LOCUS       NM_019308               2053 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus gap junction protein, alpha 6 (Gja6), mRNA.
ACCESSION   NM_019308
VERSION     NM_019308.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2053)
  AUTHORS   Fiorini,C., Decrouy,X., Defamie,N., Segretain,D. and Pointis,G.
  TITLE     Opposite regulation of connexin33 and connexin43 by LPS and
            IL-1alpha in spermatogenesis
  JOURNAL   Am J Physiol Cell Physiol 290 (3), C733-C740 (2006)
   PUBMED   16236818
  REMARK    GeneRIF: Cx33 and Cx43 genes are controlled differently within the
            testis and suggest that these two Cxs may exert opposite and
            complementary effects on spermatogenesis.
REFERENCE   2  (bases 1 to 2053)
  AUTHORS   Fiorini,C., Mograbi,B., Cronier,L., Bourget,I., Decrouy,X.,
            Nebout,M., Ferrua,B., Malassine,A., Samson,M., Fenichel,P.,
            Segretain,D. and Pointis,G.
  TITLE     Dominant negative effect of connexin33 on gap junctional
            communication is mediated by connexin43 sequestration
  JOURNAL   J Cell Sci 117 (Pt 20), 4665-4672 (2004)
   PUBMED   15331631
  REMARK    GeneRIF: Data show that in the testis, connexin33 could exert a
            specific role on germ cell proliferation by suppressing the
            regulatory effect of connexin43.
REFERENCE   3  (bases 1 to 2053)
  AUTHORS   Haefliger,J.A., Bruzzone,R., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Paul,D.L.
  TITLE     Four novel members of the connexin family of gap junction proteins.
            Molecular cloning, expression, and chromosome mapping
  JOURNAL   J Biol Chem 267 (3), 2057-2064 (1992)
   PUBMED   1370487
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Sep 6, 2022 this sequence version replaced NM_019308.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.32513.1,
                                           SRR26360186.1532270.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               JAXUCZ010000021.1  37649393-37649492
            101-2053            JAXUCZ010000021.1  37652337-37654289
FEATURES             Location/Qualifiers
     source          1..2053
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq14"
     gene            1..2053
                     /gene="Gja6"
                     /gene_synonym="cx33; cxn-33; Cxnk2"
                     /note="gap junction protein, alpha 6"
                     /db_xref="GeneID:54256"
                     /db_xref="RGD:2693"
     exon            1..100
                     /gene="Gja6"
                     /gene_synonym="cx33; cxn-33; Cxnk2"
                     /inference="alignment:Splign:2.1.0"
     exon            101..2053
                     /gene="Gja6"
                     /gene_synonym="cx33; cxn-33; Cxnk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..1017
                     /gene="Gja6"
                     /gene_synonym="cx33; cxn-33; Cxnk2"
                     /note="gap junction membrane channel protein alpha 6;
                     connexin k2; connexin-33"
                     /codon_start=1
                     /product="gap junction alpha-6 protein"
                     /protein_id="NP_062181.1"
                     /db_xref="GeneID:54256"
                     /db_xref="RGD:2693"
                     /translation="MSDWSALHQLLEKVQPYSTAGGKVWIKVLFIFRILLLGTAIESA
                     WSDEQFEFHCNTQQPGCENVCYDQAFPISHVRLWVLQVIFVSVPTLLHLAHVYYVIRQ
                     NEKLKKQEEEELKVAHFNGASGERRLQKHTGKHIKCGSKEHGNRKMRGRLLLTYMASI
                     FFKSVFEVAFLLIQWYLYGFTLSAVYICEQSPCPHRVDCFLSRPTEKTIFILFMLVVS
                     MVSFVLNVIELFYVLFKAIKNHLGNEKEEVYCNPVELQKPSCVSSSAVLTTICSSDQV
                     VPVGLSSFYM"
ORIGIN      
        1 ctcttctcct tagagcgctc attccacaaa ctggtctcac ttagcacttg gcagatttat
       61 tttcattact aatattttac tctagagcct ttggccacag gcgtgcactc acttggtgtg
      121 cccacctttt aagtgcaaga acaacggaca ggcaacatga gtgattggag tgccttacac
      181 cagctcctag aaaaggttca accctactcc acagctggag gaaaggtatg gatcaaggtc
      241 cttttcattt tccgcatcct gctcctgggc actgctatcg agtcagcctg gagtgatgag
      301 cagtttgaat tccattgcaa cactcaacag cctggttgtg aaaatgtctg ctatgaccaa
      361 gccttcccaa tctctcacgt gcgcctctgg gtcctacagg tcatattcgt atctgtgcct
      421 acactcttac acctggcaca tgtgtactat gtgattcgac agaatgagaa gttgaagaag
      481 caagaggagg aggaacttaa agttgctcat tttaatgggg ccagtgggga aaggcgcttg
      541 cagaaacata caggaaagca tatcaagtgt ggcagtaaag aacatggtaa caggaaaatg
      601 agaggcagat tgctgctaac ctacatggcc agcatcttct tcaagtctgt cttcgaggtg
      661 gccttccttc tgatccagtg gtacctttat ggattcactc tgagtgccgt ttacatctgt
      721 gaacagtctc cttgcccaca tcgggtggac tgcttcctct ctcgccccac agaaaaaacc
      781 atcttcatcc tcttcatgtt ggtggtgtca atggtgtctt ttgtcttgaa tgtcatcgag
      841 ctgttctatg tcttatttaa ggctattaag aatcatctgg ggaatgagaa ggaggaagtt
      901 tactgtaatc cagttgagct acaaaaacct tcctgtgtct cttcgtcagc tgttctcacc
      961 accatatgtt ctagtgatca ggtagtcccg gtgggacttt cttccttcta tatgtaaaga
     1021 gaacagaacc atgtcagtta cagtgcatag tcaaaggggg aagggcaggc aggaagtatc
     1081 ctttctggct tgttctgagc cttttttccc cctctgtgat gataaacaga attcttagag
     1141 ggttttaggt agacagaaaa gcaaagcaag ggtactggac attaacattc tagaactatc
     1201 taacagaagc aatgactgag ttaacagcag cctgataacc tagactttgt gatttatgct
     1261 tgaaaacatt gtggaagtaa attatctttt ttttttggtt cttttttttc tggagctggg
     1321 gaccgaaccc agggccttgc gctttctagg taagcgctct accactgagc taaatcccca
     1381 gccccgtaaa ttatcttttc ccttaaaatg catcatccaa tttattgaat aatatgtaat
     1441 agttctgtta attgaaaaga gtatatattt ctcttataca ctatagcagt aatcccattg
     1501 ctgagataaa caacatattt tacttgttca aggtagagtc atacttaact ggatcagttg
     1561 tactgacaaa agcacttgga gagcactaca aacttaacga aatgcttaga ggtaaactct
     1621 gaaatgtgcc tacgtgaact tggcaatcat aggcactctc ggctttgttc tcagtaatgc
     1681 atattaattc agatcttaca ttctgcggtg agttttgcag tctcatggga tgactggcat
     1741 ttttcatgtt catattaaga ttttatttgg aaatcaggag agggtgaagg gggtttgtac
     1801 aattcctgtg taattggcct gaaacatatc aagaaagggt acccatttct tccaatgcct
     1861 tttaaaacat tccacaggtg gttgaaagtg ttgagctgca gactttcatt cttgtatgac
     1921 agcccccccc cacaatttta tacaagaaat gcttaccata tgatgttaag ctactgtcgt
     1981 gttcagcttc atttcatgca atgccagctt agtatatctt gtggagaatt ctttagtcaa
     2041 taaagccttt gga
//
