LOCUS       NM_001085381            1594 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus gap junction protein, gamma 1 (Gjc1), mRNA.
ACCESSION   NM_001085381 XM_001081521
VERSION     NM_001085381.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1594)
  AUTHORS   Luetic,M., Kretzschmar,G., Grobe,M., Jercic,L., Bota,I., Ivic,V.,
            Balog,M., Zjalic,M., Vitlov Uljevic,M., Heffer,M., Gaspar,R.,
            Tabi,T., Vukojevic,K., Vari,S.G. and Filipovic,N.
  TITLE     Sex-specific effects of metformin and liraglutide on renal
            pathology and expression of connexin 45 and pannexin 1 following
            long-term high-fat high-sugar diet
  JOURNAL   Acta Histochem 123 (8), 151817 (2021)
   PUBMED   34808525
  REMARK    GeneRIF: Sex-specific effects of metformin and liraglutide on renal
            pathology and expression of connexin 45 and pannexin 1 following
            long-term high-fat high-sugar diet.
REFERENCE   2  (bases 1 to 1594)
  AUTHORS   Nagy,J.I. and Rash,J.E.
  TITLE     Cx36, Cx43 and Cx45 in mouse and rat cerebellar cortex:
            species-specific expression, compensation in Cx36 null mice and
            co-localization in neurons vs. glia
  JOURNAL   Eur J Neurosci 46 (2), 1790-1804 (2017)
   PUBMED   28561933
  REMARK    GeneRIF: Cx45-puncta in the cerebellar molecular layer were
            co-localized with Cx36-puncta and additionally occurred along
            Bergmann glial processes adjacent to Cx43-puncta. Expression of
            both Cx43 and Cx45 in Bergmann glia of rat may contribute to the
            complex properties of junctional coupling between these cells and
            perhaps to their reported coupling with Purkinje cells.
REFERENCE   3  (bases 1 to 1594)
  AUTHORS   Beheshti,S., Zeinali,R. and Esmaeili,A.
  TITLE     Rapid upregulation of the hippocampal connexins 36 and 45 mRNA
            levels during memory consolidation
  JOURNAL   Behav Brain Res 320, 85-90 (2017)
   PUBMED   27913256
  REMARK    GeneRIF: The results of the present study revealed that during
            memory consolidation in a passive avoidance paradigm, a rapid
            upregulation of Cx45 mRNAs level occurs in the hippocampus, which
            declines to the control level by 24 h after training.
REFERENCE   4  (bases 1 to 1594)
  AUTHORS   Guo,C.X., Tran,H., Green,C.R., Danesh-Meyer,H.V. and Acosta,M.L.
  TITLE     Gap junction proteins in the light-damaged albino rat
  JOURNAL   Mol Vis 20, 670-682 (2014)
   PUBMED   24883012
  REMARK    GeneRIF: Changes in connexins, including Cx36, Cx43, and Cx45, may
            contribute to the damage process.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1594)
  AUTHORS   Cea,L.A., Cisterna,B.A., Puebla,C., Frank,M., Figueroa,X.F.,
            Cardozo,C., Willecke,K., Latorre,R. and Saez,J.C.
  TITLE     De novo expression of connexin hemichannels in denervated fast
            skeletal muscles leads to atrophy
  JOURNAL   Proc Natl Acad Sci U S A 110 (40), 16229-16234 (2013)
   PUBMED   24043768
  REMARK    GeneRIF: The absence of Cx43/Cx45 hemichannels in skeltal muscles
            cells greatly attenuates the inflammasome activation and muscle
            atrophy.
REFERENCE   6  (bases 1 to 1594)
  AUTHORS   Johnson,C.M., Kanter,E.M., Green,K.G., Laing,J.G., Betsuyaku,T.,
            Beyer,E.C., Steinberg,T.H., Saffitz,J.E. and Yamada,K.A.
  TITLE     Redistribution of connexin45 in gap junctions of
            connexin43-deficient hearts
  JOURNAL   Cardiovasc Res 53 (4), 921-935 (2002)
   PUBMED   11922902
REFERENCE   7  (bases 1 to 1594)
  AUTHORS   Li,X. and Simard,J.M.
  TITLE     Connexin45 gap junction channels in rat cerebral vascular smooth
            muscle cells
  JOURNAL   Am J Physiol Heart Circ Physiol 281 (5), H1890-H1898 (2001)
   PUBMED   11668048
REFERENCE   8  (bases 1 to 1594)
  AUTHORS   Laing,J.G., Manley-Markowski,R.N., Koval,M., Civitelli,R. and
            Steinberg,T.H.
  TITLE     Connexin45 interacts with zonula occludens-1 in osteoblastic cells
  JOURNAL   Cell Commun Adhes 8 (4-6), 209-212 (2001)
   PUBMED   12064590
  REMARK    GeneRIF: data suggests that connexin 45 and ZO-1 directly interact
            in osteoblastic cells (ROS/Cx45) [ZO-1]
REFERENCE   9  (bases 1 to 1594)
  AUTHORS   Kruger,O., Plum,A., Kim,J.S., Winterhager,E., Maxeiner,S.,
            Hallas,G., Kirchhoff,S., Traub,O., Lamers,W.H. and Willecke,K.
  TITLE     Defective vascular development in connexin 45-deficient mice
  JOURNAL   Development 127 (19), 4179-4193 (2000)
   PUBMED   10976050
REFERENCE   10 (bases 1 to 1594)
  AUTHORS   Davis,L.M., Kanter,H.L., Beyer,E.C. and Saffitz,J.E.
  TITLE     Distinct gap junction protein phenotypes in cardiac tissues with
            disparate conduction properties
  JOURNAL   J Am Coll Cardiol 24 (4), 1124-1132 (1994)
   PUBMED   7930207
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001085381.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.41211.1,
                                           SRR26643299.45972.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840107, SAMN12840132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-307               JAXUCZ010000010.1  88283931-88284237   c
            308-383             JAXUCZ010000010.1  88265846-88265921   c
            384-1594            JAXUCZ010000010.1  88263238-88264448   c
FEATURES             Location/Qualifiers
     source          1..1594
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..1594
                     /gene="Gjc1"
                     /gene_synonym="Cx45; Cxnq; Gja7"
                     /note="gap junction protein, gamma 1"
                     /db_xref="GeneID:266706"
                     /db_xref="RGD:628889"
     exon            1..307
                     /gene="Gjc1"
                     /gene_synonym="Cx45; Cxnq; Gja7"
                     /inference="alignment:Splign:2.1.0"
     exon            308..383
                     /gene="Gjc1"
                     /gene_synonym="Cx45; Cxnq; Gja7"
                     /inference="alignment:Splign:2.1.0"
     exon            384..1594
                     /gene="Gjc1"
                     /gene_synonym="Cx45; Cxnq; Gja7"
                     /inference="alignment:Splign:2.1.0"
     CDS             404..1594
                     /gene="Gjc1"
                     /gene_synonym="Cx45; Cxnq; Gja7"
                     /note="gap junction channel protein connexin 45;
                     connexin-45; gap junction alpha-7 protein; gap junction
                     membrane channel protein alpha 7; connexin q"
                     /codon_start=1
                     /product="gap junction gamma-1 protein"
                     /protein_id="NP_001078850.1"
                     /db_xref="GeneID:266706"
                     /db_xref="RGD:628889"
                     /translation="MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIY
                     YDEQSKFVCNTEQPGCENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKM
                     EHGEADKKAARSKPYAMRWKQHRALEETEEDHEEDPMMYPEMELESEKENKEQSQPKP
                     KHDGRRRIREDGLMKIYVLQLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKI
                     DCFISRPTEKTIFLLIMYGVTGLCLLLNIWEMLHLGFGTIRDSLNSKRRELDDPGAYN
                     YPFTWNTPSAPPGYNIAVKPDQIQYTELSNAKIAYKQNKANIAQEQQYGSHEEHLPAD
                     LETLQREIRMAQERLDLAIQAYHHQNNPHGPREKKAKVGSKSGSNKSSISSKSGDGKT
                     SVWI"
ORIGIN      
        1 ttgttcttcg ttgactctcc agattgaaaa tagagaggag gcgctaatgc tgtgattggg
       61 ctggctgctg cgtttggatt ttcgagttga aaagatttac gtgacttgtg tttagaattt
      121 ggggtccttc ctccccgctt ttcggattat ttgggattgc ttttcttttt gcgaagtggg
      181 tgaatttggt tttttttgtc atttgaagtc atttttggtc ctcggggact ggcagcgcta
      241 cagatttcat tgtgctcgtg ctttattttt tttctcatcc acactgggtg ccatcgagga
      301 actcaagaga gaatttggga aagtaacaaa cacagcacag agtctgaaag gaggttttgg
      361 gtaacggagg ttctggttaa cagggcaaac caattccacc accatgagtt ggagcttcct
      421 gactcgcctg ctagaggaga tacacaacca ttcgacgttt gtagggaaga tctggctcac
      481 tgtgctgatt gtctttcgaa ttgtcctaac tgcggtagga ggagagtcca tctactatga
      541 tgagcaaagc aaatttgtgt gcaacacaga gcagccgggc tgtgagaacg tctgctatga
      601 tgcctttgcc ccgctctccc acgtgcgctt ctgggtattc cagatcatcc tggttgctac
      661 tccctctgtg atgtacctgg gatatgctat tcacaagatt gccaaaatgg agcacggcga
      721 ggcagacaag aaggcagctc ggagcaaacc ctatgccatg cgttggaagc agcaccgggc
      781 tctggaagaa acggaagagg accatgaaga ggatcctatg atgtacccag agatggagtt
      841 agaaagcgag aaagaaaata aagagcagag ccaaccaaaa cccaagcatg atggccgccg
      901 acgcattcgt gaggatgggc tcatgaaaat ctatgtgttg cagctgctag ccaggactgt
      961 gtttgaggtg ggctttctca tagggcagta tttcctgtat ggcttccaag tacacccatt
     1021 ttatgtgtgc agcagacttc cttgtcctca taagatagac tgctttattt ctagacccac
     1081 tgaaaagacc atcttccttc tgataatgta tggtgtcaca ggcctctgcc tattgcttaa
     1141 catttgggag atgcttcatc tagggtttgg gaccattcga gactcactaa acagtaaaag
     1201 gagggaactt gatgatccgg gtgcttataa ttatcctttc acttggaata caccatctgc
     1261 tcccccaggc tataacattg ctgtcaaacc agatcaaatc cagtacactg agttgtccaa
     1321 tgctaagatt gcctacaagc agaacaaagc caatatcgcc caggagcagc agtacggcag
     1381 ccacgaggag cacctcccgg ccgatctgga gaccctgcag cgggagatca gaatggccca
     1441 ggaacgcttg gatctagcaa tccaggccta ccatcaccag aacaaccccc atggtcctcg
     1501 ggaaaagaag gccaaagtgg ggtccaaatc tgggtccaac aaaagcagta ttagtagcaa
     1561 atcaggagat gggaagacct ccgtctggat ttaa
//
