LOCUS       NM_001415944            3799 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus glycine decarboxylase (Gldc), mRNA; nuclear gene
            for mitochondrial product.
ACCESSION   NM_001415944 XM_006231210
VERSION     NM_001415944.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3799)
  AUTHORS   Bravo-Alonso,I., Navarrete,R., Arribas-Carreira,L., Perona,A.,
            Abia,D., Couce,M.L., Garcia-Cazorla,A., Morais,A., Domingo,R.,
            Ramos,M.A., Swanson,M.A., Van Hove,J.L.K., Ugarte,M., Perez,B.,
            Perez-Cerda,C. and Rodriguez-Pombo,P.
  TITLE     Nonketotic hyperglycinemia: Functional assessment of missense
            variants in GLDC to understand phenotypes of the disease
  JOURNAL   Hum Mutat 38 (6), 678-691 (2017)
   PUBMED   28244183
REFERENCE   2  (bases 1 to 3799)
  AUTHORS   Min,H.L., Kim,J., Kim,W.H., Jang,B.G. and Kim,M.A.
  TITLE     Epigenetic Silencing of the Putative Tumor Suppressor Gene GLDC
            (Glycine Dehydrogenase) in Gastric Carcinoma
  JOURNAL   Anticancer Res 36 (1), 179-187 (2016)
   PUBMED   26722042
REFERENCE   3  (bases 1 to 3799)
  AUTHORS   Pai,Y.J., Leung,K.Y., Savery,D., Hutchin,T., Prunty,H., Heales,S.,
            Brosnan,M.E., Brosnan,J.T., Copp,A.J. and Greene,N.D.
  TITLE     Glycine decarboxylase deficiency causes neural tube defects and
            features of non-ketotic hyperglycinemia in mice
  JOURNAL   Nat Commun 6, 6388 (2015)
   PUBMED   25736695
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3799)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   5  (bases 1 to 3799)
  AUTHORS   Tibbetts,A.S. and Appling,D.R.
  TITLE     Compartmentalization of Mammalian folate-mediated one-carbon
            metabolism
  JOURNAL   Annu Rev Nutr 30, 57-81 (2010)
   PUBMED   20645850
  REMARK    Review article
REFERENCE   6  (bases 1 to 3799)
  AUTHORS   Kanno,J., Hutchin,T., Kamada,F., Narisawa,A., Aoki,Y., Matsubara,Y.
            and Kure,S.
  TITLE     Genomic deletion within GLDC is a major cause of non-ketotic
            hyperglycinaemia
  JOURNAL   J Med Genet 44 (3), e69 (2007)
   PUBMED   17361008
REFERENCE   7  (bases 1 to 3799)
  AUTHORS   Flusser,H., Korman,S.H., Sato,K., Matsubara,Y., Galil,A. and
            Kure,S.
  TITLE     Mild glycine encephalopathy (NKH) in a large kindred due to a
            silent exonic GLDC splice mutation
  JOURNAL   Neurology 64 (8), 1426-1430 (2005)
   PUBMED   15851735
REFERENCE   8  (bases 1 to 3799)
  AUTHORS   Hayasaka,K., Kochi,H., Hiraga,K. and Kikuchi,G.
  TITLE     Purification and properties of glycine decarboxylase, a component
            of the glycine cleavage system, from rat liver mitochondria and
            immunochemical comparison of this enzyme from various sources
  JOURNAL   J Biochem 88 (4), 1193-1199 (1980)
   PUBMED   6778858
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jan 5, 2023 this sequence version replaced XM_006231210.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.3623.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760400 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-467               JAXUCZ010000001.1  237375138-237375604 c
            468-546             JAXUCZ010000001.1  237374582-237374660 c
            547-682             JAXUCZ010000001.1  237356383-237356518 c
            683-847             JAXUCZ010000001.1  237349362-237349526 c
            848-925             JAXUCZ010000001.1  237345348-237345425 c
            926-1073            JAXUCZ010000001.1  237343895-237344042 c
            1074-1270           JAXUCZ010000001.1  237343375-237343571 c
            1271-1367           JAXUCZ010000001.1  237341722-237341818 c
            1368-1473           JAXUCZ010000001.1  237336806-237336911 c
            1474-1613           JAXUCZ010000001.1  237334623-237334762 c
            1614-1694           JAXUCZ010000001.1  237334022-237334102 c
            1695-1792           JAXUCZ010000001.1  237330231-237330328 c
            1793-1877           JAXUCZ010000001.1  237329723-237329807 c
            1878-1919           JAXUCZ010000001.1  237329516-237329557 c
            1920-2062           JAXUCZ010000001.1  237327681-237327823 c
            2063-2138           JAXUCZ010000001.1  237321022-237321097 c
            2139-2264           JAXUCZ010000001.1  237315081-237315206 c
            2265-2414           JAXUCZ010000001.1  237312920-237313069 c
            2415-2527           JAXUCZ010000001.1  237311738-237311850 c
            2528-2669           JAXUCZ010000001.1  237310350-237310491 c
            2670-2781           JAXUCZ010000001.1  237307555-237307666 c
            2782-2877           JAXUCZ010000001.1  237301040-237301135 c
            2878-3050           JAXUCZ010000001.1  237298978-237299150 c
            3051-3131           JAXUCZ010000001.1  237298081-237298161 c
            3132-3799           JAXUCZ010000001.1  237296753-237297420 c
FEATURES             Location/Qualifiers
     source          1..3799
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     gene            1..3799
                     /gene="Gldc"
                     /note="glycine decarboxylase"
                     /db_xref="GeneID:309312"
                     /db_xref="RGD:1308660"
     exon            1..467
                     /gene="Gldc"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..3275
                     /gene="Gldc"
                     /EC_number="1.4.4.2"
                     /note="glycine dehydrogenase (decarboxylating; glycine
                     decarboxylase, glycine cleavage system protein P); glycine
                     dehydrogenase [decarboxylating], mitochondrial; glycine
                     dehydrogenase (decarboxylating); glycine dehydrogenase
                     (decarboxylating), mitochondrial-like; glycine
                     dehydrogenase [decarboxylating], mitochondrial-like"
                     /codon_start=1
                     /product="glycine dehydrogenase (decarboxylating),
                     mitochondrial"
                     /protein_id="NP_001402873.1"
                     /db_xref="GeneID:309312"
                     /db_xref="RGD:1308660"
                     /translation="MQLCARAWGLRLGPGAGGGHRLARGTGLSWAPRSRDSSSGGGGG
                     GGDRGAAGASRLLERLLPRHDDFARRHIGPGDKDRREMLQALGLASIDELIEKTVPAS
                     IRLKRPLKLEDPVCENEILETLHAIASKNQIWRSYIGMGYYNCSVPQTILRNLLENSG
                     WVTQYTPYQPEVSQGRLESLLNYQTMVSDITGLDMANASLLDEATAAAEAMQLCHRHN
                     KRKRFFIDPRCHPQTIAVVQTRAKYRGVIVELKLPHEMDFSGKDVSGVLFQYPDTEGK
                     VEDFTELVERAHQTGSLTCCATDLLALCILRPPGEFGVDIALGNSQRFGVPLGYGGPH
                     AAFFAVRESLVRMMPGRMVGVTRDATGKEVYRLALQTREQHIRRDKATSNICTAQALL
                     ANMAAMFAIYHGSHGLQHIAKRVHNATLILSEGLKRAGHQLQHDLFFDTLKVQCGCSL
                     KEVLGRAAQRQINFRLFDDGTLGISLDETVTEKDLDDLLWIFGCESSTELVAEGMGEE
                     WRGLLGSSFKRTSPFLTHQVFNSYHSETNLVRYMKKLENKDISLVHSMIPLGSCTMKL
                     NSSSELTPITWREFANIHPFVPLDQAQGYQQLFQELEKDLCELTGYDRVSFQPNSGAQ
                     GEYAGLATIRAYLDQKGERHRTVCLIPKSAHGTNPASAYMAGMKIQPVEVDRYGNIDV
                     AHLKAMVDKHKENLAAIMITYPSTNGVFEENISDVCALIHQHGGQVYLDGANMNAQVG
                     ICRPGDFGSDVSHLNLHKTFCIPHGGGGPGMGPIGVKKHLVPFLPSHPIVCLKPNEDT
                     WPVGTVSAAPWGSSSILPISWAYIKMMGGKGLKEATEIAILNANYMAKRLERYYRVLF
                     RGARGYVAHEFILDTRPFKKSANIEAVDVAKRLQDYGFHAPTMSWPVAGTLMIEPTES
                     EDKAELDRFCDAMISIRQEIADIEEGRIDPRVNPLKMSPHSLTCVTSSRWDRPYSREV
                     AAFPLPFVKPENKFWPTIARIDDIYGDQHLVCTCPPMEVYESPFSEQKRASS"
     exon            468..546
                     /gene="Gldc"
                     /inference="alignment:Splign:2.1.0"
     exon            547..682
                     /gene="Gldc"
                     /inference="alignment:Splign:2.1.0"
     exon            683..847
                     /gene="Gldc"
                     /inference="alignment:Splign:2.1.0"
     exon            848..925
                     /gene="Gldc"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1073
                     /gene="Gldc"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1270
                     /gene="Gldc"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1367
                     /gene="Gldc"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1473
                     /gene="Gldc"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1613
                     /gene="Gldc"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1694
                     /gene="Gldc"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1792
                     /gene="Gldc"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1877
                     /gene="Gldc"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..1919
                     /gene="Gldc"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2062
                     /gene="Gldc"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2138
                     /gene="Gldc"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2264
                     /gene="Gldc"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2414
                     /gene="Gldc"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..2527
                     /gene="Gldc"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2669
                     /gene="Gldc"
                     /inference="alignment:Splign:2.1.0"
     exon            2670..2781
                     /gene="Gldc"
                     /inference="alignment:Splign:2.1.0"
     exon            2782..2877
                     /gene="Gldc"
                     /inference="alignment:Splign:2.1.0"
     exon            2878..3050
                     /gene="Gldc"
                     /inference="alignment:Splign:2.1.0"
     exon            3051..3131
                     /gene="Gldc"
                     /inference="alignment:Splign:2.1.0"
     exon            3132..3799
                     /gene="Gldc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagggaggag gaactttgcc ggagttagtg cagttcgctg cacccattca ttgcccgcaa
       61 gtccccgtcc tccggtccgg cccacagtgg tcagggaggg aatccacgga ctgcagcggc
      121 cactcgcggg gcattggggc cagaggaggg ccggagagcg ccgctgaccc tcgtggactg
      181 ggaaggaggt gacggcgtcc atgcagctgt gtgccagggc atgggggctg cgcttgggcc
      241 ctggagccgg gggcggccac cgcctggctc ggggcaccgg cttgagttgg gcgccgcgga
      301 gccgggacag cagcagcggc ggtggcggcg gtggcgggga ccgcggcgcg gctggggcct
      361 cgcgcctcct ggagcgcctc ctgcccagac acgatgactt cgctcggaga cacatcggcc
      421 cgggagacaa agaccggagg gagatgctgc aggcgctggg gctggcgagc attgatgaac
      481 tcatcgagaa aaccgtcccc gccagcatcc gcttgaagag acccttgaaa ctggaagacc
      541 ctgtatgtga gaatgagatc ctggaaactc tgcatgccat tgcaagcaaa aaccagatct
      601 ggagatccta tattggcatg ggctactata actgctcggt gccccagacc attctgcgga
      661 acttactgga gaattctgga tgggtcactc agtacactcc gtatcagccc gaggtgtctc
      721 aggggaggtt ggagagttta ctcaactacc agaccatggt gtctgacatc acaggcttgg
      781 acatggccaa tgcctcccta ctggatgagg cgacggcggc cgcagaggca atgcaactgt
      841 gtcacagaca caacaagagg aagagatttt tcattgatcc tcgttgccac ccacagacaa
      901 tagctgtcgt ccagactcga gccaaatata ggggggtgat tgtcgagctg aagttacccc
      961 acgaaatgga tttcagtggc aaagatgtca gtggggtgct gttccagtac ccagacactg
     1021 aggggaaggt ggaggacttc acggaacttg tagaaagagc ccatcagact gggagcctga
     1081 cctgctgtgc tactgacctt ttagctctgt gtattttgag gccacctgga gagtttggag
     1141 tggacattgc cctgggcaac tcccagagat ttggagtacc acttggctat gggggaccac
     1201 acgcagcctt ttttgctgtc agagaaagtc tggtgaggat gatgcctgga aggatggtgg
     1261 gggtgacaag ggatgccacg gggaaagaag tgtatcgcct tgctcttcag accagagaac
     1321 aacacatccg gagagacaaa gccaccagca acatctgcac cgctcaggcc ctgttagcca
     1381 acatggccgc catgtttgcc atttaccatg gatcccatgg gcttcagcac attgccaaaa
     1441 gagttcataa tgctactttg attttgtctg aaggtctcaa gcgagcggga caccaactcc
     1501 agcacgacct gttctttgac actttgaagg ttcagtgtgg ctgctcactg aaggaggtgt
     1561 tgggcagagc agctcagagg caaatcaact ttcgactctt cgatgacggc acacttggca
     1621 tttctttgga tgaaacagtc actgagaaag atctggatga tttactgtgg atctttggct
     1681 gtgagtcatc caccgaattg gttgctgaag gcatgggaga ggaatggagg ggtcttctag
     1741 ggtcttcatt caagagaacc agcccgttcc tcactcatca ggtgttcaac agctaccact
     1801 cagaaaccaa tcttgttcga tatatgaaga aactggagaa caaggacatc tccctcgttc
     1861 acagcatgat tccactggga tcctgcacca tgaagctcaa tagctcatct gaactcacgc
     1921 ccatcacctg gagagaattt gccaacatcc acccctttgt gccactggac caggcccagg
     1981 gataccagca gcttttccaa gagcttgaga aggatctgtg tgagctcacg gggtatgacc
     2041 gagtctcatt ccagccaaac agtggagcgc agggggagta tgctggcctg gccaccatcc
     2101 gagcgtactt agaccagaaa ggagagaggc acagaacggt ttgtctcatt cctaagtcag
     2161 cacatggaac gaatccagca agtgcctaca tggccggcat gaagatccag cctgtggagg
     2221 tggacagata cgggaacatc gatgtcgctc acctcaaggc catggtggat aagcacaagg
     2281 agaacctggc cgccatcatg atcacgtatc catctaccaa tggtgtgttt gaagagaaca
     2341 tcagtgatgt gtgcgccctg attcaccaac atggaggaca ggtctacctc gacggggcaa
     2401 acatgaatgc ccaggtgggg atctgccgtc ctggagactt tgggtctgat gtctctcacc
     2461 taaatcttca caagaccttc tgcattcccc atggaggagg tggtcctggc atggggccca
     2521 tcggagtgaa gaagcatctt gtgccttttc tgcccagcca tcccattgtt tgcctaaaac
     2581 caaatgagga cacctggcct gtggggactg tcagtgcggc cccatggggc tccagctcca
     2641 tcttgcccat ctcatgggct tatattaaga tgatgggggg aaagggtctc aaagaggcca
     2701 cagaaatcgc cattctaaat gccaactaca tggccaaacg attagagaga tactacagag
     2761 tcctcttcag aggtgcaaga gggtacgtgg ctcatgaatt cattttggac acacgaccct
     2821 tcaaaaaatc tgccaacatc gaggctgtgg atgttgccaa gaggctccag gattacggat
     2881 tccatgcccc taccatgtcc tggcccgtgg cagggaccct catgattgag cccaccgagt
     2941 cggaagacaa ggccgagttg gacagattct gtgatgctat gatcagcatc cggcaggaaa
     3001 tcgcggacat agaggagggc cgcatcgacc cacgggtcaa ccccctgaag atgtctccac
     3061 actccttgac ctgtgtcaca tcctcccgct gggatcgccc atattccaga gaggtggcag
     3121 catttcctct gccctttgtg aaaccagaga acaaattctg gccaaccatt gctcggatcg
     3181 acgacatcta cggagatcag cacctcgtct gcacctgccc acccatggag gtctacgagt
     3241 ctccgttttc tgaacagaaa agggcctctt cttagtcctt cctccccagg ttcaaaggac
     3301 tgactggacg tctcctgctg cagcatttga caagcaagga catttcttct ccttcatgtg
     3361 gctcacatga gttttatacg ctgtctattt ttataatctt tcaaggtaat gtaaacacgg
     3421 ttggcatggt gagtggcggc tgcctgcagt acggcgaggc ggccgctctt cctattgcct
     3481 tgattgggag ccatttagtt tactgaatag aaaatttggg gtgtgctagc catcttaacc
     3541 ttttaattca agaatctgca gaggtcagag cctatgctgg gaattcaata gacattcttt
     3601 tttgttccaa ataagtcctt gtggactgtg gtctctgtgg gaaaccccag ggcaaatgtt
     3661 tacattttgt atacactgac aagttcttcc tcactaatgt gcctgatctg tcacagcatt
     3721 caagtgtctt cctttcactg tgtggatttt tttttttatc tgcttttatt agcattctaa
     3781 taaaactgag tttgaataa
//
