LOCUS       NM_001413771            1516 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus guanosine monophosphate reductase 2 (Gmpr2),
            transcript variant 2, mRNA.
ACCESSION   NM_001413771 XM_006251925
VERSION     NM_001413771.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1516)
  AUTHORS   Patton,G.C., Stenmark,P., Gollapalli,D.R., Sevastik,R., Kursula,P.,
            Flodin,S., Schuler,H., Swales,C.T., Eklund,H., Himo,F., Nordlund,P.
            and Hedstrom,L.
  TITLE     Cofactor mobility determines reaction outcome in the IMPDH and GMPR
            (beta-alpha)8 barrel enzymes
  JOURNAL   Nat Chem Biol 7 (12), 950-958 (2011)
   PUBMED   22037469
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1516)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   3  (bases 1 to 1516)
  AUTHORS   Zhang,J., Zhang,W., Zou,D., Chen,G., Wan,T., Zhang,M. and Cao,X.
  TITLE     Cloning and functional characterization of GMPR2, a novel human
            guanosine monophosphate reductase, which promotes the monocytic
            differentiation of HL-60 leukemia cells
  JOURNAL   J Cancer Res Clin Oncol 129 (2), 76-83 (2003)
   PUBMED   12669231
REFERENCE   4  (bases 1 to 1516)
  AUTHORS   Deng,Y., Wang,Z., Ying,K., Gu,S., Ji,C., Huang,Y., Gu,X., Wang,Y.,
            Xu,Y., Li,Y., Xie,Y. and Mao,Y.
  TITLE     NADPH-dependent GMP reductase isoenzyme of human (GMPR2).
            Expression, purification, and kinetic properties
  JOURNAL   Int J Biochem Cell Biol 34 (9), 1035-1050 (2002)
   PUBMED   12009299
REFERENCE   5  (bases 1 to 1516)
  AUTHORS   Spector,T., Jones,T.E. and Miller,R.L.
  TITLE     Reaction mechanism and specificity of human GMP reductase.
            Substrates, inhibitors, activators, and inactivators
  JOURNAL   J Biol Chem 254 (7), 2308-2315 (1979)
   PUBMED   218932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Nov 8, 2022 this sequence version replaced XM_006251925.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.40092.1,
                                           SRR26360194.2530506.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                JAXUCZ010000015.1  33135739-33135835
            98-193              JAXUCZ010000015.1  33136343-33136438
            194-313             JAXUCZ010000015.1  33137060-33137179
            314-397             JAXUCZ010000015.1  33139500-33139583
            398-571             JAXUCZ010000015.1  33139736-33139909
            572-653             JAXUCZ010000015.1  33141133-33141214
            654-760             JAXUCZ010000015.1  33141305-33141411
            761-803             JAXUCZ010000015.1  33141758-33141800
            804-963             JAXUCZ010000015.1  33142521-33142680
            964-1516            JAXUCZ010000015.1  33142879-33143431
FEATURES             Location/Qualifiers
     source          1..1516
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p13"
     gene            1..1516
                     /gene="Gmpr2"
                     /note="guanosine monophosphate reductase 2"
                     /db_xref="GeneID:192357"
                     /db_xref="RGD:628875"
     exon            1..97
                     /gene="Gmpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            98..193
                     /gene="Gmpr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1153
                     /gene="Gmpr2"
                     /EC_number="1.7.1.7"
                     /note="isoform 2 is encoded by transcript variant 2;
                     guanosine monophosphate reductase isolog; GMP reductase 2"
                     /codon_start=1
                     /product="GMP reductase 2 isoform 2"
                     /protein_id="NP_001400700.1"
                     /db_xref="GeneID:192357"
                     /db_xref="RGD:628875"
                     /translation="MPHIDNDVKLDFKDVLLRPKRSTLKSRSEVDLTRSFSFRNSKQM
                     YSGIPIIAANMDTVGTFEMAKVLCKFSLFTAIHKHYSIHQWQEFANQNPDCLEYLAAS
                     SGTGSADFEQLEQILEAIPQVKYICLDVANGYSEHFVESVKDVRKRFPQHTIMAGNVV
                     TGEMVEELILSGADIIKVGIGPGSVCTTRKKTGVGYPQLSAVMECADAAHGLKGHIIS
                     DGGCSCPGDVAKAFGAGADFVMLGGMLAGHSESGGELIERNGKKYKLFYGMSSEMAMK
                     KYSGGVAEYRASEGKIVEVPFKGDVEHTIRDILGGIRSTCTYVGAAKLKELSRRTTFI
                     RVTQQVNPIFSDCQ"
     exon            194..313
                     /gene="Gmpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            314..397
                     /gene="Gmpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            398..571
                     /gene="Gmpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            572..653
                     /gene="Gmpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            654..760
                     /gene="Gmpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            761..803
                     /gene="Gmpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            804..963
                     /gene="Gmpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1516
                     /gene="Gmpr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttcgagtcg ccctcaaggc tcatcgaggc cccacgcggc tagttgctaa gcaaaagaat
       61 ctttggtcaa ctgccatctg agtcaaagca acaggaacac ttcatcatgc ctcatattga
      121 caatgatgtg aaactagact tcaaggatgt cctgttgagg cccaaacgca gcactctaaa
      181 gtctcgaagt gaggtagatc tcacaagatc attttcattc cggaactcaa agcagatgta
      241 cagtggcatc cccatcattg ctgccaatat ggataccgtg ggtacttttg aaatggctaa
      301 ggttctctgt aagttttccc tgttcactgc catccataag cactacagca tccatcagtg
      361 gcaagagttt gctaaccaga atcctgactg tcttgagtat ctagctgcca gctcaggcac
      421 aggctctgct gactttgagc agctggaaca gatcctagaa gctattcccc aagtcaaata
      481 tatatgcctg gatgtggcta atggctactc agaacatttt gttgaatccg taaaggatgt
      541 acggaagcga ttcccccaac acaccatcat ggcaggcaat gtggtaacag gagagatggt
      601 agaagagcta atcctctctg gggctgacat catcaaagtg ggaattggtc ctggctctgt
      661 ctgtacaact cggaagaaaa ctggagttgg gtatccacag ctcagtgcag tgatggagtg
      721 tgcagatgct gctcatggcc tcaaaggcca catcatttca gacggaggct gcagctgccc
      781 tggagatgtg gcaaaggcct ttggcgcagg ggctgacttt gtgatgctgg gtggcatgct
      841 ggccgggcac agtgaatcag gtggtgaact cattgagaga aatggcaaga aatacaagct
      901 cttctatgga atgagttctg aaatggctat gaagaagtat tcaggaggcg tggctgagta
      961 cagggcctca gagggaaaga tagtagaagt tccctttaaa ggtgatgtgg aacatactat
     1021 tcgtgacatc ctaggaggca tccggtctac atgcacatat gtaggggctg ctaaactgaa
     1081 ggaattaagt cggagaacta cctttatccg agtcacccag caagtgaatc caatcttcag
     1141 cgactgccaa tagacccaag aagtctactt ttctgaggca gtaacactgc cactggagcc
     1201 tccccccaca gggtgtgcct cattcatggc agcctctgtg gtggtgtgct actttccagt
     1261 tctggtcctc ctccctcctg agtgctcctc tgttcactca tgcttctcta gctgcacata
     1321 taaaatgcta cgggcactat gggagaggca aggaagaaga cttgaaatca acaaatgaga
     1381 acctgggcac agccatgaag atgagggaag aaagaagctg atccacacat aaatggcaga
     1441 ctttggtctg gaaaaggaag gctgttggaa tcatgttaac cagcttcatt aaataagatc
     1501 atcaaatgtc taagca
//
