LOCUS       NM_001106978            3360 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus GLIS family zinc finger 2 (Glis2), mRNA.
ACCESSION   NM_001106978 XM_001077298 XM_220169
VERSION     NM_001106978.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3360)
  AUTHORS   Ke K, Song Y, Shen J, Niu M, Zhang H, Yuan D, Ni H, Zhang Y, Liu X,
            Dai A and Cao M.
  TITLE     Up-regulation of Glis2 involves in neuronal apoptosis after
            intracerebral hemorrhage in adult rats
  JOURNAL   Cell Mol Neurobiol 35 (3), 345-354 (2015)
   PUBMED   25370802
  REMARK    GeneRIF: Glis2 exerts pro-apoptotic functions in neurons following
            intracerebral hemorrhage.
REFERENCE   2  (bases 1 to 3360)
  AUTHORS   Li B, Rauhauser AA, Dai J, Sakthivel R, Igarashi P, Jetten AM and
            Attanasio M.
  TITLE     Increased hedgehog signaling in postnatal kidney results in
            aberrant activation of nephron developmental programs
  JOURNAL   Hum Mol Genet 20 (21), 4155-4166 (2011)
   PUBMED   21816948
REFERENCE   3  (bases 1 to 3360)
  AUTHORS   Vasanth S, ZeRuth G, Kang HS and Jetten AM.
  TITLE     Identification of nuclear localization, DNA binding, and
            transactivating mechanisms of Kruppel-like zinc finger protein
            Gli-similar 2 (Glis2)
  JOURNAL   J Biol Chem 286 (6), 4749-4759 (2011)
   PUBMED   21127075
REFERENCE   4  (bases 1 to 3360)
  AUTHORS   Sakai-Kato K, Ishiguro A, Mikoshiba K, Aruga J and Utsunomiya-Tate
            N.
  TITLE     CD spectra show the relational style between Zic-, Gli-, Glis-zinc
            finger protein and DNA
  JOURNAL   Biochim Biophys Acta 1784 (7-8), 1011-1019 (2008)
   PUBMED   18298960
REFERENCE   5  (bases 1 to 3360)
  AUTHORS   Kim YS, Kang HS, Herbert R, Beak JY, Collins JB, Grissom SF and
            Jetten AM.
  TITLE     Kruppel-like zinc finger protein Glis2 is essential for the
            maintenance of normal renal functions
  JOURNAL   Mol Cell Biol 28 (7), 2358-2367 (2008)
   PUBMED   18227149
REFERENCE   6  (bases 1 to 3360)
  AUTHORS   Attanasio M, Uhlenhaut NH, Sousa VH, O'Toole JF, Otto E, Anlag K,
            Klugmann C, Treier AC, Helou J, Sayer JA, Seelow D, Nurnberg G,
            Becker C, Chudley AE, Nurnberg P, Hildebrandt F and Treier M.
  TITLE     Loss of GLIS2 causes nephronophthisis in humans and mice by
            increased apoptosis and fibrosis
  JOURNAL   Nat Genet 39 (8), 1018-1024 (2007)
   PUBMED   17618285
REFERENCE   7  (bases 1 to 3360)
  AUTHORS   Hosking CR, Ulloa F, Hogan C, Ferber EC, Figueroa A, Gevaert K,
            Birchmeier W, Briscoe J and Fujita Y.
  TITLE     The transcriptional repressor Glis2 is a novel binding partner for
            p120 catenin
  JOURNAL   Mol Biol Cell 18 (5), 1918-1927 (2007)
   PUBMED   17344476
REFERENCE   8  (bases 1 to 3360)
  AUTHORS   Zhang F, Nakanishi G, Kurebayashi S, Yoshino K, Perantoni A, Kim YS
            and Jetten AM.
  TITLE     Characterization of Glis2, a novel gene encoding a Gli-related,
            Kruppel-like transcription factor with transactivation and
            repressor functions. Roles in kidney development and neurogenesis
  JOURNAL   J Biol Chem 277 (12), 10139-10149 (2002)
   PUBMED   11741991
REFERENCE   9  (bases 1 to 3360)
  AUTHORS   Lamar E, Kintner C and Goulding M.
  TITLE     Identification of NKL, a novel Gli-Kruppel zinc-finger protein that
            promotes neuronal differentiation
  JOURNAL   Development 128 (8), 1335-1346 (2001)
   PUBMED   11262234
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474017.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_220169.4, XM_001077298.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3360
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..3360
                     /gene="Glis2"
                     /note="GLIS family zinc finger 2"
                     /db_xref="GeneID:302946"
                     /db_xref="RGD:1309177"
     exon            1..93
                     /gene="Glis2"
                     /inference="alignment:Splign:2.1.0"
     exon            94..312
                     /gene="Glis2"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1706
                     /gene="Glis2"
                     /codon_start=1
                     /product="zinc finger protein GLIS2"
                     /protein_id="NP_001100448.1"
                     /db_xref="GeneID:302946"
                     /db_xref="RGD:1309177"
                     /translation="MHSLDEPLDLKLSITKLRAAREKRERTLGVPRHHALHRELGLVD
                     DSPTPGSPGSPPPGFLLNPKFPEKLDGRFSAAPLVDLSLSPPSGLDSPNGSSSLSPER
                     QGNGDLPPLPTAVDFQPLRYLDGVPSSFQFFLPLGSGGALHLPASSFLTPPKDKCLSP
                     ELPLAKQLVCRWAKCNQLFELLQDLVDHVNDHHVKPEQDARYCCHWEGCARHGRGFNA
                     RYKMLIHIRTHTNEKPHRCPTCNKSFSRLENLKIHNRSHTGEKPYVCPYEGCNKRYSN
                     SSDRFKHTRTHYVDKPYYCKMPGCHKRYTDPSSLRKHIKAHGHFVSHEQQELLQLRPP
                     PKPPLPTPDSGSYVSGAQIIIPNPAALFGGPSLPGLPLPLAPGPLDLSALACGNGGGG
                     GGGMGPGLPGSVLPLNLAKNPLLPSPFGAGGLGLPVVSLLGGSAGSKAEGEKGRGSVP
                     ARVLGLEDHKTSLERTERSRSRPSPDGLPLLPGTVLDLSTGNSAASSPEALTPGWVVI
                     PPGSVLLKPAVVN"
     exon            313..485
                     /gene="Glis2"
                     /inference="alignment:Splign:2.1.0"
     exon            486..662
                     /gene="Glis2"
                     /inference="alignment:Splign:2.1.0"
     exon            663..796
                     /gene="Glis2"
                     /inference="alignment:Splign:2.1.0"
     exon            797..915
                     /gene="Glis2"
                     /inference="alignment:Splign:2.1.0"
     exon            916..3360
                     /gene="Glis2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccccgcccg ccccggccct ccccctcgcc cgctctccgc tgccccacga ccgccggaac
       61 ccgcagccgg agccactcag cccggcagcc gaggttcctg cctagaccag cagggtgccg
      121 tcttcacgct ccctcccacc atgcactcct tggacgagcc gctcgaccta aagctgagca
      181 tcaccaagct gcgggcggca agagagaagc gagaaaggac actgggtgta ccccggcacc
      241 atgctttgca tcgggagctg ggcctggtgg acgacagccc cactcctggc tccccaggct
      301 ccccaccacc aggtttcctg ctgaacccca aattccctga gaagctggat ggacgctttt
      361 ctgcagcccc cttggtggac ctcagcttgt caccaccatc tggactggac tcccccaatg
      421 gcagcagctc cctgtcccct gagcgccaag gcaacgggga cctgcctcca ctgcctacag
      481 ctgtggattt ccagccactt cgctatttgg atggcgttcc cagctccttc cagttcttct
      541 tgcccctggg ttctggtggg gccctgcacc tacctgcctc ctccttcctt actcccccca
      601 aggacaagtg cctctcacca gagctgcccc tggccaagca gctggtgtgt cgatgggcca
      661 agtgtaacca gctcttcgag ctcctccaag acctggttga tcacgtcaat gaccatcatg
      721 tcaagccgga acaggacgct cggtactgct gccactggga gggctgtgcc cgccatggtc
      781 gtggcttcaa tgccaggtac aagatgctca tccacatccg gactcatacc aacgagaagc
      841 cacaccgatg ccccacctgt aacaagagct tctcccgcct ggaaaacctg aagatccaca
      901 accgctccca cacaggtgag aagccctacg tctgccccta tgagggctgc aacaagcgtt
      961 actccaactc gagtgaccgc ttcaagcata cccgtaccca ctacgtcgac aaaccctact
     1021 actgcaagat gccgggctgt cacaagcgct acacggaccc cagttcactg cgcaaacaca
     1081 tcaaagctca cggccacttt gtgtcccatg aacagcagga gctcctgcag ctgcgcccac
     1141 cccctaaacc accactgccc acccctgaca gtggctccta tgtcagtggg gctcagatca
     1201 tcatcccaaa ccctgctgcc ctttttggag gccccagtct gcctggcctg cccttacctc
     1261 tggcccctgg cccccttgac ctcagtgccc tggcctgtgg caatggtgga ggcgggggtg
     1321 ggggtatggg ccctgggctg ccaggatctg ttctgcccct caatctggcc aagaacccac
     1381 tgttgccctc accctttggg gctggtggac taggcctgcc tgtggtctct ctcctgggtg
     1441 gctctgctgg tagcaaggct gagggggaga agggtcgtgg gtcagtgcct gccagggtcc
     1501 tgggcctgga agaccacaag acgtccctgg aaaggacgga gcgcagccgc tcccggccaa
     1561 gccctgatgg actccctttg ctaccaggca ctgtgctgga cctgtccaca ggcaactcag
     1621 cagccagcag tccagaggcg ttaactcctg gctgggtggt catcccacca gggtctgtgc
     1681 tgctcaaacc agctgtggta aactgaaact gggctacccg tctaccagct gtggcagtcc
     1741 agccacctac tgtgggctca tccctgacga acagaaactc ttctgcgaaa tagcaataat
     1801 atcctactgc cccagggcca cgctgcagcc ccagggccac actgcagccc cagacaagct
     1861 gggtggcaag gtggcaagga tggtgctaga aggtctttgc tgacctcctg gctccagagt
     1921 gaggacctgg cttggactcg ctgtccaaga agagccattc ctcttgggtg ctaaggcctc
     1981 gctcactccc acttccctag tccatagtct gggtgaggcc ttcctctgcc tgtcctccca
     2041 ggacctccca gtcctgcctc ttgctctggt gcattcctct ccatgaccag cctgactggg
     2101 caggtttcca ttcctccctg ccttacctac ttgtcaacta gggagccccc agtgatcata
     2161 gataggctca tgcttgggaa ttccttagac ccctttccct ctggtccacc ttctagaggg
     2221 agagcaagac agacacaggc tgccttttcc cacctgctgc tatgacaagg tgcttccctg
     2281 cttgcttagc agagaagcct gctctgccag cgcttctctt tcctgccaga attagcactg
     2341 ccaaagggtt ggcaacactt tccaaagagg agggtagcta gctgaccact caaccttctt
     2401 gggaatgtgc aagcaggttc aaaggatctc tgtactgacc tgatccagct tggcttgggc
     2461 agtgttactc tgcagcagct tgtaaggcat cagtctatac cgggtgggct atcaggcttg
     2521 ggaagcagct acaggttcgg gggctacaag gaaggaagcc tcattggaaa gcagctttct
     2581 ggaaagcact gactgaagcc cctgggtgta agggaggcta ggcagccaag cacagcatta
     2641 ggagaaccag ctctttgctg gggaaaagct gactggagag aggcctagac atggagcagg
     2701 gttctttcct gactttccag ctgagccttt tcttggtgct gcctctcttg cccgtgaact
     2761 ctgcccaagc cagctacccc agggtgtgtg ctgtgcagaa tagggtccag cacttgcttg
     2821 gggctagaac aagccaagga cattggagga ctatgtgctc tacagctcca aaaggttagc
     2881 tgccccagct tgggcctctt gctgtcccct gtactatact tgcagtggct aagcccctca
     2941 tctctcatct atagaacaat agagctgctg gggtcatagt gggttccttg gctctgtggc
     3001 tcctctgagc agctctgcct agtctttttc tcagactgcc cttctgtttt agaagggtca
     3061 ccctgacctg cctgactgct ggtcttagga ccccagccct gacggggctc ggctgtgatg
     3121 gctctacccc ttgaaggggc tgtgagcatg tgaaggagct ggtctcctac ctttgggtct
     3181 gcctaggatc caagcgacct cctggctctg ttagggccct aggccttacg tccctggctg
     3241 ggggattggg tttgagactc aagcccaaga gcagaggaac agagcactgg aacattagct
     3301 cagcatgtga ttcagtgata gaccaggcct ggaagggcca gctggtctac ctatcagttc
//
