LOCUS       NP_001099582             206 aa            linear   ROD 22-MAY-2025
DEFINITION  geminin isoform 1 [Rattus norvegicus].
ACCESSION   NP_001099582 XP_001063272 XP_006253989 XP_214477
VERSION     NP_001099582.1
DBSOURCE    REFSEQ: accession NM_001106112.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 206)
  AUTHORS   Jiang,Z.Q., Zhou,Y.L., Chen,X., Li,L.Y., Liang,S.Y., Lin,S. and
            Shu,M.Q.
  TITLE     Different effects of neuropeptide Y on proliferation of vascular
            smooth muscle cells via regulation of Geminin
  JOURNAL   Mol Cell Biochem 433 (1-2), 205-211 (2017)
   PUBMED   28386846
  REMARK    GeneRIF: modulation of Geminin was effectively blocked by the Y1
            receptor antagonist. The stimulation of NPY on proliferation of
            VSMCs could be a double-edged sword in the development of
            atherosclerosis and thus provides new knowledge for therapy of
            atherosclerosis.
REFERENCE   2  (residues 1 to 206)
  AUTHORS   Zhang,Y., Jiang,Z., Li,L., Zhou,Y., Song,Z. and Shu,M.
  TITLE     Geminin interference facilitates vascular smooth muscle cell
            proliferation by upregulation of CDK-1
  JOURNAL   Cardiovasc Drugs Ther 28 (5), 407-414 (2014)
   PUBMED   25189787
  REMARK    GeneRIF: Geminin gene inhibition could augment Vacular Smooth
            Muscle Cell proliferation by increasing cyclin-dependent kinase-1
            expression.
REFERENCE   3  (residues 1 to 206)
  AUTHORS   Mosammaparast,N., Kim,H., Laurent,B., Zhao,Y., Lim,H.J.,
            Majid,M.C., Dango,S., Luo,Y., Hempel,K., Sowa,M.E., Gygi,S.P.,
            Steen,H., Harper,J.W., Yankner,B. and Shi,Y.
  TITLE     The histone demethylase LSD1/KDM1A promotes the DNA damage response
  JOURNAL   J Cell Biol 203 (3), 457-470 (2013)
   PUBMED   24217620
REFERENCE   4  (residues 1 to 206)
  AUTHORS   Guo,J. and Sun,N.
  TITLE     Cell cycle regulator geminin is dispensable for the proliferation
            of vascular smooth muscle cells
  JOURNAL   Sci China Life Sci 56 (8), 731-738 (2013)
   PUBMED   23838810
  REMARK    GeneRIF: geminin expression was low in quiescent vascular smooth
            muscle cells (approximately 90% and 10% of cells in the G1 and in
            S/G2/M phases of the cell cycle, respectively), increased as more
            cells entered in S/G2/M, and then decreased as cells exited S/G2/M
REFERENCE   5  (residues 1 to 206)
  AUTHORS   Pefani,D.E., Dimaki,M., Spella,M., Karantzelis,N., Mitsiki,E.,
            Kyrousi,C., Symeonidou,I.E., Perrakis,A., Taraviras,S. and
            Lygerou,Z.
  TITLE     Idas, a novel phylogenetically conserved geminin-related protein,
            binds to geminin and is required for cell cycle progression
  JOURNAL   J Biol Chem 286 (26), 23234-23246 (2011)
   PUBMED   21543332
REFERENCE   6  (residues 1 to 206)
  AUTHORS   Kim,M.Y., Jeong,B.C., Lee,J.H., Kee,H.J., Kook,H., Kim,N.S.,
            Kim,Y.H., Kim,J.K., Ahn,K.Y. and Kim,K.K.
  TITLE     A repressor complex, AP4 transcription factor and geminin,
            negatively regulates expression of target genes in nonneuronal
            cells
  JOURNAL   Proc Natl Acad Sci U S A 103 (35), 13074-13079 (2006)
   PUBMED   16924111
REFERENCE   7  (residues 1 to 206)
  AUTHORS   Yanagi,K., Mizuno,T., You,Z. and Hanaoka,F.
  TITLE     Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a
            novel intrinsic Cdt1 DNA binding activity
  JOURNAL   J Biol Chem 277 (43), 40871-40880 (2002)
   PUBMED   12192004
REFERENCE   8  (residues 1 to 206)
  AUTHORS   Wohlschlegel,J.A., Dwyer,B.T., Dhar,S.K., Cvetic,C., Walter,J.C.
            and Dutta,A.
  TITLE     Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
  JOURNAL   Science 290 (5500), 2309-2312 (2000)
   PUBMED   11125146
REFERENCE   9  (residues 1 to 206)
  AUTHORS   Kroll,K.L., Salic,A.N., Evans,L.M. and Kirschner,M.W.
  TITLE     Geminin, a neuralizing molecule that demarcates the future neural
            plate at the onset of gastrulation
  JOURNAL   Development 125 (16), 3247-3258 (1998)
   PUBMED   9671596
REFERENCE   10 (residues 1 to 206)
  AUTHORS   McGarry,T.J. and Kirschner,M.W.
  TITLE     Geminin, an inhibitor of DNA replication, is degraded during
            mitosis
  JOURNAL   Cell 93 (6), 1043-1053 (1998)
   PUBMED   9635433
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On or before May 13, 2025 this sequence version replaced
            XP_006253989.1, XP_214477.2, XP_001063272.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2777675.1,
                                           SRR26360186.1133483.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..206
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p11"
     Protein         1..206
                     /product="geminin isoform 1"
                     /calculated_mol_wt=22990
     Region          1..181
                     /region_name="Geminin"
                     /note="pfam07412"
                     /db_xref="CDD:462159"
     CDS             1..206
                     /gene="Gmnn"
                     /coded_by="NM_001106112.2:134..754"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:291137"
                     /db_xref="RGD:1308137"
ORIGIN      
        1 mnlsmkqkqe gaqenvkssp vprrtlkmiq psaagslvgr enelpkglsk rklwddqlts
       61 kisscgpean ennsvgdltq eacdlmtken pssqywkeva eqrrkalyea lteneklhke
      121 ieqkdseiar lrkenkdlae vaehvqymae vierlsnepl dnfespdsqe fdseketvey
      181 sepedsdtgt caeetvssss dgtact
//
