LOCUS       NM_053296               3054 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Rattus norvegicus glycine receptor, beta (Glrb), mRNA.
ACCESSION   NM_053296 XM_006232506
VERSION     NM_053296.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3054)
  AUTHORS   Velazquez-Flores,M.A., Sanchez-Chavez,G., Morales-Lazaro,S.L., Ruiz
            Esparza-Garrido,R., Canizales-Ontiveros,A. and Salceda,R.
  TITLE     Streptozotocin-Induced Diabetic Rats Showed a Differential Glycine
            Receptor Expression in the Spinal Cord: A GlyR Role in Diabetic
            Neuropathy
  JOURNAL   Neurochem Res 49 (3), 684-691 (2024)
   PUBMED   38017313
  REMARK    GeneRIF: Streptozotocin-Induced Diabetic Rats Showed a Differential
            Glycine Receptor Expression in the Spinal Cord: A GlyR Role in
            Diabetic Neuropathy.
REFERENCE   2  (bases 1 to 3054)
  AUTHORS   Ivica,J., Lape,R. and Sivilotti,L.G.
  TITLE     Acidic pH reduces agonist efficacy and responses to synaptic-like
            glycine applications in zebrafish alpha1 and rat alpha1beta
            recombinant glycine receptors
  JOURNAL   J Physiol 600 (2), 333-347 (2022)
   PUBMED   34802146
  REMARK    GeneRIF: Acidic pH reduces agonist efficacy and responses to
            synaptic-like glycine applications in zebrafish alpha1 and rat
            alpha1beta recombinant glycine receptors.
REFERENCE   3  (bases 1 to 3054)
  AUTHORS   Grunewald,N., Jan,A., Salvatico,C., Kress,V., Renner,M.,
            Triller,A., Specht,C.G. and Schwarz,G.
  TITLE     Sequences Flanking the Gephyrin-Binding Site of GlyRbeta Tune
            Receptor Stabilization at Synapses
  JOURNAL   eNeuro 5 (1) (2018)
   PUBMED   29464196
  REMARK    GeneRIF: Study shows that the glycine receptors beta-loop sequences
            flanking the core-binding site differentially regulate the affinity
            of the receptor for gephyrin and its trapping at synapses.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3054)
  AUTHORS   Zhou,W., Zhou,L.Q., Shi,H., Leng,Y.M., Liu,B., Zhang,S.L. and
            Kong,W.J.
  TITLE     Expression of glycine receptors and gephyrin in rat medial
            vestibular nuclei and flocculi following unilateral labyrinthectomy
  JOURNAL   Int J Mol Med 38 (5), 1481-1489 (2016)
   PUBMED   28026001
  REMARK    GeneRIF: the role of gephyrin and glycine receptor (GlyR) in
            vestibular compensation, was investigated.
REFERENCE   5  (bases 1 to 3054)
  AUTHORS   Del Pino,I., Koch,D., Schemm,R., Qualmann,B., Betz,H. and
            Paarmann,I.
  TITLE     Proteomic analysis of glycine receptor beta subunit
            (GlyRbeta)-interacting proteins: evidence for syndapin I regulating
            synaptic glycine receptors
  JOURNAL   J Biol Chem 289 (16), 11396-11409 (2014)
   PUBMED   24509844
  REMARK    GeneRIF: The SdpI-binding site was mapped to a proline-rich
            sequence of 22 amino acids within the intracellular loop of
            GlyRbeta.
REFERENCE   6  (bases 1 to 3054)
  AUTHORS   Stone,C. and Pinto,L.H.
  TITLE     Receptive field organization of retinal ganglion cells in the
            spastic mutant mouse
  JOURNAL   J Physiol 456, 125-142 (1992)
   PUBMED   1338094
REFERENCE   7  (bases 1 to 3054)
  AUTHORS   Braun,C.M. and Chouinard,M.J.
  TITLE     Is anorexia nervosa a neuropsychological disease?
  JOURNAL   Neuropsychol Rev 3 (2), 171-212 (1992)
   PUBMED   1300220
  REMARK    Review article
REFERENCE   8  (bases 1 to 3054)
  AUTHORS   Grenningloh,G., Pribilla,I., Prior,P., Multhaup,G., Beyreuther,K.,
            Taleb,O. and Betz,H.
  TITLE     Cloning and expression of the 58 kd beta subunit of the inhibitory
            glycine receptor
  JOURNAL   Neuron 4 (6), 963-970 (1990)
   PUBMED   2163264
REFERENCE   9  (bases 1 to 3054)
  AUTHORS   White,W.F.
  TITLE     The glycine receptor in the mutant mouse spastic (spa): strychnine
            binding characteristics and pharmacology
  JOURNAL   Brain Res 329 (1-2), 1-6 (1985)
   PUBMED   2983837
REFERENCE   10 (bases 1 to 3054)
  AUTHORS   Meier,H. and Chai,C.K.
  TITLE     Spastic, an hereditary neurological mutation in the mouse
            characterized by vertebral arthropathy and leptomeningeal cyst
            formation
  JOURNAL   Exp Med Surg 28 (1), 24-38 (1970)
   PUBMED   4323808
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On or before Oct 3, 2022 this sequence version replaced
            XM_006232506.3, NM_053296.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ212388.1, SRR26643298.11484.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               JAXUCZ010000002.1  168505484-168505614 c
            132-282             JAXUCZ010000002.1  168503997-168504147 c
            283-389             JAXUCZ010000002.1  168469119-168469225 c
            390-457             JAXUCZ010000002.1  168467513-168467580 c
            458-687             JAXUCZ010000002.1  168450533-168450762 c
            688-770             JAXUCZ010000002.1  168450344-168450426 c
            771-911             JAXUCZ010000002.1  168448440-168448580 c
            912-1064            JAXUCZ010000002.1  168444411-168444563 c
            1065-1357           JAXUCZ010000002.1  168439733-168440025 c
            1358-3054           JAXUCZ010000002.1  168432736-168434432 c
FEATURES             Location/Qualifiers
     source          1..3054
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q33"
     gene            1..3054
                     /gene="Glrb"
                     /note="glycine receptor, beta"
                     /db_xref="GeneID:25456"
                     /db_xref="RGD:2706"
     exon            1..131
                     /gene="Glrb"
                     /inference="alignment:Splign:2.1.0"
     exon            132..282
                     /gene="Glrb"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..1651
                     /gene="Glrb"
                     /function="ion channel"
                     /note="glycine receptor subunit beta; glycine receptor 58
                     kDa subunit; glycine receptor, beta subunit"
                     /codon_start=1
                     /product="glycine receptor subunit beta precursor"
                     /protein_id="NP_445748.1"
                     /db_xref="GeneID:25456"
                     /db_xref="RGD:2706"
                     /translation="MKFSLAVSFFILMSLLFEDACSKEKSSKKGKGKKKQYLCPSQQS
                     AEDLARVPPNSTSNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYR
                     VNIFLRQKWNDPRLKLPSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQEN
                     ILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSG
                     DPVQLEKIALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAP
                     TLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLI
                     ACLLFGFASLVEYAVVQVMLNNPKRVEAEKARIAKAEQADGKGGNAAKKNTVNGTGTP
                     VHISTLQVGETRCKKVCTSKSDLRSNDFSIVGSLPRDFELSNYDCYGKPIEVNNGLGK
                     PQAKNKKPPPAKPVIPTAAKRIDLYARALFPFCFLFFNVIYWSIYL"
     exon            283..389
                     /gene="Glrb"
                     /inference="alignment:Splign:2.1.0"
     exon            390..457
                     /gene="Glrb"
                     /inference="alignment:Splign:2.1.0"
     exon            458..687
                     /gene="Glrb"
                     /inference="alignment:Splign:2.1.0"
     exon            688..770
                     /gene="Glrb"
                     /inference="alignment:Splign:2.1.0"
     exon            771..911
                     /gene="Glrb"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1064
                     /gene="Glrb"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1357
                     /gene="Glrb"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..3054
                     /gene="Glrb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacgcgtca agctcggcgg cggcggtggc ggcggaggcg cgggcggcgg cgggactcga
       61 gggtcacagc tgcctctgcg cccgccacct gcgccgccgt cacctcggcg gagggctgcg
      121 gggcgcgtgc gattgagcgg ctgtgccttc agttttcaag atgaagtttt cgttggcagt
      181 ctcctttttt attttaatgt ccttgttgtt tgaagacgct tgttctaagg aaaagtcttc
      241 caagaaaggg aaggggaaaa agaagcagta tttgtgccca tctcaacagt cggccgagga
      301 ccttgcccgt gtgcccccca actccaccag caatatcttg aacaggctgc tggtcagtta
      361 tgatcccagg ataagaccaa acttcaaagg cattcctgtt gatgtagtag tcaacatttt
      421 tattaatagt tttggatcta ttcaagagac aacaatggac tatagagtta atattttcct
      481 gaggcagaag tggaacgacc ccagactcaa gctccctagt gacttcagag gctcagatgc
      541 actgacagtt gaccccacca tgtataagtg cttgtggaag cccgacttat tcttcgcaaa
      601 tgaaaaaagt gccaattttc atgatgtaac ccaagaaaac atcctgttgt ttatttttcg
      661 ggatggagac gtccttgtga gcatgaggtt gtccatcact ctttcatgtc ctttggactt
      721 aactctgttt cccatggaca cacaacgctg caagatgcaa cttgagagct ttggttacac
      781 cactgatgat ttgagattca tctggcagtc aggagatcct gttcagttgg aaaaaattgc
      841 tttgcctcag tttgatatta aaaaggagga tatcgaatat ggcaactgta caaaatacta
      901 taaaggcact ggttactaca cctgtgtgga ggtcatcttc accctgagga gacaggttgg
      961 gttctacatg atgggtgtgt atgcaccaac cctgctgatt gtggtcctct cctggctctc
     1021 tttctggatc aaccctgatg ccagtgctgc cagagtacct ctgggcatct tctccgtgct
     1081 cagtttggcc tcagagtgca ccaccctcgc agcggagctt cccaaagtgt cctacgtgaa
     1141 ggcactggat gtgtggctca ttgcctgcct gctcttcggg tttgcctccc tcgtggagta
     1201 tgctgttgtc caggtgatgt tgaacaatcc caaaagggtt gaagctgaga aagcccgaat
     1261 cgccaaggct gagcaagcag atgggaaagg tggaaacgca gctaagaaga acactgtgaa
     1321 cggcacgggg acccctgttc atatcagcac tttgcaggtt ggtgagacca gatgcaaaaa
     1381 agtttgtact tccaagtctg atctgagatc caatgacttc agcattgttg gcagcttacc
     1441 aagagatttt gaattatcca attatgactg ctatgggaaa cccattgaag tcaacaatgg
     1501 acttgggaaa ccacaggcaa agaacaagaa gcctccgcct gccaagcctg tcatccccac
     1561 ggcagccaag cgcattgacc tctatgcaag agcattattt cccttctgct tcttgttctt
     1621 caacgttata tattggtcta tatatttatg ataaaccatt tccgtttgta tgaagtacaa
     1681 caccatttca ttgtgaccaa tgcaattcat aattgctgat ctgtgaaaac tttgcatttt
     1741 catagcaata tattgcattt tggatgccac ttgattataa tgaaatgcag caccttactt
     1801 tgaatggcag catgaccctg taacgtctgt gctccaacca tgagatagat agatagatag
     1861 atagatagat agatagatag atagatagat agatagatgt acattaagca tagtacttta
     1921 ggaatcaatg acaaatacac atactgcata atcttcataa tgtgctcttc ggctactgta
     1981 actctgtaac tacaaatact tccagtaatc cagatggaaa catgatgtgc acgctgaccc
     2041 ctgtcatgtt cactattcta tgtatgcagt atcttacatc cccttccttg taagaaagaa
     2101 agccatctta ttaaataatt ttcaatagta ttattacaga ttaagcaaga ctatatggca
     2161 tagtgtttaa agtttttaag agagatagat cagtaatagt tatgcaggtt ccttaagaaa
     2221 taaaatcaaa attatacatt tatacagcaa gcttattttt aagtgtgctt gtgctgtcaa
     2281 aatgccagat aatagaacag taagcatttt tgaggaaaag agaaacctgg gctagtataa
     2341 atgcatagtg agttctggct tctggcaaaa tacaaacaaa taaaggatag atgtattagt
     2401 taaatatttt ggataaagta aattctttaa tcaaccttaa aaatcaaagt ctattttcat
     2461 gcctttcatt tgttgatatg gagagcatta agcataagcc ttaaaaagag ttgcacacat
     2521 ttcaaatcta agtggtgtgg tgacatgtga ttccagatca ctgttagact ccaggaatca
     2581 tcagcgtgaa cttgaactgg aaaaatcatc atcattggag gtcttagctt gtttatttta
     2641 ttaaaatgtt tctatatttc aagtaatatt cgaactgttt ttgaaatttt ttatttattt
     2701 gaatgtattt gaatatgtta taaaccaatg atttagttaa taatattttt tttaatttaa
     2761 acttgagact tcttttccct tcttgctgaa agtctagata ttggggctaa ctttatcttg
     2821 attctacctg aaaagaaccc ctaagcctca tcttataaag ccccattttc taaaagagtc
     2881 ataatgaaac tgtttatttc tgtcttagct aaaatcggag gtattagtaa taatgtaatg
     2941 taaacataga ccataaaacc gttttacatt atttggagtg cttttgttct tgttgatagt
     3001 ttgtacagcc aactaatacg atgcattaaa agtattattt gtgcaactgc cgta
//
