LOCUS       NM_001105993            1993 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus glomulin, FKBP associated protein (Glmn), mRNA.
ACCESSION   NM_001105993 XM_001057583 XM_213992
VERSION     NM_001105993.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1993)
  AUTHORS   Tron,A.E., Arai,T., Duda,D.M., Kuwabara,H., Olszewski,J.L.,
            Fujiwara,Y., Bahamon,B.N., Signoretti,S., Schulman,B.A. and
            DeCaprio,J.A.
  TITLE     The glomuvenous malformation protein Glomulin binds Rbx1 and
            regulates cullin RING ligase-mediated turnover of Fbw7
  JOURNAL   Mol Cell 46 (1), 67-78 (2012)
   PUBMED   22405651
REFERENCE   2  (bases 1 to 1993)
  AUTHORS   Krummrei,U., Baulieu,E.E. and Chambraud,B.
  TITLE     The FKBP-associated protein FAP48 is an antiproliferative molecule
            and a player in T cell activation that increases IL2 synthesis
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2444-2449 (2003)
   PUBMED   12604780
REFERENCE   3  (bases 1 to 1993)
  AUTHORS   Brouillard,P., Boon,L.M., Mulliken,J.B., Enjolras,O., Ghassibe,M.,
            Warman,M.L., Tan,O.T., Olsen,B.R. and Vikkula,M.
  TITLE     Mutations in a novel factor, glomulin, are responsible for
            glomuvenous malformations ('glomangiomas')
  JOURNAL   Am J Hum Genet 70 (4), 866-874 (2002)
   PUBMED   11845407
REFERENCE   4  (bases 1 to 1993)
  AUTHORS   Grisendi,S., Chambraud,B., Gout,I., Comoglio,P.M. and Crepaldi,T.
  TITLE     Ligand-regulated binding of FAP68 to the hepatocyte growth factor
            receptor
  JOURNAL   J Biol Chem 276 (49), 46632-46638 (2001)
   PUBMED   11571281
REFERENCE   5  (bases 1 to 1993)
  AUTHORS   Chambraud,B., Radanyi,C., Camonis,J.H., Shazand,K., Rajkowski,K.
            and Baulieu,E.E.
  TITLE     FAP48, a new protein that forms specific complexes with both
            immunophilins FKBP59 and FKBP12. Prevention by the
            immunosuppressant drugs FK506 and rapamycin
  JOURNAL   J Biol Chem 271 (51), 32923-32929 (1996)
   PUBMED   8955134
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474079.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001057583.1, XM_213992.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760389,
                              SAMN12840122 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1993
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1993
                     /gene="Glmn"
                     /note="glomulin, FKBP associated protein"
                     /db_xref="GeneID:289437"
                     /db_xref="RGD:1588600"
     exon            1..77
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            78..153
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1905
                     /gene="Glmn"
                     /note="FKBP associated protein"
                     /codon_start=1
                     /product="glomulin"
                     /protein_id="NP_001099463.1"
                     /db_xref="GeneID:289437"
                     /db_xref="RGD:1588600"
                     /translation="MAVEELQCIIKRCQILEEHDFKEEDFGLFQLAGQRCIEDGYINQ
                     LLEIIQDEKNKTIIKTMGWNLVGPVVRCLLRGREEDKREECFLIFDLLVKLCNPKELL
                     LGLLELIEEPSGKQISQIILLLLQPLQTVIQKLPNNKAYSAGLALSTLWSQLSLLPVP
                     HSEEQIQADDYGLCQCCRALIEFTKPFVAEVASDKEDPANTKLKDELLKFCFKSLKCP
                     LLTAQFLEQSEEVGNDPFRCFASEIIGFLSQIGYPVPQIILNHGRKKRTWDYLEFEEE
                     EDRQLADSVAALTYLVFVQGIGTDQLPMVLSPSYLLQLNMEHIEVLLQRTEQSVYSKG
                     LELLETSLLRLEDNSLCYQYLEIKSFLAVPQGLVKVMTLCPIETLRKTGLAMLQLYID
                     KLDSQGKYTLFRCLLNTSNHSGVEAFVIQNIKNQIDLSYKKTHNRWFAGAQLTSLLDL
                     VLSLPEGAETDLLQNSDRIMASLNLLRYLVIKDNEDDNQTGLWTELGKIENNFLQPLH
                     VGLNMSKAHYEAEIKNSQQNSQAASMCKSVCSVTVGGEEIPTMPPEMQLKVLHSALFT
                     FDLIESVLARVEELIEIKSKSTSEENAGMK"
     exon            154..279
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            280..396
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            397..505
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            506..743
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            744..846
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            847..1034
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1088
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1119
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1209
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1251
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1325
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1410
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1517
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1581
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1705
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1788
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1993
                     /gene="Glmn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caacctggga agaggctctt gttcgtaccg gtagcgactc ggtgggtgct ggaagcccgg
       61 gcacttgggc ccagagattc atttcagcat caaaactagg aaaagtaatt aggaatggct
      121 gtggaggaac ttcagtgcat aataaaaaga tgtcaaatcc tagaagagca tgattttaaa
      181 gaagaagatt ttggcctctt tcagctagca ggccaaagat gcattgaaga tgggtatata
      241 aaccagctgc tagagattat tcaagatgaa aagaacaaga ccatcattaa gactatgggg
      301 tggaatcttg ttggtcctgt tgtccgatgc ctcctgaggg gcagggaaga ggataaaaga
      361 gaagagtgtt ttctgatctt tgatttgctg gtgaagttgt gtaatccaaa ggaattgttg
      421 ttgggtttgc ttgaactcat tgaagagccc tccgggaaac agatatctca aattattctt
      481 cttttactgc aaccattaca gacagttatt cagaaacttc ctaacaacaa ggcatactcg
      541 gctggattag cattgtccac gctctggagt cagctgtctc ttcttcctgt cccacactca
      601 gaagaacaaa tacaggcaga tgactatggc ctttgtcagt gttgcagggc cttgatagag
      661 ttcacgaaac cctttgtggc agaagttgct agtgataaag aagacccagc aaacacaaag
      721 ctgaaggatg aactactgaa attctgtttc aaaagcttga aatgcccttt gctgacagca
      781 caattcctcg aacagtctga agaagttgga aatgaccctt tccggtgttt tgcatctgaa
      841 ataataggat ttttatcaca aattggatat cctgtccccc aaattattct taatcatgga
      901 aggaaaaaaa ggacttggga ttaccttgaa tttgaagaag aagaagacag acaactggca
      961 gactctgtgg ctgctctgac atacctagtc tttgttcagg gcatcggtac cgaccagctt
     1021 cccatggtct taagcccttc ataccttttg cagttgaaca tggagcacat tgaagtgctt
     1081 ctgcaaagaa cagaacagtc tgtttactcc aaaggcttgg aactgctgga gactagctta
     1141 ttgagattag aagacaacag cctatgttat cagtacctag aaatcaagag tttccttgct
     1201 gtgcctcagg gcttagtcaa agtcatgaca ctctgtccca ttgagacact gaggaaaaca
     1261 gggttagcca tgcttcagct gtacatcgac aagttggact cccaaggcaa atacacatta
     1321 tttaggtgct tactaaatac gagtaatcac tcaggtgtgg aagcctttgt aattcaaaat
     1381 atcaaaaatc agattgattt atcatataag aaaacccata acaggtggtt tgcaggcgca
     1441 cagctgacct ctctgttaga cctggtcctg tccctccctg agggcgctga gacagattta
     1501 ctgcagaact cagaccggat tatggcttca ctaaatttgt tgaggtattt ggttatcaaa
     1561 gataatgaag atgacaacca aactggatta tggacagagc ttggaaagat tgaaaataac
     1621 tttctacagc cacttcatgt aggacttaat atgtcaaagg cacattatga agcagagatt
     1681 aaaaacagcc aacaaaatag ccaagctgcc tcaatgtgta aaagtgtttg ttctgtgact
     1741 gtaggcggag aagaaatccc cactatgcct cctgagatgc agcttaaggt cttacattcc
     1801 gccctcttca cattcgactt gattgaaagt gtcctggctc gagtcgaaga actcattgaa
     1861 atcaaatcaa agtctacctc tgaggaaaac gctgggatga agtaaaagct ctacttcatg
     1921 aataaaaacc aataaaatgc catttttcat tatagtttat actgccataa aatagttgca
     1981 gaaattttac tac
//
