LOCUS       NM_031032               1424 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus glia maturation factor, beta (Gmfb), mRNA.
ACCESSION   NM_031032
VERSION     NM_031032.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1424)
  AUTHORS   Zhu,T., Li,Y., Zhu,L., Xu,J., Feng,Z., Chen,H., Shi,S., Liu,C.,
            Ou,Q., Gao,F., Zhang,J., Jin,C., Xu,J., Li,J., Zhang,J., Bi,Y.,
            Xu,G.T., Wang,J., Tian,H. and Lu,L.
  TITLE     GMFB/AKT/TGF-beta3 in Muller cells mediated early retinal
            degeneration in a streptozotocin-induced rat diabetes model
  JOURNAL   Glia 72 (3), 504-528 (2024)
   PUBMED   37904673
  REMARK    GeneRIF: GMFB/AKT/TGF-beta3 in Muller cells mediated early retinal
            degeneration in a streptozotocin-induced rat diabetes model.
REFERENCE   2  (bases 1 to 1424)
  AUTHORS   Shi,S., Gu,H., Xu,J., Sun,W., Liu,C., Zhu,T., Wang,J., Gao,F.,
            Zhang,J., Ou,Q., Jin,C., Xu,J., Chen,H., Li,J., Xu,G., Tian,H. and
            Lu,L.
  TITLE     Glia maturation factor beta deficiency protects against diabetic
            osteoporosis by suppressing osteoclast hyperactivity
  JOURNAL   Exp Mol Med 55 (5), 898-909 (2023)
   PUBMED   37121966
  REMARK    GeneRIF: Glia maturation factor beta deficiency protects against
            diabetic osteoporosis by suppressing osteoclast hyperactivity.
REFERENCE   3  (bases 1 to 1424)
  AUTHORS   Xu,F.F., Zhang,Z.B., Wang,Y.Y. and Wang,T.H.
  TITLE     Brain-Derived Glia Maturation Factor beta Participates in Lung
            Injury Induced by Acute Cerebral Ischemia by Increasing ROS in
            Endothelial Cells
  JOURNAL   Neurosci Bull 34 (6), 1077-1090 (2018)
   PUBMED   30191459
  REMARK    GeneRIF: This study demonstrated that GMFB is up-regulated in
            astrocytes after Acute Cerebral Ischemia.
REFERENCE   4  (bases 1 to 1424)
  AUTHORS   Lim,R., Zaheer,A., Khosravi,H., Freeman,J.H. Jr., Halverson,H.E.,
            Wemmie,J.A. and Yang,B.
  TITLE     Impaired motor performance and learning in glia maturation
            factor-knockout mice
  JOURNAL   Brain Res 1024 (1-2), 225-232 (2004)
   PUBMED   15451385
REFERENCE   5  (bases 1 to 1424)
  AUTHORS   Zaheer,A., Fink,B.D. and Lim,R.
  TITLE     Expression of glia maturation factor beta mRNA and protein in rat
            organs and cells
  JOURNAL   J Neurochem 60 (3), 914-920 (1993)
   PUBMED   8436977
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081778.1.
            
            On Oct 17, 2004 this sequence version replaced NM_031032.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081778.1, FQ222145.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840105, SAMN12840107
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1424
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p14"
     gene            1..1424
                     /gene="Gmfb"
                     /note="glia maturation factor, beta"
                     /db_xref="GeneID:81661"
                     /db_xref="RGD:70910"
     exon            1..86
                     /gene="Gmfb"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..512
                     /gene="Gmfb"
                     /note="GMF-beta; DNA for thyroid hormone receptor binding
                     site (276bp)"
                     /codon_start=1
                     /product="glia maturation factor beta"
                     /protein_id="NP_112294.1"
                     /db_xref="GeneID:81661"
                     /db_xref="RGD:70910"
                     /translation="MSESLVVCDVAEDLVEKLRKFRFRKETHNAAIIMKIDKDKRLVV
                     LDEELEGVSPDELKDELPERQPRFIVYSYKYQHDDGRVSYPLCFIFSSPLGCKPEQQM
                     MYAGSKNKLVQTAELTKVFEIRNTEDLTEEWLREKLGFFH"
     exon            87..183
                     /gene="Gmfb"
                     /inference="alignment:Splign:2.1.0"
     exon            184..233
                     /gene="Gmfb"
                     /inference="alignment:Splign:2.1.0"
     exon            234..283
                     /gene="Gmfb"
                     /inference="alignment:Splign:2.1.0"
     exon            284..366
                     /gene="Gmfb"
                     /inference="alignment:Splign:2.1.0"
     exon            367..440
                     /gene="Gmfb"
                     /inference="alignment:Splign:2.1.0"
     exon            441..1398
                     /gene="Gmfb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caggaaggga ggtggctgca gagccattct taaaggggcc caagagatca tacggcaacg
       61 gacggctgac gaccggaagg aaaatgagtg agtctttggt ggtttgtgat gttgctgaag
      121 atttagtgga aaagctgaga aagtttcgtt ttcgaaaaga aacccacaat gctgctatta
      181 taatgaagat tgacaaggat aaacgcttgg tggtgctgga tgaggagctc gagggtgtct
      241 ctccagatga acttaaagat gaactacctg aacggcaacc tcgcttcatt gtgtatagtt
      301 ataaatacca gcacgacgat ggccgggtct cctaccctct gtgctttatc ttctccagtc
      361 ctctggggtg caaacctgag cagcagatga tgtacgctgg gagtaagaac aagctggtcc
      421 agaccgccga gctaactaag gtatttgaaa taagaaacac cgaagaccta actgaagaat
      481 ggttacgtga gaaacttgga tttttccact aatgtgaact tctgtgtttc taaagtattt
      541 atgtattaac ctgaccatac tggaaccaga cataaatagt tatttatgcc taaaaatgca
      601 ctgttactta cagtttgttt cctgcagtaa agaaaaattc atttgtgcag tttgaacaaa
      661 ggggaaatca tcttcatagt aatgaaactt tgtgaagtgt ttccttgtat ctgtcattgt
      721 taggtggact acttttctcc agggatggtt cgcacccttg tgactaattt ctataattta
      781 tgattcagaa tttgttactg ttgcagacac tataggaaag tgggtataga ctgtgataga
      841 caacagttcc tccttggcca ctcctggtac tggcatggca gtttgtaagt gccaagagca
      901 tttcatcacc tatcgcatca ttgaggttca ctggggctga agtgtaagtg accgctctga
      961 gccgtgagtg gcgatgtagt ggaccctctg ctgctctcgt cacattcctc ctctcttgca
     1021 ttcctgtatc ctttcaatca agtgtagagt cgccatcaat cactcctcct taaggaccgg
     1081 gggcttagtt ttatggtaga gttaggatta ttagaggttt tcttctgatg gaacatagtc
     1141 ctagtcttag agactcgtgg gctgtataat caagggcttc cgtctaggtt atgtcaccag
     1201 taggcagcta gagcggagct tggtaacaga aagcacctcc taacgtctcg tgagcactgt
     1261 tctggatatg ttaacctgtg cctttgattt gtcagcttta acattagctt cagactccta
     1321 cactgccagt attctagatt tggtgagatt aatacttttt taaagggttc aaataaaaca
     1381 attttctaat atgtgtaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
