LOCUS       NP_077357                524 aa            linear   ROD 27-APR-2025
DEFINITION  glycerol kinase [Rattus norvegicus].
ACCESSION   NP_077357 XP_346875
VERSION     NP_077357.2
DBSOURCE    REFSEQ: accession NM_024381.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 524)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (residues 1 to 524)
  AUTHORS   Parr,L.S., Sriram,G., Nazarian,R., Rahib,L. and Dipple,K.M.
  TITLE     The ATP-stimulated translocation promoter (ASTP) activity of
            glycerol kinase plays central role in adipogenesis
  JOURNAL   Mol Genet Metab 124 (4), 254-265 (2018)
   PUBMED   29960856
  REMARK    GeneRIF: To further elucidate the contributions of the enzymatic
            (phosphorylation) and alternative (ASTP) functions of GK in
            adipogenesis, we performed experiments on mammalian GK and E. coli
            GK. We determined that the ASTP function of GK (which is absent in
            E. coli GK) plays a greater role than the enzymatic activity in
            these processes.
REFERENCE   3  (residues 1 to 524)
  AUTHORS   Kosuga,M., Henderson-MacLennan,N.K., Zhang,Y.H., Huang,B.L.,
            Dipple,K.M. and McCabe,E.R.
  TITLE     Glycerol homeostasis and metabolism in glycerol kinase carrier mice
  JOURNAL   Mol Genet Metab 103 (3), 297-299 (2011)
   PUBMED   21536471
REFERENCE   4  (residues 1 to 524)
  AUTHORS   Sriram,G., Parr,L.S., Rahib,L., Liao,J.C. and Dipple,K.M.
  TITLE     Moonlighting function of glycerol kinase causes systems-level
            changes in rat hepatoma cells
  JOURNAL   Metab Eng 12 (4), 332-340 (2010)
   PUBMED   20399282
  REMARK    GeneRIF: This systems biology approach further emphasizes glucose
            kinase's essential role in central and lipid metabolism and
            experimentally verifies lucose kinase's alternative function of
            affecting glucocorticoid receptor transcription factor activity.
REFERENCE   5  (residues 1 to 524)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (residues 1 to 524)
  AUTHORS   Okamoto,K., Hirano,H. and Isohashi,F.
  TITLE     Molecular cloning of rat liver glucocorticoid-receptor
            translocation promoter
  JOURNAL   Biochem Biophys Res Commun 193 (3), 848-854 (1993)
   PUBMED   8323560
REFERENCE   7  (residues 1 to 524)
  AUTHORS   Walker,A.P., Muscatelli,F. and Monaco,A.P.
  TITLE     Isolation of the human Xp21 glycerol kinase gene by positional
            cloning
  JOURNAL   Hum Mol Genet 2 (2), 107-114 (1993)
   PUBMED   8499898
REFERENCE   8  (residues 1 to 524)
  AUTHORS   Okamoto,K., Isohashi,F., Ueda,K. and Sakamoto,Y.
  TITLE     Properties of an adenosine triphosphate-stimulated factor that
            enhances the nuclear binding of activated glucocorticoid-receptor
            complex: binding to histone-agarose
  JOURNAL   Endocrinology 124 (2), 675-680 (1989)
   PUBMED   2912694
REFERENCE   9  (residues 1 to 524)
  AUTHORS   Seltzer,W.K. and McCabe,E.R.
  TITLE     Human and rat adrenal glycerol kinase: subcellular distribution and
            bisubstrate kinetics
  JOURNAL   Mol Cell Biochem 62 (1), 43-50 (1984)
   PUBMED   6330523
REFERENCE   10 (residues 1 to 524)
  AUTHORS   Jenkins,B.T. and Hajra,A.K.
  TITLE     Glycerol kinase and dihydroxyacetone kinase in rat brain
  JOURNAL   J Neurochem 26 (2), 377-385 (1976)
   PUBMED   3631
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            D16102.1, CO564445.1, CO557097.1 and JAXUCZ010000021.1.
            
            On Oct 12, 2007 this sequence version replaced NP_077357.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.21438.1,
                                           SRR26643429.59037.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..524
                     /organism="Rattus norvegicus"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq21"
     Protein         1..524
                     /product="glycerol kinase"
                     /EC_number="2.7.1.30"
                     /note="glycerokinase; ATP:glycerol 3-phosphotransferase;
                     ATP-stimulated glucocorticoid-receptor translocation
                     promoter; ATP-stimulated glucocorticoid-receptor
                     translocaton promoter"
                     /calculated_mol_wt=57332
     Region          11..510
                     /region_name="ASKHA_NBD_FGGY_GK1-3-like"
                     /note="nucleotide-binding domain (NBD) of metazoan
                     glycerol kinase 1-3 (GK1-3) and similar proteins; cd07792"
                     /db_xref="CDD:466802"
     CDS             1..524
                     /gene="Gk"
                     /gene_synonym="ASTP; Gyk"
                     /coded_by="NM_024381.2:97..1671"
                     /db_xref="GeneID:79223"
                     /db_xref="RGD:70893"
ORIGIN      
        1 maaakkavlg plvgavdqgt sstrflvfns ktaellshhq veikqefpre gwveqdpkei
       61 lqsvyeciek tceklgqlni disnikaigv snqrettvvw dkltgeplyn avvwldlrtq
      121 stveklskri pgnnnfvksk tglplstyfs avklrwlldn vkkvqeavee nralfgtids
      181 wliwsltggi nggvhctdvt nasrtmlfni hslewdkelc effgipmeil pnvrssseiy
      241 glmkagaleg vpisgclgdq saalvgqmcf qdgqakntyg tgcfllcntg hkcvfsehgl
      301 lttvayklgr dkpvyyaleg svaiagavir wlrdnlgiik sseeieklak evgtsygcyf
      361 vpafsglyap ywepsargii cgltqftnkc hiafaaleav cfqtreilda mnrdcgipls
      421 hlqvdggmts nkilmqlqad ilyipvvkps mpettalgaa maagaaegvg vwslepedls
      481 avtmerfepq inaeeseiry stwkkavmks igwvttqspe sgip
//
