LOCUS       NM_001100784            2081 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus gap junction protein, gamma 2 (Gjc2), mRNA.
ACCESSION   NM_001100784 XM_001076914 XM_002727715 XM_573100
VERSION     NM_001100784.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2081)
  AUTHORS   Jiang,L., Xu,D., Zhang,W.J., Tang,Y. and Peng,Y.
  TITLE     Astrocytes induce proliferation of oligodendrocyte progenitor cells
            via connexin 47-mediated activation of Chi3l1 expression
  JOURNAL   Eur Rev Med Pharmacol Sci 23 (7), 3012-3020 (2019)
   PUBMED   31002152
  REMARK    GeneRIF: Astrocytes induce proliferation of oligodendrocyte
            progenitor cells via connexin 47-mediated activation of Chi3l1
            expression.
REFERENCE   2  (bases 1 to 2081)
  AUTHORS   Xu,D., Liu,Z., Wang,S., Peng,Y. and Sun,X.
  TITLE     Astrocytes regulate the expression of Sp1R3 on oligodendrocyte
            progenitor cells through Cx47 and promote their proliferation
  JOURNAL   Biochem Biophys Res Commun 490 (3), 670-675 (2017)
   PUBMED   28634078
  REMARK    GeneRIF: Astrocytes regulate the expression of S1pR3 in
            oligodendrocyte progenitor cells via Cx47, which could be a
            valuable approach for promoting oligodendrocyte progenitor cells
            proliferation.
REFERENCE   3  (bases 1 to 2081)
  AUTHORS   Liu,Z., Xu,D., Wang,S., Chen,Y., Li,Z., Gao,X., Jiang,L., Tang,Y.
            and Peng,Y.
  TITLE     Astrocytes induce proliferation of oligodendrocyte progenitor cells
            via connexin 47-mediated activation of the ERK/Id4 pathway
  JOURNAL   Cell Cycle 16 (7), 714-722 (2017)
   PUBMED   28278052
  REMARK    GeneRIF: Astrocytes can cause Ca(2+) signaling activation, ERK1/2
            phosphorylation, and Id4 expression stimulation in oligodendrocyte
            progenitor cells inducing proliferation of these cells, mainly
            through Cx47.
REFERENCE   4  (bases 1 to 2081)
  AUTHORS   Mukhamedshina,Y.O., Shaymardanova,G.F., Garanina capital IE,
            Cyrilliccapital,I.E. Cyrillic, Salafutdinov,I.I., Rizvanov capital
            A, Cyrilliccapital,A. Cyrillic, Islamov,R.R. and Chelyshev,Y.A.
  TITLE     Adenoviral vector carrying glial cell-derived neurotrophic factor
            for direct gene therapy in comparison with human umbilical cord
            blood cell-mediated therapy of spinal cord injury in rat
  JOURNAL   Spinal Cord 54 (5), 347-359 (2016)
   PUBMED   26415641
REFERENCE   5  (bases 1 to 2081)
  AUTHORS   Cui,Y., Masaki,K., Yamasaki,R., Imamura,S., Suzuki,S.O.,
            Hayashi,S., Sato,S., Nagara,Y., Kawamura,M.F. and Kira,J.
  TITLE     Extensive dysregulations of oligodendrocytic and astrocytic
            connexins are associated with disease progression in an amyotrophic
            lateral sclerosis mouse model
  JOURNAL   J Neuroinflammation 11, 42 (2014)
   PUBMED   24597481
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2081)
  AUTHORS   Cruciani,V., Heintz,K.M., Husoy,T., Hovig,E., Warren,D.J. and
            Mikalsen,S.O.
  TITLE     The detection of hamster connexins: a comparison of expression
            profiles with wild-type mouse and the cancer-prone Min mouse
  JOURNAL   Cell Commun Adhes 11 (5-6), 155-171 (2004)
   PUBMED   16194882
REFERENCE   7  (bases 1 to 2081)
  AUTHORS   Kleopa,K.A., Orthmann,J.L., Enriquez,A., Paul,D.L. and Scherer,S.S.
  TITLE     Unique distributions of the gap junction proteins connexin29,
            connexin32, and connexin47 in oligodendrocytes
  JOURNAL   Glia 47 (4), 346-357 (2004)
   PUBMED   15293232
REFERENCE   8  (bases 1 to 2081)
  AUTHORS   Uhlenberg,B., Schuelke,M., Ruschendorf,F., Ruf,N., Kaindl,A.M.,
            Henneke,M., Thiele,H., Stoltenburg-Didinger,G., Aksu,F.,
            Topaloglu,H., Nurnberg,P., Hubner,C., Weschke,B. and Gartner,J.
  TITLE     Mutations in the gene encoding gap junction protein alpha 12
            (connexin 46.6) cause Pelizaeus-Merzbacher-like disease
  JOURNAL   Am J Hum Genet 75 (2), 251-260 (2004)
   PUBMED   15192806
  REMARK    Erratum:[Am J Hum Genet. 2004 Oct;5(4):737]
REFERENCE   9  (bases 1 to 2081)
  AUTHORS   Condorelli,D.F., Trovato-Salinaro,A., Mudo,G., Mirone,M.B. and
            Belluardo,N.
  TITLE     Cellular expression of connexins in the rat brain: neuronal
            localization, effects of kainate-induced seizures and expression in
            apoptotic neuronal cells
  JOURNAL   Eur J Neurosci 18 (7), 1807-1827 (2003)
   PUBMED   14622215
REFERENCE   10 (bases 1 to 2081)
  AUTHORS   Teubner,B., Odermatt,B., Guldenagel,M., Sohl,G., Degen,J.,
            Bukauskas,F., Kronengold,J., Verselis,V.K., Jung,Y.T., Kozak,C.A.,
            Schilling,K. and Willecke,K.
  TITLE     Functional expression of the new gap junction gene connexin47
            transcribed in mouse brain and spinal cord neurons
  JOURNAL   J Neurosci 21 (4), 1117-1126 (2001)
   PUBMED   11160382
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before May 13, 2010 this sequence version replaced
            XM_573100.3, XM_002727715.1, XM_001076914.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399481.1454895.1, CB713303.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                JAXUCZ010000010.1  44469967-44470028   c
            63-2081             JAXUCZ010000010.1  44462203-44464221   c
FEATURES             Location/Qualifiers
     source          1..2081
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..2081
                     /gene="Gjc2"
                     /gene_synonym="Cx47; Gja12"
                     /note="gap junction protein, gamma 2"
                     /db_xref="GeneID:497913"
                     /db_xref="RGD:1562712"
     exon            1..62
                     /gene="Gjc2"
                     /gene_synonym="Cx47; Gja12"
                     /inference="alignment:Splign:2.1.0"
     exon            63..2081
                     /gene="Gjc2"
                     /gene_synonym="Cx47; Gja12"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1404
                     /gene="Gjc2"
                     /gene_synonym="Cx47; Gja12"
                     /note="connexin-47; gap junction alpha-12 protein; gap
                     junction membrane channel protein alpha 12; gap junction
                     protein, alpha 12"
                     /codon_start=1
                     /product="gap junction gamma-2 protein"
                     /protein_id="NP_001094254.1"
                     /db_xref="GeneID:497913"
                     /db_xref="RGD:1562712"
                     /translation="MTNMSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGE
                     SIYSDEQSKFTCNTRQPGCDNVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRL
                     ARASEQERRRALRRRPGPRRLPRAQLPPPPPGWPDTTDLGEAEPILALEEDEDEEPGA
                     PEGPGEDTEEERTEDVAAKGGGGDGKTVVTPGPAGQHDGRRRIQREGLMRVYVAQLVV
                     RAAFEVAFLVGQYLLYGFEVPPFFACSRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCL
                     CLLLNLCEMAHLGLGSAQDAVRGRRGASAAGPGPAPRPPPCAFPAAAAGLACPPDYSL
                     VVRAAERARAHDQNLANLALQALRDGAAVAAVSADRDSPPCSGLNATSRGPPRAGGPA
                     SGTGSATSGGTVGEQGRSGAQEQLATKPRVGSEKGSTGSRDGKATVWI"
ORIGIN      
        1 ccagtatcca gccgacaggt ggaagggctc atcagaaggt ttgcatttcc agcctggaga
       61 aggtcccacc tgcccgctcc catgaccaac atgagctgga gcttcctgac gcggctgctg
      121 gaggagatcc acaatcattc caccttcgtg ggcaaagttt ggctcactgt actggtggtc
      181 ttccgcattg tgctaacggc tgtcggtggt gagtccatct attcagatga gcaatccaag
      241 ttcacctgca acacgcgcca accgggttgt gacaacgtct gctacgacgc ctttgcgccc
      301 ctgtctcatg tgcgcttctg ggtcttccag atagtggtca tctctacacc ttctgtcatg
      361 tacctgggct atgctgtcca tcgcctggcg cgcgcctcgg agcaggagcg caggcgggcc
      421 ctccgacgtc gccctggccc ccggcgcttg cccagggcgc agctgccacc gccaccacct
      481 ggctggccgg acaccaccga tctgggcgag gcggagccca tactggcgct ggaggaggat
      541 gaggacgagg aaccaggggc gcccgagggc cccggggaag acacggagga ggagcgaacg
      601 gaagatgtgg ctgccaaggg gggcggaggt gatggaaaga cggtggtcac tcctggcccg
      661 gccgggcagc atgacgggcg gcggcgcatc cagagggagg gcctgatgcg cgtgtacgta
      721 gctcagctgg tggttagggc ggccttcgag gtggcctttc tggtgggcca gtacctactg
      781 tatggcttcg aggtgccgcc cttctttgcc tgcagccgcc agccttgccc acacgtagtg
      841 gactgcttcg tgtcgcggcc aaccgagaag actgtcttct tgctggttat gtatgtggtt
      901 agctgcctat gcctgttgct caacctttgt gaaatggcac acctgggtct cggcagtgcg
      961 caggacgctg tgcgcggccg tcggggagcc tcagcggctg gtcctggtcc cgcgccgcgc
     1021 ccaccgccct gcgctttccc ggctgcggcc gcgggcctgg cttgccctcc ggactacagc
     1081 ctggtagtgc gtgcagctga gcgcgcgcga gcgcacgatc agaacctggc gaacctggca
     1141 ctgcaggcgc tgcgtgatgg ggcggcggtg gcggcggttt ccgcggatcg cgacagtccg
     1201 ccgtgttcag ggctcaatgc aacctctcgg ggaccaccca gggcgggcgg cccagcttcc
     1261 ggaaccggta gcgccacgtc ggggggtacc gttggagagc agggcaggtc gggagctcag
     1321 gaacagctcg ccactaagcc cagggttggc tctgagaagg gcagtacagg cagcagagac
     1381 ggcaaggcca ccgtgtggat ctgagggcac tgcggagaga tcagggaggg cctggcatga
     1441 ggattcagtt gaaatctttc tgccctcaac cagtgatctc tggcaaaccc tgttagggat
     1501 ctttaaagga ggagctgaag ccccttagga ggtgctggct cgggtacctc tctgcaggat
     1561 aggaagggga atgccagggc cttatatgtg gcctctgagg tggggagtgg gcagaactgt
     1621 gtcccaggaa ttgcccctcc aggctatact acacaggaat gacctctctg ctgggcctgc
     1681 cagcccttcc ttctgggctc ttatgcagtt tccccatagg attggaggtg tctggcatga
     1741 atcctcacag agagagccag agaaaagtcc ggtgcaggca gacagcgtta gttactccca
     1801 gcccttggct ccctacttga ggcagcagac tgagtgagac ctgaaggagg cctttagaga
     1861 aaagtccttt cattgagctg agatcgcttg gcatgactcc ttagaagttc tgttgcccct
     1921 tgctgcctag ttgcctcagg ctgtggtcca gggctgtggc tttggccatg ctgaaaaatt
     1981 agagctctgg ggagcctgtc cccatcccct gtgaccttcc cctgttttaa agccaacttc
     2041 cagaacaaag gaagtaaaat aaaactaacc ttttgtttac a
//
