LOCUS       NM_207594               1048 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus glyoxalase 1 (Glo1), mRNA.
ACCESSION   NM_207594 XM_215365
VERSION     NM_207594.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1048)
  AUTHORS   Gao,M., Sun,L., Liu,Y.L., Xie,J.W., Qin,L., Xue,J., Wang,Y.T.,
            Guo,K.M., Ma,M.M. and Li,X.Y.
  TITLE     Reduction of glyoxalase 1 (GLO1) aggravates cerebrovascular
            remodeling via promoting the proliferation of basilar smooth muscle
            cells in hypertension
  JOURNAL   Biochem Biophys Res Commun 518 (2), 278-285 (2019)
   PUBMED   31420161
  REMARK    GeneRIF: Knockdown of GLO1 promoted while overexpression of GLO1
            prevented angiotensin II -induced cell proliferation and cell cycle
            transition in rat basilar smooth muscle cells.
REFERENCE   2  (bases 1 to 1048)
  AUTHORS   Stratmann,B., Goldstein,B., Thornalley,P.J., Rabbani,N. and
            Tschoepe,D.
  TITLE     Intracellular Accumulation of Methylglyoxal by Glyoxalase 1 Knock
            Down Alters Collagen Homoeostasis in L6 Myoblasts
  JOURNAL   Int J Mol Sci 18 (3), 480 (2017)
   PUBMED   28241483
  REMARK    GeneRIF: Increased biosynthesis of collagens 1 and 4 was detected
            at mRNA and protein level following knockdown of glyoxalase 1 in L6
            myoblasts.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1048)
  AUTHORS   Hollenbach,M., Thonig,A., Pohl,S., Ripoll,C., Michel,M. and
            Zipprich,A.
  TITLE     Expression of glyoxalase-I is reduced in cirrhotic livers: A
            possible mechanism in the development of cirrhosis
  JOURNAL   PLoS One 12 (2), e0171260 (2017)
   PUBMED   28231326
  REMARK    GeneRIF: These results show the importance of Glo-I as major
            detoxifying enzyme for methylglyoxal in cirrhosis. The reduced
            expression of Glo-I in cirrhosis demonstrates a possible
            explanation for increased inflammatory injury and suggests a
            'vicious circle' in liver disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1048)
  AUTHORS   Brouwers,O., Yu,L., Niessen,P., Slenter,J., Jaspers,K.,
            Wagenaar,A., Post,M., Miyata,T., Backes,W., Stehouwer,C.,
            Huijberts,M. and Schalkwijk,C.
  TITLE     Glyoxalase-1 overexpression partially prevents diabetes-induced
            impaired arteriogenesis in a rat hindlimb ligation model
  JOURNAL   Glycoconj J 33 (4), 627-630 (2016)
   PUBMED   27296676
  REMARK    GeneRIF: Diabetes-induced impairment of arteriogenic adaptation can
            be partially rescued by overexpressing of GLO-I, indicating a role
            of AGEs in diabetes-induced impaired collateral formation
REFERENCE   5  (bases 1 to 1048)
  AUTHORS   Pieroh,P., Koch,M., Wagner,D.C., Boltze,J., Ehrlich,A., Ghadban,C.,
            Hobusch,C., Birkenmeier,G. and Dehghani,F.
  TITLE     Temporal dynamics of glyoxalase 1 in secondary neuronal injury
  JOURNAL   PLoS One 9 (2), e87364 (2014)
   PUBMED   24498315
  REMARK    GeneRIF: Data suggest that the high dynamics of glyoxalase 1
            expression and distribution following neuronal injury may indicate
            a role of Glyoxalase 1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1048)
  AUTHORS   Yasue,M., Serikawa,T. and Yamada,J.
  TITLE     Chromosomal assignments of 23 biochemical loci of the rat by using
            rat x mouse somatic cell hybrids
  JOURNAL   Cytogenet Cell Genet 57 (2-3), 142-148 (1991)
   PUBMED   1914521
REFERENCE   7  (bases 1 to 1048)
  AUTHORS   Stallings,R.L. and Siciliano,M.J.
  TITLE     Confirmational, provisional, and/or regional assignment of 15
            enzyme loci onto Chinese hamster autosomes 1, 2, and 7
  JOURNAL   Somatic Cell Genet 7 (6), 683-698 (1981)
   PUBMED   7323947
REFERENCE   8  (bases 1 to 1048)
  AUTHORS   Szymura,J.M., Wabl,M.R. and Klein,J.
  TITLE     Mouse mitochondrial superoxide dismutase locus is on chromosome 17
  JOURNAL   Immunogenetics 14 (3-4), 231-240 (1981)
   PUBMED   7333654
REFERENCE   9  (bases 1 to 1048)
  AUTHORS   Minna,J.D., Bruns,G.A., Krinsky,A.H., Lalley,P.A., Francke,U. and
            Gerald,P.S.
  TITLE     Assignment of a Mus musculus gene for triosephosphate isomerase to
            chromosome 6 and for glyoxalase-I to chromosome 17 using somatic
            cell hybrids
  JOURNAL   Somatic Cell Genet 4 (2), 241-252 (1978)
   PUBMED   566476
REFERENCE   10 (bases 1 to 1048)
  AUTHORS   Meo,T., Douglas,T. and Rijnbeek,A.M.
  TITLE     Glyoxalase I polymorphism in the mouse: a new genetic marker linked
            to H-2
  JOURNAL   Science 198 (4314), 311-313 (1977)
   PUBMED   910130
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC061570.1.
            
            On Mar 18, 2021 this sequence version replaced NM_207594.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061570.1, FQ220772.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMEA5756307
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1048              BC061570.1         5-1052
FEATURES             Location/Qualifiers
     source          1..1048
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1048
                     /gene="Glo1"
                     /note="glyoxalase 1"
                     /db_xref="GeneID:294320"
                     /db_xref="RGD:2702"
     exon            1..161
                     /gene="Glo1"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..632
                     /gene="Glo1"
                     /EC_number="4.4.1.5"
                     /note="glx I; glyoxalase I; aldoketomutase;
                     methylglyoxalase; ketone-aldehyde mutase;
                     S-D-lactoylglutathione methylglyoxal lyase; glyoxylase 1"
                     /codon_start=1
                     /product="lactoylglutathione lyase"
                     /protein_id="NP_997477.1"
                     /db_xref="GeneID:294320"
                     /db_xref="RGD:2702"
                     /translation="MAEPQPASSGLTDEAALSCCSDPDPSTKDFLLQQTMLRIKDPKK
                     SLDFYTRVLGLTLLQKLDFPSMKFSLYFLAYEDKNDIPKDKTERTAWAFSRKATLELT
                     HNWGTEDDETQSYHNGNSDPRGFGHIGIAVPDVYEACKRFEELGVKFVKKPDDGKMKG
                     LAFVQDPDGYWIEILNPNKMATII"
     exon            162..244
                     /gene="Glo1"
                     /inference="alignment:Splign:2.1.0"
     exon            245..385
                     /gene="Glo1"
                     /inference="alignment:Splign:2.1.0"
     exon            386..453
                     /gene="Glo1"
                     /inference="alignment:Splign:2.1.0"
     exon            454..543
                     /gene="Glo1"
                     /inference="alignment:Splign:2.1.0"
     exon            544..1048
                     /gene="Glo1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctatagcaaa ggcggcccac ggtcctttcg gagcgtgtcg ccggcttgtt tgcttgcagc
       61 gattctccag ggcagccatg gcagagccac agccagcgtc cagtggtctt actgatgagg
      121 ccgccctcag ttgctgctct gacccggatc caagcaccaa ggattttcta ctgcagcaaa
      181 cgatgctgag aattaaggac cctaagaagt ccctggattt ttatacgagg gttcttggac
      241 tgacgcttct ccagaagctt gacttccctt ctatgaagtt ctcgctctat ttcttagcgt
      301 acgaggataa gaacgatatc cccaaggaca agacggagag gacagcgtgg gctttttcca
      361 gaaaggctac cctggagctc acacacaact ggggcactga agatgacgag acgcagagtt
      421 accacaacgg caactcggac cctcggggat ttggccacat tgggattgct gttcctgatg
      481 tctacgaggc ctgtaagaga tttgaagaac taggtgtcaa gtttgtgaag aagcctgatg
      541 atgggaaaat gaaaggtctg gcgttcgttc aagatcctga tggctactgg attgaaattc
      601 tgaatcctaa caaaatggca acaattattt agttccgtga tggagacagc ggggacaaga
      661 aacatcgtga ttcgagatgc tgagatgctg aagcaccaga agtgttgggg gactgatggg
      721 tctttgctcc agttcaagcc attctgaaat ccttttcatt gtcctgattc agtgggttta
      781 aaaaatctcc cctctgttaa gccaacctag ttttcaagta gcaatttatc ttacgacctt
      841 gacaaagttg tgtgagttta cttttaagat aataattaga actgttctcc tgagagacca
      901 catgtgctgc tgcctgcctc ttaaagacta ctccagtctg tttctgattc atcatttaag
      961 attgcgtttc aaacgtttct ttttggggtc tgctaccttc tgggctttcg gttcctcaga
     1021 gataagtttt cataaaggga agcagaga
//
