LOCUS       NM_019281               1892 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus gap junction protein, delta 2 (Gjd2), mRNA.
ACCESSION   NM_019281
VERSION     NM_019281.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1892)
  AUTHORS   Singhal,P., Senecal,J.M.M. and Nagy,J.I.
  TITLE     Expression of the gap junction protein connexin36 in small
            intensely fluorescent (SIF) cells in cardiac parasympathetic
            ganglia of rodents
  JOURNAL   Neurosci Lett 793, 136989 (2023)
   PUBMED   36471528
  REMARK    GeneRIF: Expression of the gap junction protein connexin36 in small
            intensely fluorescent (SIF) cells in cardiac parasympathetic
            ganglia of rodents.
REFERENCE   2  (bases 1 to 1892)
  AUTHORS   Brown,C.A., Del Corsso,C., Zoidl,C., Donaldson,L.W., Spray,D.C. and
            Zoidl,G.
  TITLE     Tubulin-Dependent Transport of Connexin-36 Potentiates the Size and
            Strength of Electrical Synapses
  JOURNAL   Cells 8 (10), 1146 (2019)
   PUBMED   31557934
  REMARK    GeneRIF: Tubulin-dependent transport of Cx36 potentiates synaptic
            strength by delivering channels to Gap-junction plaques,
            reinforcing the role of protein transport at chemical and
            electrical synapses to fine-tune communication between neurons.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1892)
  AUTHORS   Wang,P., Wang,S.C., Li,D., Li,T., Yang,H.P., Wang,L., Wang,Y.F. and
            Parpura,V.
  TITLE     Role of Connexin 36 in Autoregulation of Oxytocin Neuronal Activity
            in Rat Supraoptic Nucleus
  JOURNAL   ASN Neuro 11, 1759091419843762 (2019)
   PUBMED   31091986
  REMARK    GeneRIF: Cx36-mediated junctional communication plays a crucial
            role in autoregulatory control of oxytocin neuronal activity
REFERENCE   4  (bases 1 to 1892)
  AUTHORS   Li,J., Zhang,S., Liu,X., Han,D., Xu,J. and Ma,Y.
  TITLE     Neuroprotective effects of leonurine against oxygen-glucose
            deprivation by targeting Cx36/CaMKII in PC12 cells
  JOURNAL   PLoS One 13 (7), e0200705 (2018)
   PUBMED   30016355
  REMARK    GeneRIF: these results suggest that leonurine might have a
            protective effect on OGD-induced PC12 cells through targeting the
            Cx36/CaMKII pathway. Thus, leonurine appears to have potential as a
            preventive or therapeutic drug against ischemic-induced neuronal
            injury.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1892)
  AUTHORS   Ouachikh,O., Hafidi,A., Boucher,Y. and Dieb,W.
  TITLE     Electrical Synapses are Involved in Orofacial Neuropathic Pain
  JOURNAL   Neuroscience 382, 69-79 (2018)
   PUBMED   29746991
  REMARK    GeneRIF: our findings demonstrated that Cx36 play an important role
            in mechanical allodynia by coupling GABA cells
REFERENCE   6  (bases 1 to 1892)
  AUTHORS   Le Gurun,S., Martin,D., Formenton,A., Maechler,P., Caille,D.,
            Waeber,G., Meda,P. and Haefliger,J.A.
  TITLE     Connexin-36 contributes to control function of insulin-producing
            cells
  JOURNAL   J Biol Chem 278 (39), 37690-37697 (2003)
   PUBMED   12766175
  REMARK    GeneRIF: Connexin-36 contributes to control function of
            insulin-producing cells.
REFERENCE   7  (bases 1 to 1892)
  AUTHORS   Deans,M.R., Gibson,J.R., Sellitto,C., Connors,B.W. and Paul,D.L.
  TITLE     Synchronous activity of inhibitory networks in neocortex requires
            electrical synapses containing connexin36
  JOURNAL   Neuron 31 (3), 477-485 (2001)
   PUBMED   11516403
REFERENCE   8  (bases 1 to 1892)
  AUTHORS   Calabrese,A., Guldenagel,M., Charollais,A., Mas,C., Caton,D.,
            Bauquis,J., Serre-Beinier,V., Caille,D., Sohl,G., Teubner,B., Le
            Gurun,S., Trovato-Salinaro,A., Condorelli,D.F., Haefliger,J.A.,
            Willecke,K. and Meda,P.
  TITLE     Cx36 and the function of endocrine pancreas
  JOURNAL   Cell Commun Adhes 8 (4-6), 387-391 (2001)
   PUBMED   12064624
  REMARK    GeneRIF: data provide evidence that connexin 36-dependent signaling
            contributes to regulate the function of native and tumoral
            insulin-producing cells
REFERENCE   9  (bases 1 to 1892)
  AUTHORS   Rash,J.E., Yasumura,T., Davidson,K.G., Furman,C.S., Dudek,F.E. and
            Nagy,J.I.
  TITLE     Identification of cells expressing Cx43, Cx30, Cx26, Cx32 and Cx36
            in gap junctions of rat brain and spinal cord
  JOURNAL   Cell Commun Adhes 8 (4-6), 315-320 (2001)
   PUBMED   12064610
REFERENCE   10 (bases 1 to 1892)
  AUTHORS   Sohl,G., Degen,J., Teubner,B. and Willecke,K.
  TITLE     The murine gap junction gene connexin36 is highly expressed in
            mouse retina and regulated during brain development
  JOURNAL   FEBS Lett 428 (1-2), 27-31 (1998)
   PUBMED   9645468
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from Y16898.1.
            
            On Feb 21, 2013 this sequence version replaced NM_019281.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y16898.1, AJ296282.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1892              Y16898.1           1-1892
FEATURES             Location/Qualifiers
     source          1..1892
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..1892
                     /gene="Gjd2"
                     /gene_synonym="Cx36; Cxns; Gja9"
                     /note="gap junction protein, delta 2"
                     /db_xref="GeneID:50564"
                     /db_xref="RGD:2694"
     exon            1..186
                     /gene="Gjd2"
                     /gene_synonym="Cx36; Cxns; Gja9"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1081
                     /gene="Gjd2"
                     /gene_synonym="Cx36; Cxns; Gja9"
                     /function="gap junction protein"
                     /note="gap junction membrane channel protein alpha 9;
                     connexin-36; connexin s; gap junction alpha-9 protein"
                     /codon_start=1
                     /product="gap junction delta-2 protein"
                     /protein_id="NP_062154.1"
                     /db_xref="GeneID:50564"
                     /db_xref="RGD:2694"
                     /translation="MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGET
                     VYDDEQTMFVCNTLQPGCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSA
                     KQRERRYSTVFLALDRDPAESIGGPGGTGGGGSGGSKREDKKLQNAIVNGVLQNTETT
                     SKETEPDCLEVKELAPHPSGLRTAARSKLRRQEGISRFYIIQVVFRNALEIGFLVGQY
                     FLYGFSVPGLYECNRYPCIKEVECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLG
                     WRKIKLAVRGAQAKRKSVYEIRNKDLPRVSVPNFGRTQSSDSAYV"
     exon            187..1892
                     /gene="Gjd2"
                     /gene_synonym="Cx36; Cxns; Gja9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctttaattg ggggcaatta gctccctgcc aggaggtgcg gcccggggag gggccaggac
       61 caagaacgtg cccggtactg cccagtcttt gtctgctgcc tccggatgca cagcgatggg
      121 ggaatggacc atcttggaga ggctgctgga agccgcggtg cagcagcact ccactatgat
      181 tgggaggatc ctgttgactg tggtggtgat cttccggata ctcattgtgg ccattgtagg
      241 ggagacggtg tacgatgatg agcagaccat gtttgtgtgc aacaccctgc agcccggctg
      301 taaccaggcc tgctatgacc gcgcctttcc catctcccat atacgttact gggtcttcca
      361 gatcataatg gtgtgcaccc ccagtctctg tttcatcacc tattctgtgc atcaatctgc
      421 caagcagaga gaacgccggt actcgactgt cttcctagcc ctggacagag accctgctga
      481 gtctataggg ggacctggag gaacgggggg tggtggcagt ggtgggagca agcgagaaga
      541 taagaagttg caaaatgcca ttgtcaatgg ggtgctccag aacacagaga ccaccagtaa
      601 ggagacagaa ccagattgct tagaggttaa agagctggct ccacatccat ctgggctgcg
      661 cacagcagca aggtccaagc ttcgaagaca ggaaggtatt tcccgcttct acatcatcca
      721 agtggtgttt cgaaatgctc tggagattgg gtttctggtg ggccagtact ttctatatgg
      781 cttcagtgtc ccagggttgt atgagtgcaa ccgctacccc tgcatcaagg aggtagaatg
      841 ttatgtgtct agacctacgg agaagacggt ctttctggtg ttcatgtttg ctgtgagcgg
      901 catttgtgtg gtgctcaatc tggctgaact taaccatctg ggatggcgga agatcaaact
      961 ggctgtccgg ggagcccagg ccaagaggaa gtcagtctat gagattcgta acaaagacct
     1021 gccaagagtc agtgttccca atttcggcag gactcagtcc agtgactccg cctatgtgtg
     1081 aaagggcagg tttggggaag gcctgctagg tggcaagtag ccccaaggca gaggatgact
     1141 cgagggtgta caggtttgcc ctcatttgcg tagtgctcgc tgtgaaggtc taggatacag
     1201 atattaagag gtcgtcatca acacaaagga gaggtagaac tgtcatcaca tgtcacacca
     1261 tcagttctac tgagaccacc gggtagagtg acaagatggc taagttggat gtccttgggc
     1321 cttcttcttt cgtggccctt cctgctcctg ataatagtga actggcatag ctgccaagca
     1381 agaattagct cggctgagct ctgtattctg gtgaatggca tgagtcaaac actcattgat
     1441 ataaaatttg tgacccatct cagcacatac ctttatcctg ggctgcagaa aaaaaaatcc
     1501 tggaggatat ttttccccct tcagcatgcc cctttccctc aaacccagga tagcatgcca
     1561 gcttttcttt ttccttgatc tggccttaca ttagccctaa cacagtttat ctgcaagctg
     1621 gagggaatta catggggtgc tttttggaga ctggccaggg cagaggtttg cagtagagcc
     1681 ccatatgact ggcccttagt cattaaaaca aaacaaaacc ttaggaatgt ctcaatattt
     1741 ccaatttttt aaaactcaaa ttgcactggt gctgtttatt aggggtgggg gatgggaggg
     1801 agggaatctc aacaacactt ctgtgagatg gtcatttcac tgttgagcat gtgtttatga
     1861 gctttgagat atttctgcct tctagattat gg
//
