LOCUS       NM_001106112            1178 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus geminin, DNA replication inhibitor (Gmnn), mRNA.
ACCESSION   NM_001106112 XM_001063272 XM_214477
VERSION     NM_001106112.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1178)
  AUTHORS   Jiang,Z.Q., Zhou,Y.L., Chen,X., Li,L.Y., Liang,S.Y., Lin,S. and
            Shu,M.Q.
  TITLE     Different effects of neuropeptide Y on proliferation of vascular
            smooth muscle cells via regulation of Geminin
  JOURNAL   Mol Cell Biochem 433 (1-2), 205-211 (2017)
   PUBMED   28386846
  REMARK    GeneRIF: modulation of Geminin was effectively blocked by the Y1
            receptor antagonist. The stimulation of NPY on proliferation of
            VSMCs could be a double-edged sword in the development of
            atherosclerosis and thus provides new knowledge for therapy of
            atherosclerosis.
REFERENCE   2  (bases 1 to 1178)
  AUTHORS   Zhang,Y., Jiang,Z., Li,L., Zhou,Y., Song,Z. and Shu,M.
  TITLE     Geminin interference facilitates vascular smooth muscle cell
            proliferation by upregulation of CDK-1
  JOURNAL   Cardiovasc Drugs Ther 28 (5), 407-414 (2014)
   PUBMED   25189787
  REMARK    GeneRIF: Geminin gene inhibition could augment Vacular Smooth
            Muscle Cell proliferation by increasing cyclin-dependent kinase-1
            expression.
REFERENCE   3  (bases 1 to 1178)
  AUTHORS   Mosammaparast,N., Kim,H., Laurent,B., Zhao,Y., Lim,H.J.,
            Majid,M.C., Dango,S., Luo,Y., Hempel,K., Sowa,M.E., Gygi,S.P.,
            Steen,H., Harper,J.W., Yankner,B. and Shi,Y.
  TITLE     The histone demethylase LSD1/KDM1A promotes the DNA damage response
  JOURNAL   J Cell Biol 203 (3), 457-470 (2013)
   PUBMED   24217620
REFERENCE   4  (bases 1 to 1178)
  AUTHORS   Guo,J. and Sun,N.
  TITLE     Cell cycle regulator geminin is dispensable for the proliferation
            of vascular smooth muscle cells
  JOURNAL   Sci China Life Sci 56 (8), 731-738 (2013)
   PUBMED   23838810
  REMARK    GeneRIF: geminin expression was low in quiescent vascular smooth
            muscle cells (approximately 90% and 10% of cells in the G1 and in
            S/G2/M phases of the cell cycle, respectively), increased as more
            cells entered in S/G2/M, and then decreased as cells exited S/G2/M
REFERENCE   5  (bases 1 to 1178)
  AUTHORS   Pefani,D.E., Dimaki,M., Spella,M., Karantzelis,N., Mitsiki,E.,
            Kyrousi,C., Symeonidou,I.E., Perrakis,A., Taraviras,S. and
            Lygerou,Z.
  TITLE     Idas, a novel phylogenetically conserved geminin-related protein,
            binds to geminin and is required for cell cycle progression
  JOURNAL   J Biol Chem 286 (26), 23234-23246 (2011)
   PUBMED   21543332
REFERENCE   6  (bases 1 to 1178)
  AUTHORS   Kim,M.Y., Jeong,B.C., Lee,J.H., Kee,H.J., Kook,H., Kim,N.S.,
            Kim,Y.H., Kim,J.K., Ahn,K.Y. and Kim,K.K.
  TITLE     A repressor complex, AP4 transcription factor and geminin,
            negatively regulates expression of target genes in nonneuronal
            cells
  JOURNAL   Proc Natl Acad Sci U S A 103 (35), 13074-13079 (2006)
   PUBMED   16924111
REFERENCE   7  (bases 1 to 1178)
  AUTHORS   Yanagi,K., Mizuno,T., You,Z. and Hanaoka,F.
  TITLE     Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a
            novel intrinsic Cdt1 DNA binding activity
  JOURNAL   J Biol Chem 277 (43), 40871-40880 (2002)
   PUBMED   12192004
REFERENCE   8  (bases 1 to 1178)
  AUTHORS   Wohlschlegel,J.A., Dwyer,B.T., Dhar,S.K., Cvetic,C., Walter,J.C.
            and Dutta,A.
  TITLE     Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
  JOURNAL   Science 290 (5500), 2309-2312 (2000)
   PUBMED   11125146
REFERENCE   9  (bases 1 to 1178)
  AUTHORS   Kroll,K.L., Salic,A.N., Evans,L.M. and Kirschner,M.W.
  TITLE     Geminin, a neuralizing molecule that demarcates the future neural
            plate at the onset of gastrulation
  JOURNAL   Development 125 (16), 3247-3258 (1998)
   PUBMED   9671596
REFERENCE   10 (bases 1 to 1178)
  AUTHORS   McGarry,T.J. and Kirschner,M.W.
  TITLE     Geminin, an inhibitor of DNA replication, is degraded during
            mitosis
  JOURNAL   Cell 93 (6), 1043-1053 (1998)
   PUBMED   9635433
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474064.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_214477.3, XM_001063272.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
FEATURES             Location/Qualifiers
     source          1..1178
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p11"
     gene            1..1178
                     /gene="Gmnn"
                     /note="geminin, DNA replication inhibitor"
                     /db_xref="GeneID:291137"
                     /db_xref="RGD:1308137"
     exon            1..344
                     /gene="Gmnn"
                     /inference="alignment:Splign:2.1.0"
     exon            345..402
                     /gene="Gmnn"
                     /inference="alignment:Splign:2.1.0"
     CDS             352..972
                     /gene="Gmnn"
                     /codon_start=1
                     /product="geminin"
                     /protein_id="NP_001099582.1"
                     /db_xref="GeneID:291137"
                     /db_xref="RGD:1308137"
                     /translation="MNLSMKQKQEGAQENVKSSPVPRRTLKMIQPSAAGSLVGRENEL
                     PKGLSKRKLWDDQLTSKISSCGPEANENNSVGDLTQEACDLMTKENPSSQYWKEVAEQ
                     RRKALYEALTENEKLHKEIEQKDSEIARLRKENKDLAEVAEHVQYMAEVIERLSNEPL
                     DNFESPDSQEFDSEKETVEYSEPEDSDTGTCAEETVSSSSDGTACT"
     exon            403..480
                     /gene="Gmnn"
                     /inference="alignment:Splign:2.1.0"
     exon            481..616
                     /gene="Gmnn"
                     /inference="alignment:Splign:2.1.0"
     exon            617..699
                     /gene="Gmnn"
                     /inference="alignment:Splign:2.1.0"
     exon            700..810
                     /gene="Gmnn"
                     /inference="alignment:Splign:2.1.0"
     exon            811..1178
                     /gene="Gmnn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgaccggggc ggcgggttag tctgcaggtt cgggtcgttt tggcgcggtt gggtccggtg
       61 tggtgccagg ggcttgtacg gctctcacgc tcgctgggaa cggagcactg ctgtctgtga
      121 gtccgaggac gcggggggtc ggcgggcgag tgcaactccg gtatcggcat agccgggttg
      181 gcccgaagcc aggcctgctt ctcagccacg gagaaccggc cggtggaggc gaggatatga
      241 agggacccaa gtctggggac tggggacttg aagggacccg agtctcggcc ctacagccag
      301 gcaaagctgg gcgagctgag atgaggggct gcgccattgg tgggctgaga aatgaatctc
      361 agtatgaagc agaaacagga aggagcccaa gagaacgtga agagtagtcc tgtcccaagg
      421 agaacgctga agatgatcca gccttctgca gctgggtctc ttgttggcag agaaaatgag
      481 ttgccaaaag gcttgtccaa aaggaaactt tgggatgacc agttaacatc taagatttca
      541 agctgtggtc ctgaagccaa tgaaaataac agtgttggag acctcaccca ggaagcatgt
      601 gatcttatga ctaaagaaaa cccatcttct cagtattgga aagaagtggc agaacaacgg
      661 aggaaagctc tctatgaagc acttacggag aacgagaaac ttcataaaga aattgagcag
      721 aaggacagtg agattgcccg cctgagaaag gagaataaag acctggcaga agtggctgag
      781 cacgtacagt acatggcaga ggtaatcgag aggctgagta atgaacctct ggataacttt
      841 gaatcaccgg atagtcaaga atttgattct gaaaaagaaa ctgttgagta ttctgaaccg
      901 gaagactcag acactgggac atgtgctgaa gagactgtgt cttcctcttc cgatggcacg
      961 gcgtgtacat gagatgtgac tgccctttgg tatagctctt ggtaaattaa ctacatggtg
     1021 caagtgctgg aatccaggag tcctggggtt actaatacat taaaaacaga tagtatgtat
     1081 ttttaacctg ttttatgtaa ataacatttt catttttgtc agtgtcagat gtgaattgtg
     1141 tatattaaat aaacttcaac ttcctattga acatttat
//
