LOCUS       NM_031803               4116 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus glucocorticoid modulatory element binding protein
            2 (Gmeb2), transcript variant 1, mRNA.
ACCESSION   NM_031803
VERSION     NM_031803.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4116)
  AUTHORS   Chen,J., He,Y. and Simons,S.S. Jr.
  TITLE     Structure/activity relationships for GMEB-2: the second member of
            the glucocorticoid modulatory element-binding complex
  JOURNAL   Biochemistry 43 (1), 245-255 (2004)
   PUBMED   14705952
REFERENCE   2  (bases 1 to 4116)
  AUTHORS   Kaul,S., Blackford,J.A. Jr., Chen,J., Ogryzko,V.V. and Simons,S.S.
            Jr.
  TITLE     Properties of the glucocorticoid modulatory element binding
            proteins GMEB-1 and -2: potential new modifiers of glucocorticoid
            receptor transactivation and members of the family of KDWK proteins
  JOURNAL   Mol Endocrinol 14 (7), 1010-1027 (2000)
   PUBMED   10894151
REFERENCE   3  (bases 1 to 4116)
  AUTHORS   Zeng,H., Kaul,S. and Simons,S.S. Jr.
  TITLE     Genomic organization of human GMEB-1 and rat GMEB-2: structural
            conservation of two multifunctional proteins
  JOURNAL   Nucleic Acids Res 28 (8), 1819-1829 (2000)
   PUBMED   10734202
REFERENCE   4  (bases 1 to 4116)
  AUTHORS   Zeng,H., Jackson,D.A., Oshima,H. and Simons,S.S. Jr.
  TITLE     Cloning and characterization of a novel binding factor (GMEB-2) of
            the glucocorticoid modulatory element
  JOURNAL   J Biol Chem 273 (28), 17756-17762 (1998)
   PUBMED   9651376
REFERENCE   5  (bases 1 to 4116)
  AUTHORS   Oshima,H., Szapary,D. and Simons,S.S. Jr.
  TITLE     The factor binding to the glucocorticoid modulatory element of the
            tyrosine aminotransferase gene is a novel and ubiquitous
            heteromeric complex
  JOURNAL   J Biol Chem 270 (37), 21893-21901 (1995)
   PUBMED   7665613
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031803.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF059273.1, SRR26360186.1403703.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                JAXUCZ010000003.1  188778240-188778336 c
            98-270              JAXUCZ010000003.1  188767256-188767428 c
            271-368             JAXUCZ010000003.1  188755548-188755645 c
            369-496             JAXUCZ010000003.1  188754740-188754867 c
            497-600             JAXUCZ010000003.1  188748588-188748691 c
            601-758             JAXUCZ010000003.1  188747263-188747420 c
            759-830             JAXUCZ010000003.1  188744622-188744693 c
            831-968             JAXUCZ010000003.1  188744251-188744388 c
            969-1091            JAXUCZ010000003.1  188743899-188744021 c
            1092-4116           JAXUCZ010000003.1  188740210-188743234 c
FEATURES             Location/Qualifiers
     source          1..4116
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q43"
     gene            1..4116
                     /gene="Gmeb2"
                     /note="glucocorticoid modulatory element binding protein
                     2"
                     /db_xref="GeneID:83635"
                     /db_xref="RGD:620481"
     exon            1..97
                     /gene="Gmeb2"
                     /inference="alignment:Splign:2.1.0"
     exon            98..270
                     /gene="Gmeb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1732
                     /gene="Gmeb2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     GMEB-2"
                     /codon_start=1
                     /product="glucocorticoid modulatory element-binding
                     protein 2 isoform 1"
                     /protein_id="NP_113991.2"
                     /db_xref="GeneID:83635"
                     /db_xref="RGD:620481"
                     /translation="MATPDVSVHMEEVVVVTTPDTAVDGSGVEEVKTVLVTTNLAPHG
                     GDLTEDNMETENAAAAAAAAFTASSQLKEAVLVKMAEEGENLEAEIVYPITCGDSRAN
                     LIWRKFVCPGINVKCVQYDEHVISPKEFVHLAGKSTLKDWKRAIRMNGIMLRKIMDSG
                     ELDFYQHDKVCSNTCRSTKIDLSGARVSLSSPTSTEYIPLTPAAADVNGSPATITIET
                     CEDPGDWTTTIGDDTFAFWRGLKDAGLLDEVIQEFQQELEETMKGLQQRVQDPPLQLR
                     DAVLLNNIVQNFGMLDLVKKVLASHKCQMDRSREQYARDLAALEQQCDEHRRRAKELK
                     HKSQHLSNVLMTLTPVSLPSPMKRPRLARATSGPAAMASQVLTQSAQIALGPGMPMSQ
                     LTSVPLGKVVSTLPSTVLGKGSPQAAPASSPASPLLGGYTVLASSGSTFPSTVEIHPD
                     TSSLTVLSTAAMQDGSTVLKVVSPLQLLTLPGLGPTLQNVAQASPAGSTIVTMPTAAA
                     TGPEEHTATIEVAAVAEDHEQK"
     exon            271..368
                     /gene="Gmeb2"
                     /inference="alignment:Splign:2.1.0"
     exon            369..496
                     /gene="Gmeb2"
                     /inference="alignment:Splign:2.1.0"
     exon            497..600
                     /gene="Gmeb2"
                     /inference="alignment:Splign:2.1.0"
     exon            601..758
                     /gene="Gmeb2"
                     /inference="alignment:Splign:2.1.0"
     exon            759..830
                     /gene="Gmeb2"
                     /inference="alignment:Splign:2.1.0"
     exon            831..968
                     /gene="Gmeb2"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1091
                     /gene="Gmeb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..4116
                     /gene="Gmeb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatccccaac aaggagcgaa agctgcggcc gccaccacca ccagccgccg ccgcacccgt
       61 cacagccggg cgccggagca ggcccgtgtg ggcccaggac ttcagactct ggagaagtga
      121 cactgttgac ctctgagcca tggcaactcc agatgtcagc gtccacatgg aagaagtagt
      181 ggttgtgaca actccagaca ctgcagttga tggcagtggt gtagaggagg tgaagacagt
      241 gcttgtgaca acgaacctag ctcctcatgg gggtgatttg acagaagata acatggaaac
      301 agaaaatgca gcagctgcag ctgctgctgc ctttacagcc tcctcacagc tcaaggaagc
      361 cgtgttagtg aagatggctg aagaggggga gaacttagag gctgaaattg tgtaccccat
      421 cacttgtgga gacagcagag ctaacctcat ctggaggaag tttgtgtgcc ctggaatcaa
      481 tgtgaaatgt gttcagtacg atgaacatgt gatcagccca aaggagtttg tgcatctggc
      541 agggaagtct accctgaagg actggaagag agccatccgg atgaacggca tcatgctcag
      601 gaagatcatg gactctgggg agctagactt ctaccagcat gacaaggtct gctctaatac
      661 ttgccgaagc accaagattg acctctcagg ggcccgtgtg tccctgagca gtccaacatc
      721 cacagagtac atcccgctca caccagctgc agctgatgtg aatggctcac ctgccaccat
      781 caccatagag acctgtgagg accctggtga ctggaccaca accattggag acgacacatt
      841 tgcattctgg cggggactga aggatgcggg cttactggat gaagtcatac aggaatttca
      901 acaggagctg gaggaaacca tgaaaggcct gcagcagcga gtgcaggacc cgcccctaca
      961 gctccgagat gctgtcctcc tcaataacat cgtgcaaaac tttggcatgc tggatctggt
     1021 aaagaaggta ctggccagcc acaagtgcca gatggatcgt tctcgagaac agtatgcacg
     1081 ggacctggca gccctggaac agcagtgtga tgaacatcgc cgccgtgcca aggaactgaa
     1141 gcacaagtcc cagcacctta gcaatgtgct catgacgttg accccagttt ccctgccatc
     1201 ccctatgaag cggccccgtc ttgcacgggc tacatctgga ccagctgcta tggcttccca
     1261 ggtgcttaca cagtctgcac agattgcact tggcccagga atgcctatgt cccagttgac
     1321 cagtgtgcca cttggcaaag tagtatctac actgccctcc actgtcctgg gcaagggctc
     1381 tcctcaagct gccccagcca gttcaccggc ctccccactg cttggaggct acacagtttt
     1441 ggcctcctct ggctctacct tccccagcac agtagagatt catccggaca catccagcct
     1501 cacagttttg agcacagctg ccatgcagga tggcagcaca gtactaaagg tggtcagccc
     1561 cctgcagctg ctcaccctgc ctggcctggg acccacacta cagaatgtgg ctcaggcatc
     1621 acctgcaggc agcaccattg tgacaatgcc tacagcagct gctactggac ctgaggaaca
     1681 cacagccact attgaggtgg ccgctgtagc agaggaccat gagcagaagt agctggcagg
     1741 gaggctaaaa tccttccaac atgggctggc tgactgcctc tcctcaggcc gctgcaggca
     1801 gaggccacta cagacacagg ccatagggct ggctcagcac aagcaggtct gatgggctga
     1861 accaaagaga ggattgccgg atgaatcaag agaagaaaag ggggcagaat gttgccagga
     1921 acctggaaaa tctgtcttca acttataaac ttcctcccct ttttttgtgg gaaatactct
     1981 tttccatctg ttgcttatta atcctgttta cacattgggc cttgagcagg aaccagaggg
     2041 tcactgacca ggaggaggcc tgggtgcttc tggtacagct acagagccag caccagagcc
     2101 cagctaacca taggtcctag tgcctgcacc cccatggggc tgagcctgct gggacattat
     2161 tgacacatgt cttaggcagc atgcctgagt gtggaagcca tagatcctat ggatttggtc
     2221 tcttcccaca gttctctgtt ggttcagtat ggccagtgtc catgttcctt cactgttggg
     2281 aacatgccct ggggctaagt gcagacccca gccaggaccc catccctcac cccataggca
     2341 ctcaggtggt gaaggggtct catggacctg gcatgttcta gacccttttg cacatgggct
     2401 gcaggtgttt ttaagtaaat cgcttagtag ccttctaggg ggggaaaatc aattatagtg
     2461 ttttcaacca aaacaatgct gagtgcctag gctcctgagt cagttctggg agggacccag
     2521 agcaccgata tatacacacc tagccaggtg ctagaggtct taagtagtgt ctttccctga
     2581 gacaaagctc tggaagattt ttgtggaggt atgccttgag acttggggta gctcaatgac
     2641 tccctgtgtg cagccgactc ttgtactccc ctatagttgc tccccctgcc cccaactctc
     2701 ttggagatag agctgggctt ctctggccaa tattcagtgt ctctatcctg agagttccag
     2761 ggtatgtaag gctgtttaga gtagtgggct ggtcagctgg aagacaggac ccagaatgtc
     2821 cacagaaggc tgtcttcagg cagtttttat gggtctaggt ttgggcccat gctagggatg
     2881 acctaggcca gagttcttgg agccaaacga tttcagggaa caaagttttg gcctcttggt
     2941 aagggatgtc ctgggatagt cctaaggtgc ctcttgaatc tcctgttctg tcaactgaag
     3001 gctttccttt caggggcccc acagcaggaa gggaccactg tcccacttta ctgctttgaa
     3061 ggttaccttg tccttccatc catacatccc ccttgagcgc ccagattcct tttacacctt
     3121 tgctgtgatt gggccctttc ctgcccccgc tctcacccta tgtcaagcta ctgaggttct
     3181 tgtatcccct ctgttacatc actgttcact gtggccacga atcagctggt tttggcagat
     3241 gtttacctgt ttatgtatat actccttttt aaaaacttgt tttgtttttc ttcattgagt
     3301 tacaagtcct gttatatgca gctgtatgac tctagggaca ctgggaggat cagcagagtg
     3361 ggtacttcct tgaagtccct cctctacaac ctcagactaa tgtcacaaat aaaaccttcc
     3421 tgccctagga accaagagcc tttccttggc acaagcccca gatgtcattt gcttttgagg
     3481 atgtgggcca gtttcctttc ttcaaaagag caaggttgaa atatttttgg cccttgcccc
     3541 tttgagcatt agagatactg gaaggtgaag tttatttcag agccgtacaa aaataattct
     3601 caaatcagct tcagaattag ttcttatcac tccttcctag tatcctcaga ggttgtctac
     3661 agtttaactt gtagaaccat gacccttgtg acagtgctgg cgttgtttca ggtcctccaa
     3721 ggccgtttct agcaggtcag cgaaggccca atagtcccat ctgcatggaa ccctcaattc
     3781 tgggagagga agtgtgatca ctgccctacc acatgtttat acctgcctct ctggttcctc
     3841 ctgactccta ttgcttccct gcttgttggg ccattcagaa cccagaaagg aaggtcttcc
     3901 ccctccacat gcaaacacgg gtgcttgtgg ctgctttcag tttggttttc tgagaaaata
     3961 ggacaggatt tggttttgca gagggtgcaa gctcctttcc atgcctgccc aggaggcacg
     4021 caaaagggca agtttgagtt ctttgagttc tactttgtat gttgtttagc aagtatctgc
     4081 ttggtacttt gatttaaaat aaaaacactt ttataa
//
