaatc
      661 gtggagcatg acttcgtgat aaagaaaatc ccatttaaga tggtggatgt gggcggccag
      721 aggtcgcagc gccagaagtg gttccagtgc ttcgacggga tcacatcgat cctgttcatg
      781 gtgtcctcaa gcgagtatga ccaggtcctc atggaggata ggcgcaccaa ccggctggtg
      841 gagtccatga acatcttcga gaccatcgtc aacaacaagc tcttcttcaa cgtctccatc
      901 atcctcttcc tcaacaagat ggacctgctg gtggagaagg tgaagtcggt gagcattaag
      961 aagcacttcc cagacttcaa gggcgacccg caccggctgg aggacgtcca gcgctacctg
     1021 gtccagtgct ttgacaggaa gcgcaggaac cgcggcaagc ctctgttcca ccacttcacc
     1081 actgccatag acaccgagaa catccgcttc gtgtttcatg ccgtgaagga caccatcctg
     1141 caggagaacc tgaaagatat catgctgcag tgagacagcc cctctgccgt cctctcgtgg
     1201 cctccgtggc ctgtggccac atgtctctgg tgtgtctgcc acctgcatgg acctgcagtg
     1261 ggcatctcga agccacacca tctaatacct ggctcaagaa tgctggactg tcagccacac
     1321 cagcgagctg cgggcaagag gacgtgggag tgtcagtgat agctactgaa tcggggactg
     1381 aaactactga atccacgcca tcgctctggt gttgatctgt aaaacctggg aacacagctt
     1441 tctccctccc tacagaaact cttccttgct gacacgactt aaccaaggtt caggtgtgca
     1501 cagacacaca tgctctcatt aatgacagaa acacaacccc agctggcctt acagacagct
     1561 cttccctctg actcgcaggt tctcacggag acacactaac tcggaagctt agcctcacgg
     1621 taggctgtag agggcatgcg ctgctgctaa gctcagagtg gctcagccgc agtgccacct
     1681 cccaaagtga acacactgcc tttaaaattg tgccaatacc ctccgagtcc ccactctgag
     1741 gcacgtcagg gccagcaaag aagccaagtc aggtgtccac actcccgact agagaacaag
     1801 gtgggagctg tgaagctgcc tcaccgcccc aggagccact taccgtgtct ccatgcccag
     1861 tgggccggcc gcagtgtgga aggtgacctc tgaagcagct ctggcagcct gtgcacacag
     1921 tggtgctcta cttccccagc ctccacagcc catggcaaag acacacaacc aagtggcctt
     1981 gtagtttgcc ttacttgaca gttgtggcat gtagcatccc ctgtcctggg ctctgaaagt
     2041 gggcccaaga cactctgcag ctgtagagcg tcttcatgtc ttggctgctg gacgggcccc
     2101 agccactggc cctttaggag aagccctggg gtctgcacac cgccctcacc attgccttca
     2161 cacagtgcac tctgctctca gagtggctgg caggccgcat tctgtcgctg tgcacataaa
     2221 gtcagtcagc accctcctag ccctggtcca tgagggtgca gaaggctggg gacatcagca
     2281 caacctgcta agcctcgcct ccttggcagg tgtcactgtt ttacaatacg ttgcattcca
     2341 gacctgcctc tgtcactgat tgctttctgg gagcgggggt gtggcttata acttccccag
     2401 agtgttgttt tggttcacta acatatccaa gggccctgtc tgcaactgaa ctactcctga
     2461 cacttgatcc ctgttgcatc cttgtcttgg ctcatttcag gcaccagaca cataggattc
     2521 ttggagcaga tgctaagcca ggagacagga tggggctgct tcttagagcc cttgttatgg
     2581 cagcgctcca tctaggaaac agcagtcagt ctctcctgct cactgttctc cctctctgtg
     2641 ctcaagtctg tcagtgctcg ctggcctctg gctcttccct ttggggaggg agcggctgtt
     2701 ctgcctgctt caccgagtct tcacaagctg aggggatgag gccaggttag taccagggac
     2761 cagcaacctt tcagggctcc ttgggggtct caggtccaca cacagtgagc atcccttgcc
     2821 aggtgcccca tgtatctgtc agtgctgaga cgccaaacac acaacctgtt cccagctgct
     2881 gctgggggcc actgtgaccg aggagagtgt ggggttgcca gggagagcgc tgtccctctg
     2941 acagcctgac cagatgatgt agctttgaaa gccggcagca tgtgagtagc aagatgtgac
     3001 cttgagctag ctgagcagaa cacaggtgga tgggcagagg cccccatcct ggcgagctga
     3061 gcctggctgt gtcctgtcag gacgccctac tctgtgaccc taccctgtga tctgtgaagt
     3121 ggtgcagtcg gaagacgagg ctggagtcct ttacaagttt ctacactaga ttgtagccag
     3181 gttttctccc aggccttagg ctttggttta cttttaattt taatttcact gttacccttg
     3241 actattgtcc tttttgttgc agtgttggag aggcaggagg tatttgtgcc tcatctatta
     3301 ctgcaaaaaa attaaataaa tgtaacaata aacgtcctaa aatca
//
