LOCUS       NM_012728               3065 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus glucagon-like peptide 1 receptor (Glp1r), mRNA.
ACCESSION   NM_012728 XM_346601
VERSION     NM_012728.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3065)
  AUTHORS   Sourris,K.C., Ding,Y., Maxwell,S.S., Al-Sharea,A., Kantharidis,P.,
            Mohan,M., Rosado,C.J., Penfold,S.A., Haase,C., Xu,Y., Forbes,J.M.,
            Crawford,S., Ramm,G., Harcourt,B.E., Jandeleit-Dahm,K., Advani,A.,
            Murphy,A.J., Timmermann,D.B., Karihaloo,A., Knudsen,L.B.,
            El-Osta,A., Drucker,D.J., Cooper,M.E. and Coughlan,M.T.
  TITLE     Glucagon-like peptide-1 receptor signaling modifies the extent of
            diabetic kidney disease through dampening the receptor for advanced
            glycation end products-induced inflammation
  JOURNAL   Kidney Int 105 (1), 132-149 (2024)
   PUBMED   38069998
  REMARK    GeneRIF: Glucagon-like peptide-1 receptor signaling modifies the
            extent of diabetic kidney disease through dampening the receptor
            for advanced glycation end products-induced inflammation.
REFERENCE   2  (bases 1 to 3065)
  AUTHORS   Chang,J.T., Liang,Y.J. and Leu,J.G.
  TITLE     Glucagon-like peptide-1 receptor regulates receptor of advanced
            glycation end products in high glucose-treated rat mesangial cells
  JOURNAL   J Chin Med Assoc 86 (1), 39-46 (2023)
   PUBMED   36599141
  REMARK    GeneRIF: Glucagon-like peptide-1 receptor regulates receptor of
            advanced glycation end products in high glucose-treated rat
            mesangial cells.
REFERENCE   3  (bases 1 to 3065)
  AUTHORS   Barron,M., Hayes,H., Fernando,D.G., Geurts,A.M. and Kindel,T.L.
  TITLE     Sleeve Gastrectomy Improves High-Fat Diet-Associated Hepatic
            Steatosis Independent of the Glucagon-like-Petpide-1 Receptor in
            Rats
  JOURNAL   J Gastrointest Surg 26 (8), 1607-1618 (2022)
   PUBMED   35618993
  REMARK    GeneRIF: Sleeve Gastrectomy Improves High-Fat Diet-Associated
            Hepatic Steatosis Independent of the Glucagon-like-Petpide-1
            Receptor in Rats.
REFERENCE   4  (bases 1 to 3065)
  AUTHORS   Zheng,Y., Xiao,Y., Zhang,D., Zhang,S., Ouyang,J., Li,L., Shi,W.,
            Zhang,R., Liu,H., Jin,Q., Chen,Z., Xu,D. and Wu,L.
  TITLE     Geniposide Ameliorated Dexamethasone-Induced Cholesterol
            Accumulation in Osteoblasts by Mediating the GLP-1R/ABCA1 Axis
  JOURNAL   Cells 10 (12), 3424 (2021)
   PUBMED   34943934
  REMARK    GeneRIF: Geniposide Ameliorated Dexamethasone-Induced Cholesterol
            Accumulation in Osteoblasts by Mediating the GLP-1R/ABCA1 Axis.
            Erratum:[Cells. 2022 Nov 30;11(23):3838. doi:
            10.3390/cells11233838.. PMID: 36497203]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3065)
  AUTHORS   Liu,X., Patel,K.P. and Zheng,H.
  TITLE     Role of Renal Sympathetic Nerves in GLP-1 (Glucagon-Like Peptide-1)
            Receptor Agonist Exendin-4-Mediated Diuresis and Natriuresis in
            Diet-Induced Obese Rats
  JOURNAL   J Am Heart Assoc 10 (21), e022542 (2021)
   PUBMED   34713714
  REMARK    GeneRIF: Role of Renal Sympathetic Nerves in GLP-1 (Glucagon-Like
            Peptide-1) Receptor Agonist Exendin-4-Mediated Diuresis and
            Natriuresis in Diet-Induced Obese Rats.
REFERENCE   6  (bases 1 to 3065)
  AUTHORS   Takhar,S., Gyomorey,S., Su,R.C., Mathi,S.K., Li,X. and Wheeler,M.B.
  TITLE     The third cytoplasmic domain of the GLP-1[7-36 amide] receptor is
            required for coupling to the adenylyl cyclase system
  JOURNAL   Endocrinology 137 (5), 2175-2178 (1996)
   PUBMED   8612565
REFERENCE   7  (bases 1 to 3065)
  AUTHORS   Gromada,J., Rorsman,P., Dissing,S. and Wulff,B.S.
  TITLE     Stimulation of cloned human glucagon-like peptide 1 receptor
            expressed in HEK 293 cells induces cAMP-dependent activation of
            calcium-induced calcium release
  JOURNAL   FEBS Lett 373 (2), 182-186 (1995)
   PUBMED   7589461
  REMARK    Erratum:[FEBS Lett 1996 Mar 4;381(3):262]
REFERENCE   8  (bases 1 to 3065)
  AUTHORS   Hjorth,S.A., Adelhorst,K., Pedersen,B.B., Kirk,O. and Schwartz,T.W.
  TITLE     Glucagon and glucagon-like peptide 1: selective receptor
            recognition via distinct peptide epitopes
  JOURNAL   J Biol Chem 269 (48), 30121-30124 (1994)
   PUBMED   7527026
REFERENCE   9  (bases 1 to 3065)
  AUTHORS   Lankat-Buttgereit,B., Goke,R., Fehmann,H.C., Richter,G. and Goke,B.
  TITLE     Molecular cloning of a cDNA encoding for the GLP-1 receptor
            expressed in rat lung
  JOURNAL   Exp Clin Endocrinol 102 (4), 341-347 (1994)
   PUBMED   7813606
REFERENCE   10 (bases 1 to 3065)
  AUTHORS   Thorens,B.
  TITLE     Expression cloning of the pancreatic beta cell receptor for the
            gluco-incretin hormone glucagon-like peptide 1
  JOURNAL   Proc Natl Acad Sci U S A 89 (18), 8641-8645 (1992)
   PUBMED   1326760
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012728.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M97797.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676784, SAMN16676785
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                JAXUCZ010000020.1  8973393-8973486
            95-191              JAXUCZ010000020.1  8979415-8979511
            192-299             JAXUCZ010000020.1  8980470-8980577
            300-418             JAXUCZ010000020.1  8991956-8992074
            419-525             JAXUCZ010000020.1  8992405-8992511
            526-679             JAXUCZ010000020.1  8998291-8998444
            680-839             JAXUCZ010000020.1  8999313-8999472
            840-900             JAXUCZ010000020.1  9004416-9004476
            901-970             JAXUCZ010000020.1  9004991-9005060
            971-1059            JAXUCZ010000020.1  9005183-9005271
            1060-1198           JAXUCZ010000020.1  9005629-9005767
            1199-1240           JAXUCZ010000020.1  9007238-9007279
            1241-3065           JAXUCZ010000020.1  9009798-9011622
FEATURES             Location/Qualifiers
     source          1..3065
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..3065
                     /gene="Glp1r"
                     /gene_synonym="Glip; RATGL1RCP"
                     /note="glucagon-like peptide 1 receptor"
                     /db_xref="GeneID:25051"
                     /db_xref="RGD:2703"
     exon            1..94
                     /gene="Glp1r"
                     /gene_synonym="Glip; RATGL1RCP"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1408
                     /gene="Glp1r"
                     /gene_synonym="Glip; RATGL1RCP"
                     /note="pancreatic beta cell receptor for the
                     gluco-incretin hormone glucagon-like peptide 1; GLP-1R;
                     GLP-1-R; GLP-1 receptor"
                     /codon_start=1
                     /product="glucagon-like peptide 1 receptor precursor"
                     /protein_id="NP_036860.2"
                     /db_xref="GeneID:25051"
                     /db_xref="RGD:2703"
                     /translation="MAVTPSLLRLALLLLGAVGRAGPRPQGATVSLSETVQKWREYRH
                     QCQRFLTEAPLLATGLFCNRTFDDYACWPDGPPGSFVNVSCPWYLPWASSVLQGHVYR
                     FCTAEGIWLHKDNSSLPWRDLSECEESKQGERNSPEEQLLSLYIIYTVGYALSFSALV
                     IASAILVSFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLL
                     SYQDSLGCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVFSEQRIFKLYLSIGWGV
                     PLLFVIPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFIRVICIVIAK
                     LKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFVKLFTELSFTS
                     FQGFMVAVLYCFVNNEVQMEFRKSWERWRLERLNIQRDSSMKPLKCPTSSVSSGATVG
                     SSVYAATCQNSCS"
     exon            95..191
                     /gene="Glp1r"
                     /gene_synonym="Glip; RATGL1RCP"
                     /inference="alignment:Splign:2.1.0"
     exon            192..299
                     /gene="Glp1r"
                     /gene_synonym="Glip; RATGL1RCP"
                     /inference="alignment:Splign:2.1.0"
     exon            300..418
                     /gene="Glp1r"
                     /gene_synonym="Glip; RATGL1RCP"
                     /inference="alignment:Splign:2.1.0"
     exon            419..525
                     /gene="Glp1r"
                     /gene_synonym="Glip; RATGL1RCP"
                     /inference="alignment:Splign:2.1.0"
     exon            526..679
                     /gene="Glp1r"
                     /gene_synonym="Glip; RATGL1RCP"
                     /inference="alignment:Splign:2.1.0"
     exon            680..839
                     /gene="Glp1r"
                     /gene_synonym="Glip; RATGL1RCP"
                     /inference="alignment:Splign:2.1.0"
     exon            840..900
                     /gene="Glp1r"
                     /gene_synonym="Glip; RATGL1RCP"
                     /inference="alignment:Splign:2.1.0"
     exon            901..970
                     /gene="Glp1r"
                     /gene_synonym="Glip; RATGL1RCP"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1059
                     /gene="Glp1r"
                     /gene_synonym="Glip; RATGL1RCP"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1198
                     /gene="Glp1r"
                     /gene_synonym="Glip; RATGL1RCP"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1240
                     /gene="Glp1r"
                     /gene_synonym="Glip; RATGL1RCP"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..3065
                     /gene="Glp1r"
                     /gene_synonym="Glip; RATGL1RCP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcctgagcgc cccgccatgg ccgtcacccc cagcctgctg cgcctggcgc tcctgctgct
       61 cggggcggtg ggcagggccg gcccccgccc ccagggtgcc acggtgtccc tctcagagac
      121 agtgcagaaa tggagagagt atcggcacca gtgccaacgt ttcctcacgg aagcgccact
      181 cctggccaca ggtctcttct gcaaccgaac ctttgatgac tacgcctgct ggccagatgg
      241 gcccccaggt tcctttgtga atgtcagctg cccctggtac ctgccgtggg ccagtagtgt
      301 gctccaaggg catgtgtacc ggttctgcac ggccgagggt atctggctgc ataaggacaa
      361 ctccagcctg ccctggaggg acctgtcgga gtgcgaagag tccaagcaag gagagagaaa
      421 ctcccctgag gaacagctcc tgtcgctgta cattatctac acggtggggt acgcactttc
      481 tttctctgcc ttggtcatcg cttcagccat ccttgtcagc ttcagacact tgcactgcac
      541 caggaactac atccacctga acctgtttgc gtccttcatc ctccgagcac tgtccgtctt
      601 catcaaagac gctgccctca agtggatgta tagcacggct gcgcaacagc accagtggga
      661 tgggctcctc tcgtatcagg actctctggg ctgccgactg gtgttcctgc tcatgcaata
      721 ctgcgtggcg gccaactact actggttgct ggtggaaggc gtgtatctgt acacactgct
      781 ggccttctcg gtgttctcgg agcagcgcat cttcaagctg tacctgagca taggctgggg
      841 agttccgctg ctgttcgtta tcccctgggg cattgtcaag tatctctacg aggacgaggg
      901 ttgctggacc aggaactcca acatgaacta ttggctcatc atacgcttgc ccattctctt
      961 tgcaatcggg gtcaacttcc ttatcttcat ccgggtcatc tgcatcgtga tagccaagct
     1021 gaaggctaat ctcatgtgta agaccgacat caaatgcaga ctcgcgaagt ccactctgac
     1081 gctcatcccg cttctgggca cgcatgaagt catctttgcc tttgtgatgg acgagcacgc
     1141 ccgaggaacc ctacgcttcg tcaagctgtt cacagagctc tccttcactt ccttccaggg
     1201 ctttatggtg gctgtcttgt actgctttgt caacaatgag gtccagatgg agtttcggaa
     1261 gagctgggag cgctggaggc tggagcgctt gaacatccag agggacagca gcatgaaacc
     1321 cctcaagtgt cccaccagca gtgtcagcag tggggccacg gtgggcagca gcgtgtatgc
     1381 agccacctgc caaaattcct gcagctgagc cccagtgctg cgcttcctgt ggtccttgct
     1441 gctggctggg tggccatccc aggtgggaga gaccctgggg acagggaata tgagggatac
     1501 aggcacatgt gtgtgcgtgc ccgcacaccg cacacacaca cacacacaca cacacacaca
     1561 cacacacaca cacacacacg ctttcctcct ccaaacctat caaacaggca atcgggcagt
     1621 gcctcctggg accacagaca catgttctcc aaggagaaca gcctgctaat ttaatctcag
     1681 cgacaggaag agaggaagaa acaattgctg ttaagacgag gaggacttct tcctgttaaa
     1741 gctgcaaggc ccttggggtt ccctcggaca gaactgcaaa tcaaccccgg aactctcgct
     1801 caagggcaat tgctgacggg tggaacttgg gcttgcgaga ggaggcaggt ccatgagaga
     1861 cctgcccttg gaacctcagc cagcacagcg ctcatcgagg tgagctggct gtgctgtgtg
     1921 cacggctggg gttgtcacct acatcagcct tcctctcgga caagaggctt ttctctgtgc
     1981 atctggagtg ccgccattcc tccatctgcc cgttcatccg ccatcctgtc tttgccttgg
     2041 ggagggggga ggtttgttga agtcatgccg tgcagctctt tctggaaaca tctgtggatg
     2101 gtgttgaaga taagcatggg ggagatacaa cagaggtagt ctttgcccat gcccacttct
     2161 tgcctggtcc tttaagccac tttgctcttg gtttctgccc tgcatgggta ctactagggc
     2221 aggtcccaag ttgagaagcc cagaggtgag gtgtgaaccc tcagttctgt tgtaaagatg
     2281 ctcaaatacc ctctaaggtt catctaaagg agtaacctgc ctaggggtgc tgttgacctg
     2341 aaatcaagag gaccaaagga tccattgcca acacccccca tcccccacac acacctcatc
     2401 tgtgaccaga gtctatgctt tgaatcagaa tgggctatat cctctgacct cagaggctat
     2461 gacccagaag agattcttcc ctgaatcctc ccactttgca cacatataga ctttatcctt
     2521 cttcactctg tgtctattca aatgtataat tctggtttct ctcaccccac ggaagaacta
     2581 gatcacagca actgttatgt ttgagggagt gggggagaag gtgattgatt tgaccccctc
     2641 tcccccaccg gtgttgataa gtagcgtctg tcccacctcc agactccacc cacacataat
     2701 gagcagcaca tagaccagga tgggggaggg gggtggtata tcatgcttgc cctcctccaa
     2761 ccactatgag aaggctagca gaagacacca ctgcacagac ccaagtccaa ggactgcctc
     2821 cccagggaat taggcagtga cttcctagag gccaagaaag actccaagag ctggagaaga
     2881 atcctagtca tctggatctc ttttgaggtt ggggttgggg tggctttcaa tggattctct
     2941 catgaggctt atctctccct catcccgtgg agagtggggg accctcccta gtgctcacac
     3001 tagacactgt gccccttgga gaggcataag gcatgtatgg gagataataa tgggctataa
     3061 aacat
//
