LOCUS       NM_019240               1901 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus gap junction protein, beta 3 (Gjb3), transcript
            variant 1, mRNA.
ACCESSION   NM_019240 XM_006238845
VERSION     NM_019240.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1901)
  AUTHORS   do Canto,A.M., Vieira,A.S., H B Matos,A., Carvalho,B.S.,
            Henning,B., Norwood,B.A., Bauer,S., Rosenow,F., Gilioli,R.,
            Cendes,F. and Lopes-Cendes,I.
  TITLE     Laser microdissection-based microproteomics of the hippocampus of a
            rat epilepsy model reveals regional differences in protein
            abundances
  JOURNAL   Sci Rep 10 (1), 4412 (2020)
   PUBMED   32157145
  REMARK    GeneRIF: Laser microdissection-based microproteomics of the
            hippocampus of a rat epilepsy model reveals regional differences in
            protein abundances.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1901)
  AUTHORS   Kang,B.W., Jeon,H.S., Chae,Y.S., Lee,S.J., Park,J.S., Choi,G.S. and
            Kim,J.G.
  TITLE     Impact of Genetic Variation in MicroRNA-binding Site on
            Susceptibility to Colorectal Cancer
  JOURNAL   Anticancer Res 36 (7), 3353-3361 (2016)
   PUBMED   27354594
REFERENCE   3  (bases 1 to 1901)
  AUTHORS   Sugiura,K., Arima,M., Matsunaga,K. and Akiyama,M.
  TITLE     The novel GJB3 mutation p.Thr202Asn in the M4 transmembrane domain
            underlies erythrokeratodermia variabilis
  JOURNAL   Br J Dermatol 173 (1), 309-311 (2015)
   PUBMED   25556823
REFERENCE   4  (bases 1 to 1901)
  AUTHORS   Wang,W., Liu,L.H., Chen,G., Gao,M., Zhu,J., Zhou,F.S., Cheng,H.,
            Tang,H.Y., Wu,B.Y., Sun,L.D., Yang,S., Wang,P.G. and Zhang,X.J.
  TITLE     A missense mutation in the GJB3 gene responsible for
            erythrokeratodermia variabilis in a Chinese family
  JOURNAL   Clin Exp Dermatol 37 (8), 919-921 (2012)
   PUBMED   22681493
REFERENCE   5  (bases 1 to 1901)
  AUTHORS   Fuchs-Telem,D., Pessach,Y., Mevorah,B., Shirazi,I., Sarig,O. and
            Sprecher,E.
  TITLE     Erythrokeratoderma variabilis caused by a recessive mutation in
            GJB3
  JOURNAL   Clin Exp Dermatol 36 (4), 406-411 (2011)
   PUBMED   21564177
REFERENCE   6  (bases 1 to 1901)
  AUTHORS   Butterweck,A., Elfgang,C., Willecke,K. and Traub,O.
  TITLE     Differential expression of the gap junction proteins connexin45,
            -43, -40, -31, and -26 in mouse skin
  JOURNAL   Eur J Cell Biol 65 (1), 152-163 (1994)
   PUBMED   7889986
REFERENCE   7  (bases 1 to 1901)
  AUTHORS   Goliger,J.A. and Paul,D.L.
  TITLE     Expression of gap junction proteins Cx26, Cx31.1, Cx37, and Cx43 in
            developing and mature rat epidermis
  JOURNAL   Dev Dyn 200 (1), 1-13 (1994)
   PUBMED   8081010
REFERENCE   8  (bases 1 to 1901)
  AUTHORS   Scacchi,R., Corbo,R.M., Cossu,G., Mureddu,L., Mulas,G. and
            Pascone,R.
  TITLE     Distribution of ORM1, C6, C7 and APO C-II allele frequencies in
            populations from mainland Italy and Sardinia
  JOURNAL   Hum Hered 42 (5), 309-315 (1992)
   PUBMED   1459576
REFERENCE   9  (bases 1 to 1901)
  AUTHORS   Overall,J.E. and Magee,K.N.
  TITLE     Baseline correction in a two-way randomized blocks design
  JOURNAL   J Biopharm Stat 2 (2), 205-217 (1992)
   PUBMED   1300214
REFERENCE   10 (bases 1 to 1901)
  AUTHORS   Hoh,J.H., John,S.A. and Revel,J.P.
  TITLE     Molecular cloning and characterization of a new member of the gap
            junction gene family, connexin-31
  JOURNAL   J Biol Chem 266 (10), 6524-6531 (1991)
   PUBMED   1706719
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Aug 30, 2022 this sequence version replaced
            XM_006238845.4, NM_019240.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.22773.1,
                                           SRR26643294.22618.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-333               JAXUCZ010000005.1  144939103-144939435 c
            334-1901            JAXUCZ010000005.1  144933692-144935259 c
FEATURES             Location/Qualifiers
     source          1..1901
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1901
                     /gene="Gjb3"
                     /gene_synonym="Cxnc"
                     /note="gap junction protein, beta 3"
                     /db_xref="GeneID:29585"
                     /db_xref="RGD:2695"
     exon            1..333
                     /gene="Gjb3"
                     /gene_synonym="Cxnc"
                     /inference="alignment:Splign:2.1.0"
     exon            334..1901
                     /gene="Gjb3"
                     /gene_synonym="Cxnc"
                     /inference="alignment:Splign:2.1.0"
     CDS             368..1180
                     /gene="Gjb3"
                     /gene_synonym="Cxnc"
                     /note="gap junction membrane channel protein beta 3;
                     connexin c; cx31; connexin-31"
                     /codon_start=1
                     /product="gap junction beta-3 protein"
                     /protein_id="NP_062113.1"
                     /db_xref="GeneID:29585"
                     /db_xref="RGD:2695"
                     /translation="MDWKKLQDLLSGVNQYSTAFGRIWLSVVFVFRVLVYVVAAERVW
                     GDEQKDFDCNTRQPGCTNVCYDNFFPISNIRLWALQLIFVTCPSMLVILHVAYREERE
                     RKHRQKHGEHCAKLYSHPGKKHGGLWWTYLFSLIFKLIIELVFLYVLHTLWHGFTMPR
                     LVQCASVVPCPNTVDCYIARPTEKKVFTYFMVGASAVCIILTICEICYLIFHRIMRGL
                     SKDKSTKSISSPKSSSRASTCRCHHKLLESGDLEAVPADDKLQASAPSLTPI"
ORIGIN      
        1 gtttgcaaag tgtttcacac cctaatgtca ttgcagtcct tgcaacagcc ctgccagtgg
       61 ccaccaatgc ccccattcca cacgcaagca aacagaagct ccacaaagga gcctgctgct
      121 ccctggtcag cgcagctgct gctggattag aacttgtatc cctgaggcgg ctccgggctc
      181 ctccccggcc gcccctcctc cacactgcct ctggctgtgc gggccaggag cctcacggag
      241 gccagagctc ggcttggctc cggcctcttt cctcttctgc tgtgggtctt gggcacgtgg
      301 agacaggcct ccacggtggc ggcgccgctg actgtgggca cagccccccg aaccctgagc
      361 aggcaccatg gattggaaga agcttcagga cctgttgagc ggtgtgaacc agtactccac
      421 cgcattcggg cgcatctggc tgtcggtagt gttcgtcttc cgggtgctgg tgtatgtggt
      481 ggctgcagag cgtgtgtggg gcgacgagca aaaagacttt gactgtaaca ccaggcagcc
      541 cggttgtacc aacgtgtgct atgacaactt cttccccatc tccaacatcc gcctctgggc
      601 cctgcagctc atcttcgtca cgtgtccctc tatgctggtc atcctgcacg tagcctaccg
      661 cgaggagcgg gaacggaagc atcgccagaa gcacggggag cattgcgcca aactgtacag
      721 ccacccgggc aagaagcacg gcggcctgtg gtggacctac ctgttcagtc tcatcttcaa
      781 gctcatcatt gaattggtct tcctgtatgt tctacacacg ctctggcatg gcttcaccat
      841 gccgcgtctg gtacagtgcg ccagcgtggt accttgcccc aacaccgtgg attgctacat
      901 cgctcggccc acggagaaga aagtctttac ctacttcatg gtaggcgcgt ctgccgtctg
      961 cattattctc accatctgtg agatctgcta cctcatcttc cacaggatta tgcgaggcct
     1021 gagcaaggac aaatcgacga agagcatcag ctccccgaag tcctccagcc gggcctccac
     1081 ctgtcgctgt caccacaagc tgctggagag tggtgatctg gaagcagtac cagccgatga
     1141 caagctgcag gcttcagcgc ctagcctgac ccccatttaa accacgcgct ggagaagggg
     1201 tgaggctggg aggtgctgca ggtggagggg tcctggggtg ctgagtgccc cccactttga
     1261 attcactaag ctagccaatc ctgtttgaag cagatgttta tgggcactgg gttctgtgct
     1321 ggctacctgg tatatgtaac ctgacagacc cagcttcaga gagacattta gataagcaaa
     1381 ttaacaacat gcatgcaagg gtctacttgg cgctaggctg gtcaacagga cttctgccta
     1441 ccctagggaa ctgcccagcc agtcaccctc tcagaaaagc acagcgaaag gaagaaagga
     1501 gatgggctct ctcatcagac tcagcaacag caaaaagaac tggggagtct cagagggagg
     1561 tgatggctct ggactcggga cagccagcta gagggagact ttactactca accatgagaa
     1621 gctgcacagg ttcctaggtg gaatcttctg gaggtcaaag tgtgggaagt agtagcaggt
     1681 cttgtcatgt caactgctat ttaagacacc catggttccc ccttccccaa ccttcacctt
     1741 caggcagcaa tactcatctt cctcccacca aggtgatgag cccgatgcac catgaccagg
     1801 accttggcgg catgcatatc ttgtcatatc ccctggcata tatccttgac atatccaagt
     1861 cggttttctt aaagcaataa agttgtgttt tatacgattc a
//
