LOCUS       NM_172335               2028 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus ganglioside GM2 activator (Gm2a), mRNA.
ACCESSION   NM_172335
VERSION     NM_172335.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2028)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   2  (bases 1 to 2028)
  AUTHORS   Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl
            E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES and
            Mann M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   3  (bases 1 to 2028)
  AUTHORS   Sarkar S, Miwa N, Kominami H, Igarashi N, Hayashi S, Okada T,
            Jahangeer S and Nakamura S.
  TITLE     Regulation of mammalian phospholipase D2: interaction with and
            stimulation by G(M2) activator
  JOURNAL   Biochem J 359 (Pt 3), 599-604 (2001)
   PUBMED   11672434
REFERENCE   4  (bases 1 to 2028)
  AUTHORS   Chen B, Rigat B, Curry C and Mahuran DJ.
  TITLE     Structure of the GM2A gene: identification of an exon 2 nonsense
            mutation and a naturally occurring transcript with an in-frame
            deletion of exon 2
  JOURNAL   Am J Hum Genet 65 (1), 77-87 (1999)
   PUBMED   10364519
REFERENCE   5  (bases 1 to 2028)
  AUTHORS   Mundel TM, Heid HW, Mahuran DJ, Kriz W and Mundel P.
  TITLE     Ganglioside GM2-activator protein and vesicular transport in
            collecting duct intercalated cells
  JOURNAL   J Am Soc Nephrol 10 (3), 435-443 (1999)
   PUBMED   10073593
REFERENCE   6  (bases 1 to 2028)
  AUTHORS   Liu Y, Hoffmann A, Grinberg A, Westphal H, McDonald MP, Miller KM,
            Crawley JN, Sandhoff K, Suzuki K and Proia RL.
  TITLE     Mouse model of GM2 activator deficiency manifests cerebellar
            pathology and motor impairment
  JOURNAL   Proc Natl Acad Sci U S A 94 (15), 8138-8143 (1997)
   PUBMED   9223328
REFERENCE   7  (bases 1 to 2028)
  AUTHORS   Kuwana T, Mullock BM and Luzio JP.
  TITLE     Identification of a lysosomal protein causing lipid transfer, using
            a fluorescence assay designed to monitor membrane fusion between
            rat liver endosomes and lysosomes
  JOURNAL   Biochem J 308 (Pt 3) (Pt 3), 937-946 (1995)
   PUBMED   8948454
REFERENCE   8  (bases 1 to 2028)
  AUTHORS   Beccari T, Palmerini CA, Servillo G, Della Fazia MA, Viola Magni MP
            and Orlacchio A.
  TITLE     GM2 activator protein expression in mouse tissues
  JOURNAL   Biochem Biophys Res Commun 204 (2), 741-745 (1994)
   PUBMED   7980537
REFERENCE   9  (bases 1 to 2028)
  AUTHORS   Bellachioma G, Stirling JL, Orlacchio A and Beccari T.
  TITLE     Cloning and sequence analysis of a cDNA clone coding for the mouse
            GM2 activator protein
  JOURNAL   Biochem J 294 (Pt 1) (Pt 1), 227-230 (1993)
   PUBMED   7689829
REFERENCE   10 (bases 1 to 2028)
  AUTHORS   Kuwana T, Mullock BM and Luzio JP.
  TITLE     Identification of a protein capable of causing fusion of endosome
            and lysosome membranes
  JOURNAL   Biochem Soc Trans 21 (2), 299-300 (1993)
   PUBMED   8359485
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC072474.1.
            
            On Jun 20, 2004 this sequence version replaced NM_172335.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072474.1, EV772107.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2028
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..2028
                     /gene="Gm2a"
                     /note="ganglioside GM2 activator"
                     /db_xref="GeneID:282838"
                     /db_xref="RGD:628651"
     exon            1..140
                     /gene="Gm2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..641
                     /gene="Gm2a"
                     /note="GM2 ganglioside activator protein"
                     /codon_start=1
                     /product="ganglioside GM2 activator precursor"
                     /protein_id="NP_758838.2"
                     /db_xref="GeneID:282838"
                     /db_xref="RGD:628651"
                     /translation="MRRVPLLLVLGLLFVLGLLFAGPVAPSRLISKRPSQLGGFSWDN
                     CDEGKDPAVIKSLTLQPDPIVVPGDVIVSAEGKTSIPLTSPQKVELTVEKEVAGFWVK
                     IPCVEQLGSCTYENVCDLIDQYIPPGETCPEPLHTYGLPCHCPFKEGTYSLPSSNFTV
                     PDLELPSWLSTGNYRIQSILSSGGKRLACIKIAASLKGK"
     exon            141..302
                     /gene="Gm2a"
                     /inference="alignment:Splign:2.1.0"
     exon            303..485
                     /gene="Gm2a"
                     /inference="alignment:Splign:2.1.0"
     exon            486..2003
                     /gene="Gm2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagagtcgc cgtgcctaga ccgacctcga ggaccgtcgc catgcgtcgt gtaccgctgc
       61 tgctcgtgct gggcttgctg ttcgtgctgg gcttgctgtt cgctggccct gtcgcccctt
      121 cgcgcctcat ctcgaagcgc ccttcccaac ttggtggctt ctcctgggat aactgtgatg
      181 aaggaaagga ccctgcagtg atcaaaagcc tcacgctcca acctgacccc attgtcgttc
      241 ctggagatgt gatcgtcagt gctgagggca agaccagcat tcccctcact tctcctcaga
      301 aggtggagct caccgtggag aaggaagtgg ctggcttctg ggtcaagatc ccttgcgtag
      361 aacagctagg aagctgtacc tatgagaatg tctgtgacct gatagaccaa tacatccccc
      421 ctggagagac ctgcccagag ccgctgcaca cctacgggct gccctgccat tgtcccttca
      481 aggaaggcac ctactcactg ccttcgagca acttcacagt gcctgatctg gagcttccaa
      541 gctggctaag cacgggcaac taccgcatcc agagcatctt gagcagcggt ggaaagcgcc
      601 tggcctgcat caagattgcc gcctctctca agggcaaata accaggcagc agccaccata
      661 gaatgaaagg gcaccaggaa ggcatgcttc ttcttctgtg ttccggggcc cagagctgcc
      721 tgcctctaac tccgttctat ggttctctac cctttctgca aatcacgaca acctgacctg
      781 agggaggatg gaccaggcgg gtctcgacat ctgttgggct gtacgccatg ctccttcgca
      841 cccctaccaa ctttctaaga gtttctctca tgtcccaaac agtcaaggaa tgggaaccaa
      901 catgttatgg aatcttaagt tcaagctggc ccaacatggg cctcctgaag ctatgctcac
      961 cccacctctt cgttttagcc accaacttaa aaaccaagat gacagtatta atctctcatt
     1021 ccaccctaaa cctctcatcc agcaaagagg tctaggtagc cagtcttagg tctgcccccc
     1081 tattaacttc catgattaac tacattccct ttgcaacttg cctagccaac actggggctg
     1141 acagatcctg aaagggcagg atggcgtgtg acagaaaccc tgggagagtt attgttgggc
     1201 atgccccatt aacctcagta aagcacaggt gcccagggcc aagcagatcg agggagccaa
     1261 agcagtcact cccaggagcg atgcccactt ttcttccttt ggtatgacgc atacagaatg
     1321 ggatgacatt ccttatacct gacaagaaac aaaactgaaa ccccaacagc acatgtgctc
     1381 cagtgccagg aggccagggt ctggaatggc atgtctagtc ctggaggtac agtccagtga
     1441 cctgtaagtg ccatgtaagg aatgttaccg gatatttgca acagttttct tccttaggcc
     1501 ccaaacccca gacttttcta tgaagtctta gattttttaa ctattagaaa caaattgttt
     1561 tttatatact gttcaggcca aaggggccac gtggacttgt ctggggggtg gggggggaca
     1621 tagctggctc acaggtggct gctttttttc tcacacctgt tcgtcttctc agtctcaagt
     1681 tatctgactt catttctctc cccctcaagg tcaagtcctt ggtaccagac ctcagagagg
     1741 gctcagcctg cactggagca ggtctgcatg gcctctgaga gctgggccct gtgccagcct
     1801 cagagcccca tcaccatcag ggtatagggg ttcacactgg agtggatctc cccaccccca
     1861 ccccccagca gccaccttgt ggaacagggg tcccatgtag agagtggatc ccacaccggg
     1921 ttgtaccatg acaacttcct gagcctccgt cagcccggtt ctggactgca agactagtct
     1981 gtcaataaat cttcttaact tgcaaaaaaa aaaaaaaaaa aaaaaaaa
//
