LOCUS       NM_021848               1757 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus glucagon-like peptide 2 receptor (Glp2r), mRNA.
ACCESSION   NM_021848
VERSION     NM_021848.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1757)
  AUTHORS   Xie,Y.C., Yao,Z.H., Yao,X.L., Pan,J.Z., Zhang,S.F., Zhang,Y. and
            Hu,J.C.
  TITLE     Glucagon-Like Peptide-2 Receptor is Involved in Spatial Cognitive
            Dysfunction in Rats After Chronic Cerebral Hypoperfusion
  JOURNAL   J Alzheimers Dis 66 (4), 1559-1576 (2018)
   PUBMED   30452417
  REMARK    GeneRIF: Our findings reveal the involvement of GLP2R via a
            modulation of the AKT-mTOR-p70S6K pathway in the mechanisms
            underlying chronic cerebral hypoperfusion-induced impairments of
            spatial learning and memory.
REFERENCE   2  (bases 1 to 1757)
  AUTHORS   Pedersen,J., Pedersen,N.B., Brix,S.W., Grunddal,K.V.,
            Rosenkilde,M.M., Hartmann,B., Orskov,C., Poulsen,S.S. and
            Holst,J.J.
  TITLE     The glucagon-like peptide 2 receptor is expressed in enteric
            neurons and not in the epithelium of the intestine
  JOURNAL   Peptides 67, 20-28 (2015)
   PUBMED   25748021
  REMARK    GeneRIF: GLP2R expression in the rat jejunum quantified by
            quantitative real time PCR.
REFERENCE   3  (bases 1 to 1757)
  AUTHORS   Ruttenstock,E., Doi,T., Dingemann,J. and Puri,P.
  TITLE     Insulinlike growth factor receptor type 1 and type 2 are
            downregulated in the nitrofen-induced hypoplastic lung
  JOURNAL   J Pediatr Surg 45 (6), 1349-1353 (2010)
   PUBMED   20620343
  REMARK    GeneRIF: Downregulation of IGF-1R and IGF-2R gene expression may
            interfere with normal alveologenesis causing pulmonary hypoplasia
            in the nitrofen-induced CDH model.
REFERENCE   4  (bases 1 to 1757)
  AUTHORS   Velazquez,E., Blazquez,E. and Ruiz-Albusac,J.M.
  TITLE     Synergistic effect of glucagon-like peptide 2 (GLP-2) and of key
            growth factors on the proliferation of cultured rat astrocytes.
            Evidence for reciprocal upregulation of the mRNAs for GLP-2 and
            IGF-I receptors
  JOURNAL   Mol Neurobiol 40 (2), 183-193 (2009)
   PUBMED   19672727
  REMARK    GeneRIF: GLP-2 and several growth factors show synergistic effects
            on the proliferation of rat astrocytes, a process in which an
            enhanced expression of GLP-2R and IGF-IR may be involved
REFERENCE   5  (bases 1 to 1757)
  AUTHORS   de Heer,J., Pedersen,J., Orskov,C. and Holst,J.J.
  TITLE     The alpha cell expresses glucagon-like peptide-2 receptors and
            glucagon-like peptide-2 stimulates glucagon secretion from the rat
            pancreas
  JOURNAL   Diabetologia 50 (10), 2135-2142 (2007)
   PUBMED   17676310
  REMARK    GeneRIF: Glucagon-like peptide 2 stimulates glucagon secretion
            through GLP-2r present on the alpha cell in rats.
REFERENCE   6  (bases 1 to 1757)
  AUTHORS   Orskov,C., Hartmann,B., Poulsen,S.S., Thulesen,J., Hare,K.J. and
            Holst,J.J.
  TITLE     GLP-2 stimulates colonic growth via KGF, released by subepithelial
            myofibroblasts with GLP-2 receptors
  JOURNAL   Regul Pept 124 (1-3), 105-112 (2005)
   PUBMED   15544847
  REMARK    GeneRIF: GLP-2 in the gut acts by activating receptors on the
            subepithelial myofibroblasts, causing the release of growth
            factors, which in turn stimulate intestinal growth
REFERENCE   7  (bases 1 to 1757)
  AUTHORS   Lovshin,J.A., Huang,Q., Seaberg,R., Brubaker,P.L. and Drucker,D.J.
  TITLE     Extrahypothalamic expression of the glucagon-like peptide-2
            receptor is coupled to reduction of glutamate-induced cell death in
            cultured hippocampal cells
  JOURNAL   Endocrinology 145 (7), 3495-3506 (2004)
   PUBMED   15059959
  REMARK    GeneRIF: presence of a functional GLP-2-GLP-2R axis in the
            developing rodent brain
REFERENCE   8  (bases 1 to 1757)
  AUTHORS   Walsh,N.A., Yusta,B., DaCambra,M.P., Anini,Y., Drucker,D.J. and
            Brubaker,P.L.
  TITLE     Glucagon-like peptide-2 receptor activation in the rat intestinal
            mucosa
  JOURNAL   Endocrinology 144 (10), 4385-4392 (2003)
   PUBMED   12960094
  REMARK    GeneRIF: Activation of the endogenous rat mucosal GLP-2 receptor is
            linked to activation of a cAMP/protein kinase A-dependent,
            growth-promoting pathway in vitro.
REFERENCE   9  (bases 1 to 1757)
  AUTHORS   Lovshin,J., Estall,J., Yusta,B., Brown,T.J. and Drucker,D.J.
  TITLE     Glucagon-like peptide (GLP)-2 action in the murine central nervous
            system is enhanced by elimination of GLP-1 receptor signaling
  JOURNAL   J Biol Chem 276 (24), 21489-21499 (2001)
   PUBMED   11262390
REFERENCE   10 (bases 1 to 1757)
  AUTHORS   Munroe,D.G., Gupta,A.K., Kooshesh,F., Vyas,T.B., Rizkalla,G.,
            Wang,H., Demchyshyn,L., Yang,Z.J., Kamboj,R.K., Chen,H.,
            McCallum,K., Sumner-Smith,M., Drucker,D.J. and Crivici,A.
  TITLE     Prototypic G protein-coupled receptor for the intestinotrophic
            factor glucagon-like peptide 2
  JOURNAL   Proc Natl Acad Sci U S A 96 (4), 1569-1573 (1999)
   PUBMED   9990065
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Oct 25, 2022 this sequence version replaced NM_021848.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF105368.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-293               JAXUCZ010000010.1  52964669-52964961   c
            294-381             JAXUCZ010000010.1  52958699-52958786   c
            382-486             JAXUCZ010000010.1  52956630-52956734   c
            487-608             JAXUCZ010000010.1  52951345-52951466   c
            609-715             JAXUCZ010000010.1  52940616-52940722   c
            716-869             JAXUCZ010000010.1  52938788-52938941   c
            870-1029            JAXUCZ010000010.1  52936074-52936233   c
            1030-1090           JAXUCZ010000010.1  52933564-52933624   c
            1091-1160           JAXUCZ010000010.1  52932684-52932753   c
            1161-1249           JAXUCZ010000010.1  52923353-52923441   c
            1250-1388           JAXUCZ010000010.1  52912896-52913034   c
            1389-1430           JAXUCZ010000010.1  52904443-52904484   c
            1431-1757           JAXUCZ010000010.1  52901707-52902033   c
FEATURES             Location/Qualifiers
     source          1..1757
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..1757
                     /gene="Glp2r"
                     /note="glucagon-like peptide 2 receptor"
                     /db_xref="GeneID:60432"
                     /db_xref="RGD:620270"
     exon            1..293
                     /gene="Glp2r"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..1757
                     /gene="Glp2r"
                     /note="GLP-2R; GLP-2-R; GLP-2 receptor"
                     /codon_start=1
                     /product="glucagon-like peptide 2 receptor"
                     /protein_id="NP_068620.1"
                     /db_xref="GeneID:60432"
                     /db_xref="RGD:620270"
                     /translation="MRPQPSPAVPSRCREAPVPRVRAQPVGIPEAQGPVPLHSQQMRL
                     LWGPGRPFLALLLLVSIKQVTGSLLKETTQKWANYKEKCLEDLHNRLSGIFCNGTFDR
                     YVCWPHSYPGNVSVPCPSYLPWWNAESPGRAYRHCLAQGTWQTRENTTDIWQDESECS
                     ENHSFRQNVDHYALLYTLQLMYTVGYSVSLISLFLALTLFLFLRKLHCTRNYIHMNLF
                     ASFILKVLAVLVKDMVSHNSYSKRPDDESGWMSYLSETSVSCRSVQVLLHYFVGTNHL
                     WLLVEGLYLHTLLEPTVFPERRLWPKYLVVGWAFPMLFVIPWGFARAHLENTRCWATN
                     GNLKIWWIIRGPMLLCVTVNFFIFLKILKLLISKLKAHQMCFRDYKYRLAKSTLLLIP
                     LLGVHEVLFTFFPDDQVQGFSKRIRLFIQLTLSSVHGFLVALQYGFANGEVKAELRKS
                     WGRFLLARHWGCRTCVLGKNFRFLGKCSKKLSEGDGSETLQKLRFSTCSSHLASETLG
                     DVGVQPHRGRGAWPRGSSLSESSEGDFTLANTMEEILEESEI"
     exon            294..381
                     /gene="Glp2r"
                     /inference="alignment:Splign:2.1.0"
     exon            382..486
                     /gene="Glp2r"
                     /inference="alignment:Splign:2.1.0"
     exon            487..608
                     /gene="Glp2r"
                     /inference="alignment:Splign:2.1.0"
     exon            609..715
                     /gene="Glp2r"
                     /inference="alignment:Splign:2.1.0"
     exon            716..869
                     /gene="Glp2r"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1029
                     /gene="Glp2r"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1090
                     /gene="Glp2r"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1160
                     /gene="Glp2r"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1249
                     /gene="Glp2r"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1388
                     /gene="Glp2r"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1430
                     /gene="Glp2r"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1757
                     /gene="Glp2r"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacacttcct ctctggacaa ggaggaatgc aggaggccac cgcctgcagt acatcttgga
       61 gtgttggagg gatgtgcctg cacttgtgaa cgggcgccag gagaatgagg ccccaaccaa
      121 gcccggcagt gcccagtaga tgcagagagg cacccgtgcc ccgagtgagg gcacagccag
      181 tgggcatccc tgaggcccag gggcccgttc ctctccactc ccaacagatg cgtctgctgt
      241 ggggccctgg gaggcccttc ctcgccctgc ttctgctggt ttccatcaag caagttacag
      301 gatcgctcct caaggagaca actcagaagt gggctaatta taaggagaag tgtctggaag
      361 acttgcacaa tagactttct ggcatatttt gtaatgggac atttgatcgg tatgtgtgct
      421 ggcctcattc ttatcctgga aatgtctctg ttccctgtcc ttcatactta ccttggtgga
      481 atgcagagag cccaggaagg gcctacagac actgcttggc tcaggggact tggcagacgc
      541 gagagaacac cacagatatt tggcaggatg aatcagaatg ctcagagaac cacagcttca
      601 gacaaaacgt ggatcactac gccttgctat acaccttgca gctgatgtac actgtgggct
      661 actccgtgtc tctcatctcc ctcttcttgg ctcttacact cttcttgttc cttcgaaaac
      721 tgcattgcac acgcaattac atccacatga acctgttcgc ttcgttcatc ctgaaagttc
      781 tggctgtcct ggtgaaggac atggtctccc acaactctta ctccaagagg cccgacgatg
      841 agagtggatg gatgtcatat ctgtcagaga catccgtctc ctgtcgctcc gtccaggtcc
      901 tcctgcacta ctttgtgggc accaatcact tgtggctgct ggttgaagga ctttacctcc
      961 acactctgct ggagcccaca gtgtttcctg aaaggcggct gtggcccaag tacctggtgg
     1021 tgggttgggc cttccccatg ctgtttgtta ttccctgggg ttttgcccgt gcacacctgg
     1081 agaacacacg gtgctgggcc acaaatggga acctgaaaat ctggtggatc atcagaggac
     1141 ccatgctgct ttgtgtaaca gttaatttct tcatcttcct caagattctc aagcttctca
     1201 tttctaagct caaagctcat cagatgtgct tcagagacta caaatacaga ttggcgaaat
     1261 caacgttgct cctcattcct ttgttggggg ttcatgaggt cctcttcact ttcttccccg
     1321 acgaccaagt tcaaggattt tcaaaacgta ttcgactctt catccagctg acactgagct
     1381 ctgtccacgg atttctggtg gccttgcagt atggctttgc caatggagag gtgaaggcag
     1441 agctgcgaaa gtcatggggc cgcttcttat tagcccgtca ctggggctgc agaacctgtg
     1501 tcctggggaa gaatttccgg ttcctgggga agtgttccaa gaagctgtcg gagggagatg
     1561 gctctgagac actccagaag ctgcggttct ccacatgcag ctcacacctg gcctctgaga
     1621 ccctgggaga cgttggggta cagcctcaca ggggccgtgg agcttggccc cggggaagca
     1681 gcctgtctga gagcagtgag ggagacttca ccctggccaa tacgatggag gagattctgg
     1741 aagagagtga gatctaa
//
