LOCUS       NM_001389258            1460 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus gap junction protein, beta 4 (Gjb4), mRNA.
ACCESSION   NM_001389258 XM_008763985
VERSION     NM_001389258.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1460)
  AUTHORS   Sbidian,E., Bousseloua,N., Jonard,L., Leclerc-Mercier,S.,
            Bodemer,C. and Hadj-Rabia,S.
  TITLE     Novel mutation in GJB4 gene (connexin 30.3) in a family with
            erythrokeratodermia variabilis
  JOURNAL   Acta Derm Venereol 93 (2), 193-195 (2013)
   PUBMED   23037955
REFERENCE   2  (bases 1 to 1460)
  AUTHORS   Wang,W.H., Yang,J.J., Lin,Y.C., Yang,J.T. and Li,S.Y.
  TITLE     Novel expression patterns of connexin 30.3 in adult rat cochlea
  JOURNAL   Hear Res 265 (1-2), 77-82 (2010)
   PUBMED   20184948
  REMARK    GeneRIF: Results indicate the presence and localization of Cx30.3
            in the rat cochlea.
REFERENCE   3  (bases 1 to 1460)
  AUTHORS   Zheng-Fischhofer,Q., Schnichels,M., Dere,E., Strotmann,J.,
            Loscher,N., McCulloch,F., Kretz,M., Degen,J., Reucher,H.,
            Nagy,J.I., Peti-Peterdi,J., Huston,J.P., Breer,H. and Willecke,K.
  TITLE     Characterization of connexin30.3-deficient mice suggests a possible
            role of connexin30.3 in olfaction
  JOURNAL   Eur J Cell Biol 86 (11-12), 683-700 (2007)
   PUBMED   17728008
REFERENCE   4  (bases 1 to 1460)
  AUTHORS   Common,J.E., O'Toole,E.A., Leigh,I.M., Thomas,A., Griffiths,W.A.,
            Venning,V., Grabczynska,S., Peris,Z., Kansky,A. and Kelsell,D.P.
  TITLE     Clinical and genetic heterogeneity of erythrokeratoderma variabilis
  JOURNAL   J Invest Dermatol 125 (5), 920-927 (2005)
   PUBMED   16297190
REFERENCE   5  (bases 1 to 1460)
  AUTHORS   Sun,J., Ahmad,S., Chen,S., Tang,W., Zhang,Y., Chen,P. and Lin,X.
  TITLE     Cochlear gap junctions coassembled from Cx26 and 30 show faster
            intercellular Ca2+ signaling than homomeric counterparts
  JOURNAL   Am J Physiol Cell Physiol 288 (3), C613-C623 (2005)
   PUBMED   15692151
REFERENCE   6  (bases 1 to 1460)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   7  (bases 1 to 1460)
  AUTHORS   Richard,G., Brown,N., Rouan,F., Van der Schroeff,J.G., Bijlsma,E.,
            Eichenfield,L.F., Sybert,V.P., Greer,K.E., Hogan,P., Campanelli,C.,
            Compton,J.G., Bale,S.J., DiGiovanna,J.J. and Uitto,J.
  TITLE     Genetic heterogeneity in erythrokeratodermia variabilis: novel
            mutations in the connexin gene GJB4 (Cx30.3) and genotype-phenotype
            correlations
  JOURNAL   J Invest Dermatol 120 (4), 601-609 (2003)
   PUBMED   12648223
REFERENCE   8  (bases 1 to 1460)
  AUTHORS   Macari,F., Landau,M., Cousin,P., Mevorah,B., Brenner,S.,
            Panizzon,R., Schorderet,D.F., Hohl,D. and Huber,M.
  TITLE     Mutation in the gene for connexin 30.3 in a family with
            erythrokeratodermia variabilis
  JOURNAL   Am J Hum Genet 67 (5), 1296-1301 (2000)
   PUBMED   11017804
REFERENCE   9  (bases 1 to 1460)
  AUTHORS   Tucker,M.A. and Barajas,L.
  TITLE     Rat connexins 30.3 and 31 are expressed in the kidney
  JOURNAL   Exp Cell Res 213 (1), 224-230 (1994)
   PUBMED   7517368
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Dec 5, 2020 this sequence version replaced XM_008763985.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ144489.1, SRR26643287.14360.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16093048, SAMN16093049
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                JAXUCZ010000005.1  144963965-144964014 c
            51-1460             JAXUCZ010000005.1  144960239-144961648 c
FEATURES             Location/Qualifiers
     source          1..1460
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1460
                     /gene="Gjb4"
                     /gene_synonym="Cnx30.3; Cnx30.3o; Cx30.3; Cx30.3o; Cxnb;
                     Gjb4o"
                     /note="gap junction protein, beta 4"
                     /db_xref="GeneID:117055"
                     /db_xref="RGD:621829"
     exon            1..50
                     /gene="Gjb4"
                     /gene_synonym="Cnx30.3; Cnx30.3o; Cx30.3; Cx30.3o; Cxnb;
                     Gjb4o"
                     /inference="alignment:Splign:2.1.0"
     exon            51..1460
                     /gene="Gjb4"
                     /gene_synonym="Cnx30.3; Cnx30.3o; Cx30.3; Cx30.3o; Cxnb;
                     Gjb4o"
                     /inference="alignment:Splign:2.1.0"
     CDS             385..1182
                     /gene="Gjb4"
                     /gene_synonym="Cnx30.3; Cnx30.3o; Cx30.3; Cx30.3o; Cxnb;
                     Gjb4o"
                     /note="connexin-30.3; gap junction membrane channel
                     protein beta 4; connexin 30.3o; connexin b"
                     /codon_start=1
                     /product="gap junction beta-4 protein"
                     /protein_id="NP_001376187.1"
                     /db_xref="GeneID:117055"
                     /db_xref="RGD:621829"
                     /translation="MNWGFLQGILSGVNKYSTALGRIWLSVVFIFRVLVYVVAAEEVW
                     DDEQKDFICNTKQPGCPNVCYDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYREERE
                     RKHRLKHGPDAPALYSNLSKKRGGLWWTYLLSLIFKAAVDSGFLYIFHCIYKDYDMPR
                     VVACSVQPCPHTVDCYISRPTEKKVFTYFMVVTAAICILLNLSEVAYLVGKRCMEVFR
                     PRRRKTSRRHQLPDTCPPYVISKGHPQDESTVLTKAGMATVDAGVYP"
ORIGIN      
        1 agacagacaa gccggcactg gagagcgagg acccacagga cccgagaagg aaggaaagag
       61 acgctgactt tcggaatctg aagaccaggg ttcaagacca ccagtgctac ttgccactgt
      121 gagatctctg gcaggagacc tctcacacct ttcagccttc gcacactttc ttgtgacatg
      181 gggaccgtga ccgtcccacc tctgaatcac tgcgtatgag gacacaaatg gcccccgtgg
      241 tggttgtgaa atagtttagc cctttacgtc atctataaag acatttatct gcaggttctc
      301 ccaggccttg tgactcccgg ggccccgaga ggttagcgca cgagtgcgcg cacgtccacg
      361 tgaggcacca aggacacagc caacatgaac tggggatttc tccaggggat cctgagcggc
      421 gtgaacaagt actccacagc gctgggccgc atctggctgt cggtggtctt catcttccgg
      481 gtgctggtgt atgtggtggc ggcggaggag gtgtgggatg acgagcagaa ggatttcatc
      541 tgcaacacca agcagcccgg ctgccccaac gtctgctatg acgagttctt tcccgtgtcc
      601 cacgtgcgcc tctgggccct gcagctcatc ctggtcacct gtccttccct gttagtggtc
      661 atgcatgtgg cctatcgcga agagcgagag aggaaacacc gcctcaaaca tgggcccgac
      721 gccccggccc tgtacagcaa cctgagcaag aagaggggcg gcttgtggtg gacgtacctg
      781 ctgagtctca tcttcaaggc tgctgtggac tcgggattcc tctatatctt ccactgcatt
      841 tacaaggact acgacatgcc ccgtgtggta gcttgctctg tgcagccctg cccccacacc
      901 gtggactgtt acatctcccg acccacggag aagaaggtct tcacctactt catggtagtc
      961 acagcagcca tctgtatcct cctcaacctc agtgaggtcg cctatctggt gggcaagaga
     1021 tgcatggagg tcttccgtcc ccggcgccgg aaaacttcca ggaggcacca gctacccgat
     1081 acgtgcccac cgtatgtgat ctccaaaggt cacccccaag atgagagcac cgtcctgaca
     1141 aaggccggga tggccacagt ggatgcaggt gtgtatccat gacctgcagg tagggttctg
     1201 agatgactgc ccgtccactg aagccaccca ggaaaatggg tgaagggagt gtggctctca
     1261 gcagcaggtc aggcggggaa tatggctgtg gggactccgg aagttcatcc gagagctagc
     1321 agaagatgag aagcaccctt gagcccctag atcctgagcc tccagggact tgatggctgg
     1381 tggggatttt atatttgtca atagagtacc tcaaccccat taataaatat gctccaagtg
     1441 ctttggagac acgtggagaa
//
