LOCUS       NM_017251               1555 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus gap junction protein, beta 1 (Gjb1), mRNA.
ACCESSION   NM_017251
VERSION     NM_017251.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1555)
  AUTHORS   Chen,L., Fang,H., Li,X., Yu,P., Guan,Y., Xiao,C., Deng,Z., Hei,Z.,
            Chen,C. and Luo,C.
  TITLE     Connexin32 gap junction channels deliver miR155-3p to mediate
            pyroptosis in renal ischemia-reperfusion injury
  JOURNAL   Cell Commun Signal 22 (1), 121 (2024)
   PUBMED   38347637
  REMARK    GeneRIF: Connexin32 gap junction channels deliver miR155-3p to
            mediate pyroptosis in renal ischemia-reperfusion injury.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1555)
  AUTHORS   Guo,H., Liu,Y., Gu,J., Luo,J., Ma,Y. and Xiao,F.
  TITLE     GJB1 mutations c.212T>G and c.311A>C induce apoptosis and inwardly
            rectifying potassium current changes in X-linked
            Charcot-Marie-Tooth type 1
  JOURNAL   Biochem Biophys Res Commun 582, 8-15 (2021)
   PUBMED   34678594
  REMARK    GeneRIF: GJB1 mutations c.212T>G and c.311A>C induce apoptosis and
            inwardly rectifying potassium current changes in X-linked
            Charcot-Marie-Tooth type 1.
REFERENCE   3  (bases 1 to 1555)
  AUTHORS   Moscato,S., Cabiati,M., Bianchi,F., Panetta,D., Burchielli,S.,
            Massimetti,G., Del Ry,S. and Mattii,L.
  TITLE     Heart and liver connexin expression related to the first stage of
            aging: A study on naturally aged animals
  JOURNAL   Acta Histochem 122 (8), 151651 (2020)
   PUBMED   33171391
  REMARK    GeneRIF: Heart and liver connexin expression related to the first
            stage of aging: A study on naturally aged animals.
REFERENCE   4  (bases 1 to 1555)
  AUTHORS   Chen,C., Yao,W., Wu,S., Zhou,S., Ge,M., Gu,Y., Li,X., Chen,G.,
            Bellanti,J.A., Zheng,S.G., Yuan,D. and Hei,Z.
  TITLE     Crosstalk Between Connexin32 and Mitochondrial Apoptotic Signaling
            Pathway Plays a Pivotal Role in Renal Ischemia Reperfusion-Induced
            Acute Kidney Injury
  JOURNAL   Antioxid Redox Signal 30 (12), 1521-1538 (2019)
   PUBMED   29790387
  REMARK    GeneRIF: Crosstalk Between Connexin32 and Mitochondrial Apoptotic
            Signaling Pathway Plays a Pivotal Role in Renal Ischemia
            Reperfusion-Induced Acute Kidney Injury.
REFERENCE   5  (bases 1 to 1555)
  AUTHORS   Alaei,S.R., Abrams,C.K., Bulinski,J.C., Hertzberg,E.L. and
            Freidin,M.M.
  TITLE     Acetylation of C-terminal lysines modulates protein turnover and
            stability of Connexin-32
  JOURNAL   BMC Cell Biol 19 (1), 22 (2018)
   PUBMED   30268116
  REMARK    GeneRIF: these results highlight the role of post translational
            modifications and lysines in the C-terminal tail of Cx32 in the
            fine-tuning of Cx32 protein stability and channel-independent
            functions.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1555)
  AUTHORS   Sakamoto,H., Oyamada,M., Enomoto,K. and Mori,M.
  TITLE     Differential changes in expression of gap junction proteins
            connexin 26 and 32 during hepatocarcinogenesis in rats
  JOURNAL   Jpn J Cancer Res 83 (11), 1210-1215 (1992)
   PUBMED   1336494
REFERENCE   7  (bases 1 to 1555)
  AUTHORS   Rahman,S. and Evans,W.H.
  TITLE     Topography of connexin32 in rat liver gap junctions. Evidence for
            an intramolecular disulphide linkage connecting the two
            extracellular peptide loops
  JOURNAL   J Cell Sci 100 (Pt 3), 567-578 (1991)
   PUBMED   1667015
REFERENCE   8  (bases 1 to 1555)
  AUTHORS   Miller,T., Dahl,G. and Werner,R.
  TITLE     Structure of a gap junction gene: rat connexin-32
  JOURNAL   Biosci Rep 8 (5), 455-464 (1988)
   PUBMED   2852976
REFERENCE   9  (bases 1 to 1555)
  AUTHORS   Paul,D.L.
  TITLE     Molecular cloning of cDNA for rat liver gap junction protein
  JOURNAL   J Cell Biol 103 (1), 123-134 (1986)
   PUBMED   3013898
REFERENCE   10 (bases 1 to 1555)
  AUTHORS   Nicholson,B.J., Gros,D.B., Kent,S.B., Hood,L.E. and Revel,J.P.
  TITLE     The Mr 28,000 gap junction proteins from rat heart and liver are
            different but related
  JOURNAL   J Biol Chem 260 (11), 6514-6517 (1985)
   PUBMED   2987225
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK476084.1 and BC078868.1.
            
            On Nov 23, 2005 this sequence version replaced NM_017251.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ210131.1, FQ218820.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                CK476084.1         1-36
            37-1555             BC078868.1         1-1519
FEATURES             Location/Qualifiers
     source          1..1555
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..1555
                     /gene="Gjb1"
                     /gene_synonym="Cx32; Cxng"
                     /note="gap junction protein, beta 1"
                     /db_xref="GeneID:29584"
                     /db_xref="RGD:61926"
     exon            1..69
                     /gene="Gjb1"
                     /gene_synonym="Cx32; Cxng"
                     /inference="alignment:Splign:2.1.0"
     exon            70..1541
                     /gene="Gjb1"
                     /gene_synonym="Cx32; Cxng"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..937
                     /gene="Gjb1"
                     /gene_synonym="Cx32; Cxng"
                     /note="gap junction membrane channel protein beta 1;
                     connexin-32; GAP junction 28 kDa liver protein; connexin
                     g"
                     /codon_start=1
                     /product="gap junction beta-1 protein"
                     /protein_id="NP_058947.1"
                     /db_xref="GeneID:29584"
                     /db_xref="RGD:61926"
                     /translation="MNWTGLYTLLSGVNRHSTAIGRVWLSVIFIFRIMVLVVAAESVW
                     GDEKSSFICNTLQPGCNSVCYDHFFPISHVRLWSLQLILVSTPALLVAMHVAHQQHIE
                     KKMLRLEGHGDPLHLEEVKRHKVHISGTLWWTYVISVVFRLLFEAVFMYVFYLLYPGY
                     AMVRLVKCEAFPCPNTVDCFVSRPTEKTVFTVFMLAASGICIILNVAEVVYLIIRACA
                     RRAQRRSNPPSRKGSGFGHRLSPEYKQNEINKLLSEQDGSLKDILRRSPGTGAGLAEK
                     SDRCSAC"
ORIGIN      
        1 cagacagaca cgcctgcata cattccctgg gaaaaagcag ttgcaaccag gtgtggcagt
       61 gccagggagg tgtgaatgag gcaggatgaa ctggacaggt ctatacacct tgctcagtgg
      121 cgtgaatcgg cattctacag ccattggccg agtatggctg tccgtcatct ttatcttcag
      181 aatcatggtg ctggtggtgg ctgcagagag cgtgtggggt gatgagaagt cttctttcat
      241 ctgtaacacc ctccagccgg gctgtaacag cgtctgctat gaccattttt tccccatctc
      301 ccatgtgcgc ctgtggtccc tgcaactcat cttggtttcc accccagctc tcctcgtggc
      361 aatgcacgtg gctcaccaac aacacataga aaagaaaatg ctacggcttg aggggcacgg
      421 ggaccccctt cacctggaag aggtaaagag gcacaaggtg cacatctcag ggacactgtg
      481 gtggacctat gtcatcagtg tggtgttccg gctgctgttt gaggctgtct tcatgtatgt
      541 cttctatctg ctctacccgg gctatgccat ggtgcggctg gtcaagtgtg aggccttccc
      601 ctgccccaac acggtggact gcttcgtgtc ccgccccact gagaaaaccg tcttcactgt
      661 ctttatgctc gccgcctccg gcatctgcat tatcctcaac gtggcggagg tggtgtacct
      721 catcatccgg gcctgtgccc gccgtgctca gcgccgctcc aatccgccct cccgcaaggg
      781 ctcgggcttc ggccaccgcc tctcacctga atacaagcag aatgagatca acaagctgct
      841 gagcgagcag gatggctctc tgaaagacat actgcgccgc agtcctggca ctggggccgg
      901 gctggctgag aagagcgacc gatgctcagc ctgctgatgc cgagtaccag gcaacctccc
      961 atccaacccc tccctcaccc cacccaggcc tgcccctcct tctcctatgc tggtgagcag
     1021 gcctctgcct cctagggatt actccatcaa accttccctc cctccctact ccccttcctc
     1081 agagagtctt ctgtcaaaga cctggccggc ttgggagtgg ggagccactt ctgcaccagg
     1141 gctcaaggtt attgagggtg tgggcaattc tttctgccta taccctttcc tcttccctct
     1201 ccctgagatg agggatgaga tgttctgaag gtgtttccaa ttaggaaact aatcttaacc
     1261 cccatgctgt caggtacccc actttgggag tcatgtcagt ggggagggct gtgagcaagc
     1321 agagtggagg aggggctctg cactgtggat ggagaaggga ggggagcttg ccttgctgcc
     1381 tgctacaagg aaaaggagga cacatctagg gtgggggagt tctggaggga gaagcaggca
     1441 gataaatcag agtgggggtt ggtcagggct gcccccagtc cccagttccc aaggcctctc
     1501 tctctgaaaa tgttacacat taaacaggat tttacagtaa aaaaaaaaaa aaaaa
//
