LOCUS       NP_001381099             157 aa            linear   ROD 06-NOV-2024
DEFINITION  glutaredoxin-2, mitochondrial isoform 1 [Rattus norvegicus].
ACCESSION   NP_001381099 XP_038946156
VERSION     NP_001381099.1
DBSOURCE    REFSEQ: accession NM_001394170.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 157)
  AUTHORS   Romero,J.I., Hanschmann,E.M., Gellert,M., Eitner,S., Holubiec,M.I.,
            Blanco-Calvo,E., Lillig,C.H. and Capani,F.
  TITLE     Thioredoxin 1 and glutaredoxin 2 contribute to maintain the
            phenotype and integrity of neurons following perinatal asphyxia
  JOURNAL   Biochim Biophys Acta 1850 (6), 1274-1285 (2015)
   PUBMED   25735211
  REMARK    GeneRIF: Grx2 and Trx1 contribute significantly to neuronal
            integrity and could be clinically relevant in neuronal damage
            following perinatal asphyxia and other neuronal disorders.
REFERENCE   2  (residues 1 to 157)
  AUTHORS   Gao,X.H., Qanungo,S., Pai,H.V., Starke,D.W., Steller,K.M.,
            Fujioka,H., Lesnefsky,E.J., Kerner,J., Rosca,M.G., Hoppel,C.L. and
            Mieyal,J.J.
  TITLE     Aging-dependent changes in rat heart mitochondrial
            glutaredoxins--Implications for redox regulation
  JOURNAL   Redox Biol 1 (1), 586-598 (2013)
   PUBMED   25126518
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 157)
  AUTHORS   Schutte,L.D., Baumeister,S., Weis,B., Hudemann,C., Hanschmann,E.M.
            and Lillig,C.H.
  TITLE     Identification of potential protein dithiol-disulfide substrates of
            mammalian Grx2
  JOURNAL   Biochim Biophys Acta 1830 (11), 4999-5005 (2013)
   PUBMED   23872354
REFERENCE   4  (residues 1 to 157)
  AUTHORS   Aon-Bertolino,M.L., Romero,J.I., Galeano,P., Holubiec,M.,
            Badorrey,M.S., Saraceno,G.E., Hanschmann,E.M., Lillig,C.H. and
            Capani,F.
  TITLE     Thioredoxin and glutaredoxin system proteins-immunolocalization in
            the rat central nervous system
  JOURNAL   Biochim Biophys Acta 1810 (1), 93-110 (2011)
   PUBMED   20620191
REFERENCE   5  (residues 1 to 157)
  AUTHORS   Hanschmann,E.M., Lonn,M.E., Schutte,L.D., Funke,M., Godoy,J.R.,
            Eitner,S., Hudemann,C. and Lillig,C.H.
  TITLE     Both thioredoxin 2 and glutaredoxin 2 contribute to the reduction
            of the mitochondrial 2-Cys peroxiredoxin Prx3
  JOURNAL   J Biol Chem 285 (52), 40699-40705 (2010)
   PUBMED   20929858
  REMARK    GeneRIF: Both thioredoxin 2 and glutaredoxin 2 contribute to the
            reduction of the mitochondrial 2-Cys peroxiredoxin Prx3.
REFERENCE   6  (residues 1 to 157)
  AUTHORS   Pai,H.V., Starke,D.W., Lesnefsky,E.J., Hoppel,C.L. and Mieyal,J.J.
  TITLE     What is the functional significance of the unique location of
            glutaredoxin 1 (GRx1) in the intermembrane space of mitochondria?
  JOURNAL   Antioxid Redox Signal 9 (11), 2027-2033 (2007)
   PUBMED   17845131
REFERENCE   7  (residues 1 to 157)
  AUTHORS   Gladyshev,V.N., Liu,A., Novoselov,S.V., Krysan,K., Sun,Q.A.,
            Kryukov,V.M., Kryukov,G.V. and Lou,M.F.
  TITLE     Identification and characterization of a new mammalian glutaredoxin
            (thioltransferase), Grx2
  JOURNAL   J Biol Chem 276 (32), 30374-30380 (2001)
   PUBMED   11397793
REFERENCE   8  (residues 1 to 157)
  AUTHORS   Lundberg,M., Johansson,C., Chandra,J., Enoksson,M., Jacobsson,G.,
            Ljung,J., Johansson,M. and Holmgren,A.
  TITLE     Cloning and expression of a novel human glutaredoxin (Grx2) with
            mitochondrial and nuclear isoforms
  JOURNAL   J Biol Chem 276 (28), 26269-26275 (2001)
   PUBMED   11297543
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Apr 5, 2021 this sequence version replaced XP_038946156.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.49341.1,
                                           SRR26643291.33789.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..157
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q21"
     Protein         1..157
                     /product="glutaredoxin-2, mitochondrial isoform 1"
                     /note="glutaredoxin-2, mitochondrial; glutaredoxin 2
                     (thioltransferase)"
                     /calculated_mol_wt=15156
     transit_peptide 1..19
                     /note="Mitochondrion. /evidence=ECO:0000255; propagated
                     from UniProtKB/Swiss-Prot (Q6AXW1.2)"
                     /calculated_mol_wt=2137
     mat_peptide     20..157
                     /product="Glutaredoxin-2, mitochondrial.
                     /id=PRO_0000011631"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6AXW1.2)"
                     /calculated_mol_wt=15156
     Region          61..142
                     /region_name="GRX_GRXh_1_2_like"
                     /note="Glutaredoxin (GRX) family, GRX human class 1 and 2
                     (h_1_2)-like subfamily; composed of proteins similar to
                     human GRXs, approximately 10 kDa in size, and proteins
                     containing a GRX or GRX-like domain. GRX is a glutathione
                     (GSH) dependent reductase; cd03419"
                     /db_xref="CDD:239511"
     Site            order(67,70,72,112..115,126..129)
                     /site_type="other"
                     /note="GSH binding site [chemical binding]"
                     /db_xref="CDD:239511"
     Site            order(70,73)
                     /site_type="active"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:239511"
     CDS             1..157
                     /gene="Glrx2"
                     /coded_by="NM_001394170.1:65..538"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:114022"
                     /db_xref="RGD:1307950"
ORIGIN      
        1 mswyraasvg rrlvasgril agrrgaagaa gsgmgnstss fwgksattpv nqiqetisnn
       61 cvvifskssc sycsmakkif hdmnvnykvv eldmveygsq fqealykmtg ertvprifvn
      121 gifiggaadt hrlhkegkll plvhqcylnk skrkdve
//
