LOCUS       NM_024381               4107 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Rattus norvegicus glycerol kinase (Gk), mRNA.
ACCESSION   NM_024381 XM_346874
VERSION     NM_024381.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4107)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 4107)
  AUTHORS   Parr,L.S., Sriram,G., Nazarian,R., Rahib,L. and Dipple,K.M.
  TITLE     The ATP-stimulated translocation promoter (ASTP) activity of
            glycerol kinase plays central role in adipogenesis
  JOURNAL   Mol Genet Metab 124 (4), 254-265 (2018)
   PUBMED   29960856
  REMARK    GeneRIF: To further elucidate the contributions of the enzymatic
            (phosphorylation) and alternative (ASTP) functions of GK in
            adipogenesis, we performed experiments on mammalian GK and E. coli
            GK. We determined that the ASTP function of GK (which is absent in
            E. coli GK) plays a greater role than the enzymatic activity in
            these processes.
REFERENCE   3  (bases 1 to 4107)
  AUTHORS   Kosuga,M., Henderson-MacLennan,N.K., Zhang,Y.H., Huang,B.L.,
            Dipple,K.M. and McCabe,E.R.
  TITLE     Glycerol homeostasis and metabolism in glycerol kinase carrier mice
  JOURNAL   Mol Genet Metab 103 (3), 297-299 (2011)
   PUBMED   21536471
REFERENCE   4  (bases 1 to 4107)
  AUTHORS   Sriram,G., Parr,L.S., Rahib,L., Liao,J.C. and Dipple,K.M.
  TITLE     Moonlighting function of glycerol kinase causes systems-level
            changes in rat hepatoma cells
  JOURNAL   Metab Eng 12 (4), 332-340 (2010)
   PUBMED   20399282
  REMARK    GeneRIF: This systems biology approach further emphasizes glucose
            kinase's essential role in central and lipid metabolism and
            experimentally verifies lucose kinase's alternative function of
            affecting glucocorticoid receptor transcription factor activity.
REFERENCE   5  (bases 1 to 4107)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 4107)
  AUTHORS   Okamoto,K., Hirano,H. and Isohashi,F.
  TITLE     Molecular cloning of rat liver glucocorticoid-receptor
            translocation promoter
  JOURNAL   Biochem Biophys Res Commun 193 (3), 848-854 (1993)
   PUBMED   8323560
REFERENCE   7  (bases 1 to 4107)
  AUTHORS   Walker,A.P., Muscatelli,F. and Monaco,A.P.
  TITLE     Isolation of the human Xp21 glycerol kinase gene by positional
            cloning
  JOURNAL   Hum Mol Genet 2 (2), 107-114 (1993)
   PUBMED   8499898
REFERENCE   8  (bases 1 to 4107)
  AUTHORS   Okamoto,K., Isohashi,F., Ueda,K. and Sakamoto,Y.
  TITLE     Properties of an adenosine triphosphate-stimulated factor that
            enhances the nuclear binding of activated glucocorticoid-receptor
            complex: binding to histone-agarose
  JOURNAL   Endocrinology 124 (2), 675-680 (1989)
   PUBMED   2912694
REFERENCE   9  (bases 1 to 4107)
  AUTHORS   Seltzer,W.K. and McCabe,E.R.
  TITLE     Human and rat adrenal glycerol kinase: subcellular distribution and
            bisubstrate kinetics
  JOURNAL   Mol Cell Biochem 62 (1), 43-50 (1984)
   PUBMED   6330523
REFERENCE   10 (bases 1 to 4107)
  AUTHORS   Jenkins,B.T. and Hajra,A.K.
  TITLE     Glycerol kinase and dihydroxyacetone kinase in rat brain
  JOURNAL   J Neurochem 26 (2), 377-385 (1976)
   PUBMED   3631
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            D16102.1, CO564445.1, CO557097.1 and JAXUCZ010000021.1.
            
            On Oct 12, 2007 this sequence version replaced NM_024381.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.21438.1,
                                           SRR26643429.59037.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1192              D16102.1           4-1195
            1193-1562           CO564445.1         326-695
            1563-1893           CO557097.1         245-575
            1894-4107           JAXUCZ010000021.1  54113311-54115524   c
FEATURES             Location/Qualifiers
     source          1..4107
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq21"
     gene            1..4107
                     /gene="Gk"
                     /gene_synonym="ASTP; Gyk"
                     /note="glycerol kinase"
                     /db_xref="GeneID:79223"
                     /db_xref="RGD:70893"
     exon            1..174
                     /gene="Gk"
                     /gene_synonym="ASTP; Gyk"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1671
                     /gene="Gk"
                     /gene_synonym="ASTP; Gyk"
                     /EC_number="2.7.1.30"
                     /note="glycerokinase; ATP:glycerol 3-phosphotransferase;
                     ATP-stimulated glucocorticoid-receptor translocation
                     promoter; ATP-stimulated glucocorticoid-receptor
                     translocaton promoter"
                     /codon_start=1
                     /product="glycerol kinase"
                     /protein_id="NP_077357.2"
                     /db_xref="GeneID:79223"
                     /db_xref="RGD:70893"
                     /translation="MAAAKKAVLGPLVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIK
                     QEFPREGWVEQDPKEILQSVYECIEKTCEKLGQLNIDISNIKAIGVSNQRETTVVWDK
                     LTGEPLYNAVVWLDLRTQSTVEKLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDN
                     VKKVQEAVEENRALFGTIDSWLIWSLTGGINGGVHCTDVTNASRTMLFNIHSLEWDKE
                     LCEFFGIPMEILPNVRSSSEIYGLMKAGALEGVPISGCLGDQSAALVGQMCFQDGQAK
                     NTYGTGCFLLCNTGHKCVFSEHGLLTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRD
                     NLGIIKSSEEIEKLAKEVGTSYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNKCHI
                     AFAALEAVCFQTREILDAMNRDCGIPLSHLQVDGGMTSNKILMQLQADILYIPVVKPS
                     MPETTALGAAMAAGAAEGVGVWSLEPEDLSAVTMERFEPQINAEESEIRYSTWKKAVM
                     KSIGWVTTQSPESGIP"
     exon            175..248
                     /gene="Gk"
                     /gene_synonym="ASTP; Gyk"
                     /inference="alignment:Splign:2.1.0"
     exon            249..355
                     /gene="Gk"
                     /gene_synonym="ASTP; Gyk"
                     /inference="alignment:Splign:2.1.0"
     exon            356..433
                     /gene="Gk"
                     /gene_synonym="ASTP; Gyk"
                     /inference="alignment:Splign:2.1.0"
     exon            434..510
                     /gene="Gk"
                     /gene_synonym="ASTP; Gyk"
                     /inference="alignment:Splign:2.1.0"
     exon            511..648
                     /gene="Gk"
                     /gene_synonym="ASTP; Gyk"
                     /inference="alignment:Splign:2.1.0"
     exon            649..758
                     /gene="Gk"
                     /gene_synonym="ASTP; Gyk"
                     /inference="alignment:Splign:2.1.0"
     exon            759..825
                     /gene="Gk"
                     /gene_synonym="ASTP; Gyk"
                     /inference="alignment:Splign:2.1.0"
     exon            826..861
                     /gene="Gk"
                     /gene_synonym="ASTP; Gyk"
                     /inference="alignment:Splign:2.1.0"
     exon            862..929
                     /gene="Gk"
                     /gene_synonym="ASTP; Gyk"
                     /inference="alignment:Splign:2.1.0"
     exon            930..972
                     /gene="Gk"
                     /gene_synonym="ASTP; Gyk"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1053
                     /gene="Gk"
                     /gene_synonym="ASTP; Gyk"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1132
                     /gene="Gk"
                     /gene_synonym="ASTP; Gyk"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1229
                     /gene="Gk"
                     /gene_synonym="ASTP; Gyk"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1314
                     /gene="Gk"
                     /gene_synonym="ASTP; Gyk"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1435
                     /gene="Gk"
                     /gene_synonym="ASTP; Gyk"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1579
                     /gene="Gk"
                     /gene_synonym="ASTP; Gyk"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1660
                     /gene="Gk"
                     /gene_synonym="ASTP; Gyk"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..4107
                     /gene="Gk"
                     /gene_synonym="ASTP; Gyk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccctccgct ctccctgctc cgccctccgc agccctccac agtcaccccg gagaccagcc
       61 ctgttaagct ctcggctctg aagctgactg atttccatgg cagccgcgaa gaaagcagtt
      121 ctggggccat tggtgggagc agtggaccag ggtaccagct cgacacgttt tttggttttc
      181 aattcaaaaa cagctgaact tcttagtcat catcaagtag aaataaaaca ggaattccca
      241 agagaaggat gggtagaaca agatccgaag gaaatcctgc agtctgttta tgaatgtata
      301 gagaaaacat gtgagaaact tggacagctc aatattgata tttccaacat caaagctatt
      361 ggtgtcagca accagaggga aaccacagta gtctgggaca agctaactgg agagccgctc
      421 tacaatgctg tggtgtggct tgacctaaga acccaatcta ctgttgagaa acttagtaaa
      481 agaattccgg gaaataataa ttttgtcaag tccaagacag gccttccact tagcacttac
      541 ttcagtgcag tgaaacttcg ttggctcctc gacaatgtga aaaaggtcca agaggctgtc
      601 gaagaaaata gagctctttt tgggaccatt gattcatggc ttatttggag tttgacaggg
      661 ggaatcaatg gcggtgttca ctgtacagat gtaacaaatg caagcaggac gatgcttttt
      721 aacattcatt ctttggaatg ggataaagag ctctgcgaat tttttggaat tccaatggaa
      781 attcttccca atgttcggag ttcttctgag atctatggcc taatgaaagc tggggccttg
      841 gaaggtgtgc caatatctgg gtgtttgggg gaccagtctg ctgctttggt gggacaaatg
      901 tgcttccagg atggacaggc caaaaacacg tatggaacag ggtgcttctt actgtgtaac
      961 acgggccata agtgtgtatt ttctgaacat ggccttttga caactgtggc ttataaactt
     1021 ggcagagaca aacctgtgta ttatgcatta gaaggttctg tagctatagc tggtgctgta
     1081 atccgctggt taagagacaa ccttggaatt attaagtcct ctgaagaaat tgaaaaactt
     1141 gctaaagaag taggtacttc ttatggctgc tactttgttc cagcattttc agggttatat
     1201 gcaccttatt gggagcctag tgcaagaggg atcatctgtg gactcactca gttcaccaat
     1261 aaatgtcata tcgcttttgc tgcattagaa gctgtttgtt ttcaaacccg agagattttg
     1321 gatgccatga accgtgactg tggaatccca ctcagccatt tgcaggtaga tggaggaatg
     1381 accagcaata aaattcttat gcagctacaa gcagacattc tgtatattcc agtagtgaag
     1441 ccctccatgc ccgagacaac tgctctagga gctgccatgg cagctggggc tgcagagggg
     1501 gttggtgtct ggagtcttga acctgaggat ttgtcagctg tcacaatgga gcggttcgaa
     1561 cctcagatca atgctgaaga aagtgaaatc cgttactcca cctggaagaa agctgtgatg
     1621 aagtccattg gttgggttac aactcaatct cctgaaagtg gtatcccata aataatacca
     1681 cctcatagaa tcccaagatg caagcccttt aacgtgatat gaaaatctga ctattctgtc
     1741 tcataatcta atgatactat tcatagactc tgatttttgc ccataaagca ctcgctgcat
     1801 gatcctccaa gcagacctat gccttgaaac aaagaaaatg cagcagaaag aatcctccag
     1861 aaacatttaa tatttttttt tgatattgac agttaagatt gggtcagtga cctttgggac
     1921 tgacccctgc ctccactctc atgatgccct atactattcc ccttaaggtc taggatgaat
     1981 ttgtatcctg tccattgaaa tgtgtcatcc agtatattcc agatgctgct ggcctaaact
     2041 tgtctgagga aggggttgtt actcacctct tcaaaatgag tggattcctg cttgtttgct
     2101 tttaacagct cagatgtctt ttctacatat tagaagacca caacaccact ggatatttca
     2161 atggaaacgt ctaaagcatt attggataat aacttgctat tcttgttgct tagacatttt
     2221 ctgtacagtg tttgccaaaa ttgaaatttt tcaggtgttt tacactgtct cactaattgt
     2281 catggcttca tggctttctg tctggatctt acagggatag atagaatact ttctttttct
     2341 gctttttttt tcattcctcc tttttatatt tttactctgt atgtataaca tacataccta
     2401 tatattttat atgctgaggg tagcccattt ttaaattaag agcacattat attcagtaag
     2461 ttataagagg gctggtctta agtggactac tatgtatata aatttgaggg gggcaagctg
     2521 tacacatttt tgggcaacgg ttatgcatat tatttaccag aagaaaaatt ttcttatcat
     2581 gaatttgaaa tttaagtatg tattcagtat caataaaata aaatgtactg tattgtaatt
     2641 tcaactatat ttcttatatt ctaccattta attatctcag ctggaagaaa agtaactgtg
     2701 gaatgtaaca gtaaatattc ttctcaaaac atgattctaa tccaaataaa attttttctt
     2761 tgaatttatg ttttccatat ttgagctcct attgaggaat taatcaaatt caaaagctaa
     2821 gtagaaaaat atgtgtgaat aaagccaata atatctccca aatgttatta ccaattaata
     2881 agatgttctt attttctggt atgatataaa attatctcta cttaatgtca taactggcaa
     2941 aaaaaaaact atcattgcaa atgcctccca gtgaaaccaa taacttctca aatatttaga
     3001 attattggtt ataactcact aacctagttt cctaacatca atttaaaatt tgatttatag
     3061 taaagaaata agaaaatgat gcttctaatt attttgtttt gtccttttgg aatggaaaat
     3121 attgatatat taatagaaaa agttttattt ggaattaatg gtagattata tttcttattc
     3181 tgattgtgct gctcctaatg attgaatttg ctggattttt actgatacag ctgccactta
     3241 agtgacataa atatagaaag gtactgtgaa attattatgg cagtgacact tttaagctta
     3301 actatatttc tacaaaggca gattgagttc attgtaaata attgtgtgaa tcactgttcc
     3361 agtaatttta aaataacatt aacttttcta caaaatggaa gatttataaa tgttggaaat
     3421 tgtacccatt gacaattaat ggtaaattta cttaaaataa atttacctct tatttcttat
     3481 tcgcatttct catttccaga tgaaagttca gtaaacagag atgtttcagc agacacaagt
     3541 caccttttaa cacttgttca catgcaccga ggagataatt agcagcagaa gtggtttctg
     3601 gaatgataaa cacctttaac cattcagata gaacagacta aacagtttct acctcagcat
     3661 tttcagaaaa tccattgtcg aggcccaagg ccattatcag tagagtctct ctagctgaga
     3721 ccaacatatc tgtaggcttc atctttcgcc tcacctctgt ctacctgagt tagtcaagga
     3781 ggtctgaaca cgactgctaa cactattgct ctttcatggt gatgccaaca tctccacatt
     3841 ttgttctcca attgatccat aaaacaaata gtgcattaat gcttcttcac tggtattctt
     3901 gtttttttga agcagggtct tgctatgtag tcctgcctgt cctgcaactc actatgtata
     3961 ccaagctggc cttgaattca tagagttctg cctgcctctg tttcttccaa ctgctggaat
     4021 taaagacata tgccaccatg cccaacgtca agagcgtcaa gtctttttaa aattttcttg
     4081 tggagtatta aaattaagta gctttta
//
