LOCUS       NM_153465               1617 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Rattus norvegicus gap junction protein, alpha 8 (Gja8), mRNA.
ACCESSION   NM_153465
VERSION     NM_153465.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1617)
  AUTHORS   Seda,O., Liska,F., Pravenec,M., Vernerova,Z., Kazdova,L.,
            Krenova,D., Zidek,V., Sedova,L., Krupkova,M. and Kren,V.
  TITLE     Connexin 50 mutation lowers blood pressure in spontaneously
            hypertensive rat
  JOURNAL   Physiol Res 66 (1), 15-28 (2017)
   PUBMED   27782748
  REMARK    GeneRIF: The connexin 50 mutation lowers blood pressure in the
            spontaneously hypertensive rat.
REFERENCE   2  (bases 1 to 1617)
  AUTHORS   Seda,O., Krenova,D., Oliyarnyk,O., Sedova,L., Krupkova,M.,
            Liska,F., Chylikova,B., Kazdova,L. and Kren,V.
  TITLE     Heterozygous connexin 50 mutation affects metabolic syndrome
            attributes in spontaneously hypertensive rat
  JOURNAL   Lipids Health Dis 15 (1), 199 (2016)
   PUBMED   27871290
  REMARK    GeneRIF: Gja8 mutation L7Q in heterozygous state affects the lipid
            profile and the oxidative stress parameters in the spontaneously
            hypertensive rat strain.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1617)
  AUTHORS   Rodriguez-Jimenez,F.J., Alastrue,A., Stojkovic,M., Erceg,S. and
            Moreno-Manzano,V.
  TITLE     Connexin 50 modulates Sox2 expression in spinal-cord-derived
            ependymal stem/progenitor cells
  JOURNAL   Cell Tissue Res 365 (2), 295-307 (2016)
   PUBMED   27221278
  REMARK    GeneRIF: Cx50 might constitute an interesting mechanism for Sox2
            induction to modulate the endogenous regenerative potential of
            neuronal tissue with a potential application in regenerative
            therapies.
REFERENCE   4  (bases 1 to 1617)
  AUTHORS   Pinto,B.I., Garcia,I.E., Pupo,A., Retamal,M.A., Martinez,A.D.,
            Latorre,R. and Gonzalez,C.
  TITLE     Charged Residues at the First Transmembrane Region Contribute to
            the Voltage Dependence of the Slow Gate of Connexins
  JOURNAL   J Biol Chem 291 (30), 15740-15752 (2016)
   PUBMED   27143357
  REMARK    GeneRIF: the role of the charged residues at the end of TM-1 in
            voltage sensing in Cx26, Cx46, and Cx50.
REFERENCE   5  (bases 1 to 1617)
  AUTHORS   Rodriguez-Jimenez,F.J., Alastrue-Agudo,A., Stojkovic,M., Erceg,S.
            and Moreno-Manzano,V.
  TITLE     Connexin 50 Expression in Ependymal Stem Progenitor Cells after
            Spinal Cord Injury Activation
  JOURNAL   Int J Mol Sci 16 (11), 26608-26618 (2015)
   PUBMED   26561800
  REMARK    GeneRIF: Upon ependymal stem cells differentiation, Cx50 expression
            favors glial cell fate, since higher expression levels, endogenous
            or by over-expression of Cx50, augmented the expression of the
            astrocyte marker GFAP and impaired the neuronal marker Tuj1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1617)
  AUTHORS   Zampighi,G.A.
  TITLE     Distribution of connexin50 channels and hemichannels in lens
            fibers: a structural approach
  JOURNAL   Cell Commun Adhes 10 (4-6), 265-270 (2003)
   PUBMED   14681027
  REMARK    GeneRIF: In lens fibers, Cx50 hemichannels are inserted via
            exocytosis and are rapidly assembled into channels assembled in gap
            junction plaques.
REFERENCE   7  (bases 1 to 1617)
  AUTHORS   Yamashita,S., Furumoto,K., Nobukiyo,A., Kamohara,M., Ushijima,T.
            and Furukawa,T.
  TITLE     Mapping of A gene responsible for cataract formation and its
            modifier in the UPL rat
  JOURNAL   Invest Ophthalmol Vis Sci 43 (10), 3153-3159 (2002)
   PUBMED   12356818
  REMARK    GeneRIF: A candidate gene for formation of cataracts in UPL rats
            was mapped to rat chr 2, and the Cx50 gene was a strong candidate.
            A potential modifier gene was mapped on chr 5.
REFERENCE   8  (bases 1 to 1617)
  AUTHORS   Rong,P., Wang,X., Niesman,I., Wu,Y., Benedetti,L.E., Dunia,I.,
            Levy,E. and Gong,X.
  TITLE     Disruption of Gja8 (alpha8 connexin) in mice leads to
            microphthalmia associated with retardation of lens growth and lens
            fiber maturation
  JOURNAL   Development 129 (1), 167-174 (2002)
   PUBMED   11782410
REFERENCE   9  (bases 1 to 1617)
  AUTHORS   Gao,Y. and Spray,D.C.
  TITLE     Structural changes in lenses of mice lacking the gap junction
            protein connexin43
  JOURNAL   Invest Ophthalmol Vis Sci 39 (7), 1198-1209 (1998)
   PUBMED   9620080
REFERENCE   10 (bases 1 to 1617)
  AUTHORS   Favor,J.
  TITLE     A comparison of the dominant cataract and recessive specific-locus
            mutation rates induced by treatment of male mice with
            ethylnitrosourea
  JOURNAL   Mutat Res 110 (2), 367-382 (1983)
   PUBMED   6877261
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from EU445788.1.
            
            On Jul 11, 2008 this sequence version replaced NM_153465.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1617
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="SHR-dca"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1617
                     /gene="Gja8"
                     /gene_synonym="Cx50; Cxnl"
                     /note="gap junction protein, alpha 8"
                     /db_xref="GeneID:29601"
                     /db_xref="RGD:628890"
     exon            1..1617
                     /gene="Gja8"
                     /gene_synonym="Cx50; Cxnl"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1400
                     /gene="Gja8"
                     /gene_synonym="Cx50; Cxnl"
                     /note="connexin-50; gap junction membrane channel protein
                     alpha 8; connexin l"
                     /codon_start=1
                     /product="gap junction alpha-8 protein"
                     /protein_id="NP_703195.2"
                     /db_xref="GeneID:29601"
                     /db_xref="RGD:628890"
                     /translation="MGDWSFQGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFV
                     WGDEQSDFVCNTQQPGCENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHHVRM
                     EEKRKDREAEELCQQSRSNGGERVPIAPDQASIRKSSSSSKGTKKFRLEGTLLRTYVC
                     HIIFKTLFEVGFIVGHYFLYGFRILPLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLS
                     VAFVSLFLNIMEMSHLGMKGIRSAFKRPAEQPLGEIAEKSLHSIAVSSIQKAKGYQLL
                     EEEKIVSHYFPLTEVGMVETSPLSAKPFSQFEEKIGTGPLADMSRGYQETLPSYAQVG
                     AQEVEREEQPVEEAVEPELGEKKQEAEKVAPEGQETVAVPDGEKVETPGVGKDDEKEE
                     LQAEKVTKQGLSAEKAPTLCPELTTDDNRPLSRLSKASSRARSDDLTI"
ORIGIN      
        1 agagctcggg aagaggtcat ctcggagttg cactgtggcc aattaggttt tgctttctgc
       61 ttcccaggtg gtgagcaatg ggcgactgga gtttccaggg aaacatcttg gaagaggtga
      121 atgaacattc caccgtcatc ggcagagttt ggctcacggt gcttttcatc ttccgcatcc
      181 tcatccttgg caccgcagcc gagtttgtgt ggggcgatga gcaatctgat tttgtatgca
      241 acacccagca gccaggttgt gagaacgtct gctatgatga ggcctttccc atctcgcaca
      301 tccgcctctg ggtcctgcag atcatcttcg tctccactcc atcgctgatg tacgtggggc
      361 acgcggtaca ccacgttcgc atggaggaga agcgaaagga ccgtgaggct gaggagctct
      421 gtcagcagtc tcgcagcaac gggggtgaga gggtaccaat cgccccagac caggccagca
      481 tcaggaagag cagcagcagt agcaaaggca ccaagaagtt ccggctggag ggcacactgc
      541 taaggaccta tgtctgccac atcatcttca agaccctctt tgaggtgggc ttcatcgtgg
      601 gccattactt cctgtatggt ttccgcatcc tgcccctcta tcgctgcagc cggtggccct
      661 gccccaatgt ggtggactgc tttgtgtccc ggcctactga gaaaaccatc ttcatcctct
      721 tcatgttgtc cgttgctttt gtgtccctct tcctcaacat catggagatg agccacctgg
      781 gcatgaaggg aatccggtct gccttcaaga ggcctgcaga gcaaccactg ggggagattg
      841 ccgagaagtc cctccactcc attgcagttt cctccatcca gaaagccaag ggctaccagc
      901 tcctagaaga agagaagatc gtttcacact atttcccttt gacggaggtt ggaatggtgg
      961 agaccagccc cctgtcagcc aagcctttta gtcagtttga ggagaagatc ggcacaggac
     1021 ccctggcaga tatgtcacgg ggttaccaag aaaccctgcc ttcttatgct caggtggggg
     1081 cccaggaagt ggagcgggaa gagcagcccg tagaggaggc tgtggaaccg gaattgggag
     1141 agaagaagca agaagcagag aaggtggccc cggaagggca ggagacggtt gcagtgccag
     1201 acggggagaa agtagagacc cctggggtag ggaaggatga tgagaaagaa gagctgcaag
     1261 ctgaaaaggt aaccaagcaa gggctgtctg cagagaaagc gcccacactc tgtccagagc
     1321 tgacaaccga tgacaaccgg cccttgagca ggctgagcaa agccagcagc agggccaggt
     1381 ctgatgatct caccatatga cacggtacag aagaaagata ccccacctcc agctaataca
     1441 gaccaagata aacccggctg gtgccaatat accttgagtc ttctgtgtcc cttgggtcac
     1501 tcccaccccg ggttggatag atgctgttct agaacaatgc acgctgtcca actaggggac
     1561 tgcctttccc atgtgtaggg cctgtcaagg taaacccact gtcctagtga agttctt
//
