LOCUS       NM_001025731            2263 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus GLE1 RNA export mediator (Gle1), mRNA.
ACCESSION   NM_001025731 XM_342402
VERSION     NM_001025731.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2263)
  AUTHORS   Jao,L.E., Akef,A. and Wente,S.R.
  TITLE     A role for Gle1, a regulator of DEAD-box RNA helicases, at
            centrosomes and basal bodies
  JOURNAL   Mol Biol Cell 28 (1), 120-127 (2017)
   PUBMED   28035044
REFERENCE   2  (bases 1 to 2263)
  AUTHORS   Folkmann,A.W., Collier,S.E., Zhan,X., Aditi, Ohi,M.D. and
            Wente,S.R.
  TITLE     Gle1 functions during mRNA export in an oligomeric complex that is
            altered in human disease
  JOURNAL   Cell 155 (3), 582-593 (2013)
   PUBMED   24243016
REFERENCE   3  (bases 1 to 2263)
  AUTHORS   Natalizio,B.J. and Wente,S.R.
  TITLE     Postage for the messenger: designating routes for nuclear mRNA
            export
  JOURNAL   Trends Cell Biol 23 (8), 365-373 (2013)
   PUBMED   23583578
  REMARK    Review article
REFERENCE   4  (bases 1 to 2263)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   5  (bases 1 to 2263)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099088.1.
            
            On Jul 22, 2005 this sequence version replaced XM_342402.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099088.1, FQ217346.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132263, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2263
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..2263
                     /gene="Gle1"
                     /gene_synonym="Gle1l"
                     /note="GLE1 RNA export mediator"
                     /db_xref="GeneID:362098"
                     /db_xref="RGD:1307329"
     exon            1..157
                     /gene="Gle1"
                     /gene_synonym="Gle1l"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..2155
                     /gene="Gle1"
                     /gene_synonym="Gle1l"
                     /note="nucleoporin GLE1; GLE1-like protein; GLE1 RNA
                     export mediator-like (yeast; GLE1 RNA export mediator
                     homolog"
                     /codon_start=1
                     /product="mRNA export factor GLE1"
                     /protein_id="NP_001020902.1"
                     /db_xref="GeneID:362098"
                     /db_xref="RGD:1307329"
                     /translation="MPSDGRCWETLRALRNSSKGRLRYDREWLLRYEDVLEECMSLPK
                     LSSYSGWVVDHILPNTSHHTQENAPSSDNSPSSGSASGLYQSTLKSPVRSSPQSPSPS
                     TPSGTQSAHESPFTEPIALQSSRAIKVEGCIRMYELAHRMRGTEGLRQWQEEQERKVQ
                     ALSEMASEQLKRFDELKELKLHKEFRDLQEVMEKSTREALGHQEKLKAEHRHRAKILN
                     LKLREAEQQRVKQAEQEQLRKEEGQIRLRSLYTLQEEVLQLNQQLDASSQHKDLLNVD
                     LAAFQTRGNQLCGLISGIIRTTLESGYPTAENQAEAERVLQEMRDLLSNLEQEITRAS
                     EMKKKDEEEARVKLQESQVQQGPGAPTKTSAPSPSLVGTQSEDLQVKVQDSTMQWYQQ
                     LQDASAKCVLAFEDLTSSKDSQIKKIKMDLQKAATIPVSQISTIAGSKLKEVFDKIHS
                     LLSGKPVQSGGRSVCVTLNPQGLDFVQYKLAEKFVKQGEEEVASHHEAAFPIAVVASG
                     IWMLHPKVGDLILAHLHKKCPYSVPFYPAFKEGMPLEDYQRMLGYQVTDSKVEQQDNF
                     LKRMSGMIRLYAAIIQLQWPYGSRQEAHPHGLNHGWRWLAQILNMEPLSDVTATLLFD
                     FLEVCGNALMKQYQVQFWKMILLIKEDYFPRIEAITSSGQMGSFIRLKQFLEKCLQRR
                     EIPVPKGFLTPSFWRS"
     exon            158..382
                     /gene="Gle1"
                     /gene_synonym="Gle1l"
                     /inference="alignment:Splign:2.1.0"
     exon            383..493
                     /gene="Gle1"
                     /gene_synonym="Gle1l"
                     /inference="alignment:Splign:2.1.0"
     exon            494..642
                     /gene="Gle1"
                     /gene_synonym="Gle1l"
                     /inference="alignment:Splign:2.1.0"
     exon            643..703
                     /gene="Gle1"
                     /gene_synonym="Gle1l"
                     /inference="alignment:Splign:2.1.0"
     exon            704..958
                     /gene="Gle1"
                     /gene_synonym="Gle1l"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1187
                     /gene="Gle1"
                     /gene_synonym="Gle1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1300
                     /gene="Gle1"
                     /gene_synonym="Gle1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1370
                     /gene="Gle1"
                     /gene_synonym="Gle1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1513
                     /gene="Gle1"
                     /gene_synonym="Gle1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1704
                     /gene="Gle1"
                     /gene_synonym="Gle1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1834
                     /gene="Gle1"
                     /gene_synonym="Gle1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1939
                     /gene="Gle1"
                     /gene_synonym="Gle1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2022
                     /gene="Gle1"
                     /gene_synonym="Gle1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2086
                     /gene="Gle1"
                     /gene_synonym="Gle1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2237
                     /gene="Gle1"
                     /gene_synonym="Gle1l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctcctcgg cggcggattc gagggtttgt tgtcagtagt atcagctggt ggcctgccat
       61 gccgtctgat ggtcgctgct gggaaactct gagggcgctc cgcaattcca gcaaaggccg
      121 cctgcgctac gaccgcgagt ggttactgcg ctacgaggat gttttggaag aatgtatgtc
      181 tcttcccaaa ctatcttctt actctggatg ggtggtggat cacatcctac ccaacacctc
      241 acaccacacg caagagaatg ctccttcctc tgataattca ccatcctctg gatctgcttc
      301 aggcctgtac caatccacac ttaagtctcc tgtcagaagt agcccacaat ctccttcacc
      361 ctcaacacca agtggaaccc agagcgcaca tgagtccccg ttcacagaac ctattgcact
      421 tcagtcctcc cgagcgatca aagtggaagg ttgcatccga atgtatgaat tggcgcacag
      481 aatgagagga acagagggcc tgaggcagtg gcaggaggag caagagagga aggtgcaagc
      541 cctctcagag atggcgtccg aacagctgaa gaggtttgac gagctgaagg agctgaagct
      601 gcataaggag ttccgggact tacaggaagt gatggagaag agtaccagag aagccctggg
      661 ccatcaggag aagctgaaag ctgagcatcg ccacagagcc aagattctca acctaaagct
      721 tcgagaggca gagcagcagc gtgtgaagca ggcagagcag gagcagctgc ggaaggagga
      781 aggccagatc cgtctgcgca gcctgtacac cctgcaagag gaggtcctgc agctcaacca
      841 gcagctggat gcttccagtc agcacaaaga cctgctgaat gtggacctgg ctgctttcca
      901 gacccggggc aaccagctgt gtggcctcat ctctggcatc attcgcacca ccttggagag
      961 tggctatccc acagcagaga accaagctga ggctgagcga gtcctgcagg aaatgcggga
     1021 cctcctctca aatttggagc aggagatcac cagagcctct gaaatgaaga agaaagatga
     1081 agaagaggct cgggtcaagc tgcaggagtc acaggtgcag caggggccag gggctcccac
     1141 caagacctct gcacccagcc caagcctagt agggacacag agtgaagacc tgcaggtgaa
     1201 ggtacaggat agtacgatgc agtggtacca gcaacttcag gatgcttctg ccaaatgcgt
     1261 gttggccttt gaggacctga ccagcagcaa ggacagtcag atcaaaaaga taaagatgga
     1321 cctgcagaag gcagccacca tcccagtgag ccagatctcc accatcgcag gttccaagct
     1381 gaaggaggtt tttgacaaga tccacagcct gctctctgga aagcctgtcc agtctggtgg
     1441 acgttctgtg tgcgtcactc ttaacccaca ggggttggac tttgtccagt acaaactggc
     1501 cgagaaattt gtgaaacaag gggaggagga agtggcctct caccacgaag cagccttccc
     1561 cattgcagtg gtggcctctg gtatctggat gctccacccc aaagtgggag acctcattct
     1621 tgcccacctc cacaagaagt gtccgtactc cgttcctttc tacccagctt tcaaggaggg
     1681 gatgcctctg gaggattatc aacggatgct tggctaccaa gtgacggatt ccaaggttga
     1741 gcaacaggac aactttctaa aacgaatgtc tgggatgatc cgtttgtatg ccgccatcat
     1801 ccagctccag tggccatatg gaagccggca ggaggctcat cctcacggct taaatcatgg
     1861 ctggcgctgg ttggcgcaga tcttaaacat ggagcctctc tcagatgtga cagccactct
     1921 cctgtttgac ttcttggagg tgtgtgggaa tgccctcatg aagcagtacc aggtccagtt
     1981 ctggaagatg atccttctca tcaaagagga ctacttcccc agaattgaag ccatcacgag
     2041 ctcaggacag atgggttcct tcatacgtct gaagcagttc ttggagaaat gtctgcaacg
     2101 cagggagatc cctgtcccta aaggctttct gacgccctcc ttctggcgct cttgatgtcc
     2161 tccatcatgt tgtgtggcag aaggggcaac aataaagcaa ctgagacagc gggtttggaa
     2221 gaatcatgtc agactgaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
