LOCUS       NP_001078850             396 aa            linear   ROD 31-MAR-2024
DEFINITION  gap junction gamma-1 protein [Rattus norvegicus].
ACCESSION   NP_001078850 XP_001081521
VERSION     NP_001078850.1
DBSOURCE    REFSEQ: accession NM_001085381.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 396)
  AUTHORS   Luetic,M., Kretzschmar,G., Grobe,M., Jercic,L., Bota,I., Ivic,V.,
            Balog,M., Zjalic,M., Vitlov Uljevic,M., Heffer,M., Gaspar,R.,
            Tabi,T., Vukojevic,K., Vari,S.G. and Filipovic,N.
  TITLE     Sex-specific effects of metformin and liraglutide on renal
            pathology and expression of connexin 45 and pannexin 1 following
            long-term high-fat high-sugar diet
  JOURNAL   Acta Histochem 123 (8), 151817 (2021)
   PUBMED   34808525
  REMARK    GeneRIF: Sex-specific effects of metformin and liraglutide on renal
            pathology and expression of connexin 45 and pannexin 1 following
            long-term high-fat high-sugar diet.
REFERENCE   2  (residues 1 to 396)
  AUTHORS   Nagy,J.I. and Rash,J.E.
  TITLE     Cx36, Cx43 and Cx45 in mouse and rat cerebellar cortex:
            species-specific expression, compensation in Cx36 null mice and
            co-localization in neurons vs. glia
  JOURNAL   Eur J Neurosci 46 (2), 1790-1804 (2017)
   PUBMED   28561933
  REMARK    GeneRIF: Cx45-puncta in the cerebellar molecular layer were
            co-localized with Cx36-puncta and additionally occurred along
            Bergmann glial processes adjacent to Cx43-puncta. Expression of
            both Cx43 and Cx45 in Bergmann glia of rat may contribute to the
            complex properties of junctional coupling between these cells and
            perhaps to their reported coupling with Purkinje cells.
REFERENCE   3  (residues 1 to 396)
  AUTHORS   Beheshti,S., Zeinali,R. and Esmaeili,A.
  TITLE     Rapid upregulation of the hippocampal connexins 36 and 45 mRNA
            levels during memory consolidation
  JOURNAL   Behav Brain Res 320, 85-90 (2017)
   PUBMED   27913256
  REMARK    GeneRIF: The results of the present study revealed that during
            memory consolidation in a passive avoidance paradigm, a rapid
            upregulation of Cx45 mRNAs level occurs in the hippocampus, which
            declines to the control level by 24 h after training.
REFERENCE   4  (residues 1 to 396)
  AUTHORS   Guo,C.X., Tran,H., Green,C.R., Danesh-Meyer,H.V. and Acosta,M.L.
  TITLE     Gap junction proteins in the light-damaged albino rat
  JOURNAL   Mol Vis 20, 670-682 (2014)
   PUBMED   24883012
  REMARK    GeneRIF: Changes in connexins, including Cx36, Cx43, and Cx45, may
            contribute to the damage process.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 396)
  AUTHORS   Cea,L.A., Cisterna,B.A., Puebla,C., Frank,M., Figueroa,X.F.,
            Cardozo,C., Willecke,K., Latorre,R. and Saez,J.C.
  TITLE     De novo expression of connexin hemichannels in denervated fast
            skeletal muscles leads to atrophy
  JOURNAL   Proc Natl Acad Sci U S A 110 (40), 16229-16234 (2013)
   PUBMED   24043768
  REMARK    GeneRIF: The absence of Cx43/Cx45 hemichannels in skeltal muscles
            cells greatly attenuates the inflammasome activation and muscle
            atrophy.
REFERENCE   6  (residues 1 to 396)
  AUTHORS   Johnson,C.M., Kanter,E.M., Green,K.G., Laing,J.G., Betsuyaku,T.,
            Beyer,E.C., Steinberg,T.H., Saffitz,J.E. and Yamada,K.A.
  TITLE     Redistribution of connexin45 in gap junctions of
            connexin43-deficient hearts
  JOURNAL   Cardiovasc Res 53 (4), 921-935 (2002)
   PUBMED   11922902
REFERENCE   7  (residues 1 to 396)
  AUTHORS   Li,X. and Simard,J.M.
  TITLE     Connexin45 gap junction channels in rat cerebral vascular smooth
            muscle cells
  JOURNAL   Am J Physiol Heart Circ Physiol 281 (5), H1890-H1898 (2001)
   PUBMED   11668048
REFERENCE   8  (residues 1 to 396)
  AUTHORS   Laing,J.G., Manley-Markowski,R.N., Koval,M., Civitelli,R. and
            Steinberg,T.H.
  TITLE     Connexin45 interacts with zonula occludens-1 in osteoblastic cells
  JOURNAL   Cell Commun Adhes 8 (4-6), 209-212 (2001)
   PUBMED   12064590
  REMARK    GeneRIF: data suggests that connexin 45 and ZO-1 directly interact
            in osteoblastic cells (ROS/Cx45) [ZO-1]
REFERENCE   9  (residues 1 to 396)
  AUTHORS   Kruger,O., Plum,A., Kim,J.S., Winterhager,E., Maxeiner,S.,
            Hallas,G., Kirchhoff,S., Traub,O., Lamers,W.H. and Willecke,K.
  TITLE     Defective vascular development in connexin 45-deficient mice
  JOURNAL   Development 127 (19), 4179-4193 (2000)
   PUBMED   10976050
REFERENCE   10 (residues 1 to 396)
  AUTHORS   Davis,L.M., Kanter,H.L., Beyer,E.C. and Saffitz,J.E.
  TITLE     Distinct gap junction protein phenotypes in cardiac tissues with
            disparate conduction properties
  JOURNAL   J Am Coll Cardiol 24 (4), 1124-1132 (1994)
   PUBMED   7930207
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Apr 27, 2007 this sequence version replaced XP_001081521.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.41211.1,
                                           SRR26643299.45972.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840107, SAMN12840132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..396
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     Protein         1..396
                     /product="gap junction gamma-1 protein"
                     /note="gap junction channel protein connexin 45;
                     connexin-45; gap junction alpha-7 protein; gap junction
                     membrane channel protein alpha 7; connexin q"
                     /calculated_mol_wt=45535
     Region          2..255
                     /region_name="Connexin"
                     /note="pfam00029"
                     /db_xref="CDD:459638"
     Site            19..39
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (A4GG66.1)"
     Site            76..96
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (A4GG66.1)"
     Region          145..165
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A4GG66.1)"
     Site            176..198
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (A4GG66.1)"
     Site            230..250
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (A4GG66.1)"
     Region          357..396
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A4GG66.1)"
     CDS             1..396
                     /gene="Gjc1"
                     /gene_synonym="Cx45; Cxnq; Gja7"
                     /coded_by="NM_001085381.2:404..1594"
                     /db_xref="GeneID:266706"
                     /db_xref="RGD:628889"
ORIGIN      
        1 mswsfltrll eeihnhstfv gkiwltvliv frivltavgg esiyydeqsk fvcnteqpgc
       61 envcydafap lshvrfwvfq iilvatpsvm ylgyaihkia kmehgeadkk aarskpyamr
      121 wkqhraleet eedheedpmm ypemelesek enkeqsqpkp khdgrrrire dglmkiyvlq
      181 llartvfevg fligqyflyg fqvhpfyvcs rlpcphkidc fisrptekti fllimygvtg
      241 lclllniwem lhlgfgtird slnskrreld dpgaynypft wntpsappgy niavkpdqiq
      301 ytelsnakia ykqnkaniaq eqqygsheeh lpadletlqr eirmaqerld laiqayhhqn
      361 nphgprekka kvgsksgsnk ssissksgdg ktsvwi
//
