LOCUS       NM_031033               1539 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus G protein subunit alpha 11 (Gna11), mRNA.
ACCESSION   NM_031033
VERSION     NM_031033.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1539)
  AUTHORS   Haga,T.
  TITLE     Molecular properties of muscarinic acetylcholine receptors
  JOURNAL   Proc Jpn Acad Ser B Phys Biol Sci 89 (6), 226-256 (2013)
   PUBMED   23759942
  REMARK    Review article
REFERENCE   2  (bases 1 to 1539)
  AUTHORS   Siegert,P., Schmidt,G., Papatheodorou,P., Wieland,T., Aktories,K.
            and Orth,J.H.
  TITLE     Pasteurella multocida toxin prevents osteoblast differentiation by
            transactivation of the MAP-kinase cascade via the
            Galpha(q/11)--p63RhoGEF--RhoA axis
  JOURNAL   PLoS Pathog 9 (5), e1003385 (2013)
   PUBMED   23696743
  REMARK    GeneRIF: Pasteurella multocida toxin prevents osteoblast
            differentiation by transactivation of the MAP-kinase cascade via
            the Galpha(q/11)--p63RhoGEF--RhoA axis.
REFERENCE   3  (bases 1 to 1539)
  AUTHORS   Nakakura,T., Mogi,C., Tobo,M., Tomura,H., Sato,K., Kobayashi,M.,
            Ohnishi,H., Tanaka,S., Wayama,M., Sugiyama,T., Kitamura,T.,
            Harada,A. and Okajima,F.
  TITLE     Deficiency of proton-sensing ovarian cancer G protein-coupled
            receptor 1 attenuates glucose-stimulated insulin secretion
  JOURNAL   Endocrinology 153 (9), 4171-4180 (2012)
   PUBMED   22733973
REFERENCE   4  (bases 1 to 1539)
  AUTHORS   Aoyama,C., Sugimoto,H., Ando,H., Yamashita,S., Horibata,Y.,
            Sugimoto,S. and Satou,M.
  TITLE     The heterotrimeric G protein subunits Galpha(q) and Gbeta(1) have
            lysophospholipase D activity
  JOURNAL   Biochem J 440 (2), 241-250 (2011)
   PUBMED   21812758
REFERENCE   5  (bases 1 to 1539)
  AUTHORS   Yajima,T., Inoue,R., Yajima,M., Tsuruta,T., Karaki,S., Hira,T. and
            Kuwahara,A.
  TITLE     The G-protein on cholesterol-rich membrane microdomains mediates
            mucosal sensing of short- chain fatty acid and secretory response
            in rat colon
  JOURNAL   Acta Physiol (Oxf) 203 (3), 381-389 (2011)
   PUBMED   21649864
  REMARK    GeneRIF: The secretory response to luminal propionate in rat colon
            is mediated by G-protein on cholesterol-rich membrane microdomains,
            provably via Galpha(q/11) .
REFERENCE   6  (bases 1 to 1539)
  AUTHORS   Kleppisch,T., Voigt,V., Allmann,R. and Offermanns,S.
  TITLE     G(alpha)q-deficient mice lack metabotropic glutamate
            receptor-dependent long-term depression but show normal long-term
            potentiation in the hippocampal CA1 region
  JOURNAL   J Neurosci 21 (14), 4943-4948 (2001)
   PUBMED   11438569
REFERENCE   7  (bases 1 to 1539)
  AUTHORS   Rhee,S.G.
  TITLE     Regulation of phosphoinositide-specific phospholipase C
  JOURNAL   Annu Rev Biochem 70, 281-312 (2001)
   PUBMED   11395409
  REMARK    Review article
REFERENCE   8  (bases 1 to 1539)
  AUTHORS   Haley,J.E., Delmas,P., Offermanns,S., Abogadie,F.C., Simon,M.I.,
            Buckley,N.J. and Brown,D.A.
  TITLE     Muscarinic inhibition of calcium current and M current in Galpha
            q-deficient mice
  JOURNAL   J Neurosci 20 (11), 3973-3979 (2000)
   PUBMED   10818132
REFERENCE   9  (bases 1 to 1539)
  AUTHORS   Rahman,M.A., Ashton,A.C., Meunier,F.A., Davletov,B.A., Dolly,J.O.
            and Ushkaryov,Y.A.
  TITLE     Norepinephrine exocytosis stimulated by alpha-latrotoxin requires
            both external and stored Ca2+ and is mediated by latrophilin, G
            proteins and phospholipase C
  JOURNAL   Philos Trans R Soc Lond B Biol Sci 354 (1381), 379-386 (1999)
   PUBMED   10212487
  REMARK    Review article
REFERENCE   10 (bases 1 to 1539)
  AUTHORS   Offermanns,S., Zhao,L.P., Gohla,A., Sarosi,I., Simon,M.I. and
            Wilkie,T.M.
  TITLE     Embryonic cardiomyocyte hypoplasia and craniofacial defects in G
            alpha q/G alpha 11-mutant mice
  JOURNAL   EMBO J 17 (15), 4304-4312 (1998)
   PUBMED   9687499
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Oct 11, 2022 this sequence version replaced NM_031033.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF239674.1, SRR26643297.24194.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-368               JAXUCZ010000007.1  8814285-8814652
            369-553             JAXUCZ010000007.1  8824104-8824288
            554-708             JAXUCZ010000007.1  8825778-8825932
            709-837             JAXUCZ010000007.1  8826599-8826727
            838-967             JAXUCZ010000007.1  8827741-8827870
            968-1121            JAXUCZ010000007.1  8827954-8828107
            1122-1539           JAXUCZ010000007.1  8828211-8828628
FEATURES             Location/Qualifiers
     source          1..1539
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1539
                     /gene="Gna11"
                     /gene_synonym="Hg1k"
                     /note="G protein subunit alpha 11"
                     /db_xref="GeneID:81662"
                     /db_xref="RGD:619749"
     exon            1..368
                     /gene="Gna11"
                     /gene_synonym="Hg1k"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..1312
                     /gene="Gna11"
                     /gene_synonym="Hg1k"
                     /note="guanine nucleotide regulatory protein G alpha 11; g
                     alpha-11; guanine nucleotide-binding protein alpha 11
                     subunit; guanine nucleotide binding protein, alpha 11;
                     heterotrimeric guanine nucleotide-binding protein 1k"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein subunit
                     alpha-11"
                     /protein_id="NP_112295.2"
                     /db_xref="GeneID:81662"
                     /db_xref="RGD:619749"
                     /translation="MTLESMMACCLSDEVKESKRINAEIEKQLRRDKRDARRELKLLL
                     LGTGESGKSTFIKQMRIIHGAGYSEEDKRGFTKLVYQNIFTAMQAVVRAMDTLKIRYK
                     YEQNKANALLIREVDVEKVTTFEHQYVNAIKTLWSDPGVQECYDRRREFQLSDSAKYY
                     LTDVDRIATVGYLPTQQDVLRVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIH
                     CFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQHSSVILFLNKK
                     DLLEDKILHSHLVDYFPEFDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDT
                     ENIRFVFAAVKDTILQLNLKEYNLV"
     exon            369..553
                     /gene="Gna11"
                     /gene_synonym="Hg1k"
                     /inference="alignment:Splign:2.1.0"
     exon            554..708
                     /gene="Gna11"
                     /gene_synonym="Hg1k"
                     /inference="alignment:Splign:2.1.0"
     exon            709..837
                     /gene="Gna11"
                     /gene_synonym="Hg1k"
                     /inference="alignment:Splign:2.1.0"
     exon            838..967
                     /gene="Gna11"
                     /gene_synonym="Hg1k"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1121
                     /gene="Gna11"
                     /gene_synonym="Hg1k"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1539
                     /gene="Gna11"
                     /gene_synonym="Hg1k"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcagcctt gcggcccctc ccattggccg cgccgcctgc ccgtcgcggg gcccgtggca
       61 gcgcttcagg tcgtcgggcg ccggcgctcg gtggcgacgg ctgcgggtgg cggcagcggc
      121 ggcagctgcg ctgcacggcg cggacggtgg acgcgcctct ggggccgggc caggccttcg
      181 gggaactggg acgaggcagg gccgtgccgg cggcggccgg gggaccgcga cgatgactct
      241 ggagtccatg atggcgtgtt gcctgagcga cgaggtgaag gagtcgaagc gcatcaacgc
      301 ggagatcgag aaacagctgc ggcgagacaa gcgcgacgcc cggcgcgagc tcaagctgct
      361 gcttctcggc actggcgaga gcgggaagag caccttcatc aagcagatgc gcatcatcca
      421 tggcgccggc tactcggagg aggacaaacg cggcttcaca aagctggtgt accagaacat
      481 cttcaccgcc atgcaggctg tggtgcgcgc tatggacacg ctcaagatcc gctacaagta
      541 tgagcagaac aaggccaatg cactcctgat ccgggaggtt gatgtggaga aggtcacgac
      601 ttttgagcat cagtatgtga acgccatcaa gacactgtgg agtgaccctg gtgtccagga
      661 gtgctacgat cgcaggcgag agttccagct ctctgactcg gctaagtact acttgacgga
      721 cgtggaccgc atcgctacag taggctacct gcccacccag caggatgtgc tgcgggtacg
      781 tgtgcccaca actggcatca tcgagtaccc gtttgacctg gagaacatca tcttcaggat
      841 ggtggatgtg ggcgggcaga ggtcagagcg caggaagtgg atccattgct ttgagaatgt
      901 cacgtccatc atgttcttgg tggcattaag cgagtatgac caggtcctgg tggagtcgga
      961 caacgagaac cgcatggagg agagcaaggc cctgttccgc acaatcatca cctacccctg
     1021 gttccagcac tcgtctgtga tcctcttcct caacaagaag gaccttctgg aagacaagat
     1081 cctgcactca cacttggtcg actacttccc cgagttcgat gggccacaga gggacgcaca
     1141 ggccgcccgc gagttcatcc tgaagatgtt tgtggatctg aaccccgaca gcgacaagat
     1201 catctactcg cacttcacct gcgccacgga caccgaaaac atccgcttcg tgtttgctgc
     1261 cgtgaaggac accatcctgc agctgaacct gaaggagtac aatctggtgt gaccgactgc
     1321 ggcaccgcca gggccagcat cggtcaccca atcaagggac ctgggcacag gggactgggg
     1381 ctcgcctctc ttcctgctca cttctgtccc tgtccctcaa gggcagagtg gcctcttttt
     1441 ggccttgatt ccatgtggct tgagggtttt tttttttttc ctagaaaaca aaaaacaaca
     1501 aaaagaaaaa agacgtgacc gacagtgtgc cctccccca
//
