LOCUS       NP_001101662             647 aa            linear   ROD 01-APR-2024
DEFINITION  beta-galactosidase precursor [Rattus norvegicus].
ACCESSION   NP_001101662 XP_001076727 XP_236675
VERSION     NP_001101662.1
DBSOURCE    REFSEQ: accession NM_001108192.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 647)
  AUTHORS   Herrmann,J., Babic,M., Tolle,M., Eckardt,K.U., van der Giet,M. and
            Schuchardt,M.
  TITLE     A Novel Protocol for Detection of Senescence and Calcification
            Markers by Fluorescence Microscopy
  JOURNAL   Int J Mol Sci 21 (10), 3475 (2020)
   PUBMED   32423114
  REMARK    GeneRIF: A Novel Protocol for Detection of Senescence and
            Calcification Markers by Fluorescence Microscopy.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 647)
  AUTHORS   Danyukova,T., Ariunbat,K., Thelen,M., Brocke-Ahmadinejad,N.,
            Mole,S.E. and Storch,S.
  TITLE     Loss of CLN7 results in depletion of soluble lysosomal proteins and
            impaired mTOR reactivation
  JOURNAL   Hum Mol Genet 27 (10), 1711-1722 (2018)
   PUBMED   29514215
REFERENCE   3  (residues 1 to 647)
  AUTHORS   Bidchol,A.M., Dalal,A., Trivedi,R., Shukla,A., Nampoothiri,S.,
            Sankar,V.H., Danda,S., Gupta,N., Kabra,M., Hebbar,S.A., Bhat,R.Y.,
            Matta,D., Ekbote,A.V., Puri,R.D., Phadke,S.R., Gowrishankar,K.,
            Aggarwal,S., Ranganath,P., Sharda,S., Kamate,M., Datar,C.A.,
            Bhat,K., Kamath,N., Shah,H., Krishna,S., Gopinath,P.M., Verma,I.C.,
            Nagarajaram,H.A., Satyamoorthy,K. and Girisha,K.M.
  TITLE     Recurrent and novel GLB1 mutations in India
  JOURNAL   Gene 567 (2), 173-181 (2015)
   PUBMED   25936995
REFERENCE   4  (residues 1 to 647)
  AUTHORS   Weismann,C.M., Ferreira,J., Keeler,A.M., Su,Q., Qui,L.,
            Shaffer,S.A., Xu,Z., Gao,G. and Sena-Esteves,M.
  TITLE     Systemic AAV9 gene transfer in adult GM1 gangliosidosis mice
            reduces lysosomal storage in CNS and extends lifespan
  JOURNAL   Hum Mol Genet 24 (15), 4353-4364 (2015)
   PUBMED   25964428
REFERENCE   5  (residues 1 to 647)
  AUTHORS   Suzuki,H., Ohto,U., Higaki,K., Mena-Barragan,T.,
            Aguilar-Moncayo,M., Ortiz Mellet,C., Nanba,E., Garcia
            Fernandez,J.M., Suzuki,Y. and Shimizu,T.
  TITLE     Structural basis of pharmacological chaperoning for human
            beta-galactosidase
  JOURNAL   J Biol Chem 289 (21), 14560-14568 (2014)
   PUBMED   24737316
REFERENCE   6  (residues 1 to 647)
  AUTHORS   Yasue,M., Serikawa,T. and Yamada,J.
  TITLE     Chromosomal assignments of 23 biochemical loci of the rat by using
            rat x mouse somatic cell hybrids
  JOURNAL   Cytogenet Cell Genet 57 (2-3), 142-148 (1991)
   PUBMED   1914521
REFERENCE   7  (residues 1 to 647)
  AUTHORS   Leeper,L.L. and Henning,S.J.
  TITLE     Hormonal control of postnatal development of ileal neuraminidase
            and acid beta-galactosidase
  JOURNAL   Biol Neonate 44 (1), 28-35 (1983)
   PUBMED   6411136
REFERENCE   8  (residues 1 to 647)
  AUTHORS   Jumawan,J., Celano,P., Horowitz,C., Lau,H. and Koldovsky,O.
  TITLE     Effect of cortisone or L-triiodothyronine administration to
            pregnant rats on the activity of fetal intestinal disaccharidases
            and lysosomal acid beta-galactosidase
  JOURNAL   Biol Neonate 32 (3-4), 211-217 (1977)
   PUBMED   414795
REFERENCE   9  (residues 1 to 647)
  AUTHORS   Majumder,G.C. and Turkington,R.W.
  TITLE     Acrosomal and lysosomal isoenzymes of beta-galactosidase and
            N-acetyl-beta-glucosaminidase in rat testis
  JOURNAL   Biochemistry 13 (14), 2857-2864 (1974)
   PUBMED   4407614
REFERENCE   10 (residues 1 to 647)
  AUTHORS   Felton,J., Meisler,M. and Paigen,K.
  TITLE     A locus determining beta-galactosidase activity in the mouse
  JOURNAL   J Biol Chem 249 (10), 3267-3272 (1974)
   PUBMED   4830244
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_236675.4, XP_001076727.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.30228.1,
                                           SRR26643289.24427.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..647
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     Protein         1..647
                     /product="beta-galactosidase precursor"
                     /EC_number="3.2.1.23"
                     /note="beta-galactosidase"
                     /calculated_mol_wt=70625
     sig_peptide     1..24
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2621
     Region          41..356
                     /region_name="Glyco_hydro_35"
                     /note="Glycosyl hydrolases family 35; pfam01301"
                     /db_xref="CDD:396048"
     Region          <553..621
                     /region_name="BetaGal_dom4_5"
                     /note="Beta-galactosidase jelly roll domain; pfam13364"
                     /db_xref="CDD:463857"
     CDS             1..647
                     /gene="Glb1"
                     /coded_by="NM_001108192.2:77..2020"
                     /db_xref="GeneID:316033"
                     /db_xref="RGD:1597145"
ORIGIN      
        1 mfrvplcmll pllallqllg aahsfynvsq rtfeldykrd rflkdgqpfr yisgsihyfr
       61 iprfywedrl lkmkmaglda iqtyvpwnfh epqpgqydfs gdrdvehfiq lahqlgllvi
      121 lrpgpyicae wdmgglpawl lekesivlrs sdpdylaavd kwlavllpkm krllyqnggp
      181 iitvqveney gsyfacdyny lrflehrfry hlgndiilft tdgaaekllk cgtlqdlyat
      241 vdfgttgnit rafliqrnfe pkgplinsef ytgwldhwgq phskvntkkl vaslynllay
      301 gasvnlymfi ggtnfaywng anmpyapqpt sydydaplse agdltekyfa vrdvirkfke
      361 vpegpippst pkfaygkval rkfktvteal gilcpngpvk slypltftqv kqyfgyvlyr
      421 ttlpqdcsnp kpifssping vrdrayvsvd gvpqgildrn rmnvlnirgk agatldilve
      481 nmgrvnygns ikdfkglisn mtlnftvltn wtmfpldtea larshlgnwe aadeghldgh
      541 stlrssnftl ptfyvgnfsi psgipdlpqd tfiqfpgwak gqvwingfnl grywptkgpq
      601 mtlfvprnil ttsapnnitv lelesspcsn gtlelctvef vdtpvig
//
