LOCUS       NM_032614               1245 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus glutaredoxin 3 (Glrx3), mRNA.
ACCESSION   NM_032614
VERSION     NM_032614.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1245)
  AUTHORS   Frey,A.G., Palenchar,D.J., Wildemann,J.D. and Philpott,C.C.
  TITLE     A Glutaredoxin.BolA Complex Serves as an Iron-Sulfur Cluster
            Chaperone for the Cytosolic Cluster Assembly Machinery
  JOURNAL   J Biol Chem 291 (43), 22344-22356 (2016)
   PUBMED   27519415
REFERENCE   2  (bases 1 to 1245)
  AUTHORS   Banci,L., Ciofi-Baffoni,S., Gajda,K., Muzzioli,R., Peruzzini,R. and
            Winkelmann,J.
  TITLE     N-terminal domains mediate [2Fe-2S] cluster transfer from
            glutaredoxin-3 to anamorsin
  JOURNAL   Nat Chem Biol 11 (10), 772-778 (2015)
   PUBMED   26302480
REFERENCE   3  (bases 1 to 1245)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 1245)
  AUTHORS   Aon-Bertolino,M.L., Romero,J.I., Galeano,P., Holubiec,M.,
            Badorrey,M.S., Saraceno,G.E., Hanschmann,E.M., Lillig,C.H. and
            Capani,F.
  TITLE     Thioredoxin and glutaredoxin system proteins-immunolocalization in
            the rat central nervous system
  JOURNAL   Biochim Biophys Acta 1810 (1), 93-110 (2011)
   PUBMED   20620191
REFERENCE   5  (bases 1 to 1245)
  AUTHORS   Jeong,D., Kim,J.M., Cha,H., Oh,J.G., Park,J., Yun,S.H., Ju,E.S.,
            Jeon,E.S., Hajjar,R.J. and Park,W.J.
  TITLE     PICOT attenuates cardiac hypertrophy by disrupting calcineurin-NFAT
            signaling
  JOURNAL   Circ Res 102 (6), 711-719 (2008)
   PUBMED   18258855
  REMARK    GeneRIF: Data suggest that PICOT inhibits cardiac hypertrophy
            largely by negatively regulating calcineurin-NFAT signaling via
            disruption of the MLP-calcineurin interaction.
REFERENCE   6  (bases 1 to 1245)
  AUTHORS   Witte,S., Villalba,M., Bi,K., Liu,Y., Isakov,N. and Altman,A.
  TITLE     Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB
            pathways by PICOT, a novel protein kinase C-interacting protein
            with a thioredoxin homology domain
  JOURNAL   J Biol Chem 275 (3), 1902-1909 (2000)
   PUBMED   10636891
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC086381.1.
            
            On Oct 27, 2005 this sequence version replaced NM_032614.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086381.1, CF110478.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1245
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..1245
                     /gene="Glrx3"
                     /gene_synonym="PICOT; Txnl2"
                     /note="glutaredoxin 3"
                     /db_xref="GeneID:58815"
                     /db_xref="RGD:69414"
     exon            1..104
                     /gene="Glrx3"
                     /gene_synonym="PICOT; Txnl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..1020
                     /gene="Glrx3"
                     /gene_synonym="PICOT; Txnl2"
                     /note="thioredoxin-like 2; PKCq-interacting protein;
                     thioredoxin-like protein 2; PKC-theta-interacting protein;
                     PKC-interacting cousin of thioredoxin"
                     /codon_start=1
                     /product="glutaredoxin-3"
                     /protein_id="NP_116003.2"
                     /db_xref="GeneID:58815"
                     /db_xref="RGD:69414"
                     /translation="MAAGAAEAAEAAVAVVEVGSARQFEELLRLKTKSLLVVHFWAPW
                     APQCVQMNDVMAELAKEHPHVSFVKLEAEAVPEVSEKYEISSVPTFLFFKNSQKVDRL
                     DGAHAPELTKKVQRHVSSGSFPPSTNEHVKEDLNLRLKKLTHAAPCMLFMKGTPQEPR
                     CGFSKQMVEILHKHNIQFSSFDIFSDEEVRQGLKTYSNWPTYPQLYVSGELIGGLDII
                     KELEASEELDTICPKAPKLEERLKVLTNKASVMLFMKGNKQEAKCGFSKQILEILNST
                     GVEYETFDILEDEEVRQGLKTFSNWPTYPQLYVRGDLVGGLDIVKELKDNGELLPILK
                     GEN"
     exon            105..213
                     /gene="Glrx3"
                     /gene_synonym="PICOT; Txnl2"
                     /inference="alignment:Splign:2.1.0"
     exon            214..288
                     /gene="Glrx3"
                     /gene_synonym="PICOT; Txnl2"
                     /inference="alignment:Splign:2.1.0"
     exon            289..490
                     /gene="Glrx3"
                     /gene_synonym="PICOT; Txnl2"
                     /inference="alignment:Splign:2.1.0"
     exon            491..663
                     /gene="Glrx3"
                     /gene_synonym="PICOT; Txnl2"
                     /inference="alignment:Splign:2.1.0"
     exon            664..725
                     /gene="Glrx3"
                     /gene_synonym="PICOT; Txnl2"
                     /inference="alignment:Splign:2.1.0"
     exon            726..783
                     /gene="Glrx3"
                     /gene_synonym="PICOT; Txnl2"
                     /inference="alignment:Splign:2.1.0"
     exon            784..836
                     /gene="Glrx3"
                     /gene_synonym="PICOT; Txnl2"
                     /inference="alignment:Splign:2.1.0"
     exon            837..876
                     /gene="Glrx3"
                     /gene_synonym="PICOT; Txnl2"
                     /inference="alignment:Splign:2.1.0"
     exon            877..969
                     /gene="Glrx3"
                     /gene_synonym="PICOT; Txnl2"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1227
                     /gene="Glrx3"
                     /gene_synonym="PICOT; Txnl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagcatgg cggcgggggc ggctgaagca gccgaggcgg ccgtggcagt ggtggaagtc
       61 ggctctgccc ggcagtttga ggagctactg cgcctcaaaa ccaagtcact ccttgtggtc
      121 catttctggg cgccatgggc tccacagtgt gtacagatga acgatgtcat ggcagagtta
      181 gctaaagagc atcctcatgt ttcatttgtg aagctggaag ccgaagctgt tcctgaagta
      241 tctgaaaaat atgaaattag ttctgttccc accttcctgt tcttcaagaa ttctcagaaa
      301 gtcgaccggt tagatggtgc acatgcccca gagttgacca aaaaagtcca gcgacacgtg
      361 tctagtggat cctttcctcc tagtactaat gaacatgtta aagaagatct caaccttcgc
      421 ctgaaaaagc tgactcacgc tgccccctgc atgctcttca tgaagggaac acctcaggaa
      481 ccacgctgtg gttttagcaa gcagatggtg gaaatccttc acaaacacaa tattcagttc
      541 agcagttttg atatcttctc agatgaagaa gttcgacagg ggctcaaaac atactctaat
      601 tggcccacct atcctcagct ctatgtttct ggagagctca taggaggact tgacataatt
      661 aaggagctgg aagcatcaga agaactagat acaatttgtc ccaaagcacc caagttagag
      721 gaaaggctca aagtgctgac caataaagct tctgtgatgc tctttatgaa aggaaacaaa
      781 caggaagcaa aatgtggatt cagcaaacaa attctggaaa tactgaatag tactggggtt
      841 gaatatgaga cttttgatat actggaggat gaagaagtgc gtcagggatt aaaaacgttc
      901 tcaaattggc caacctaccc tcagctgtat gtgagagggg atcttgttgg aggactggat
      961 attgtcaagg aactgaaaga caacggtgaa ttgctaccta tactgaaggg agaaaattag
     1021 tgaacgttaa gcacggtgtc caaggactgc aagaagtatt tagttatcgt ggaatagttg
     1081 atgacttggt cctgcgaagt ggactgagag tagaaatgcg acatagtcag ctgtgctcaa
     1141 tgtgcttcac aaagttgtgc tgaaaaaaac atatgttaca ttttccatga agcatagaag
     1201 gcaataaact ccagattcag ctaaaaaaaa aaaaaaaaaa aaaaa
//
