LOCUS       NM_001108722            2149 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus glutaredoxin 5 (Glrx5), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_001108722 XM_001069239 XM_343103
VERSION     NM_001108722.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2149)
  AUTHORS   Maio,N. and Rouault,T.A.
  TITLE     Iron-sulfur cluster biogenesis in mammalian cells: New insights
            into the molecular mechanisms of cluster delivery
  JOURNAL   Biochim Biophys Acta 1853 (6), 1493-1512 (2015)
   PUBMED   25245479
  REMARK    Review article
REFERENCE   2  (bases 1 to 2149)
  AUTHORS   Baker,P.R. 2nd, Friederich,M.W., Swanson,M.A., Shaikh,T.,
            Bhattacharya,K., Scharer,G.H., Aicher,J., Creadon-Swindell,G.,
            Geiger,E., MacLean,K.N., Lee,W.T., Deshpande,C., Freckmann,M.L.,
            Shih,L.Y., Wasserstein,M., Rasmussen,M.B., Lund,A.M., Procopis,P.,
            Cameron,J.M., Robinson,B.H., Brown,G.K., Brown,R.M., Compton,A.G.,
            Dieckmann,C.L., Collard,R., Coughlin,C.R. 2nd, Spector,E.,
            Wempe,M.F. and Van Hove,J.L.
  TITLE     Variant non ketotic hyperglycinemia is caused by mutations in LIAS,
            BOLA3 and the novel gene GLRX5
  JOURNAL   Brain 137 (Pt 2), 366-379 (2014)
   PUBMED   24334290
REFERENCE   3  (bases 1 to 2149)
  AUTHORS   Aon-Bertolino,M.L., Romero,J.I., Galeano,P., Holubiec,M.,
            Badorrey,M.S., Saraceno,G.E., Hanschmann,E.M., Lillig,C.H. and
            Capani,F.
  TITLE     Thioredoxin and glutaredoxin system proteins-immunolocalization in
            the rat central nervous system
  JOURNAL   Biochim Biophys Acta 1810 (1), 93-110 (2011)
   PUBMED   20620191
REFERENCE   4  (bases 1 to 2149)
  AUTHORS   Ye,H., Jeong,S.Y., Ghosh,M.C., Kovtunovych,G., Silvestri,L.,
            Ortillo,D., Uchida,N., Tisdale,J., Camaschella,C. and Rouault,T.A.
  TITLE     Glutaredoxin 5 deficiency causes sideroblastic anemia by
            specifically impairing heme biosynthesis and depleting cytosolic
            iron in human erythroblasts
  JOURNAL   J Clin Invest 120 (5), 1749-1761 (2010)
   PUBMED   20364084
REFERENCE   5  (bases 1 to 2149)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473982.1.
            
            [WARNING] On Apr 10, 2024 this sequence was replaced by
            NM_001108722.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_343103.3, XM_001069239.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FN802418.1, FM037546.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2149
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..2149
                     /gene="Glrx5"
                     /gene_synonym="RGD1308383"
                     /note="glutaredoxin 5"
                     /db_xref="GeneID:362776"
                     /db_xref="RGD:1308383"
     exon            1..314
                     /gene="Glrx5"
                     /gene_synonym="RGD1308383"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..490
                     /gene="Glrx5"
                     /gene_synonym="RGD1308383"
                     /note="glutaredoxin 5 homolog"
                     /codon_start=1
                     /product="glutaredoxin-related protein 5, mitochondrial"
                     /protein_id="NP_001102192.1"
                     /db_xref="GeneID:362776"
                     /db_xref="RGD:1308383"
                     /translation="MSASLSRAAAALLRWGRGAGGGVLPRAGVRAASSGGQAEQLDAL
                     VKKDKVVVFLKGTPEQPQCGFSNAVVQILRLHGVRDYAAYNVLEDPELRQGIKDYSNW
                     PTIPQVYLNGEFVGGCDILLQMHQNGDLVEELKKLGIRSALIDEKDQDSK"
     exon            315..2149
                     /gene="Glrx5"
                     /gene_synonym="RGD1308383"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggccgcaga agcggtgatc agcgagcggg catgagcgcg tccctgagcc gggcggccgc
       61 ggctctgctc cgctgggggc gcggcgcggg tggcggagtc ctgccccgag ccggcgtgcg
      121 ggcagcaagc tcgggcggcc aggcggagca gctggacgcg ctggtgaaga aggacaaggt
      181 ggtggtgttc ctcaagggga cgcccgagca gccccagtgc ggcttcagca acgccgtggt
      241 acagatcctg cggctgcacg gagtccgcga ctatgcggcc tacaacgtgc tggaggaccc
      301 ggagctgagg caaggtatta aagactattc caactggcca accatcccgc aagtgtacct
      361 caatggcgag tttgtggggg gctgtgacat ccttctgcag atgcaccaga atggggacct
      421 agtggaagaa ctgaaaaagc tgggaatccg ctctgccctg atagatgaga aggaccaaga
      481 ctccaagtga gggccccggg tcctcgccgg gcgggcagag cgccctcccc gtcgtcaggg
      541 ccagaaaagc ctcactgcgt ggtggtgtcc tgttgctgtg gcgcttgcac tgggtctcct
      601 ggcctgcaag cgggcagggt gcttttactt tagtctttgg ctcagaatcc cctctggtga
      661 actcaccacc actgcactgt aaatcaacgt cgtgatcctg tattgctgta acccaatcgt
      721 tcttacgttg actttactct gccagcttcg ggagtcagtc ctgatcttgt acgtggtttg
      781 ggttataaca atggcaaagc cccctgatgc ttttgtaact tcctctaaaa gggaaatgat
      841 agacagagaa gaaaatgtgg tggctggagt gttgtttttt tttaaaataa attgccaata
      901 cagacgtgtg tgtgagtaat taaacccagc aagtacacat ctgtgggatg tcgagaacta
      961 gcctcctttg tattttcttt catccttccc cctttctgct accctctgct tctcacgcct
     1021 ccctctctcc tctctgcccc tctttcttcc ctctttcttt ctgtgcagcc caggccggcc
     1081 tcggctcatc gggtacccaa aggtgaactt gaccttcaga tcttctgcct tcaccctcca
     1141 ggtgctgagg tgtcagccac catagcactg agaacaggat ccagggcaat gtacacgcta
     1201 ggcagacacc gtccactgag gtatagcccc tggccttcct ccctcctctt cttttgagta
     1261 actaattaac agtaactctc attcaccgct aggttgctct gaagttcctt taggctacta
     1321 gggagtccct gtaccgtgtg tgtccttgag ccagatggta atggtggctc ccccaacctc
     1381 tctagacggg agaacgggag aacgcaagaa cgcacctgct ggcctctgac gcattttctt
     1441 tctcatgaac tggggtctca gaggaaataa gtggaactgt gctgcctccc agtccagtgt
     1501 cttggtggga catctctagg gctgattgat ccaattcgcc accctcacct gtgggaccct
     1561 tcccttccag acacgggaca gaattgccta gacgtcccag aggctgccta gacatcacag
     1621 gcaggagaaa ggctgccttc tccatgagta gtggcctctc agaagctggt ccagggaagc
     1681 gttctgtgtt cagacatcct cagctccact cccttcctga ggttggatgg gcctccctgc
     1741 ccacagggta tgctgggctc ccagagtctg gggttcccca agaagggaag gagagctgca
     1801 gcctaaggct gccccttccc ccatttcact agggacccag tcagaggatg acagccctca
     1861 ccagtgacct acctcaaggc tgtaggaagg agaaaaggca gatgagtctg aaggtttttg
     1921 atacattaat cgcccactca cttcttttga gcaggcagct gggtctgcac agattcctcg
     1981 tagaccttgg aagccactaa aaaccttgtg ttcaggtgag gaagaaagcc cagaaggaag
     2041 actgtgtagc gtcctgcctg ggatagcagc tttctctgtc tctgggaata acactattag
     2101 caaatgactt ctccgcctga gcatgagtac caggctgtgg gccagacat
//
