LOCUS       NM_001394170            2640 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Rattus norvegicus glutaredoxin 2 (Glrx2), transcript variant 1,
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001394170 XM_039090228
VERSION     NM_001394170.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2640)
  AUTHORS   Romero,J.I., Hanschmann,E.M., Gellert,M., Eitner,S., Holubiec,M.I.,
            Blanco-Calvo,E., Lillig,C.H. and Capani,F.
  TITLE     Thioredoxin 1 and glutaredoxin 2 contribute to maintain the
            phenotype and integrity of neurons following perinatal asphyxia
  JOURNAL   Biochim Biophys Acta 1850 (6), 1274-1285 (2015)
   PUBMED   25735211
  REMARK    GeneRIF: Grx2 and Trx1 contribute significantly to neuronal
            integrity and could be clinically relevant in neuronal damage
            following perinatal asphyxia and other neuronal disorders.
REFERENCE   2  (bases 1 to 2640)
  AUTHORS   Gao,X.H., Qanungo,S., Pai,H.V., Starke,D.W., Steller,K.M.,
            Fujioka,H., Lesnefsky,E.J., Kerner,J., Rosca,M.G., Hoppel,C.L. and
            Mieyal,J.J.
  TITLE     Aging-dependent changes in rat heart mitochondrial
            glutaredoxins--Implications for redox regulation
  JOURNAL   Redox Biol 1 (1), 586-598 (2013)
   PUBMED   25126518
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2640)
  AUTHORS   Schutte,L.D., Baumeister,S., Weis,B., Hudemann,C., Hanschmann,E.M.
            and Lillig,C.H.
  TITLE     Identification of potential protein dithiol-disulfide substrates of
            mammalian Grx2
  JOURNAL   Biochim Biophys Acta 1830 (11), 4999-5005 (2013)
   PUBMED   23872354
REFERENCE   4  (bases 1 to 2640)
  AUTHORS   Aon-Bertolino,M.L., Romero,J.I., Galeano,P., Holubiec,M.,
            Badorrey,M.S., Saraceno,G.E., Hanschmann,E.M., Lillig,C.H. and
            Capani,F.
  TITLE     Thioredoxin and glutaredoxin system proteins-immunolocalization in
            the rat central nervous system
  JOURNAL   Biochim Biophys Acta 1810 (1), 93-110 (2011)
   PUBMED   20620191
REFERENCE   5  (bases 1 to 2640)
  AUTHORS   Hanschmann,E.M., Lonn,M.E., Schutte,L.D., Funke,M., Godoy,J.R.,
            Eitner,S., Hudemann,C. and Lillig,C.H.
  TITLE     Both thioredoxin 2 and glutaredoxin 2 contribute to the reduction
            of the mitochondrial 2-Cys peroxiredoxin Prx3
  JOURNAL   J Biol Chem 285 (52), 40699-40705 (2010)
   PUBMED   20929858
  REMARK    GeneRIF: Both thioredoxin 2 and glutaredoxin 2 contribute to the
            reduction of the mitochondrial 2-Cys peroxiredoxin Prx3.
REFERENCE   6  (bases 1 to 2640)
  AUTHORS   Pai,H.V., Starke,D.W., Lesnefsky,E.J., Hoppel,C.L. and Mieyal,J.J.
  TITLE     What is the functional significance of the unique location of
            glutaredoxin 1 (GRx1) in the intermembrane space of mitochondria?
  JOURNAL   Antioxid Redox Signal 9 (11), 2027-2033 (2007)
   PUBMED   17845131
REFERENCE   7  (bases 1 to 2640)
  AUTHORS   Gladyshev,V.N., Liu,A., Novoselov,S.V., Krysan,K., Sun,Q.A.,
            Kryukov,V.M., Kryukov,G.V. and Lou,M.F.
  TITLE     Identification and characterization of a new mammalian glutaredoxin
            (thioltransferase), Grx2
  JOURNAL   J Biol Chem 276 (32), 30374-30380 (2001)
   PUBMED   11397793
REFERENCE   8  (bases 1 to 2640)
  AUTHORS   Lundberg,M., Johansson,C., Chandra,J., Enoksson,M., Jacobsson,G.,
            Ljung,J., Johansson,M. and Holmgren,A.
  TITLE     Cloning and expression of a novel human glutaredoxin (Grx2) with
            mitochondrial and nuclear isoforms
  JOURNAL   J Biol Chem 276 (28), 26269-26275 (2001)
   PUBMED   11297543
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Apr 5, 2021 this sequence version replaced XM_039090228.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.49341.1,
                                           SRR26643291.33789.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               JAXUCZ010000013.1  58033007-58033168
            163-226             JAXUCZ010000013.1  58036156-58036219
            227-403             JAXUCZ010000013.1  58039599-58039775
            404-2640            JAXUCZ010000013.1  58040921-58043157
FEATURES             Location/Qualifiers
     source          1..2640
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q21"
     gene            1..2640
                     /gene="Glrx2"
                     /note="glutaredoxin 2"
                     /db_xref="GeneID:114022"
                     /db_xref="RGD:1307950"
     exon            1..162
                     /gene="Glrx2"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..538
                     /gene="Glrx2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     glutaredoxin-2, mitochondrial; glutaredoxin 2
                     (thioltransferase)"
                     /codon_start=1
                     /product="glutaredoxin-2, mitochondrial isoform 1"
                     /protein_id="NP_001381099.1"
                     /db_xref="GeneID:114022"
                     /db_xref="RGD:1307950"
                     /translation="MSWYRAASVGRRLVASGRILAGRRGAAGAAGSGMGNSTSSFWGK
                     SATTPVNQIQETISNNCVVIFSKSSCSYCSMAKKIFHDMNVNYKVVELDMVEYGSQFQ
                     EALYKMTGERTVPRIFVNGIFIGGAADTHRLHKEGKLLPLVHQCYLNKSKRKDVE"
     exon            163..226
                     /gene="Glrx2"
                     /inference="alignment:Splign:2.1.0"
     exon            227..403
                     /gene="Glrx2"
                     /inference="alignment:Splign:2.1.0"
     exon            404..2640
                     /gene="Glrx2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggctcccgg cgtcgtggtc gcgctcgcgt gctccgttcc ctgcggctgc ccggaccctt
       61 ggccatgtcc tggtaccgcg cggcttcggt ggggaggcgg ctggtggcga gcgggaggat
      121 cttggcgggg cggcgcggcg cggctggagc tgcgggctcg ggaatgggaa acagcacatc
      181 ctcgttttgg gggaagtcag ccactactcc tgtgaaccag atccaagaaa caatttctaa
      241 taattgtgtg gtgattttct caaaatcatc ctgctcttac tgttcaatgg ccaagaagat
      301 tttccatgac atgaatgtca actataaagt cgtggagttg gatatggtgg aatatggtag
      361 ccagtttcaa gaggctcttt acaagatgac tggagaaaga actgttccca ggatatttgt
      421 gaatggaata tttatcggag gtgcggccga cactcacagg cttcacaaag aagggaaatt
      481 gctgcctctg gttcaccagt gctatttaaa caaaagcaag aggaaagacg tcgaatgacg
      541 tggctagtcg ccgtaccagt aaacgttagt gcagtcataa cctttcactt gaggatgttt
      601 tcagtgtgtg gattgccctc ataaagatga aaataatgaa caataaattg ccatggaccc
      661 ctcatcttcc gactggccag tttttgagca cgggatggaa tataaaactg aagggggtgg
      721 agttacatca aaagtaaaga atgcttatta agactttaag aattttacag cgaagaggaa
      781 gttaagcact taaaatctta ctccccgtgg tattcaggaa ttaacttctc acagtcacta
      841 agctttcagc agcgaggact gacatgtggt ttctttaaaa tttaacatgg tacagatgtg
      901 cagtaggttg ggatacccta tcatggcaac ccttcatgtt ctagaccatc agacatatta
      961 aatatataga atgcgatgaa gtttatagtt gggaaaacca aactgccaat tacttcatgg
     1021 tcagaaagca aaagggtttc aatgtagtga gaatgaactt tttaaacaat tcagaagtgt
     1081 tatttagtcc tgtcagttgg agtgttctac ctttcagaat ctgtaacagc tattggaatt
     1141 ttttttcctt tggcagacag ggtcactcgg tagctcagga tggccacaaa ctcacctcag
     1201 tcctcctacc tcagtctcta tgcttggatt gcatgctgag ccaccacgcc cagcttggga
     1261 atgctttaga gaaccaggta ttaggtggac tttagactaa aggtccttgt tgtcctccga
     1321 atgtgcctca tcataggctt catgtgttgg agacacatga tgcattatga tatggtcaga
     1381 ggtgaggcct ttatgaagaa gttaatcctg agggcagatg ggttagtgct ctttagaggt
     1441 ggttcttggt agacgaatga gtttgccccc ttacctctca tgcctgtgtt cttgcccttc
     1501 tttctctgca gcgtcctgat gcagcaagga aatcctcact agatgctggc actttaacct
     1561 caacatccca acctatgaac tataagaagt ccttctcatc ttcataaatt acttagtctc
     1621 aggtattctg tctgagtagc acagatagat tgtccctaaa gtcccttctg ttatcttact
     1681 attttctaac taggaagaca ctgtttaaac tgattacatt tcagataaac ttagcgaaca
     1741 ggattaactt ttaagaagta ttatttgaaa gaattgaaaa cattttcaat actttactaa
     1801 tctggtcata tttatagcct ctggtcaaga atattttaag tgcctaagaa gtaatgcatt
     1861 tcctagtaga ttccgagagt caggttggaa agattattaa atgctgagcc tatctcagaa
     1921 ataggaagaa catggacttc ccgagtaagt gcttcagctt tctggtcaag atggactaag
     1981 gaatcatgga gaatttggag ggagacagtg gcttgctgtc ggtgacattt cctacatgga
     2041 cttcaactgc attttgaata ccttgataca gttgagaagt taagttctcc tgatatttct
     2101 ttcttttaag ttgtcatgtt ggtagggaag gaaaatggtg tatttctact cctttatttt
     2161 acattttatc atgaaaattg tataattttg ctatgctgta aaattcacat tagagattag
     2221 aggaagtctg ttatgcataa gaaaggtaaa attgttactc ttgtcactag taatcttatt
     2281 aggatataag attaggttgc ttaaatgcat agcccaccaa ccaagtaata tggtatttgg
     2341 ctttgaggaa tttttgtggt attcagactc agacccaggg cctgaatatt aggcaggcgc
     2401 ctgaccactg aactatacaa ctaatcctta agaaggatgt tccaacagct ctacctaggc
     2461 ttgtggaaaa caagaggatg tgtagtactt aattcttagg gtccgatgtt aaaataatcc
     2521 agctctttaa aaagccttag cagaaggctc aagaatatgg aaggtaacag ggtatcttga
     2581 ttttcaatta tacgtttaag gaataaagaa ataaactctt ccaatgattg cctaatagta
//
