LOCUS       NM_001039606            1492 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus GDP-mannose 4, 6-dehydratase (Gmds), mRNA.
ACCESSION   NM_001039606
VERSION     NM_001039606.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1492)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1492)
  AUTHORS   Gharahkhani,P., Burdon,K.P., Fogarty,R., Sharma,S., Hewitt,A.W.,
            Martin,S., Law,M.H., Cremin,K., Bailey,J.N.C., Loomis,S.J.,
            Pasquale,L.R., Haines,J.L., Hauser,M.A., Viswanathan,A.C.,
            McGuffin,P., Topouzis,F., Foster,P.J., Graham,S.L., Casson,R.J.,
            Chehade,M., White,A.J., Zhou,T., Souzeau,E., Landers,J.,
            Fitzgerald,J.T., Klebe,S., Ruddle,J.B., Goldberg,I., Healey,P.R.,
            Mills,R.A., Wang,J.J., Montgomery,G.W., Martin,N.G.,
            RadfordSmith,G., Whiteman,D.C., Brown,M.A., Wiggs,J.L.,
            Mackey,D.A., Mitchell,P., MacGregor,S. and Craig,J.E.
  CONSRTM   Wellcome Trust Case Control Consortium 2, NEIGHBORHOOD consortium
  TITLE     Common variants near ABCA1, AFAP1 and GMDS confer risk of primary
            open-angle glaucoma
  JOURNAL   Nat Genet 46 (10), 1120-1125 (2014)
   PUBMED   25173105
REFERENCE   3  (bases 1 to 1492)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   4  (bases 1 to 1492)
  AUTHORS   Ohyama,C., Smith,P.L., Angata,K., Fukuda,M.N., Lowe,J.B. and
            Fukuda,M.
  TITLE     Molecular cloning and expression of GDP-D-mannose-4,6-dehydratase,
            a key enzyme for fucose metabolism defective in Lec13 cells
  JOURNAL   J Biol Chem 273 (23), 14582-14587 (1998)
   PUBMED   9603974
REFERENCE   5  (bases 1 to 1492)
  AUTHORS   Sullivan,F.X., Kumar,R., Kriz,R., Stahl,M., Xu,G.Y., Rouse,J.,
            Chang,X.J., Boodhoo,A., Potvin,B. and Cumming,D.A.
  TITLE     Molecular cloning of human GDP-mannose 4,6-dehydratase and
            reconstitution of GDP-fucose biosynthesis in vitro
  JOURNAL   J Biol Chem 273 (14), 8193-8202 (1998)
   PUBMED   9525924
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC104708.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC104708.1, SRR8487226.177997.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132263, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1492
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p12"
     gene            1..1492
                     /gene="Gmds"
                     /note="GDP-mannose 4, 6-dehydratase"
                     /db_xref="GeneID:291095"
                     /db_xref="RGD:1311008"
     exon            1..123
                     /gene="Gmds"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1140
                     /gene="Gmds"
                     /EC_number="4.2.1.47"
                     /codon_start=1
                     /product="GDP-mannose 4,6 dehydratase"
                     /protein_id="NP_001034695.1"
                     /db_xref="GeneID:291095"
                     /db_xref="RGD:1311008"
                     /translation="MAHAPASCRRYPGSGDGEMGKLRKVALITGITGQDGSYLAEFLL
                     EKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKP
                     TEIYNLGAQSHVKISFDLAEYTADVDGVGTLRLLDAIKTCGLINSVKFYQASTSELYG
                     KVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFREAYNLFAVNGILFNHESPRRGANF
                     VTRKISRSVAKIYLGQLECFSLGNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATG
                     EVHSVREFVEKSFMHIGKTIVWEGKNENEVGRCKETGKIHVTVDLKYYRPTEVDFLQG
                     DCSKAQQKLNWKPRVAFDELVREMVQADVELMRTNPNA"
     exon            124..168
                     /gene="Gmds"
                     /inference="alignment:Splign:2.1.0"
     exon            169..256
                     /gene="Gmds"
                     /inference="alignment:Splign:2.1.0"
     exon            257..366
                     /gene="Gmds"
                     /inference="alignment:Splign:2.1.0"
     exon            367..559
                     /gene="Gmds"
                     /inference="alignment:Splign:2.1.0"
     exon            560..664
                     /gene="Gmds"
                     /inference="alignment:Splign:2.1.0"
     exon            665..792
                     /gene="Gmds"
                     /inference="alignment:Splign:2.1.0"
     exon            793..911
                     /gene="Gmds"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1008
                     /gene="Gmds"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1077
                     /gene="Gmds"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1465
                     /gene="Gmds"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctcacccg cctgaagcga catggcccac gctcccgcta gctgccggag atacccgggc
       61 tccggggatg gcgagatggg caagctcagg aaggtagctc tcatcaccgg catcactggc
      121 caggatggtt catacttggc agaattcctg ctggagaaag gatacgaggt ccatggaata
      181 gtacggcgat ctagttcatt taatacaggt cgaattgaac atttatataa gaatcctcag
      241 gctcatattg aaggaaacat gaagttgcac tatggcgacc tgactgacag cacctgcctg
      301 gtgaaaatca tcaatgaagt gaagcctaca gagatctaca atcttggcgc tcagagccat
      361 gtcaagatct cctttgactt agctgaatac accgcagacg ttgatggagt tggcaccttg
      421 cggcttctgg atgcaattaa aacttgcggc cttataaatt ctgtgaagtt ctaccaggcc
      481 tcgacaagtg aactttatgg aaaagttcag gaaatacccc agaaagagac cacacctttc
      541 tatccgaggt caccctatgg agccgccaag ctctatgcct attggattgt ggtgaatttc
      601 cgtgaagctt ataatctctt tgcagtgaat ggcattctct tcaatcacga gagccccaga
      661 agaggagcta attttgttac tcgaaaaatt agccggtcag tagctaagat ttaccttgga
      721 caactggaat gtttcagttt gggaaatctg gatgccaaac gagactgggg ccatgccaag
      781 gactatgtag aggctatgtg gctgatgttg caaaatgatg agccggagga ctttgtcata
      841 gctactgggg aagttcacag tgtccgtgaa tttgttgaaa aatcattcat gcacattgga
      901 aaaaccattg tgtgggaagg aaagaatgaa aatgaagtag gcagatgtaa ggagaccggc
      961 aaaattcacg tgactgtgga tctgaaatac taccgaccga ctgaagtgga ctttctacag
     1021 ggagactgct ccaaggctca gcagaaactg aactggaaac cccgcgttgc cttcgatgag
     1081 ctggtgagag agatggtgca ggccgacgtg gagctcatga ggaccaaccc caacgcttga
     1141 gcccctctgc agaaactaga ggcatggcaa cagtgcagag ccagtgaacc ggagttcagt
     1201 cactcctgcc aatcatggac cctcgacctc ctgtgttgtc cctgcatcta gagctgggcc
     1261 acagaggttt gtagacccca agacaggaca cgccagacct aaggccgcat tgcttttgtc
     1321 aaagcctcct ctgaatggtt ttgggaaatc aagaagtttt aatcacatat tcattttact
     1381 tgaaattatg tcactagaca acttatattt tggagtcttg agattgtttt tctcttttct
     1441 tattaaataa tctttctata aactaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
