LOCUS       NM_001108781            1788 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus GDP-mannose pyrophosphorylase B (Gmppb), mRNA.
ACCESSION   NM_001108781 XM_001074797 XM_343482
VERSION     NM_001108781.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1788)
  AUTHORS   Jensen,B.S., Willer,T., Saade,D.N., Cox,M.O., Mozaffar,T.,
            Scavina,M., Stefans,V.A., Winder,T.L., Campbell,K.P., Moore,S.A.
            and Mathews,K.D.
  TITLE     GMPPB-Associated Dystroglycanopathy: Emerging Common Variants with
            Phenotype Correlation
  JOURNAL   Hum Mutat 36 (12), 1159-1163 (2015)
   PUBMED   26310427
REFERENCE   2  (bases 1 to 1788)
  AUTHORS   Carss,K.J., Stevens,E., Foley,A.R., Cirak,S., Riemersma,M.,
            Torelli,S., Hoischen,A., Willer,T., van Scherpenzeel,M.,
            Moore,S.A., Messina,S., Bertini,E., Bonnemann,C.G., Abdenur,J.E.,
            Grosmann,C.M., Kesari,A., Punetha,J., Quinlivan,R., Waddell,L.B.,
            Young,H.K., Wraige,E., Yau,S., Brodd,L., Feng,L., Sewry,C.,
            MacArthur,D.G., North,K.N., Hoffman,E., Stemple,D.L., Hurles,M.E.,
            van Bokhoven,H., Campbell,K.P., Lefeber,D.J., Lin,Y.Y. and
            Muntoni,F.
  CONSRTM   UK10K Consortium
  TITLE     Mutations in GDP-mannose pyrophosphorylase B cause congenital and
            limb-girdle muscular dystrophies associated with hypoglycosylation
            of alpha-dystroglycan
  JOURNAL   Am J Hum Genet 93 (1), 29-41 (2013)
   PUBMED   23768512
REFERENCE   3  (bases 1 to 1788)
  AUTHORS   Ning,B. and Elbein,A.D.
  TITLE     Cloning, expression and characterization of the pig liver
            GDP-mannose pyrophosphorylase. Evidence that GDP-mannose and
            GDP-Glc pyrophosphorylases are different proteins
  JOURNAL   Eur J Biochem 267 (23), 6866-6874 (2000)
   PUBMED   11082198
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Apr 13, 2021 this sequence version replaced NM_001108781.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.29897.1,
                                           SRR26643429.32089.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-358               JAXUCZ010000008.1  117616405-117616762
            359-439             JAXUCZ010000008.1  117616870-117616950
            440-488             JAXUCZ010000008.1  117617038-117617086
            489-631             JAXUCZ010000008.1  117617226-117617368
            632-790             JAXUCZ010000008.1  117617562-117617720
            791-869             JAXUCZ010000008.1  117617803-117617881
            870-997             JAXUCZ010000008.1  117617954-117618081
            998-1180            JAXUCZ010000008.1  117618165-117618347
            1181-1788           JAXUCZ010000008.1  117618430-117619037
FEATURES             Location/Qualifiers
     source          1..1788
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1788
                     /gene="Gmppb"
                     /gene_synonym="RGD1560458"
                     /note="GDP-mannose pyrophosphorylase B"
                     /db_xref="GeneID:363145"
                     /db_xref="RGD:1560458"
     exon            1..358
                     /gene="Gmppb"
                     /gene_synonym="RGD1560458"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..1312
                     /gene="Gmppb"
                     /gene_synonym="RGD1560458"
                     /EC_number="2.7.7.22"
                     /codon_start=1
                     /product="mannose-1-phosphate guanyltransferase beta"
                     /protein_id="NP_001102251.1"
                     /db_xref="GeneID:363145"
                     /db_xref="RGD:1560458"
                     /translation="MKALILVGGYGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAA
                     GVDHVILAVSYMSQMLEKEMKAQEQRLGIRISMSHEEEPLGTAGPLALARDLLSETAD
                     PFFVLNSDVICDFPFQAMVQFHRHHGQEGSILVTKVEEPSKYGVVVCEADTGRIHRFV
                     EKPQVFVSNKINAGMYILSPAVLQRIQLKPTSIEKEIFPVMAKEGQLYAMELQGFWMD
                     IGQPKDFLTGMCLFLQSLRQKHPERLYSGPGVVGNVLVDPSARIGQNCSIGPNVSLGP
                     GVVVEDGVCIRRCTVLRDAHIRSHSWLESCIVGWRCRVGQWVRMENVTVLGEDVIVND
                     ELYLNGASVLPHKSIGESVPEPRIIM"
     exon            359..439
                     /gene="Gmppb"
                     /gene_synonym="RGD1560458"
                     /inference="alignment:Splign:2.1.0"
     exon            440..488
                     /gene="Gmppb"
                     /gene_synonym="RGD1560458"
                     /inference="alignment:Splign:2.1.0"
     exon            489..631
                     /gene="Gmppb"
                     /gene_synonym="RGD1560458"
                     /inference="alignment:Splign:2.1.0"
     exon            632..790
                     /gene="Gmppb"
                     /gene_synonym="RGD1560458"
                     /inference="alignment:Splign:2.1.0"
     exon            791..869
                     /gene="Gmppb"
                     /gene_synonym="RGD1560458"
                     /inference="alignment:Splign:2.1.0"
     exon            870..997
                     /gene="Gmppb"
                     /gene_synonym="RGD1560458"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1180
                     /gene="Gmppb"
                     /gene_synonym="RGD1560458"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1788
                     /gene="Gmppb"
                     /gene_synonym="RGD1560458"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aactccgggc cagccggtct ccaaccagtt cctcctcctc ctgtgttctg gctgccccta
       61 gacccccaca tcaaggtaga gcaggcggac gaggtgacac cagagttggt cactctagct
      121 ggtgaagggt gcagtcaggg cacggcagcg ggagtgcgca gcaggggttg gtcagacggc
      181 ctgtaagtac tttggaccga gggatccact tctatcatct gcagacgcca tgaaggcact
      241 gatcttggtg ggtgggtatg ggacacggtt gcggccgctg acgctgagca ctccgaagcc
      301 attggtggac ttctgcaata agcccatttt gctgcaccaa gtggaggcac ttgccgcggc
      361 gggtgtagac catgtgatcc tagcagtgag ctacatgtca cagatgttgg agaaggaaat
      421 gaaggcacaa gagcaaaggc ttggaatccg aatctctatg tctcatgaag aggagccttt
      481 gggaacagct gggcctctgg ccttggcccg agacctactc tctgagactg ccgatccttt
      541 cttcgttctc aacagtgatg tgatatgtga tttccccttc caagccatgg tgcagtttca
      601 tcgacaccat ggccaagagg gctccatctt ggtaaccaag gtggaagagc cttccaagta
      661 cggtgtggtg gtgtgcgagg ctgacacagg ccgcattcac cgttttgttg agaagccgca
      721 ggtatttgtg tccaataaga tcaatgcagg catgtacatc ctgagccctg ctgtgctgca
      781 gcgcatccag ctgaagccta catccattga gaaggagatc ttcccagtta tggccaagga
      841 ggggcagcta tatgccatgg agctgcaggg cttctggatg gacattggac agcctaagga
      901 cttcctcact ggcatgtgcc tcttcctaca gtcactgaga cagaagcatc cagagagact
      961 gtactcaggc cctggcgttg tggggaatgt gcttgtggac ccaagtgccc gtatcggtca
     1021 gaactgcagc attggcccca atgtgagcct gggtcccggt gtggtggtgg aggacggcgt
     1081 gtgcatccgg cggtgcacgg tgcttcgtga tgctcacatc cgctcccatt cctggcttga
     1141 gtcatgcatc gtgggctggc gctgccgtgt aggccaatgg gtgcgcatgg agaatgtcac
     1201 agtgctgggt gaggatgtca tagttaatga tgaactttac ctcaacggag ccagcgtgct
     1261 gccccacaag tctatcgggg agtcggtgcc agaacctcgt attatcatgt gaaggatatg
     1321 cagggctggc caagccccca ctttaccatt ggcagggtag gactcagtgc ttcagaaggc
     1381 tctggacttg gtgccacttg tatagggagg agtggatggc tctgaagctg ttggacatct
     1441 accttctggt ggagacagaa gtggacagga tcctgctggg catagcacac aggcccccac
     1501 tccctcaaga agcactgggc cagggctgaa gggaataata atttaatgct cactgtggcc
     1561 tggactggac tcaggctccc tcccaccagt gaggctatgc acacacaggc agatgggtgg
     1621 gagtggtaag agcgagggtg atggggacag ggccaaggga gctcataaat aggactcgga
     1681 ctgcgtctga tggtgggttt ccaggacagc ctaggcagct gaggatgtgg cacttgtgct
     1741 ggctgccttg tcccagtcct ctacagatac aatggtggct ttgcagaa
//
