LOCUS       NP_001094254             440 aa            linear   ROD 31-MAR-2024
DEFINITION  gap junction gamma-2 protein [Rattus norvegicus].
ACCESSION   NP_001094254 XP_001076914 XP_002727761 XP_573100
VERSION     NP_001094254.1
DBSOURCE    REFSEQ: accession NM_001100784.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 440)
  AUTHORS   Jiang,L., Xu,D., Zhang,W.J., Tang,Y. and Peng,Y.
  TITLE     Astrocytes induce proliferation of oligodendrocyte progenitor cells
            via connexin 47-mediated activation of Chi3l1 expression
  JOURNAL   Eur Rev Med Pharmacol Sci 23 (7), 3012-3020 (2019)
   PUBMED   31002152
  REMARK    GeneRIF: Astrocytes induce proliferation of oligodendrocyte
            progenitor cells via connexin 47-mediated activation of Chi3l1
            expression.
REFERENCE   2  (residues 1 to 440)
  AUTHORS   Xu,D., Liu,Z., Wang,S., Peng,Y. and Sun,X.
  TITLE     Astrocytes regulate the expression of Sp1R3 on oligodendrocyte
            progenitor cells through Cx47 and promote their proliferation
  JOURNAL   Biochem Biophys Res Commun 490 (3), 670-675 (2017)
   PUBMED   28634078
  REMARK    GeneRIF: Astrocytes regulate the expression of S1pR3 in
            oligodendrocyte progenitor cells via Cx47, which could be a
            valuable approach for promoting oligodendrocyte progenitor cells
            proliferation.
REFERENCE   3  (residues 1 to 440)
  AUTHORS   Liu,Z., Xu,D., Wang,S., Chen,Y., Li,Z., Gao,X., Jiang,L., Tang,Y.
            and Peng,Y.
  TITLE     Astrocytes induce proliferation of oligodendrocyte progenitor cells
            via connexin 47-mediated activation of the ERK/Id4 pathway
  JOURNAL   Cell Cycle 16 (7), 714-722 (2017)
   PUBMED   28278052
  REMARK    GeneRIF: Astrocytes can cause Ca(2+) signaling activation, ERK1/2
            phosphorylation, and Id4 expression stimulation in oligodendrocyte
            progenitor cells inducing proliferation of these cells, mainly
            through Cx47.
REFERENCE   4  (residues 1 to 440)
  AUTHORS   Mukhamedshina,Y.O., Shaymardanova,G.F., Garanina capital IE,
            Cyrilliccapital,I.E. Cyrillic, Salafutdinov,I.I., Rizvanov capital
            A, Cyrilliccapital,A. Cyrillic, Islamov,R.R. and Chelyshev,Y.A.
  TITLE     Adenoviral vector carrying glial cell-derived neurotrophic factor
            for direct gene therapy in comparison with human umbilical cord
            blood cell-mediated therapy of spinal cord injury in rat
  JOURNAL   Spinal Cord 54 (5), 347-359 (2016)
   PUBMED   26415641
REFERENCE   5  (residues 1 to 440)
  AUTHORS   Cui,Y., Masaki,K., Yamasaki,R., Imamura,S., Suzuki,S.O.,
            Hayashi,S., Sato,S., Nagara,Y., Kawamura,M.F. and Kira,J.
  TITLE     Extensive dysregulations of oligodendrocytic and astrocytic
            connexins are associated with disease progression in an amyotrophic
            lateral sclerosis mouse model
  JOURNAL   J Neuroinflammation 11, 42 (2014)
   PUBMED   24597481
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 440)
  AUTHORS   Cruciani,V., Heintz,K.M., Husoy,T., Hovig,E., Warren,D.J. and
            Mikalsen,S.O.
  TITLE     The detection of hamster connexins: a comparison of expression
            profiles with wild-type mouse and the cancer-prone Min mouse
  JOURNAL   Cell Commun Adhes 11 (5-6), 155-171 (2004)
   PUBMED   16194882
REFERENCE   7  (residues 1 to 440)
  AUTHORS   Kleopa,K.A., Orthmann,J.L., Enriquez,A., Paul,D.L. and Scherer,S.S.
  TITLE     Unique distributions of the gap junction proteins connexin29,
            connexin32, and connexin47 in oligodendrocytes
  JOURNAL   Glia 47 (4), 346-357 (2004)
   PUBMED   15293232
REFERENCE   8  (residues 1 to 440)
  AUTHORS   Uhlenberg,B., Schuelke,M., Ruschendorf,F., Ruf,N., Kaindl,A.M.,
            Henneke,M., Thiele,H., Stoltenburg-Didinger,G., Aksu,F.,
            Topaloglu,H., Nurnberg,P., Hubner,C., Weschke,B. and Gartner,J.
  TITLE     Mutations in the gene encoding gap junction protein alpha 12
            (connexin 46.6) cause Pelizaeus-Merzbacher-like disease
  JOURNAL   Am J Hum Genet 75 (2), 251-260 (2004)
   PUBMED   15192806
  REMARK    Erratum:[Am J Hum Genet. 2004 Oct;5(4):737]
REFERENCE   9  (residues 1 to 440)
  AUTHORS   Condorelli,D.F., Trovato-Salinaro,A., Mudo,G., Mirone,M.B. and
            Belluardo,N.
  TITLE     Cellular expression of connexins in the rat brain: neuronal
            localization, effects of kainate-induced seizures and expression in
            apoptotic neuronal cells
  JOURNAL   Eur J Neurosci 18 (7), 1807-1827 (2003)
   PUBMED   14622215
REFERENCE   10 (residues 1 to 440)
  AUTHORS   Teubner,B., Odermatt,B., Guldenagel,M., Sohl,G., Degen,J.,
            Bukauskas,F., Kronengold,J., Verselis,V.K., Jung,Y.T., Kozak,C.A.,
            Schilling,K. and Willecke,K.
  TITLE     Functional expression of the new gap junction gene connexin47
            transcribed in mouse brain and spinal cord neurons
  JOURNAL   J Neurosci 21 (4), 1117-1126 (2001)
   PUBMED   11160382
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before May 13, 2010 this sequence version replaced
            XP_573100.1, XP_002727761.1, XP_001076914.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399481.1454895.1, CB713303.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     Protein         1..440
                     /product="gap junction gamma-2 protein"
                     /note="connexin-47; gap junction alpha-12 protein; gap
                     junction membrane channel protein alpha 12; gap junction
                     protein, alpha 12"
                     /calculated_mol_wt=46859
     Region          5..290
                     /region_name="Connexin"
                     /note="pfam00029"
                     /db_xref="CDD:459638"
     Site            22..42
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XF7.2)"
     Site            79..99
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XF7.2)"
     Region          108..199
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XF7.2)"
     Site            224..244
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XF7.2)"
     Site            265..285
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XF7.2)"
     Region          368..440
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XF7.2)"
     Site            372
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8BQU6; propagated from
                     UniProtKB/Swiss-Prot (Q80XF7.2)"
     CDS             1..440
                     /gene="Gjc2"
                     /gene_synonym="Cx47; Gja12"
                     /coded_by="NM_001100784.1:82..1404"
                     /db_xref="GeneID:497913"
                     /db_xref="RGD:1562712"
ORIGIN      
        1 mtnmswsflt rlleeihnhs tfvgkvwltv lvvfrivlta vggesiysde qskftcntrq
       61 pgcdnvcyda faplshvrfw vfqivvistp svmylgyavh rlaraseqer rralrrrpgp
      121 rrlpraqlpp pppgwpdttd lgeaepilal eededeepga pegpgedtee ertedvaakg
      181 gggdgktvvt pgpagqhdgr rriqreglmr vyvaqlvvra afevaflvgq yllygfevpp
      241 ffacsrqpcp hvvdcfvsrp tektvfllvm yvvsclclll nlcemahlgl gsaqdavrgr
      301 rgasaagpgp aprpppcafp aaaaglacpp dyslvvraae rarahdqnla nlalqalrdg
      361 aavaavsadr dsppcsglna tsrgppragg pasgtgsats ggtvgeqgrs gaqeqlatkp
      421 rvgsekgstg srdgkatvwi
//
