LOCUS       NM_057188               1433 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus guanosine monophosphate reductase (Gmpr), mRNA.
ACCESSION   NM_057188
VERSION     NM_057188.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1433)
  AUTHORS   Deng,Y., Wang,Z., Ying,K., Gu,S., Ji,C., Huang,Y., Gu,X., Wang,Y.,
            Xu,Y., Li,Y., Xie,Y. and Mao,Y.
  TITLE     NADPH-dependent GMP reductase isoenzyme of human (GMPR2).
            Expression, purification, and kinetic properties
  JOURNAL   Int J Biochem Cell Biol 34 (9), 1035-1050 (2002)
   PUBMED   12009299
REFERENCE   2  (bases 1 to 1433)
  AUTHORS   Salvatore,D., Bartha,T. and Larsen,P.R.
  TITLE     The guanosine monophosphate reductase gene is conserved in rats and
            its expression increases rapidly in brown adipose tissue during
            cold exposure
  JOURNAL   J Biol Chem 273 (47), 31092-31096 (1998)
   PUBMED   9813009
REFERENCE   3  (bases 1 to 1433)
  AUTHORS   Spector,T., Jones,T.E. and Miller,R.L.
  TITLE     Reaction mechanism and specificity of human GMP reductase.
            Substrates, inhibitors, activators, and inactivators
  JOURNAL   J Biol Chem 254 (7), 2308-2315 (1979)
   PUBMED   218932
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Nov 26, 2020 this sequence version replaced NM_057188.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF090867.1, SRR26360172.2226619.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760475,
                                           SAMN11044071 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               JAXUCZ010000017.1  19395484-19395647   c
            165-284             JAXUCZ010000017.1  19389079-19389198   c
            285-368             JAXUCZ010000017.1  19386442-19386525   c
            369-542             JAXUCZ010000017.1  19382377-19382550   c
            543-624             JAXUCZ010000017.1  19374958-19375039   c
            625-731             JAXUCZ010000017.1  19372292-19372398   c
            732-774             JAXUCZ010000017.1  19364840-19364882   c
            775-934             JAXUCZ010000017.1  19361336-19361495   c
            935-1433            JAXUCZ010000017.1  19357992-19358490   c
FEATURES             Location/Qualifiers
     source          1..1433
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..1433
                     /gene="Gmpr"
                     /gene_synonym="GMPR 1; Gmpr1"
                     /note="guanosine monophosphate reductase"
                     /db_xref="GeneID:117533"
                     /db_xref="RGD:70980"
     exon            1..164
                     /gene="Gmpr"
                     /gene_synonym="GMPR 1; Gmpr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1115
                     /gene="Gmpr"
                     /gene_synonym="GMPR 1; Gmpr1"
                     /EC_number="1.7.1.7"
                     /note="guanosine 5'-monophosphate oxidoreductase 1;
                     guanosine monophosphate reductase 1"
                     /codon_start=1
                     /product="GMP reductase 1"
                     /protein_id="NP_476536.2"
                     /db_xref="GeneID:117533"
                     /db_xref="RGD:70980"
                     /translation="MPRIDADLKLDFKDVLLRPKRSSLKSRSEVDLERTFTFRNSKQT
                     YSGIPVIVANMDTVGTFEMAVVMSQHAMFTAIHKHYSLDDWKHFAENHPECLQHVAVS
                     SGSGQNDLEKMSLILEAVPQVKFICLDVANGYSEHFVEFVKLVRSKFPEHTIMAGNVV
                     TGEMVEELILSGADIIKVGVGPGSVCTTRTKTGVGYPQLSAVIECADSAHGLKGHIIS
                     DGGCTCPGDVAKAFGAGADFVMLGGMFSGHTECAGEVIERNGQKLKLFYGMSSDTAMK
                     KHAGGVAEYRASEGKTVEVPYKGDVENTILDILGGLRSTCTYVGAAKLKELSRRATFI
                     RVTQQHNTVFG"
     exon            165..284
                     /gene="Gmpr"
                     /gene_synonym="GMPR 1; Gmpr1"
                     /inference="alignment:Splign:2.1.0"
     exon            285..368
                     /gene="Gmpr"
                     /gene_synonym="GMPR 1; Gmpr1"
                     /inference="alignment:Splign:2.1.0"
     exon            369..542
                     /gene="Gmpr"
                     /gene_synonym="GMPR 1; Gmpr1"
                     /inference="alignment:Splign:2.1.0"
     exon            543..624
                     /gene="Gmpr"
                     /gene_synonym="GMPR 1; Gmpr1"
                     /inference="alignment:Splign:2.1.0"
     exon            625..731
                     /gene="Gmpr"
                     /gene_synonym="GMPR 1; Gmpr1"
                     /inference="alignment:Splign:2.1.0"
     exon            732..774
                     /gene="Gmpr"
                     /gene_synonym="GMPR 1; Gmpr1"
                     /inference="alignment:Splign:2.1.0"
     exon            775..934
                     /gene="Gmpr"
                     /gene_synonym="GMPR 1; Gmpr1"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1433
                     /gene="Gmpr"
                     /gene_synonym="GMPR 1; Gmpr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgccccgc agctcctgac tgacgccggc cttcgcaccg cctccgccgc aggaagctac
       61 cgcgcaccgc tagcaccatg ccccgcatag acgcggacct gaaactcgac ttcaaggatg
      121 ttctgctgcg acctaaacgg agcagcctca agagccgatc cgaggtggac cttgagcgaa
      181 cctttacgtt tcgaaactca aagcagacct actcagggat tcccgtcatc gtggccaaca
      241 tggacaccgt ggggacattt gagatggctg tggtgatgtc acagcatgcc atgttcacag
      301 ccattcacaa gcattactcc ctggatgact ggaaacattt tgctgaaaat caccccgaat
      361 gcctgcagca tgtagccgtg agttctggca gcgggcagaa tgatcttgag aagatgagcc
      421 tcatcttgga agctgtgcct caggtgaagt tcatctgcct ggatgtggcc aatgggtatt
      481 cggaacattt tgtggaattc gtgaaactgg tccgatccaa atttcccgaa cacaccatca
      541 tggcagggaa cgtggtgacg ggagagatgg tggaggagct catcctttct ggagcagata
      601 tcatcaaagt gggagtcgga ccaggctctg tgtgcaccac ccgaaccaag acaggcgtgg
      661 gctacccgca gctgagcgct gtgatagagt gtgctgactc agcacacggc ctcaagggac
      721 acatcatctc tgacggaggc tgcacatgtc caggagatgt cgccaaagcc tttggagctg
      781 gcgcggattt tgtcatgctg ggaggcatgt tttccggaca caccgagtgt gcaggagagg
      841 tgatcgagag gaacgggcag aagctgaagc ttttctacgg catgagctca gacacagcca
      901 tgaagaaaca cgcgggaggc gtcgctgagt acagggcctc tgagggcaag actgtggaag
      961 tgccttacaa aggggacgta gagaacacaa ttctggatat ccttggagga cttcggtcta
     1021 cctgtaccta cgtgggggcc gccaagctca aagagctcag taggagagcc acattcatcc
     1081 gcgtgaccca acagcacaac acggtgttcg gctaacctcg gggatgttcg gttaacctcg
     1141 gggaagcgga agcctccttt cgccacgctt caccccatcc cgcctcctta tctgccctag
     1201 caggctgcct gctatcacag acgctgagac tgagtcctca tcctgatctc ggggcttgcc
     1261 ctagtgcctg tgtggggccc agaaacaggg tgctcgaggg gccctgggtc agcacctaga
     1321 actcattgtc tccttgtttc aaccagccct tgcaccctcc tttccacccc ttaccctttg
     1381 ttttctttct aaaggacaat ggtttcactt ttaatataag gctgtggtct tga
//
