LOCUS       NM_001191910            3501 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus GLI family zinc finger 1 (Gli1), mRNA.
ACCESSION   NM_001191910 XM_345832
VERSION     NM_001191910.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3501)
  AUTHORS   Salem,G.A., Mohamed,A.A., Khater,S.I., Noreldin,A.E., Alosaimi,M.,
            Alansari,W.S., Shamlan,G., Eskandrani,A.A., Awad,M.M.,
            El-Shaer,R.A.A., Nassan,M.A., Mostafa,M. and Khamis,T.
  TITLE     Enhancement of biochemical and genomic pathways through
            lycopene-loaded nano-liposomes: Alleviating insulin resistance,
            hepatic steatosis, and autophagy in obese rats with non-alcoholic
            fatty liver disease: Involvement of SMO, GLI-1, and PTCH-1 genes
  JOURNAL   Gene 883, 147670 (2023)
   PUBMED   37516284
  REMARK    GeneRIF: Enhancement of biochemical and genomic pathways through
            lycopene-loaded nano-liposomes: Alleviating insulin resistance,
            hepatic steatosis, and autophagy in obese rats with non-alcoholic
            fatty liver disease: Involvement of SMO, GLI-1, and PTCH-1 genes.
REFERENCE   2  (bases 1 to 3501)
  AUTHORS   Wang,Q., Chai,L., Zhang,Q., Wang,J., Liu,J., Chen,H., Wang,Y.,
            Chen,Y., Shen,N., Xie,X. and Li,M.
  TITLE     Induction of GLI1 by miR-27b-3p/FBXW7/KLF5 pathway contributes to
            pulmonary arterial hypertension
  JOURNAL   J Mol Cell Cardiol 171, 16-29 (2022)
   PUBMED   35810662
  REMARK    GeneRIF: Induction of GLI1 by miR-27b-3p/FBXW7/KLF5 pathway
            contributes to pulmonary arterial hypertension.
REFERENCE   3  (bases 1 to 3501)
  AUTHORS   Xu,Y., Wang,J. and Ding,H.
  TITLE     Regulation of epithelial-mesenchymal transition via sonic
            hedgehog/glioma-associated oncogene homolog 1 signaling pathway in
            peritoneal mesothelial cells
  JOURNAL   Cell Biol Int 44 (8), 1691-1700 (2020)
   PUBMED   32298032
  REMARK    GeneRIF: Regulation of epithelial-mesenchymal transition via sonic
            hedgehog/glioma-associated oncogene homolog 1 signaling pathway in
            peritoneal mesothelial cells.
REFERENCE   4  (bases 1 to 3501)
  AUTHORS   He,S., Ma,C., Zhang,L., Bai,J., Wang,X., Zheng,X., Zhang,J.,
            Xin,W., Li,Y., Jiang,Y., Wang,S. and Zhu,D.
  TITLE     GLI1-mediated pulmonary artery smooth muscle cell pyroptosis
            contributes to hypoxia-induced pulmonary hypertension
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 318 (3), L472-L482 (2020)
   PUBMED   31868509
  REMARK    GeneRIF: GLI1 enhanced apoptosis-associated speck-like protein
            containing a caspase recruitment domain (ASC) expression by binding
            with its promoter
REFERENCE   5  (bases 1 to 3501)
  AUTHORS   Ding,X., Fan,K., Hu,J., Zang,Z., Zhang,S., Zhang,Y., Lin,Z.,
            Pei,X., Zheng,X., Zhu,F., Yang,H. and Li,S.
  TITLE     SCP2-mediated cholesterol membrane trafficking promotes the growth
            of pituitary adenomas via Hedgehog signaling activation
  JOURNAL   J Exp Clin Cancer Res 38 (1), 404 (2019)
   PUBMED   31519191
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3501)
  AUTHORS   Wang,B., Fallon,J.F. and Beachy,P.A.
  TITLE     Hedgehog-regulated processing of Gli3 produces an
            anterior/posterior repressor gradient in the developing vertebrate
            limb
  JOURNAL   Cell 100 (4), 423-434 (2000)
   PUBMED   10693759
REFERENCE   7  (bases 1 to 3501)
  AUTHORS   Ghali,L., Wong,S.T., Green,J., Tidman,N. and Quinn,A.G.
  TITLE     Gli1 protein is expressed in basal cell carcinomas, outer root
            sheath keratinocytes and a subpopulation of mesenchymal cells in
            normal human skin
  JOURNAL   J Invest Dermatol 113 (4), 595-599 (1999)
   PUBMED   10504446
REFERENCE   8  (bases 1 to 3501)
  AUTHORS   Dassule,H.R. and McMahon,A.P.
  TITLE     Analysis of epithelial-mesenchymal interactions in the initial
            morphogenesis of the mammalian tooth
  JOURNAL   Dev Biol 202 (2), 215-227 (1998)
   PUBMED   9769173
REFERENCE   9  (bases 1 to 3501)
  AUTHORS   Sasaki,H., Hui,C., Nakafuku,M. and Kondoh,H.
  TITLE     A binding site for Gli proteins is essential for HNF-3beta floor
            plate enhancer activity in transgenics and can respond to Shh in
            vitro
  JOURNAL   Development 124 (7), 1313-1322 (1997)
   PUBMED   9118802
REFERENCE   10 (bases 1 to 3501)
  AUTHORS   Walterhouse,D., Ahmed,M., Slusarski,D., Kalamaras,J., Boucher,D.,
            Holmgren,R. and Iannaccone,P.
  TITLE     gli, a zinc finger transcription factor and oncogene, is expressed
            during normal mouse development
  JOURNAL   Dev Dyn 196 (2), 91-102 (1993)
   PUBMED   8364225
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Jul 17, 2010 this sequence version replaced XM_345832.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               JAXUCZ010000007.1  65051308-65051407   c
            101-193             JAXUCZ010000007.1  65050986-65051078   c
            194-389             JAXUCZ010000007.1  65050320-65050515   c
            390-534             JAXUCZ010000007.1  65049829-65049973   c
            535-624             JAXUCZ010000007.1  65049443-65049532   c
            625-762             JAXUCZ010000007.1  65049215-65049352   c
            763-912             JAXUCZ010000007.1  65048757-65048906   c
            913-1077            JAXUCZ010000007.1  65046747-65046911   c
            1078-1308           JAXUCZ010000007.1  65046053-65046283   c
            1309-1573           JAXUCZ010000007.1  65044873-65045137   c
            1574-3501           JAXUCZ010000007.1  65042237-65044164   c
FEATURES             Location/Qualifiers
     source          1..3501
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..3501
                     /gene="Gli1"
                     /gene_synonym="Gli"
                     /note="GLI family zinc finger 1"
                     /db_xref="GeneID:140589"
                     /db_xref="RGD:621673"
     CDS             1..3330
                     /gene="Gli1"
                     /gene_synonym="Gli"
                     /note="GLI-Kruppel family member GLI1"
                     /codon_start=1
                     /product="zinc finger protein GLI1"
                     /protein_id="NP_001178839.1"
                     /db_xref="GeneID:140589"
                     /db_xref="RGD:621673"
                     /translation="MFNPMTSPQVNSYGEPCCLRPLPSQGVPSMGTEGLSGLPFCHQA
                     NFMSGSQGYGSARETSSCTEGSLFPPPRSSVKLTKKRALSISPLSDASLDLQTVIRTS
                     PSSLVAFINSRCTSPGGSYGHLSIGTMSPSLGFPPQMSHQKGTSPPYGVQPCVPHDST
                     QGSMMLHPQSRGPRATCQLKSELDIMVGKCPEEPLEGDMSSPNSTSTQDHLLGMLDGR
                     EDLEREEKPEPESVYETDCRWDGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCS
                     RELRPFKAQYMLVVHMRRHTGEKPHKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCE
                     QEGCSKAFSNASDRAKHQNRTHSNEKPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAH
                     VTKRHRGDGPLPRAQPLSTVEPKREREGGSGREESRLTVPEGTMPQQSPGAQSSCSSD
                     HSPAGSAANTDSGVEMAGNAGGSTEDLSSLDEGPCVAATGLSTLRRLENLRLDQLHQL
                     RPIGSRGLKLPSLTHAGAPVSRRLGPPVSLDRRSSSSSSISSAYTVSRRSSLASPFPP
                     GSPPENGASSLPGLTPAQHYMLRARYASARGSGTPPTAAHSLDRIGGLPAPPWRSRAE
                     YPGYNPNAGVTRRASDPARAADHPAPARVQRFKSLGCVHTPPSVATGRNFDPHLPTSV
                     YSPQPPSITENVAMDTRGLQGELEVGTSMMGNDLNPYMDFSSADTLGYGGPEGTAAES
                     YGSKGPGSLPLGPGPPTNYGPGHCAQQVSYPDPTPETWGEFPSHAGVYPGTKALGTAY
                     NQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSEGSPDPQPLFSHHSQLPPPQ
                     YLQSGPYPQPPHDCLSLESRPGLNFNPSSHSTGQLKAQLLCNYVQSQQELLWEGRSRG
                     GIPNQELPYQSPKFLGGSQVSQSPTKVPAAAAAATFGSGFASPALANHKSVSYPAPSP
                     CHETFTMGVNRPPHRPAAPPRLLPPLPPCYGPLKVGDANPSCGHPEVGRLGAGPALYP
                     PPEGQVCNPLDSLDLDNTQLDFVAILDEAQGLSPPPSHEQGDSSKNTPPPSGPPNMAV
                     GNMSVLLGSLPGETQFLNSSA"
     exon            1..100
                     /gene="Gli1"
                     /gene_synonym="Gli"
                     /inference="alignment:Splign:2.1.0"
     exon            101..193
                     /gene="Gli1"
                     /gene_synonym="Gli"
                     /inference="alignment:Splign:2.1.0"
     exon            194..389
                     /gene="Gli1"
                     /gene_synonym="Gli"
                     /inference="alignment:Splign:2.1.0"
     exon            390..534
                     /gene="Gli1"
                     /gene_synonym="Gli"
                     /inference="alignment:Splign:2.1.0"
     exon            535..624
                     /gene="Gli1"
                     /gene_synonym="Gli"
                     /inference="alignment:Splign:2.1.0"
     exon            625..762
                     /gene="Gli1"
                     /gene_synonym="Gli"
                     /inference="alignment:Splign:2.1.0"
     exon            763..912
                     /gene="Gli1"
                     /gene_synonym="Gli"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1077
                     /gene="Gli1"
                     /gene_synonym="Gli"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1308
                     /gene="Gli1"
                     /gene_synonym="Gli"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1573
                     /gene="Gli1"
                     /gene_synonym="Gli"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..3501
                     /gene="Gli1"
                     /gene_synonym="Gli"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgttcaatc caatgacttc accacaagtc aatagctatg gtgagccatg ctgtctccga
       61 cccctcccca gccaaggggt ccccagcatg ggaacagaag gactttctgg tctgcccttt
      121 tgccaccaag ccaattttat gtcagggtcc cagggttatg ggtctgccag agagaccagc
      181 agctgcactg aggggtcact ctttcctcct cctcggagtt cagtcaaact gactaagaag
      241 cgggctcttt ccatctcgcc tctctctgac gccagcctcg acctgcaaac cgtaatccgt
      301 acctcaccca gctccctcgt ggctttcatc aactctcgtt gtacatctcc aggcggttcc
      361 tacggccatc tctccattgg caccatgagc ccttctttag gattcccacc tcagatgagt
      421 caccagaaag gaacttcacc tccctatgga gtccagccct gtgttccaca tgattctact
      481 cagggttcaa tgatgcttca cccccagtcc cgaggaccac gtgcaacctg ccagctgaag
      541 tcagagctgg acatcatggt tggcaagtgc ccagaggaac ctttggaagg ggacatgtct
      601 agccccaact ccacgagcac acaggatcac ctgctgggga tgctggatgg acgggaggac
      661 ctggagagag aggagaaacc tgagcctgag tctgtgtatg agacggactg ccgctgggat
      721 ggttgcagcc aggagttcga ttcccaagaa cagctggtgc accacatcaa cagtgagcac
      781 atccacgggg agcggaagga gttcgtgtgc cactggggag gctgctccag ggagctgagg
      841 cccttcaagg cccagtacat gctggtggtg cacatgcgca gacacacggg cgagaagcca
      901 cacaagtgca cgtttgaagg ctgtcggaag tcctattcac gcctcgaaaa cctgaagaca
      961 caccttcggt cgcacaccgg tgagaagcct tatatgtgtg agcaggaagg ctgcagcaag
     1021 gccttcagca acgccagtga ccgtgccaag caccagaata ggacccactc caatgagaag
     1081 ccatatgtgt gcaaactccc cggctgcacc aagcgctaca cagatcccag ctcgctccgc
     1141 aaacatgtca agactgtgca cggtccggat gcccacgtga ccaaacgaca tcgaggggat
     1201 ggccccttac cacgggcaca gcccctctcc acagtggagc ccaagcgaga aagggaagga
     1261 ggatccggca gggaagagag cagactgact gtgccggagg gcaccatgcc tcagcagagc
     1321 cctggagcac aatcctcctg cagcagtgac cactccccag caggcagcgc ggccaacacg
     1381 gacagcggcg tggagatggc cggcaacgca gggggcagca ctgaggactt gtccagcttg
     1441 gatgaaggac cttgcgttgc ggctaccgga ctctccaccc ttcgccgcct tgagaacctc
     1501 aggctggatc agctgcatca gctccggcca atagggtccc ggggtctcaa actgcccagc
     1561 ttaacccacg ctggcgcacc tgtgtctcga cgtctgggcc caccggtctc ccttgaccgc
     1621 cgcagcagca gctccagcag cattagctcc gcgtacacag tcagccgccg gtcctcgctg
     1681 gcatccccgt tcccgccggg atccccacca gagaacgggg cgtcgtcact acctggcctc
     1741 acacctgccc agcactacat gctccgggca agatatgctt cagccagggg gagtggcacc
     1801 ccacccactg cagcacacag cctggatcgg atcgggggtc ttcctgcacc tccttggaga
     1861 agccgagctg agtacccagg atacaacccc aatgcagggg tcacgaggag ggccagtgac
     1921 ccagcccggg ctgctgacca cccggctcca gctagagtac aacggttcaa gagcttgggg
     1981 tgtgtacaca cgcctcctag tgtggcaaca ggacggaact tcgatcccca cctccctacc
     2041 tctgtctatt cgccacagcc ccccagcatc accgaaaatg ttgctatgga tactagaggg
     2101 ctacaggggg agctagaggt tggaacttcc atgatgggca atgatctgaa cccatacatg
     2161 gacttttctt ctgctgacac tctgggatat ggggggcctg aggggacggc ggctgagtct
     2221 tatggatcta agggtccagg ttccctgcct cttgggcctg gtccaccaac caactatggc
     2281 cctggccact gtgcccagca ggtctcctat cctgatccca ccccagaaac atggggtgag
     2341 tttccttcac atgctggggt gtaccctggc actaaggctc taggtacagc ctataaccag
     2401 tgtcctcgac ttgagcatta tggacaagtg caagtaaaac cagaacaagg gtgcccagtg
     2461 gggtctgact ccaccgggtt ggcaccctgc ctcaatgccc accccagtga agggtcccca
     2521 gacccacagc ctctgttttc acatcactcc cagctccctc caccccagta tctccagtca
     2581 ggtccctacc ctcagcctcc ccatgactgt ctctcgttag aatccaggcc tggcctcaat
     2641 ttcaacccct cctctcattc cacaggacag ctcaaagctc agctcctgtg taattacgtt
     2701 cagtcgcagc aggaattgtt gtgggagggc agaagccggg gagggatccc caaccaggaa
     2761 cttccatatc agagccccaa gtttctggga ggttctcaag ttagtcagag ccccaccaag
     2821 gtcccagcag cagcagcagc agctacgttt ggatctggct ttgcatcacc tgctttggcc
     2881 aatcacaaat cagtctccta tcctgcccct tcaccgtgcc atgaaacttt caccatggga
     2941 gtaaacaggc ctccccatag gccagcagca ccaccccggc ttctgccccc gctaccacct
     3001 tgctatgggc ccctcaaggt gggagatgcc aaccccagct gtgggcatcc tgaagtgggc
     3061 aggttaggag caggccctgc cttgtaccct ccccctgaag ggcaggtgtg taaccctctg
     3121 gactctcttg acctggacaa cactcagctg gactttgtgg ctatcctaga tgaagctcaa
     3181 gggctgagcc ctcctccttc ccacgagcaa ggggacagct ctaaaaacac cccacctccc
     3241 tccgggcccc ccaacatggc agtcggtaac atgagtgtct tactggggtc tctgcctgga
     3301 gagacgcagt tcctcaactc tagtgcctaa aaggataagg aaccccaact ggaccacgtc
     3361 tcctaaatgg ctacacacac gcggtaccca gggatgggag gtttgggttg ggggctgtat
     3421 ttagtctatg tatgttccag gggaaaaaaa aactttaatg atgacacagt ttcctgacaa
     3481 taaaggaacg ctgagaacaa g
//
