LOCUS       NM_001024754            2187 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus guanine monophosphate synthase (Gmps), mRNA.
ACCESSION   NM_001024754 XM_215574
VERSION     NM_001024754.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2187)
  AUTHORS   Camici,M., Micheli,V., Ipata,P.L. and Tozzi,M.G.
  TITLE     Pediatric neurological syndromes and inborn errors of purine
            metabolism
  JOURNAL   Neurochem Int 56 (3), 367-378 (2010)
   PUBMED   20005278
  REMARK    Review article
REFERENCE   2  (bases 1 to 2187)
  AUTHORS   Pegram,L.D., Megonigal,M.D., Lange,B.J., Nowell,P.C., Rowley,J.D.,
            Rappaport,E.F. and Felix,C.A.
  TITLE     t(3;11) translocation in treatment-related acute myeloid leukemia
            fuses MLL with the GMPS (GUANOSINE 5' MONOPHOSPHATE SYNTHETASE)
            gene
  JOURNAL   Blood 96 (13), 4360-4362 (2000)
   PUBMED   11110714
REFERENCE   3  (bases 1 to 2187)
  AUTHORS   Nakamura,J. and Lou,L.
  TITLE     Biochemical characterization of human GMP synthetase
  JOURNAL   J Biol Chem 270 (13), 7347-7353 (1995)
   PUBMED   7706277
REFERENCE   4  (bases 1 to 2187)
  AUTHORS   Hirst,M., Haliday,E., Nakamura,J. and Lou,L.
  TITLE     Human GMP synthetase. Protein purification, cloning, and functional
            expression of cDNA
  JOURNAL   J Biol Chem 269 (38), 23830-23837 (1994)
   PUBMED   8089153
REFERENCE   5  (bases 1 to 2187)
  AUTHORS   Harendza,S.G., Thaiss,F. and Stahl,R.A.
  TITLE     Enhanced in vitro growth of glomerular cells derived from rats with
            immune-mediated mesangial injury
  JOURNAL   Exp Nephrol 1 (1), 55-61 (1993)
   PUBMED   8081953
REFERENCE   6  (bases 1 to 2187)
  AUTHORS   Jayaram,H.N., Lui,M.S., Plowman,J., Pillwein,K., Reardon,M.A.,
            Elliott,W.L. and Weber,G.
  TITLE     Oncolytic activity and mechanism of action of a novel L-cysteine
            derivative, L-cysteine, ethyl ester, S-(N-methylcarbamate)
            monohydrochloride
  JOURNAL   Cancer Chemother Pharmacol 26 (2), 88-92 (1990)
   PUBMED   2347042
REFERENCE   7  (bases 1 to 2187)
  AUTHORS   Prajda,N., Natsumeda,Y., Ikegami,T., Reardon,M.A., Szondy,S.,
            Hashimoto,Y., Emrani,J. and Weber,G.
  TITLE     Enzymic programs of rat bone marrow and the impact of acivicin and
            tiazofurin
  JOURNAL   Biochem Pharmacol 37 (5), 875-880 (1988)
   PUBMED   3345200
REFERENCE   8  (bases 1 to 2187)
  AUTHORS   Pillwein,K., Reardon,M.A., Jayaram,H.N., Natsumeda,Y.,
            Elliott,W.L., Faderan,M.A., Prajda,N., Sperl,W. and Weber,G.
  TITLE     Insulin regulatory effects on purine- and pyrimidine metabolism in
            alloxan diabetic rat liver
  JOURNAL   Padiatr Padol 23 (2), 135-144 (1988)
   PUBMED   3043317
REFERENCE   9  (bases 1 to 2187)
  AUTHORS   Hirai,K., Matsuda,Y. and Nakagawa,H.
  TITLE     Purification and characterization of GMP synthetase from Yoshida
            sarcoma ascites cells
  JOURNAL   J Biochem 102 (4), 893-902 (1987)
   PUBMED   3436958
REFERENCE   10 (bases 1 to 2187)
  AUTHORS   Zoref-Shani,E., Shainberg,A. and Sperling,O.
  TITLE     Characterization of purine nucleotide metabolism in primary rat
            muscle cultures
  JOURNAL   Biochim Biophys Acta 716 (3), 324-330 (1982)
   PUBMED   6180773
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098016.1.
            
            On Jun 10, 2005 this sequence version replaced XM_215574.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098016.1, SRR8487226.17623.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2187
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q31"
     gene            1..2187
                     /gene="Gmps"
                     /note="guanine monophosphate synthase"
                     /db_xref="GeneID:295088"
                     /db_xref="RGD:1310063"
     exon            1..89
                     /gene="Gmps"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..2144
                     /gene="Gmps"
                     /EC_number="6.3.5.2"
                     /note="GMP synthase; GMP synthetase; glutamine
                     amidotransferase; guanine monophosphate synthetase"
                     /codon_start=1
                     /product="GMP synthase [glutamine-hydrolyzing]"
                     /protein_id="NP_001019925.1"
                     /db_xref="GeneID:295088"
                     /db_xref="RGD:1310063"
                     /translation="MALCNGDSKPENAGGDLKDGCHHYEGAVVILDAGAQYGKVIDRR
                     VRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLG
                     ICYGMQMMNKVFGGTVHKKSVREDGVFNISMDNTCSLFRGLQKEEIVLLTHGDSVDKV
                     ADGFKVVARSGNIVAGIANESKKLYGVQFHPEVGLTENGKVILKNFLYDIAGCSGNFT
                     VQNRELECIREIKEKVGTSKVLVLLSGGVDSTVCTALLNRALNQDQVIAVHIDNGFMR
                     KRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPE
                     EKRKIIGDTFVKIANEVIGEMSLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHH
                     NDTELIRKLREEGKVIEPLKDFHKDEVRILGRELDLPEELVSRHPFPGPGLAIRVICA
                     EEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMEITSQHSLN
                     AFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNINRVVYIFGP
                     PVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDP
                     LQKQPSCQRSVVIRTFITSDFMTGVPATPGNEIPVEVVLKMVTEIKKIPGISRIMYDL
                     TSKPPGTTEWE"
     exon            90..271
                     /gene="Gmps"
                     /inference="alignment:Splign:2.1.0"
     exon            272..386
                     /gene="Gmps"
                     /inference="alignment:Splign:2.1.0"
     exon            387..484
                     /gene="Gmps"
                     /inference="alignment:Splign:2.1.0"
     exon            485..588
                     /gene="Gmps"
                     /inference="alignment:Splign:2.1.0"
     exon            589..782
                     /gene="Gmps"
                     /inference="alignment:Splign:2.1.0"
     exon            783..948
                     /gene="Gmps"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1100
                     /gene="Gmps"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1274
                     /gene="Gmps"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1380
                     /gene="Gmps"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1496
                     /gene="Gmps"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1622
                     /gene="Gmps"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1738
                     /gene="Gmps"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1869
                     /gene="Gmps"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..2042
                     /gene="Gmps"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2163
                     /gene="Gmps"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggtgctgtg ctgctcgcgt ccaggccttg ccagcggtct gcgcccgccg cgctggtccc
       61 cgatggccct gtgcaacgga gattccaagc cggagaatgc tggaggagac cttaaggatg
      121 gttgtcacca ctacgaagga gctgttgtca ttctggatgc tggggctcag tatggaaaag
      181 tcattgaccg aagagtgcgg gagctctttg tacagtctga aatctttcct ttggaaacac
      241 cagcttttgc cataaaggaa caaggatttc gggctattat catatctgga ggacctaatt
      301 ctgtgtatgc agaggatgct ccctggtttg atccagcaat atttaccatt ggcaagcctg
      361 tcctaggaat ttgctatgga atgcagatga tgaataaggt ttttggaggc actgtgcata
      421 aaaaaagtgt tagagaggat ggcgttttca acattagtat ggacaataca tgttcattgt
      481 tcaggggcct gcagaaggaa gaaattgttt tacttacaca tggagacagt gtagacaaag
      541 tagctgatgg attcaaggtt gtagctcgtt ctgggaacat tgttgcaggt atagccaatg
      601 aatctaagaa gctatatggt gtacagttcc accctgaagt tggccttaca gaaaatggaa
      661 aagtaatact gaagaatttc ctatatgata tagctggatg cagtgggaac tttactgtgc
      721 agaaccgaga acttgagtgc attcgagaga ttaaagagaa agtaggaacg tcaaaagtgt
      781 tggttttact cagtggtggt gtagattcaa ctgtttgtac tgctttgcta aatcgtgctt
      841 tgaaccaaga tcaagtcatt gctgtacaca ttgataatgg ctttatgaga aaacgagaaa
      901 gccagtctgt tgaagaggcc ctcaaaaagc ttggaattca ggtcaaagtg ataaatgctg
      961 ctcattcctt ctataatgga acaactactc tgccaatatc agatgaagac aggaccccac
     1021 ggaaaagaat tagcaaaaca ttaaatatga caacaagtcc tgaggagaaa agaaaaatta
     1081 ttggtgatac ttttgttaag attgccaatg aagtcattgg agaaatgagt ctgaagccag
     1141 aggaggtttt tcttgcccaa ggcactttac ggcctgatct aatcgaaagt gcatcccttg
     1201 ttgcaagcgg caaagctgaa ctcatcaaaa cccaccacaa cgacacagag cttatcagga
     1261 agttaaggga agaggggaaa gtaatagaac ctctgaaaga ttttcataaa gatgaagtta
     1321 ggattttagg cagagagctt gacctgccag aagaattggt ttccaggcat ccttttccag
     1381 gtcctggcct ggcaatcaga gtaatatgtg ctgaagaacc ttatatttgt aaagactttc
     1441 ctgaaaccaa caatattttg aaaatagtag ctgatttttc tgcaagtgtt aagaagcctc
     1501 atacactgtt acaaagagtc aaagcttgca caacagaaga ggaccaggag aaactcatgg
     1561 aaattacaag tcagcattca ttgaatgctt tcttgctgcc aattaagact gtgggtgtgc
     1621 agggtgactg tcgttcttat agttatgtgt gtggaatctc cagtaaagat gaacctgact
     1681 gggaatctct tattttcctt gccagactta tacctcgaat gtgtcataac attaacagag
     1741 ttgtctatat ctttggccca ccagttaaag aacctcctac agatgttact ccaacatttt
     1801 tgacaacagg ggtgctcagt actttacgcc aagctgattt tgaggcccat aacattctcc
     1861 gggagtctgg gtatgctggg aaaatcagcc agatgccagt gattttgacc ccattacatt
     1921 tcgatcgaga tccacttcag aagcagcctt catgccagag gtctgtggtt attcgaacct
     1981 ttattactag tgacttcatg actggagtac ctgcaacacc tggcaatgaa attcctgtag
     2041 aggtggtgct aaagatggtc actgagataa agaagattcc tggaatttct agaattatgt
     2101 atgacctaac gtcaaagccc ccgggaacca ctgagtggga gtaataaatg tgttgttgaa
     2161 gaaaaaaaaa aaaaaaaaaa aaaaaaa
//
