LOCUS       NM_019280               3115 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Rattus norvegicus gap junction protein, alpha 5 (Gja5), mRNA.
ACCESSION   NM_019280 XM_001063632
VERSION     NM_019280.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3115)
  AUTHORS   Ma,J., Ma,S., Yin,C. and Wu,H.
  TITLE     Shengmai San-derived herbal prevents the development of a
            vulnerable substrate for atrial fibrillation in a rat model of
            ischemic heart failure
  JOURNAL   Biomed Pharmacother 100, 156-167 (2018)
   PUBMED   29428663
REFERENCE   2  (bases 1 to 3115)
  AUTHORS   Zhou,H.S., Li,M., Sui,B.D., Wei,L., Hou,R., Chen,W.S., Li,Q.,
            Bi,S.H., Zhang,J.Z. and Yi,D.H.
  TITLE     Lipopolysaccharide impairs permeability of pulmonary microvascular
            endothelial cells via Connexin40
  JOURNAL   Microvasc Res 115, 58-67 (2018)
   PUBMED   28870649
  REMARK    GeneRIF: Lipopolysaccharide impairs permeability of pulmonary
            microvascular endothelial cells via Connexin40/protein kinase
            C/nfkappaB pathway.
REFERENCE   3  (bases 1 to 3115)
  AUTHORS   Kanthan,A., Fahmy,P., Rao,R., Pouliopoulos,J., Alexander,I.E.,
            Thomas,S.P. and Kizana,E.
  TITLE     Human Connexin40 Mutations Slow Conduction and Increase Propensity
            for Atrial Fibrillation
  JOURNAL   Heart Lung Circ 27 (1), 114-121 (2018)
   PUBMED   28457700
  REMARK    GeneRIF: The A96S, G38D, and P88S Cx40 mutations slow conduction
            and increased the propensity for inducible AF.
REFERENCE   4  (bases 1 to 3115)
  AUTHORS   Chen,W., Guo,Y., Yang,W., Zheng,P., Zeng,J. and Tong,W.
  TITLE     Connexin40 correlates with oxidative stress in brains of traumatic
            brain injury rats
  JOURNAL   Restor Neurol Neurosci 35 (2), 217-224 (2017)
   PUBMED   28157110
  REMARK    GeneRIF: This study demonstrated the Cx40 was upregulated after
            traumatic brain injury in a linear correlated manner with increased
            oxidative stress.
REFERENCE   5  (bases 1 to 3115)
  AUTHORS   Xu,Q., Lin,X., Matiukas,A., Zhang,X. and Veenstra,R.D.
  TITLE     Specificity of the connexin W3/4 locus for functional gap junction
            formation
  JOURNAL   Channels (Austin) 10 (6), 453-465 (2016)
   PUBMED   27304225
  REMARK    GeneRIF: data are consistent with contributions of G2 and D3
            residues to Cx40 channel pore structure, but not with postulated
            hydrophobic W4 intermolecular interactions; results indicate an
            absolute requirement for an amphipathic W3/4 residue; alternatively
            hypothesize that the connexin D2/3-W3/4 locus interacts with the
            highly conserved FIFR M1 motif to stabilize the NT domain within
            the pore
REFERENCE   6  (bases 1 to 3115)
  AUTHORS   Beblo,D.A., Wang,H.Z., Beyer,E.C., Westphale,E.M. and Veenstra,R.D.
  TITLE     Unique conductance, gating, and selective permeability properties
            of gap junction channels formed by connexin40
  JOURNAL   Circ Res 77 (4), 813-822 (1995)
   PUBMED   7554128
REFERENCE   7  (bases 1 to 3115)
  AUTHORS   Davis,L.M., Kanter,H.L., Beyer,E.C. and Saffitz,J.E.
  TITLE     Distinct gap junction protein phenotypes in cardiac tissues with
            disparate conduction properties
  JOURNAL   J Am Coll Cardiol 24 (4), 1124-1132 (1994)
   PUBMED   7930207
REFERENCE   8  (bases 1 to 3115)
  AUTHORS   Beyer,E.C., Reed,K.E., Westphale,E.M., Kanter,H.L. and Larson,D.M.
  TITLE     Molecular cloning and expression of rat connexin40, a gap junction
            protein expressed in vascular smooth muscle
  JOURNAL   J Membr Biol 127 (1), 69-76 (1992)
   PUBMED   1328644
REFERENCE   9  (bases 1 to 3115)
  AUTHORS   Kanter,H.L., Saffitz,J.E. and Beyer,E.C.
  TITLE     Cardiac myocytes express multiple gap junction proteins
  JOURNAL   Circ Res 70 (2), 438-444 (1992)
   PUBMED   1310450
REFERENCE   10 (bases 1 to 3115)
  AUTHORS   Haefliger,J.A., Bruzzone,R., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Paul,D.L.
  TITLE     Four novel members of the connexin family of gap junction proteins.
            Molecular cloning, expression, and chromosome mapping
  JOURNAL   J Biol Chem 267 (3), 2057-2064 (1992)
   PUBMED   1370487
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF021806.1.
            
            On Jun 25, 2006 this sequence version replaced XM_001063632.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF021806.1, CK365277.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3115
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..3115
                     /gene="Gja5"
                     /gene_synonym="Cx40; Cxni"
                     /note="gap junction protein, alpha 5"
                     /db_xref="GeneID:50563"
                     /db_xref="RGD:2692"
     exon            1..57
                     /gene="Gja5"
                     /gene_synonym="Cx40; Cxni"
                     /inference="alignment:Splign:2.1.0"
     exon            58..3099
                     /gene="Gja5"
                     /gene_synonym="Cx40; Cxni"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1161
                     /gene="Gja5"
                     /gene_synonym="Cx40; Cxni"
                     /note="connexin 40; connexin i; gap junction membrane
                     channel protein alpha 5"
                     /codon_start=1
                     /product="gap junction alpha-5 protein"
                     /protein_id="NP_062153.1"
                     /db_xref="GeneID:50563"
                     /db_xref="RGD:2692"
                     /translation="MGDWSFLGEFLEEVHKHSTVIGKVWLTVLFIFRMLVLGTAAESS
                     WGDEQADFRCDTIQPGCQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRM
                     QEKQKLREAEKAKEAGGTGTYEYLAEKAELSCWKEVNGKIVLQGTLLNTYVCTILIRT
                     AMEVAFMVGQYLLYGIFLDTLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMMAVAGLSL
                     FLSLAELYHLGWKKIRQRLAKSRQGDKHQLLGPSTSLVQGLTPPPDFNQCLKNSPDEK
                     FFSDFSNNMGSRKNPDPLATEEVPNQEQIPEEGFIHTQYGQKPEQPSGASAGHRFPQG
                     YHSDKRRLSKASSKARSDDLSV"
ORIGIN      
        1 gttgaacagc agccagagcc tgaagaagcc aactccaggg cggaggaaag gaagcagaag
       61 gctcagcacc agtctccaac acttggcaag atgggtgact ggagcttcct gggggagttc
      121 ctggaggagg tccacaagca ctctacggtc atcggcaagg tctggctcac cgtcctgttc
      181 attttccgca tgctggtcct cggcaccgct gctgagtcct cctggggaga tgagcaggct
      241 gatttccggt gtgataccat tcagcctggt tgccaaaatg tctgctacga ccaagccttc
      301 cccatctccc acattcgtta ctgggtactg cagatcatct ttgtgtccac accatctctg
      361 gtgtacatgg gccacgccat gcacactgtg cgcatgcagg aaaagcagaa gctgcgggag
      421 gctgagaaag ctaaagaggc cggtggcacc ggcacctatg agtacttggc ggagaaagcc
      481 gagctgtcct gctggaaaga ggtgaacggg aagattgtcc tccagggcac cctactcaac
      541 acctatgtct gcaccattct catccgcacc gctatggagg tggccttcat ggtgggccag
      601 tacctcctct atgggatctt cctggacacc ctgcatgtct gccgcagaag tccctgtccc
      661 caccccgtca actgttatgt ctcgaggccc acagagaaga acgtcttcat tgtctttatg
      721 atggctgtgg ctggactgtc tctgtttctc agcctggctg aactctacca cctgggctgg
      781 aagaagatcc gacagcgcct ggccaagtca cggcagggtg acaagcacca gcttcttggc
      841 ccctccacca gcctggtcca gggcctcact cctcctcctg acttcaacca gtgcctaaag
      901 aacagcccag atgagaaatt cttcagtgac ttcagtaata acatgggctc ccggaagaat
      961 ccagaccctc tggccactga ggaagtgcca aaccaggagc agatcccgga ggaaggtttc
     1021 atccacacac agtatggcca gaagcccgag cagcccagtg gcgcctctgc aggccaccgc
     1081 tttcctcagg gctaccacag tgacaagcgc cgccttagta aggccagcag caaagcaagg
     1141 tcagatgacc tgtcagtgtg accctcctct tagggaggac cagtcccaga aggaagccaa
     1201 ggagggtgag gcaggacaga agcggtctct ctgactgtat accttcctca gcaccttctc
     1261 tcccgggtct ggatggtgtt gctcattaat cctccaaatt tcagttctga gccgtattct
     1321 caaagattgg gctactcctc aaatccccaa ccccacatcc tctaccagta ttcgcagtga
     1381 agactttcaa gtgatttagt gatatggtgg gagcaggaat gggaaccttg gcaaaatctg
     1441 gtctgggtag gacagacatg aagattcgac attagcaaca gataaaccct caccccaaat
     1501 cttgtcttct tcggtactag gcccatcctt tttatttttt aaaggaagaa tccaaggttg
     1561 agagtattca tcaaataatc tgcattgtat tgttcctttg aatctgtcgt ttccatgtgc
     1621 catacctcag agtgctggtg aggtaactgt gggttgccct tggctgcatc tccctcctcc
     1681 cagtcttaaa ggggtgtcct tggtcctcgg ccagcatcag ctttacaagt gccttggtat
     1741 gtgcctttgg aaaacactgc atgttgatga tgctgcagcc ttactgccag gctagacacc
     1801 cagctcagaa gggtgccaag acctctagaa gtcactgtgc acataagcat tgctggaatt
     1861 gccaccagct gtcatcctgc agtcctttac agttcaacct agtgatagaa accgtcctgg
     1921 acagctcacc cagtgttcct ctaaaatctt ggttaacagg aatgtccaaa gtcaccatcc
     1981 tctcttggac cctggccaga ttaccagcca ccaagttcag tggaatttcc ccaggattta
     2041 atgaaacaaa gagagcattg tgcttctcag gttccttggg gggtgttggg ggggattctt
     2101 ctgtggagat gaaaagagag gagggggagg acactggaaa actattttcc cttctgcata
     2161 tgccttccac tgcctcccag cttggactgc tgagaggtgt ggtgatagat agcaacggag
     2221 gcccaagatc tctctcttag aggcatcaag gggacctgga agccgagatg gagctccggt
     2281 tggttttgac acggccctta tttagtgcag atgctcctgt gtttccttgg gacccttagg
     2341 tacatcaggg agggactgta gaaaattcct gccttcctca gggtctatcc tgggctatct
     2401 actgagagga tccacagtcg gtgtctctcc ttatgcagat ggaaagatgc tcagcgtcag
     2461 atatcaagac ttacaaacac aatgctctgt gtgtgtgtgt gtgtgtgcat gtgtgtgtat
     2521 gagtgtgtgc atactcaacc atctatgtgt gtatatgtgt gtgtgtgcat gctcaaccat
     2581 ctgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtataccc gtgtatgcat
     2641 gcagatagaa tggtaaagaa gagccctgaa gaactgtaag gaaacatgta gaaaacttgg
     2701 gtttttctgc ctccttttct gttgcccgac aggacagctg agcttgcttc ctaatcagcc
     2761 taaaggtcaa acctgggaag tcagtacagg agggtgaagg ttcagaggtc aacccctgcc
     2821 catgtgacca tctctgggtc cctctgctgg tatttggatg gctgaagata cttgggaaag
     2881 gctgactggc tgtcccagcc ccagtgtatc tcattcattc ctgacaccga cgctatgatt
     2941 ctctgctttt ctagttatgg gatgtgtgtt tgtcttctga aatggggcct tttgagttag
     3001 aaaatctgag accagtcttc gatggtgagg tttttcagaa gagaaagaga aagtaatatg
     3061 tgtgactggt tttaaataaa atacgtctct acatgttaaa aaaaaaaaaa aaaaa
//
