LOCUS       NM_181382               2385 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus gliomedin (Gldn), mRNA.
ACCESSION   NM_181382
VERSION     NM_181382.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2385)
  AUTHORS   Maluenda,J., Manso,C., Quevarec,L., Vivanti,A., Marguet,F.,
            Gonzales,M., Guimiot,F., Petit,F., Toutain,A., Whalen,S.,
            Grigorescu,R., Coeslier,A.D., Gut,M., Gut,I., Laquerriere,A.,
            Devaux,J. and Melki,J.
  TITLE     Mutations in GLDN, Encoding Gliomedin, a Critical Component of the
            Nodes of Ranvier, Are Responsible for Lethal Arthrogryposis
  JOURNAL   Am J Hum Genet 99 (4), 928-933 (2016)
   PUBMED   27616481
REFERENCE   2  (bases 1 to 2385)
  AUTHORS   Han,H. and Kursula,P.
  TITLE     Expression, purification, crystallization and preliminary X-ray
            crystallographic analysis of the extracellular olfactomedin domain
            of gliomedin
  JOURNAL   Acta Crystallogr F Struct Biol Commun 70 (Pt 11), 1536-1539 (2014)
   PUBMED   25372825
  REMARK    GeneRIF: The crystallization of the rat GLDN olfactomedin domain
            was expressed in an insect-cell system.
REFERENCE   3  (bases 1 to 2385)
  AUTHORS   Devaux,J.J.
  TITLE     Antibodies to gliomedin cause peripheral demyelinating neuropathy
            and the dismantling of the nodes of Ranvier
  JOURNAL   Am J Pathol 181 (4), 1402-1413 (2012)
   PUBMED   22885108
  REMARK    GeneRIF: Primary immune reaction against gliomedin, a peripheral
            nervous system adhesion molecule, can be responsible for the
            initiation or progression of the demyelinating form of
            Guillain-Barre syndrome.
REFERENCE   4  (bases 1 to 2385)
  AUTHORS   Feinberg,K., Eshed-Eisenbach,Y., Frechter,S., Amor,V., Salomon,D.,
            Sabanay,H., Dupree,J.L., Grumet,M., Brophy,P.J., Shrager,P. and
            Peles,E.
  TITLE     A glial signal consisting of gliomedin and NrCAM clusters axonal
            Na+ channels during the formation of nodes of Ranvier
  JOURNAL   Neuron 65 (4), 490-502 (2010)
   PUBMED   20188654
REFERENCE   5  (bases 1 to 2385)
  AUTHORS   Maertens,B., Hopkins,D., Franzke,C.W., Keene,D.R.,
            Bruckner-Tuderman,L., Greenspan,D.S. and Koch,M.
  TITLE     Cleavage and oligomerization of gliomedin, a transmembrane collagen
            required for node of ranvier formation
  JOURNAL   J Biol Chem 282 (14), 10647-10659 (2007)
   PUBMED   17293346
REFERENCE   6  (bases 1 to 2385)
  AUTHORS   Eshed,Y., Feinberg,K., Poliak,S., Sabanay,H., Sarig-Nadir,O.,
            Spiegel,I., Bermingham,J.R. Jr. and Peles,E.
  TITLE     Gliomedin mediates Schwann cell-axon interaction and the molecular
            assembly of the nodes of Ranvier
  JOURNAL   Neuron 47 (2), 215-229 (2005)
   PUBMED   16039564
REFERENCE   7  (bases 1 to 2385)
  AUTHORS   Graveel,C.R., Harkins-Perry,S.R., Acevedo,L.G. and Farnham,P.J.
  TITLE     Identification and characterization of CRG-L2, a new marker for
            liver tumor development
  JOURNAL   Oncogene 22 (11), 1730-1736 (2003)
   PUBMED   12642876
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Dec 3, 2020 this sequence version replaced NM_181382.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY266116.1, SRR26643285.31185.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-535               JAXUCZ010000008.1  63575270-63575804
            536-587             JAXUCZ010000008.1  63595120-63595171
            588-605             JAXUCZ010000008.1  63602491-63602508
            606-713             JAXUCZ010000008.1  63602824-63602931
            714-860             JAXUCZ010000008.1  63610597-63610743
            861-980             JAXUCZ010000008.1  63611935-63612054
            981-1064            JAXUCZ010000008.1  63613174-63613257
            1065-1190           JAXUCZ010000008.1  63613814-63613939
            1191-1341           JAXUCZ010000008.1  63614818-63614968
            1342-2385           JAXUCZ010000008.1  63618303-63619346
FEATURES             Location/Qualifiers
     source          1..2385
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2385
                     /gene="Gldn"
                     /gene_synonym="Colm; Crgl2"
                     /note="gliomedin"
                     /db_xref="GeneID:315675"
                     /db_xref="RGD:727879"
     exon            1..535
                     /gene="Gldn"
                     /gene_synonym="Colm; Crgl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1822
                     /gene="Gldn"
                     /gene_synonym="Colm; Crgl2"
                     /note="collomin; olfactomedin-related protein"
                     /codon_start=1
                     /product="gliomedin"
                     /protein_id="NP_852047.2"
                     /db_xref="GeneID:315675"
                     /db_xref="RGD:727879"
                     /translation="MTRAAERGQGATGWGLRGALMAVALLSVLNAVGTVFVLYQWREL
                     SAALRALEAQHGREQREDSALRAFLAELSRAPARVPEPPQDPMSAARNKRSHGGEPAS
                     HIRAESQDMMMMMTYSMVPIRVMIDLCNSTQGICLTGPPGPPGPPGAGGLPGHNGSDG
                     QPGLQGPKGEKGAVGKRGKMGLPGATGNPGEKGEKGDAGELGLPGNEGPPGQKGDKGD
                     KGDVSNDVLLTGAKGDQGPPGPPGPPGPPGPPGSRRAKGPRQPNSFTNQCPGETCVIP
                     NDDTLVGRADEKVNERHSPQTEPMITSIGNPAQVLKVKETFGTWLRESANRSDDRIWV
                     TEHFSGIMVKEFEDLPALLNSSFTLLHLPHYFHGCGHAVYNNSLYYHKGGSNTIVRFE
                     FGKETPQTLKLEDALYFDRKYLFANSKTYFNIAVDEKGLWIIYASSVDGSSILVAQLD
                     ERTFSVLQHINTTYPKSKAGNAFIAQGILYVTDTKDTRVTFAFDLLRGKQINANFGLR
                     MSQSVLAMLSYNMRDQHLYSWEDGHLMLYPVHFSSTAPSQR"
     exon            536..587
                     /gene="Gldn"
                     /gene_synonym="Colm; Crgl2"
                     /inference="alignment:Splign:2.1.0"
     exon            588..605
                     /gene="Gldn"
                     /gene_synonym="Colm; Crgl2"
                     /inference="alignment:Splign:2.1.0"
     exon            606..713
                     /gene="Gldn"
                     /gene_synonym="Colm; Crgl2"
                     /inference="alignment:Splign:2.1.0"
     exon            714..860
                     /gene="Gldn"
                     /gene_synonym="Colm; Crgl2"
                     /inference="alignment:Splign:2.1.0"
     exon            861..980
                     /gene="Gldn"
                     /gene_synonym="Colm; Crgl2"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1064
                     /gene="Gldn"
                     /gene_synonym="Colm; Crgl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1190
                     /gene="Gldn"
                     /gene_synonym="Colm; Crgl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1341
                     /gene="Gldn"
                     /gene_synonym="Colm; Crgl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..2385
                     /gene="Gldn"
                     /gene_synonym="Colm; Crgl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcttctgg ggcgccacga ttactgtccc caacccgcct cgccagacgg gtctaaaggc
       61 agcttgactc acgactctgc caccagccca ccactcgcgc gagggtataa aacctgccac
      121 tgcgggagga ggcccagtgc tgccctgagt cgttcggcct gagcacagag acatgacccg
      181 agccgcagag cgaggccaag gggctacagg ctggggactg cgaggcgccc tgatggccgt
      241 ggcgctgctg tcagtgctga acgccgtggg caccgtgttc gtgctgtacc agtggcgcga
      301 gctgagcgcg gcgctgcggg cactggaggc gcaacacggc cgggagcagc gcgaggacag
      361 cgccctacgc gcctttctag ctgaattaag tcgtgcgcca gcccgagtcc ccgaaccacc
      421 ccaggacccc atgagtgcag cgcgcaataa gcgcagccac ggcggcgagc ctgcgtcaca
      481 catccgcgcc gagagccagg acatgatgat gatgatgacc tactccatgg tgccgatccg
      541 ggtgatgata gacctgtgca acagcaccca gggcatctgc cttacaggac caccgggccc
      601 accaggacct ccaggagctg gtgggttacc aggccacaat ggatcagatg gacagcctgg
      661 tctccagggc ccaaaaggag aaaaaggagc agttgggaag agaggaaaaa tggggttacc
      721 cggagccaca ggaaatccag gggaaaaggg agagaaggga gatgctggtg aactgggcct
      781 acctggaaat gagggaccac caggacagaa aggagacaaa ggagacaaag gagatgtgtc
      841 caatgacgtg cttttgacag gtgccaaagg tgaccaaggg ccccctggcc cacctggacc
      901 cccagggcct ccaggccctc ctggaagcag aagagccaaa ggccctcggc agccaaattc
      961 gttcaccaac cagtgtccag gggagacgtg tgtcataccc aatgatgata ccttggtggg
     1021 gagagctgat gagaaagtca atgagcgcca ttctccacaa acagaaccca tgatcacgtc
     1081 cattggtaac ccggcccaag tcctcaaagt gaaagagact tttgggacct ggctaagaga
     1141 gtctgctaac aggagtgatg accgcatttg ggtgactgaa catttttcag gcatcatggt
     1201 gaaggagttt gaagacctgc ccgccctcct gaatagcagc ttcaccctcc tccacctccc
     1261 acattacttc catggctgcg ggcacgctgt ttacaacaac tctctctact accacaaagg
     1321 aggctccaac accatagtga gatttgaatt tgggaaagag acacctcaaa ctctgaagct
     1381 tgaagatgct ttgtattttg atcgaaaata cctctttgca aattccaaga cttacttcaa
     1441 catagcagtg gatgagaagg gcctctggat tatctacgcc tcgagtgtgg atggctcaag
     1501 catccttgtg gcacagctgg acgagaggac attctctgtg ctgcagcaca tcaataccac
     1561 ataccccaag tccaaggctg gcaatgcctt catagctcaa gggatcctct atgtcacgga
     1621 caccaaagat acaagggtca cgtttgcctt tgatttgtta cgagggaagc agatcaatgc
     1681 aaacttcggt ctcagaatgt cacagtctgt tcttgccatg ttgtcataca atatgagaga
     1741 ccagcatttg tactcgtggg aagacggcca cctgatgctc tatcctgtgc acttttcgtc
     1801 aacagcaccc agccagcgat aggcctgcag tcggctccct cattatgcac cacacatttt
     1861 ctggggtttg accaagccca acggaaagaa ggcctgtaaa ggatatccag atactcagag
     1921 catacgcccg tgctacgggc tcttgtgcat gtggcaagtc cccctgtaag ccaggttagc
     1981 tagaggctgg aagttgaaat ggataacatc tggtgaccct tggtccctct tcaaacttag
     2041 caagttagtg ctcccccctg accttagtgt ccccatcagt aatatgaaac atctgtgtga
     2101 ttgacagcat ttcctctacc tatatgaagt tctgtgattc ttgcctggtt atatattaga
     2161 ttgctttctg gtttcttttt ttttctccac atgtaaatga gtttacctgc agcttgaggg
     2221 gtgtgcctat cagtgatgac ggacatttgt ttggtgttta gggaagatgc attgtctctt
     2281 atggcttcta aagtattata ttatccataa tttgatattt ttctctgaat acgcacctgc
     2341 cactacagaa tgattattgt tttcagctcc taagtacaaa tccaa
//
