LOCUS       NM_001108192            2825 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus galactosidase, beta 1 (Glb1), mRNA.
ACCESSION   NM_001108192 XM_001076727 XM_236675
VERSION     NM_001108192.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2825)
  AUTHORS   Herrmann,J., Babic,M., Tolle,M., Eckardt,K.U., van der Giet,M. and
            Schuchardt,M.
  TITLE     A Novel Protocol for Detection of Senescence and Calcification
            Markers by Fluorescence Microscopy
  JOURNAL   Int J Mol Sci 21 (10), 3475 (2020)
   PUBMED   32423114
  REMARK    GeneRIF: A Novel Protocol for Detection of Senescence and
            Calcification Markers by Fluorescence Microscopy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2825)
  AUTHORS   Danyukova,T., Ariunbat,K., Thelen,M., Brocke-Ahmadinejad,N.,
            Mole,S.E. and Storch,S.
  TITLE     Loss of CLN7 results in depletion of soluble lysosomal proteins and
            impaired mTOR reactivation
  JOURNAL   Hum Mol Genet 27 (10), 1711-1722 (2018)
   PUBMED   29514215
REFERENCE   3  (bases 1 to 2825)
  AUTHORS   Bidchol,A.M., Dalal,A., Trivedi,R., Shukla,A., Nampoothiri,S.,
            Sankar,V.H., Danda,S., Gupta,N., Kabra,M., Hebbar,S.A., Bhat,R.Y.,
            Matta,D., Ekbote,A.V., Puri,R.D., Phadke,S.R., Gowrishankar,K.,
            Aggarwal,S., Ranganath,P., Sharda,S., Kamate,M., Datar,C.A.,
            Bhat,K., Kamath,N., Shah,H., Krishna,S., Gopinath,P.M., Verma,I.C.,
            Nagarajaram,H.A., Satyamoorthy,K. and Girisha,K.M.
  TITLE     Recurrent and novel GLB1 mutations in India
  JOURNAL   Gene 567 (2), 173-181 (2015)
   PUBMED   25936995
REFERENCE   4  (bases 1 to 2825)
  AUTHORS   Weismann,C.M., Ferreira,J., Keeler,A.M., Su,Q., Qui,L.,
            Shaffer,S.A., Xu,Z., Gao,G. and Sena-Esteves,M.
  TITLE     Systemic AAV9 gene transfer in adult GM1 gangliosidosis mice
            reduces lysosomal storage in CNS and extends lifespan
  JOURNAL   Hum Mol Genet 24 (15), 4353-4364 (2015)
   PUBMED   25964428
REFERENCE   5  (bases 1 to 2825)
  AUTHORS   Suzuki,H., Ohto,U., Higaki,K., Mena-Barragan,T.,
            Aguilar-Moncayo,M., Ortiz Mellet,C., Nanba,E., Garcia
            Fernandez,J.M., Suzuki,Y. and Shimizu,T.
  TITLE     Structural basis of pharmacological chaperoning for human
            beta-galactosidase
  JOURNAL   J Biol Chem 289 (21), 14560-14568 (2014)
   PUBMED   24737316
REFERENCE   6  (bases 1 to 2825)
  AUTHORS   Yasue,M., Serikawa,T. and Yamada,J.
  TITLE     Chromosomal assignments of 23 biochemical loci of the rat by using
            rat x mouse somatic cell hybrids
  JOURNAL   Cytogenet Cell Genet 57 (2-3), 142-148 (1991)
   PUBMED   1914521
REFERENCE   7  (bases 1 to 2825)
  AUTHORS   Leeper,L.L. and Henning,S.J.
  TITLE     Hormonal control of postnatal development of ileal neuraminidase
            and acid beta-galactosidase
  JOURNAL   Biol Neonate 44 (1), 28-35 (1983)
   PUBMED   6411136
REFERENCE   8  (bases 1 to 2825)
  AUTHORS   Jumawan,J., Celano,P., Horowitz,C., Lau,H. and Koldovsky,O.
  TITLE     Effect of cortisone or L-triiodothyronine administration to
            pregnant rats on the activity of fetal intestinal disaccharidases
            and lysosomal acid beta-galactosidase
  JOURNAL   Biol Neonate 32 (3-4), 211-217 (1977)
   PUBMED   414795
REFERENCE   9  (bases 1 to 2825)
  AUTHORS   Majumder,G.C. and Turkington,R.W.
  TITLE     Acrosomal and lysosomal isoenzymes of beta-galactosidase and
            N-acetyl-beta-glucosaminidase in rat testis
  JOURNAL   Biochemistry 13 (14), 2857-2864 (1974)
   PUBMED   4407614
REFERENCE   10 (bases 1 to 2825)
  AUTHORS   Felton,J., Meisler,M. and Paigen,K.
  TITLE     A locus determining beta-galactosidase activity in the mouse
  JOURNAL   J Biol Chem 249 (10), 3267-3272 (1974)
   PUBMED   4830244
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001108192.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.30228.1,
                                           SRR26643289.24427.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               JAXUCZ010000008.1  122963718-122963871
            155-324             JAXUCZ010000008.1  122978634-122978803
            325-475             JAXUCZ010000008.1  122981916-122982066
            476-536             JAXUCZ010000008.1  122982876-122982936
            537-631             JAXUCZ010000008.1  122984999-122985093
            632-812             JAXUCZ010000008.1  122991611-122991791
            813-871             JAXUCZ010000008.1  122994349-122994407
            872-993             JAXUCZ010000008.1  122997623-122997744
            994-1034            JAXUCZ010000008.1  122997825-122997865
            1035-1147           JAXUCZ010000008.1  123003658-123003770
            1148-1222           JAXUCZ010000008.1  123011269-123011343
            1223-1312           JAXUCZ010000008.1  123014640-123014729
            1313-1429           JAXUCZ010000008.1  123016984-123017100
            1430-1561           JAXUCZ010000008.1  123020436-123020567
            1562-1816           JAXUCZ010000008.1  123023889-123024143
            1817-2825           JAXUCZ010000008.1  123035318-123036326
FEATURES             Location/Qualifiers
     source          1..2825
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2825
                     /gene="Glb1"
                     /note="galactosidase, beta 1"
                     /db_xref="GeneID:316033"
                     /db_xref="RGD:1597145"
     exon            1..154
                     /gene="Glb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..2020
                     /gene="Glb1"
                     /EC_number="3.2.1.23"
                     /note="beta-galactosidase"
                     /codon_start=1
                     /product="beta-galactosidase precursor"
                     /protein_id="NP_001101662.1"
                     /db_xref="GeneID:316033"
                     /db_xref="RGD:1597145"
                     /translation="MFRVPLCMLLPLLALLQLLGAAHSFYNVSQRTFELDYKRDRFLK
                     DGQPFRYISGSIHYFRIPRFYWEDRLLKMKMAGLDAIQTYVPWNFHEPQPGQYDFSGD
                     RDVEHFIQLAHQLGLLVILRPGPYICAEWDMGGLPAWLLEKESIVLRSSDPDYLAAVD
                     KWLAVLLPKMKRLLYQNGGPIITVQVENEYGSYFACDYNYLRFLEHRFRYHLGNDIIL
                     FTTDGAAEKLLKCGTLQDLYATVDFGTTGNITRAFLIQRNFEPKGPLINSEFYTGWLD
                     HWGQPHSKVNTKKLVASLYNLLAYGASVNLYMFIGGTNFAYWNGANMPYAPQPTSYDY
                     DAPLSEAGDLTEKYFAVRDVIRKFKEVPEGPIPPSTPKFAYGKVALRKFKTVTEALGI
                     LCPNGPVKSLYPLTFTQVKQYFGYVLYRTTLPQDCSNPKPIFSSPINGVRDRAYVSVD
                     GVPQGILDRNRMNVLNIRGKAGATLDILVENMGRVNYGNSIKDFKGLISNMTLNFTVL
                     TNWTMFPLDTEALARSHLGNWEAADEGHLDGHSTLRSSNFTLPTFYVGNFSIPSGIPD
                     LPQDTFIQFPGWAKGQVWINGFNLGRYWPTKGPQMTLFVPRNILTTSAPNNITVLELE
                     SSPCSNGTLELCTVEFVDTPVIG"
     exon            155..324
                     /gene="Glb1"
                     /inference="alignment:Splign:2.1.0"
     exon            325..475
                     /gene="Glb1"
                     /inference="alignment:Splign:2.1.0"
     exon            476..536
                     /gene="Glb1"
                     /inference="alignment:Splign:2.1.0"
     exon            537..631
                     /gene="Glb1"
                     /inference="alignment:Splign:2.1.0"
     exon            632..812
                     /gene="Glb1"
                     /inference="alignment:Splign:2.1.0"
     exon            813..871
                     /gene="Glb1"
                     /inference="alignment:Splign:2.1.0"
     exon            872..993
                     /gene="Glb1"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1034
                     /gene="Glb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1147
                     /gene="Glb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1222
                     /gene="Glb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1312
                     /gene="Glb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1429
                     /gene="Glb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1561
                     /gene="Glb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1816
                     /gene="Glb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..2825
                     /gene="Glb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcagtaacc cccggaggtg gagcggctgg ccagagcgcc cactgcagag tggagcggtc
       61 ccatcgcggc gccgtcatgt tccgggtccc cctgtgtatg ctgctcccgc tcctggcgct
      121 cctgcagttg ctgggcgctg cgcacagttt ctataatgtc tcccagagga catttgagct
      181 ggactacaaa cgggaccgct tcctcaagga tgggcagcca ttccgctaca tctcgggaag
      241 cattcactac ttccggatac cccgattcta ctgggaggac cggctgctaa agatgaagat
      301 ggctgggctg gatgcaatcc agacgtacgt gccctggaac ttccatgaac cccagccagg
      361 acaatatgac ttttctgggg accgtgatgt ggaacatttc attcagctgg ctcaccagct
      421 gggactcctg gtgatcctga ggcctgggcc ctacatctgt gcagagtggg acatgggggg
      481 cttacccgct tggttactag agaaagaatc gatcgttctc cggtcttccg acccagatta
      541 ccttgcagct gtggataaat ggctggcagt ccttctgccc aagatgaagc gtctgctcta
      601 ccagaacgga gggcccatca taaccgtgca ggttgagaat gagtacgggt cctacttcgc
      661 ctgcgattat aactacctgc gtttcctgga gcaccgcttc cgctaccatt tgggtaacga
      721 catcattctc ttcaccactg acggagcagc tgaaaaatta ctcaagtgtg ggaccctgca
      781 ggacctctac gccacagtgg attttggaac aaccggcaat atcacacgag ctttcctgat
      841 ccagaggaat tttgaaccca aaggaccttt gatcaattct gagttctata ctggctggtt
      901 agaccactgg ggtcaacccc attccaaagt gaatactaag aagttggtgg cctccctcta
      961 taacctgctt gcctacgggg ccagcgtgaa cttgtacatg tttataggtg ggaccaattt
     1021 tgcctattgg aatggtgcca acatgcccta tgccccacag ccaaccagct atgactatga
     1081 cgccccactg agcgaggcag gagacctcac tgagaagtac ttcgcagtac gagatgtcat
     1141 tcggaagttt aaagaagtcc cagaaggccc tatccctcca tctacaccca agttcgcata
     1201 tggaaaagtt gctctgagaa agttcaagac ggtgacggaa gctctgggta tactgtgtcc
     1261 caacgggccc gtgaaaagcc tctacccctt gacgttcact caggtaaaac agtattttgg
     1321 gtatgtgcta taccgaacga cacttcctca agattgcagt aacccgaaac ccattttctc
     1381 ttcacccata aatggtgtcc gtgatcgggc ctacgtctct gtggacgggg tcccccaagg
     1441 aatccttgat cgaaaccgta tgaacgttct gaacattcgg gggaaggccg gagccacgct
     1501 agacattctg gtggagaaca tggggcgtgt gaactatggc aactccatca aagactttaa
     1561 gggtttgatt tccaacatga ccctcaactt cactgtcctc accaactgga caatgttccc
     1621 actggacact gaggccctgg cacgcagcca tcttgggaac tgggaggccg ctgatgaggg
     1681 tcacctcgat ggacactcga ccttacgttc ttcaaatttc acactcccca ccttttacgt
     1741 gggcaacttc tccatcccct cgggcatccc agacctgccg caggacacct tcatccagtt
     1801 tcccggatgg gccaagggcc aagtatggat caatggcttt aacctcgggc gatactggcc
     1861 cacaaagggc ccacaaatga ccttgtttgt gccaaggaac atcctgacca cttcagcccc
     1921 aaacaacatc acagtgctag aactggagtc gtcaccctgc agtaatggga ccctagagct
     1981 atgtacagta gagtttgttg acactccggt tattggctga cctcagtggc cattttccag
     2041 gccagtctgg tcaagactca gggctgaccc gcctgcgacg actgatcctc tgggcacaca
     2101 accctactct tgctacgtgg accaccctta tggtacagaa ttgtggaatg tgtgtatcct
     2161 gctggtgact gcagccctgc cttgcctgac cacccaccct cgtggccacc aggaaggctg
     2221 aagagagtgg ataccatagg aatacacagc tggtgtgccg agttggaaca aaacttgaat
     2281 aatgtccctt attctgactt gaaataatca tgtctttctg atgaataaaa tttgaatgca
     2341 agctgtggtc ttcctgtcat tagtgtatca ggcaggtatt aaactctgag gtctgactta
     2401 aatctcaact agacttgagt gggctgggtg aagccacttc actagcttga gattcaaagt
     2461 gggtaggaga gagtgctggt ttaggctagc agagggcttc gtttttgatc ccggtttgac
     2521 tgtttctgaa tctctgtgat atctacgagg tgagacatct ccagttacaa accacctaag
     2581 agattaacag ttgctcaaag taggtgctgc ggtctctctt tacagttaag tagaagtgtg
     2641 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtt catgtatgta tggagatgca
     2701 tgtgtattta catgtatttg tgcaggtcaa aggcccatct ttggcccatt tctcaggact
     2761 gccttagtgt ctaggaacat acggaatgta taaaatgtaa ttctgcttat gtttgagacg
     2821 ctgtc
//
