LOCUS       NM_001108820            2151 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Rattus norvegicus galactosidase, alpha (Gla), mRNA.
ACCESSION   NM_001108820 XM_001068735 XM_343817
VERSION     NM_001108820.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2151)
  AUTHORS   Burand,A.J. Jr., Waltz,T.B., Manis,A.D., Hodges,M.R. and
            Stucky,C.L.
  TITLE     HomeCageScan analysis reveals ongoing pain in Fabry rats
  JOURNAL   Neurobiol Pain 13, 100113 (2023)
   PUBMED   36660199
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2151)
  AUTHORS   Waltz,T.B., Burand,A.J. Jr., Sadler,K.E. and Stucky,C.L.
  TITLE     Sensory-specific peripheral nerve pathology in a rat model of Fabry
            disease
  JOURNAL   Neurobiol Pain 10, 100074 (2021)
   PUBMED   34541380
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2151)
  AUTHORS   Kanack,A.J., Aoki,K., Tiemeyer,M. and Dahms,N.M.
  TITLE     Platelet and myeloid cell phenotypes in a rat model of Fabry
            disease
  JOURNAL   FASEB J 35 (8), e21818 (2021)
   PUBMED   34320241
REFERENCE   4  (bases 1 to 2151)
  AUTHORS   Miller,J.J., Aoki,K., Reid,C.A., Tiemeyer,M., Dahms,N.M. and
            Kassem,I.S.
  TITLE     Rats deficient in alpha-galactosidase A develop ocular
            manifestations of Fabry disease
  JOURNAL   Sci Rep 9 (1), 9392 (2019)
   PUBMED   31253878
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2151)
  AUTHORS   Miller,J.J., Aoki,K., Mascari,C.A., Beltrame,A.K., Sokumbi,O.,
            North,P.E., Tiemeyer,M., Kriegel,A.J. and Dahms,N.M.
  TITLE     alpha-Galactosidase A-deficient rats accumulate glycosphingolipids
            and develop cardiorenal phenotypes of Fabry disease
  JOURNAL   FASEB J 33 (1), 418-429 (2019)
   PUBMED   29979634
  REMARK    GeneRIF: Alpha-Galactosidase A-deficient develop cardiorenal
            phenotypes of Fabry disease.
REFERENCE   6  (bases 1 to 2151)
  AUTHORS   Dean,K.J. and Sweeley,C.C.
  TITLE     Studies on human liver alpha-galactosidases. I. Purification of
            alpha-galactosidase A and its enzymatic properties with glycolipid
            and oligosaccharide substrates
  JOURNAL   J Biol Chem 254 (20), 9994-10000 (1979)
   PUBMED   39940
REFERENCE   7  (bases 1 to 2151)
  AUTHORS   Lusis,A.J. and West,J.D.
  TITLE     X-linked and autosomal genes controlling mouse alpha-galactosidase
            expression
  JOURNAL   Genetics 88 (2), 327-342 (1978)
   PUBMED   205481
REFERENCE   8  (bases 1 to 2151)
  AUTHORS   Adler,D.A., West,J.D. and Chapman,V.M.
  TITLE     Expression of alpha-galactosidase in preimplantation mouse embryos
  JOURNAL   Nature 267 (5614), 838-839 (1977)
   PUBMED   895843
REFERENCE   9  (bases 1 to 2151)
  AUTHORS   Francke,U., Lalley,P.A., Moss,W., Ivy,J. and Minna,J.D.
  TITLE     Gene mapping in Mus musculus by interspecific cell hybridization:
            assignment of the genes for tripeptidase-1 to chromosome 10,
            dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome
            12, and adenylate kinase-1 to chromosome 2
  JOURNAL   Cytogenet Cell Genet 19 (2-3), 57-84 (1977)
   PUBMED   198184
REFERENCE   10 (bases 1 to 2151)
  AUTHORS   Lusis,A.J. and West,J.D.
  TITLE     X-linked inheritance of a structural gene for alpha-galactosidase
            in Mus musculus
  JOURNAL   Biochem Genet 14 (9-10), 849-855 (1976)
   PUBMED   1008807
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM137073.1, FM104174.1, FM135509.1, FM134560.1, CR468644.1,
            FM128994.1 and FM042657.1.
            
            On Oct 8, 2014 this sequence version replaced NM_001108820.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-362               FM137073.1         1-362
            363-664             FM104174.1         361-662
            665-817             FM135509.1         207-359
            818-1226            FM134560.1         231-639
            1227-1236           CR468644.1         253-262             c
            1237-1867           FM128994.1         1-631
            1868-2151           FM042657.1         355-638
FEATURES             Location/Qualifiers
     source          1..2151
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq32"
     gene            1..2151
                     /gene="Gla"
                     /note="galactosidase, alpha"
                     /db_xref="GeneID:363494"
                     /db_xref="RGD:1589721"
     exon            1..208
                     /gene="Gla"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..1274
                     /gene="Gla"
                     /EC_number="3.2.1.22"
                     /note="alpha-galactosidase A"
                     /codon_start=1
                     /product="alpha-galactosidase A precursor"
                     /protein_id="NP_001102290.2"
                     /db_xref="GeneID:363494"
                     /db_xref="RGD:1589721"
                     /translation="MAMKLLSGDTPLVCELALRPLALVFWSILGARALDNGLARTPTM
                     GWLHWERFMCNLDCQEEPDACISEQLFMQMAELMVSDGWRDAGYEYLCIDDCWMAPER
                     DSKGRLQADPKRFPSGIKHLANYVHSKGLKLGIYADVGKKTCAGFPGSFGSYDIDAQT
                     FADWGIDLLKFDGCHCDSVVSLANGYKYMSLALNRTGRSIVYSCEWPLYLRPFHKPNY
                     TDIQYYCNHWRNFDDVYDSWESIKSILAWTVTHQKDIVEVAGPGGWNDPDMLVIGNFG
                     LSWDQQVTQMALWAIMAAPLLMSNDLRQISSQAKALLQNEDVIAINQDPLGKQGYCFR
                     KENEIEVWERPLSNLAWAVAVRNLQEIGGPRFYTIQISSLGRGLACNPGCIITQILPE
                     KVHLGFYEWPLTLKTRINPSGTVLLRLER"
     exon            209..383
                     /gene="Gla"
                     /inference="alignment:Splign:2.1.0"
     exon            384..561
                     /gene="Gla"
                     /inference="alignment:Splign:2.1.0"
     exon            562..653
                     /gene="Gla"
                     /inference="alignment:Splign:2.1.0"
     exon            654..815
                     /gene="Gla"
                     /inference="alignment:Splign:2.1.0"
     exon            816..1013
                     /gene="Gla"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..2151
                     /gene="Gla"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggatttctat ggccatgaag cttttgagcg gagatacacc gctggtctgt gagcttgcgc
       61 ttcgccccct ggctttagtt ttctggagca ttcttggggc cagagcattg gacaatggct
      121 tggcgcggac acctactatg ggctggctgc actgggaacg tttcatgtgc aaccttgact
      181 gccaagaaga gcctgatgcc tgcataagtg agcaactgtt catgcagatg gcagagctca
      241 tggtctctga tggctggagg gacgcgggtt atgaatacct ctgcatagat gactgctgga
      301 tggctcccga gagggattca aagggccggc ttcaggcaga tcccaagcgc tttcctagtg
      361 ggatcaaaca cctcgctaat tacgtccaca gcaaaggctt aaagctaggg atttatgcag
      421 atgttggcaa gaaaacctgt gcaggtttcc ctgggagctt tggatcctat gacattgatg
      481 cccagacatt tgctgactgg ggtatagatc tgctaaaatt tgatggttgt cactgtgaca
      541 gtgtggtatc cttggcgaat ggttacaagt acatgtcctt ggccttgaac aggactggca
      601 gaagtattgt gtactcctgt gagtggcctc tttatttgag accctttcat aagcctaatt
      661 atacagatat ccaatattac tgcaatcact ggagaaattt tgatgatgtt tatgattcct
      721 gggaaagcat aaagtctatc ttggcctgga cagtaactca ccagaaggac attgttgaag
      781 tcgccggacc agggggctgg aatgacccag acatgttagt gattggcaac tttggcctca
      841 gttgggacca gcaggtaaca cagatggccc tctgggctat catggcagct cctctactca
      901 tgtccaatga tctccgacaa atcagctctc aagccaaggc tctacttcag aatgaggatg
      961 taattgccat caaccaagac cccttgggca agcaggggta ctgttttaga aaggaaaacg
     1021 aaattgaggt ttgggaacgg ccactctcaa acctagcctg ggccgtggct gtgagaaacc
     1081 tgcaggagat tggtggacct cgtttttaca ccatccagat ttcttccctg ggtcgaggac
     1141 tagcctgcaa tcctggctgc atcatcactc agattctccc tgagaaagta catctaggct
     1201 tctatgaatg gcctttaacc ttaaaaactc gaataaatcc ctcaggtact gttttgcttc
     1261 ggttagaaag ataaactata ctatgttgga aggcagagat ctgcataagt gcccagtttt
     1321 cctaaagacc aaactattcc ctgcccttcc ctgtttcacc ttaggctttt gaaattaagt
     1381 gggtactcct gtgccaggca ctgtaacaga tgcttcctgt ctaccggttg attttaatca
     1441 tcacaacccc aaagcaggtg tttatccact ataatctgta cagctagatc agattaaaaa
     1501 aacttgattg tttttttttt aaatgtggtt caagtgtttt gcttttatgt atgagttcca
     1561 catgcatacc tggtgcccag gaagtcagaa gccggcacga aatcctctgg aactgaacct
     1621 gagacctctg taaagaacaa gtgctcttaa tcgctgagcc agctctctag cacctataac
     1681 caggattcag agctaagcca actagacaca aatcagtagg ggtacttggc atggactgct
     1741 tatagtctaa taaaaaggaa aaaaaatgaa aatctgtttc ctcagttaaa aactcatgta
     1801 cctaagttac tctaagatta gagtaagcca gcagtatatt ttagaaattt acaagcagtt
     1861 tcatttcaga aagctgaagc agaattgcca atgtggaaac cagtccagga tatgtaacag
     1921 aatcacaagc aaaatgatgt acctctgata ttctgaatgt gcaaaaacac ctgagatatt
     1981 gaaggggttg gatgaaaccc agtcacgggt gagagtcgag catgtaagca gtatggctgc
     2041 tctctgtgag gactcattcc cagtactcac atggaggcag aggactgcta acattagtcc
     2101 caggggatct gaccaccctt ttgagtcatt tgtagactag ttttactgct g
//
